Free for academic non-profit institutions. Other users need a Commercial license
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptos... See more...
Aliases for CASP8AP2 Gene
Aliases for CASP8AP2 Gene
External Ids for CASP8AP2 Gene
- HGNC: 1510
- NCBI Entrez Gene: 9994
- Ensembl: ENSG00000118412
- OMIM®: 606880
- UniProtKB/Swiss-Prot: Q9UKL3
Previous GeneCards Identifiers for CASP8AP2 Gene
- GC06P090485
- GC06P090535
- GC06P090597
- GC06P090601
- GC06P090539
- GC06P087756
Summaries for CASP8AP2 Gene
-
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
GeneCards Summary for CASP8AP2 Gene
CASP8AP2 (Caspase 8 Associated Protein 2) is a Protein Coding gene. Among its related pathways are Apoptosis and survival Caspase cascade and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding.
UniProtKB/Swiss-Prot Summary for CASP8AP2 Gene
-
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Additional gene information for CASP8AP2 Gene
- HGNC (1510)
- NCBI Entrez Gene (9994)
- Ensembl (ENSG00000118412)
- OMIM® (606880)
- UniProtKB/Swiss-Prot (Q9UKL3)
- Open Targets Platform(ENSG00000118412)
- Alliance of Genome Resources
- Search for CASP8AP2 at DataMed
- Search for CASP8AP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASP8AP2 Gene
Genomics for CASP8AP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CASP8AP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CASP8AP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CASP8AP2
- Top Transcription factor binding sites by QIAGEN in the CASP8AP2 gene promoter:
-
- Arnt
- HNF-1
- HNF-1A
- ITF-2
- Nkx5-1
- Roaz
- Tal-1beta
- TGIF
Genomic Locations for CASP8AP2 Gene
Latest Assembly
- chr6:89,829,880-89,874,436
- (GRCh38/hg38)
- Size:
- 44,557 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:90,539,599-90,584,155
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 44,557 bases
- Orientation:
- Plus strand
Alternative Locations (GRCh38/hg38)
- chr6(PATCHES):25,225-72,124 (+)
Genomic View for CASP8AP2 Gene
Genes around CASP8AP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q15 by HGNC
- 6q15 by Entrez Gene
- 6q15 by Ensembl
CASP8AP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CASP8AP2 Gene
Proteins for CASP8AP2 Gene
-
Protein details for CASP8AP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKL3-C8AP2_HUMAN
- Recommended name:
- CASP8-associated protein 2
- Protein Accession:
- Q9UKL3
- A2RUB7
- E1P553
- Q6PH76
- Q7LCQ7
- Q86YD9
- Q9NUQ4
- Q9NZV9
- Q9P2N1
- Q9Y563
Protein attributes for CASP8AP2 Gene
- Size:
- 1982 amino acids
- Molecular mass:
- 222658 Da
- Quaternary structure:
-
- Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with NCOA2 and NCOA3. Interacts with SRRT. Interacts with TRAF2. Interacts with NPAT. Interacts (via SIM domains) with SUMO1 and SUMO2. Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm.
- SequenceCaution:
-
- Sequence=AAH56685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 364.; Evidence={ECO:0000305}; Sequence=BAA92067.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for CASP8AP2 Gene
Post-translational modifications for CASP8AP2 Gene
Other Protein References for CASP8AP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CASP8AP2 / FLASH Antibody (LS-B206) and CASP8AP2 / FLASH Antibody (LS-B198)
- Novus Biologicals Antibodies for CASP8AP2
-
Abcam antibodies for CASP8AP2
- Invitrogen Antibodies for CASP8AP2 (AFLGC-CASP8AP2)
-
Boster Bio Antibodies for CASP8AP2
-
Custom Antibody ServicesProSci Antibodies for CASP8AP2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CASP8AP2
- Origene Custom Protein Services for CASP8AP2
- Novus Biologicals proteins for CASP8AP2
-
Abcam proteins for CASP8AP2
Assay products for research
No data available for DME Specific Peptides for CASP8AP2 Gene
Domains & Families for CASP8AP2 Gene
Gene Families for CASP8AP2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CASP8AP2 Gene
- InterPro:
Suggested Antigen Peptide Sequences for CASP8AP2 Gene
- GenScript: Design optimal peptide antigens:
-
- CASP8AP2 protein (A7E2C0_HUMAN)
- FLICE-associated huge protein (C8AP2_HUMAN)
- CASP8 associated protein 2 (Q5T791_HUMAN)
- CASP8 associated protein 2 (Q5T792_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CASP8AP2 Gene
Function for CASP8AP2 Gene
Molecular function for CASP8AP2 Gene
- UniProtKB/Swiss-Prot Function:
- Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
- UniProtKB/Swiss-Prot Induction:
- By TNF which induces strong nuclear localization.
