This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active en... See more...

Aliases for CASP6 Gene

Aliases for CASP6 Gene

  • Caspase 6 2 3 5
  • Caspase 6, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 6, Apoptosis-Related Cysteine Protease 2 3
  • EC 3.4.22.59 4 52
  • Caspase-6 3 4
  • MCH2 3 4
  • Apoptotic Protease MCH-2 3
  • Apoptotic Protease Mch-2 4
  • EC 3.4.22 52
  • CASP-6 4

External Ids for CASP6 Gene

Previous GeneCards Identifiers for CASP6 Gene

  • GC04M111026
  • GC04M110880
  • GC04M111068
  • GC04M110967
  • GC04M110829
  • GC04M110609
  • GC04M106342

Summaries for CASP6 Gene

Entrez Gene Summary for CASP6 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]

GeneCards Summary for CASP6 Gene

CASP6 (Caspase 6) is a Protein Coding gene. Diseases associated with CASP6 include Thoracic Cancer and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Direct p53 effectors and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include identical protein binding and cysteine-type peptidase activity. An important paralog of this gene is CASP3.

UniProtKB/Swiss-Prot Summary for CASP6 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

Tocris Summary for CASP6 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP6 Gene

Additional gene information for CASP6 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASP6 Gene

Genomics for CASP6 Gene

GeneHancer (GH) Regulatory Elements for CASP6 Gene

Promoters and enhancers for CASP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J109701 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 504.6 +10.9 10882 3.6 ZBTB40 ZNF217 EP300 CTCF MYC POLR2G USF1 ZFX ZBTB5 ZIC2 CASP6 PLA2G12A RBMXP4 LRIT3 RF00994-756 ENSG00000273447
GH04J109713 Enhancer 0.3 dbSUPER 500.7 -0.1 -85 1.8 HLF CASP6 lnc-CASP6-1 CFI lnc-CASP6-2 PLA2G12A ENSG00000285330
GH04J109727 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 -15.8 -15849 4.2 SIN3A NRF1 MYC USF1 POLR2G ZFX ZIC2 POLR2A ZBTB10 AFF1 PLA2G12A SEC24B SETP20 CDC42P4 CFI GAR1 CASP6 lnc-CASP6-2 ENSG00000285330 lnc-PLA2G12A-1
GH04J109589 Enhancer 0.8 Ensembl ENCODE 6.4 +124.3 124303 4.8 ELF1 BATF GATA3 POU2F2 ZNF574 TBX21 NFIC SMARCE1 BCL6B FOS CASP6 PLA2G12A piR-54764-496 piR-55238 MCUB lnc-CASP6-4
GH04J109631 Enhancer 0.6 Ensembl 5.9 +82.5 82503 1.6 ZNF341 OSR2 FOXA2 ZBTB17 ZNF335 PRDM6 ZNF366 SREBF1 FOXA1 NR3C1 CASP6 lnc-CASP6-4 piR-36393-395 MCUB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CASP6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CASP6

Top Transcription factor binding sites by QIAGEN in the CASP6 gene promoter:
  • AML1a
  • FOXF2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • PPAR-alpha

Genomic Locations for CASP6 Gene

Genomic Locations for CASP6 Gene
chr4:109,688,622-109,713,904
(GRCh38/hg38)
Size:
25,283 bases
Orientation:
Minus strand
chr4:110,609,785-110,624,739
(GRCh37/hg19)
Size:
14,955 bases
Orientation:
Minus strand

Genomic View for CASP6 Gene

Genes around CASP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP6 Gene

Proteins for CASP6 Gene

  • Protein details for CASP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55212-CASP6_HUMAN
    Recommended name:
    Caspase-6
    Protein Accession:
    P55212
    Secondary Accessions:
    • Q9BQE7

    Protein attributes for CASP6 Gene

    Size:
    293 amino acids
    Molecular mass:
    33310 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for CASP6 Gene

    Alternative splice isoforms for CASP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASP6 Gene