Phenotypes From GWAS Catalog for CASP8AP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | IDA, IBA | 12477726 |
| GO:0005123 | death receptor binding | TAS | 10235259 |
| GO:0005515 | protein binding | IPI | 12477726 |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | ISS | -- |
| GO:0016505 | peptidase activator activity involved in apoptotic process | ISS | -- |
Phenotypes for CASP8AP2 Gene
- MGI mutant phenotypes for CASP8AP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CASP8AP2:
-
- Decreased NF-kappaB reporter expression
- Decreased viability
- no effect
- Decreased viability ratio
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased ionizing radiation sensitivity
- Increased IL-8 secretion
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability (cell death)
- FOXO1 nuclear localization
- Increased HPV18 LCR reporter activity
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability in colon lineage
- Increased gamma-H2AX phosphorylation
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after ionizing radiation
- S arrest
- Lethal upon entry into mitosis
- Increased S DNA content, increased G2M DNA content
Animal Models for research
-
Taconic Biosciences Mouse Models for CASP8AP2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CASP8AP2 - Starting at $85 >
- * CASP8AP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CASP8AP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CASP8AP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CASP8AP2
miRNA for CASP8AP2 Gene
- miRTarBase miRNAs that target CASP8AP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CASP8AP2
- Browse OriGene Inhibitory RNA Products For CASP8AP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CASP8AP2
Clone products for research
- Applied Biological Materials (abm): Clones for CASP8AP2 - Starting at $45 >
- * CASP8AP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CASP8AP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CASP8AP2
Cell Lines for research
-
Horizon Cell Lines for CASP8AP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASP8AP2 Gene
Localization for CASP8AP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CASP8AP2 Gene
- Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | 19721136 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,ISS | 19721136 |
| GO:0005739 | mitochondrion | IDA, IBA | 17245429 |
| GO:0016605 | PML body | IDA, IBA | 17245429 |
Pathways & Interactions for CASP8AP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
Apoptosis and survival TNFR1 signaling pathway
.52
|
Fas Signaling
.35
|
| 2 | Apoptosis and survival Caspase cascade |
Apoptosis and survival FAS signaling cascades
.44
|
|
Pathways by source for CASP8AP2 Gene
2 GeneGo (Thomson Reuters) pathways for CASP8AP2 Gene
- Apoptosis and survival FAS signaling cascades
- Apoptosis and survival TNFR1 signaling pathway
1 Qiagen pathway for CASP8AP2 Gene
- Fas Signaling
Interacting Proteins for CASP8AP2 Gene
Selected Interacting proteins:
Q9UKL3-C8AP2_HUMAN
ENSP00000478179
for CASP8AP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CASP8AP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP, ISS, IBA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007165 | signal transduction | TAS | 10235259 |
| GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | IMP, ISS, IBA | -- |
| GO:0036337 | Fas signaling pathway | IMP, IBA | 17245429 |
Transcripts for CASP8AP2 Gene
mRNA/cDNA for CASP8AP2 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000237177 6719 nts (view in UCSC)
- ENST00000419040 1280 nts (view in UCSC)
- ENST00000547893 2003 nts (view in UCSC)
- ENST00000548224 1300 nts (view in UCSC)
- ENST00000551025 6088 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CASP8AP2 - Starting at $85 >
- * CASP8AP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CASP8AP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CASP8AP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CASP8AP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CASP8AP2
- Browse OriGene Inhibitory RNA Products For CASP8AP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CASP8AP2
Clone products for research
- Applied Biological Materials (abm): Clones for CASP8AP2 - Starting at $45 >
- * CASP8AP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CASP8AP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CASP8AP2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: |
Relevant External Links for CASP8AP2 Gene
- GeneLoc Exon Structure for
- CASP8AP2
Expression for CASP8AP2 Gene
This gene is overexpressed in Bone (36.2), Pancreas (8.8), and Plasma (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CASP8AP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASP8AP2