Selected DME Specific Peptides for CASP6 Gene

P55212:
  • CVFLSHGEGNH
  • GSSLEFTELLTLVNRKVSQRRVDFC
  • IIQACRG
  • ALIFNHE
  • LVGKPKIF
  • SLVGKPKIFIIQACRG
  • AIGKKQVPCFASMLTKKLHF

Post-translational modifications for CASP6 Gene

  • Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASP6 Gene

Antibody Products

Domains & Families for CASP6 Gene

Gene Families for CASP6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CASP6 Gene

Blocks:
  • Caspase-1, p20
  • Interleukin-1B converting enzyme signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CASP6 Gene

GenScript: Design optimal peptide antigens:
  • Apoptotic protease Mch-2 (CASP6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55212

UniProtKB/Swiss-Prot:

CASP6_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP6: view

Function for CASP6 Gene

Molecular function for CASP6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp- -.; EC=3.4.22.59;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation is suppressed by phosphorylation at Ser-257.
GENATLAS Biochemistry:
caspase 6,effector,cysteine containing aspartate-specific protease,CASP3 subfamily,with two isoforms alpha and beta,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis

Enzyme Numbers (IUBMB) for CASP6 Gene

Phenotypes From GWAS Catalog for CASP6 Gene

Gene Ontology (GO) - Molecular Function for CASP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12888622
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA,TAS 7796396
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CASP6: view
genes like me logo Genes that share phenotypes with CASP6: view

Animal Models for CASP6 Gene

MGI Knock Outs for CASP6:

Animal Model Products

  • Taconic Biosciences Mouse Models for CASP6

CRISPR Products

miRNA for CASP6 Gene

miRTarBase miRNAs that target CASP6

Clone Products

  • Addgene plasmids for CASP6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASP6 Gene

Localization for CASP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP6 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CASP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CASP6: view

Pathways & Interactions for CASP6 Gene

PathCards logo

SuperPathways for CASP6 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
.87
.87
.56
.55
.52
.46
.42
2 Apoptosis Modulation and Signaling
.41
.31
3 Apoptosis and survival Caspase cascade
.44
.44
4 p53 Signaling
.44
5 TRAF Pathway
.42
.42
.33
genes like me logo Genes that share pathways with CASP6: view

Pathways by source for CASP6 Gene

1 KEGG pathway for CASP6 Gene
3 GeneGo (Thomson Reuters) pathways for CASP6 Gene
  • Apoptosis and survival Caspase cascade
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival TNFR1 signaling pathway
1 R&D Systems pathway for CASP6 Gene
2 Tocris pathways for CASP6 Gene
24 Qiagen pathways for CASP6 Gene
  • 14-3-3 Induced Apoptosis
  • Apoptotic Pathways Triggered By HIV1
  • Caspase Cascade
  • Ceramide Pathway
  • CTL Mediated Apoptosis
1 Cell Signaling Technology pathway for CASP6 Gene
1 GeneTex pathway for CASP6 Gene

SIGNOR curated interactions for CASP6 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CASP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA,IEA 12888622
GO:0006915 apoptotic process IBA,IEA 21873635
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0042981 regulation of apoptotic process TAS --
GO:0072734 cellular response to staurosporine IMP 22253444
genes like me logo Genes that share ontologies with CASP6: view

Drugs & Compounds for CASP6 Gene

(18) Drugs for CASP6 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3311
Z-VEID-FMK Pharma Inhibition, Inhibitor Caspase-6 inhibitor 0
Apoptosis Activator 2 Pharma Indoledione caspase activator, cell-permeable, Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis 0
Z-DEVD-FMK Pharma Inhibition, Inhibitor Caspase-3 inhibitor 0
PETCM Pharma Activator Caspase-3 activator, Activator of caspase-3 0

(7) Additional Compounds for CASP6 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PAC 1
315183-21-2

(4) Tocris Compounds for CASP6 Gene

Compound Action Cas Number
Apoptosis Activator 2 Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis 79183-19-0
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 15663-27-1
PAC 1 Activator of procaspase-3; pro-apoptotic 315183-21-2
PETCM Activator of caspase-3 10129-56-3

(3) ApexBio Compounds for CASP6 Gene

Compound Action Cas Number
Apoptosis Activator 2 Indoledione caspase activator, cell-permeable 79183-19-0
Z-DEVD-FMK Caspase-3 inhibitor 210344-95-9
Z-VEID-FMK Caspase-6 inhibitor
genes like me logo Genes that share compounds with CASP6: view

Drug Products

Transcripts for CASP6 Gene

mRNA/cDNA for CASP6 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CASP6

Alternative Splicing Database (ASD) splice patterns (SP) for CASP6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - - - - -

Relevant External Links for CASP6 Gene

GeneLoc Exon Structure for
CASP6

Expression for CASP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP6 Gene

This gene is overexpressed in Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for CASP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.7), Lymph node (9.4), and Fetal gut (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CASP6 Gene



Protein tissue co-expression partners for CASP6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASP6

SOURCE GeneReport for Unigene cluster for CASP6 Gene:

Hs.654616

Evidence on tissue expression from TISSUES for CASP6 Gene

  • Blood(4.4)
  • Lung(4.3)
  • Intestine(2.7)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with CASP6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP6 Gene

Orthologs for CASP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP6 30
  • 96.79 (n)
dog
(Canis familiaris)
Mammalia CASP6 31 30
  • 88.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CASP6 31 30
  • 86.3 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp6 30
  • 84.73 (n)
mouse
(Mus musculus)
Mammalia Casp6 17 31 30
  • 84.43 (n)
oppossum
(Monodelphis domestica)
Mammalia CASP6 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP6 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP6 31 30
  • 72.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP6 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp6 30
  • 67.16 (n)
Str.15354 30
African clawed frog
(Xenopus laevis)
Amphibia xCaspase-6 30
zebrafish
(Danio rerio)
Actinopterygii casp6 31 30
  • 67.04 (n)
OneToMany
casp6l2 31
  • 52 (a)
OneToMany
casp6l1 31
  • 33 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.144 30
fruit fly
(Drosophila melanogaster)
Insecta Ice 31 32
  • 31 (a)
ManyToMany
Dcp-1 31 32
  • 31 (a)
ManyToMany
decay 31 32
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6562 31
  • 34 (a)
OneToOne
Cin.7590 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7590 30
Species where no ortholog for CASP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP6 Gene

ENSEMBL:
Gene Tree for CASP6 (if available)
TreeFam:
Gene Tree for CASP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CASP6: view image

Paralogs for CASP6 Gene

(4) SIMAP similar genes for CASP6 Gene using alignment to 3 proteins:

  • CASP6_HUMAN
  • D6RBM3_HUMAN
  • D6RHU3_HUMAN
genes like me logo Genes that share paralogs with CASP6: view

Variants for CASP6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CASP6 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11574697 - p.Glu35Lys
rs5030593 - p.Thr182Ser
rs5030674 - p.Ala109Thr

Additional dbSNP identifiers (rs#s) for CASP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for CASP6 Gene

Variant ID Type Subtype PubMed ID
nsv1123829 CNV deletion 24896259
nsv595142 CNV loss 21841781

Variation tolerance for CASP6 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CASP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP6 Gene

Disorders for CASP6 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CASP6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thoracic cancer
  • thoracic tumor
cardiomyopathy, familial hypertrophic, 1
  • fhc
dystrophinopathies
  • dystrophinopathy
coronavirus infection
  • coronavirus infections
huntington disease
  • hd
- elite association - COSMIC cancer census association via MalaCards
Search CASP6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CASP6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CASP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP6 Gene

Publications for CASP6 Gene

  1. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. (PMID: 7796396) Fernandes-Alnemri T … Alnemri ES (Cancer research 1995) 2 3 4 23 54
  2. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. (PMID: 15273717) Suzuki A … Esumi H (Oncogene 2004) 3 4 23 54
  3. Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. (PMID: 8780721) Tiso N … Danieli GA (Biochemical and biophysical research communications 1996) 2 3 23 54
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 41 54
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41 54

Products for CASP6 Gene

  • Addgene plasmids for CASP6

Sources for CASP6 Gene