SOURCE GeneReport for Unigene cluster for CASP8AP2 Gene:
Hs.558218Evidence on tissue expression from TISSUES for CASP8AP2 Gene
- Blood(4.3)
Primer products for research
-
OriGene qPCR primer pairs for CASP8AP2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP8AP2 Gene
Orthologs for CASP8AP2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CASP8AP2 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | CASP8AP2 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | CASP8AP2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Casp8ap2 29 16 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Casp8ap2 29 |
|
- Species where no ortholog for CASP8AP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CASP8AP2 Gene
- ENSEMBL:
- Gene Tree for CASP8AP2 (if available)
- TreeFam:
- Gene Tree for CASP8AP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CASP8AP2: view image
- Alliance of Genome Resources:
- Additional Orthologs for CASP8AP2
Paralogs for CASP8AP2 Gene
No data available for Paralogs for CASP8AP2 Gene
Variants for CASP8AP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CASP8AP2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3799896 | -- |
p.Pro1659Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2732412 | CNV | deletion | 23290073 |
| esv3890901 | CNV | gain | 25118596 |
| esv997597 | CNV | insertion | 20482838 |
| nsv1128266 | CNV | deletion | 24896259 |
| nsv480276 | CNV | novel sequence insertion | 20440878 |
| nsv512888 | CNV | insertion | 21212237 |
| nsv5391 | CNV | insertion | 18451855 |
| nsv604125 | CNV | gain | 21841781 |
Additional Variant Information for CASP8AP2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASP8AP2 Gene
Disorders for CASP8AP2 Gene
Additional Disease Information for CASP8AP2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for CASP8AP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASP8AP2 Gene
Publications for CASP8AP2 Gene
- FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. (PMID: 17245429) Milovic-Holm K … Hofmann TG (The EMBO journal 2007) 2 3 4 22
- FLASH is required for histone transcription and S-phase progression. (PMID: 17003125) Barcaroli D … De Laurenzi V (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22
- FLASH is an essential component of Cajal bodies. (PMID: 17003126) Barcaroli D … De Laurenzi V (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 22
- Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. (PMID: 23086935) Sun H … Hunter T (The Journal of biological chemistry 2012) 3 4
- Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PMID: 19546234) Kiriyama M … Yonehara S (Molecular and cellular biology 2009) 3 4
ExternalLinks
Products for CASP8AP2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CASP8AP2
- Origene Custom Protein Services for CASP8AP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CASP8AP2
- Browse OriGene Inhibitory RNA Products For CASP8AP2
- OriGene qPCR primer pairs for CASP8AP2
- OriGene CRISPR knockouts for CASP8AP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CASP8AP2
- Sino Biological Human cDNA Clone for CASP8AP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CASP8AP2
- Novus Biologicals proteins for CASP8AP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CASP8AP2
- Abcam proteins for CASP8AP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for CASP8AP2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CASP8AP2 (AFLGC-CASP8AP2)
- VectorBuilder Custom and pre-made DNA vectors for CASP8AP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CASP8AP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CASP8AP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CASP8AP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CASP8AP2
- antibodies-online: Show 11 available FLASH Antibodies ranked by validation data
- Compare Top FLASH Antibodies
- antibodies-online: Show 11 available FLASH Elisa Kits ranked by validation data
- Compare Top FLASH Elisa Kits
- antibodies-online: Search results for available FLASH related products ranked by validation data
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for CASP8AP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CASP8AP2
- Horizon Cell Lines for CASP8AP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CASP8AP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CASP8AP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CASP8AP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CASP8AP2
- Boster Bio Antibodies for CASP8AP2
- Browse Boster Bio ELISA Kits
Sources for CASP8AP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources