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Aliases for CASP5 Gene

Aliases for CASP5 Gene

  • Caspase 5 2 3 5
  • Caspase 5, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 5, Apoptosis-Related Cysteine Protease 2 3
  • Protease ICH-3 3 4
  • Protease TY 3 4
  • ICE(Rel)-III 4
  • EC 3.4.22.58 4
  • TY Protease 3
  • ICE(Rel)III 3
  • ICEREL-III 3
  • Caspase-5 3
  • EC 3.4.22 56
  • CASP-5 4
  • ICH-3 3
  • ICH3 4

External Ids for CASP5 Gene

Previous GeneCards Identifiers for CASP5 Gene

  • GC11M107058
  • GC11M106221
  • GC11M104899
  • GC11M104402
  • GC11M104370
  • GC11M104864
  • GC11M100795

Summaries for CASP5 Gene

Entrez Gene Summary for CASP5 Gene

  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CASP5 Gene

CASP5 (Caspase 5) is a Protein Coding gene. Diseases associated with CASP5 include Cowpox. Among its related pathways are Toll-like receptor signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and scaffold protein binding. An important paralog of this gene is CASP4.

UniProtKB/Swiss-Prot for CASP5 Gene

  • Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts MB21D1 and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).

Tocris Summary for CASP5 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Additional gene information for CASP5 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASP5 Gene

Genomics for CASP5 Gene

GeneHancer (GH) Regulatory Elements for CASP5 Gene

Promoters and enhancers for CASP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I105022 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -246 2.2 EBF1 CEBPG CASP5 CARD16 CASP1
GH11I105032 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 -11.1 -11102 3.7 TAF1 MAX CEBPG BATF RAD21 YY1 POLR2A IKZF2 CEBPB JUNB CASP1 CARD17 CASP4 CASP5 CARD16 CASP1P2
GH11I105043 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 -22.8 -22758 4.8 FOXA2 MLX ARID4B DMAP1 BRCA1 ETS1 YY1 FOS SP5 ZHX2 CARD16 CASP5 CARD17 CASP1 CASP1P2
GH11I104965 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 11.8 +55.5 55484 4.9 ELF3 ARID4B BRCA1 ZNF48 RAD21 YY1 ETV6 IKZF2 THAP11 MIXL1 CASP4 LOC643733 CASP5 CASP12 CARD17 CARD16
GH11I105000 Enhancer 0.6 ENCODE 12.3 +22.2 22222 0.2 CTCF TRIM22 MAX IRF4 RAD21 TARDBP ZNF143 MYC CASP5 CASP1 ENSG00000284715
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CASP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CASP5 gene promoter:

Genomic Locations for CASP5 Gene

Genomic Locations for CASP5 Gene
chr11:104,992,633-105,023,221
(GRCh38/hg38)
Size:
30,589 bases
Orientation:
Minus strand
chr11:104,864,962-104,893,895
(GRCh37/hg19)

Genomic View for CASP5 Gene

Genes around CASP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP5 Gene

Proteins for CASP5 Gene

  • Protein details for CASP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51878-CASP5_HUMAN
    Recommended name:
    Caspase-5
    Protein Accession:
    P51878
    Secondary Accessions:
    • B4DKP5
    • Q0QVY7
    • Q0QVY8
    • Q0QVZ0
    • Q0QVZ1
    • Q0QVZ2
    • Q14DD6
    • Q1HBJ3
    • Q6DJV7

    Protein attributes for CASP5 Gene

    Size:
    434 amino acids
    Molecular mass:
    49736 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.
    SequenceCaution:
    • Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI13407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABF47103.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG59257.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=CAA64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CASP5 Gene

neXtProt entry for CASP5 Gene

Selected DME Specific Peptides for CASP5 Gene

P51878:
  • SSTPHNVSWR
  • LITCFQKY
  • DKPKVII
  • SDSTFLV
  • EKDFIAFCSSTP
  • QMPTIER

Post-translational modifications for CASP5 Gene

  • The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CASP5 Gene

Gene Families for CASP5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CASP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51878

UniProtKB/Swiss-Prot:

CASP5_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP5: view

Function for CASP5 Gene

Molecular function for CASP5 Gene

GENATLAS Biochemistry:
caspase 5,cysteine containing aspartate-specific protease,CASP1 subfamily,potentially involved in procytokine activation,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting apoptosis,target gene in the microsatellite mutator pathway for cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp- - but also cleaves at Asp-Glu-Val-Asp- -.
UniProtKB/Swiss-Prot Function:
Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts MB21D1 and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharides (LPS).

Enzyme Numbers (IUBMB) for CASP5 Gene

Gene Ontology (GO) - Molecular Function for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 16920334
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity TAS 7797592
GO:0016787 hydrolase activity IEA --
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA --
genes like me logo Genes that share ontologies with CASP5: view
genes like me logo Genes that share phenotypes with CASP5: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASP5 Gene

Localization for CASP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP5 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072557 NOT IPAF inflammasome complex IBA --
GO:0072558 NLRP1 inflammasome complex IDA 12191486
GO:0072559 NOT NLRP3 inflammasome complex IBA --
GO:0097169 NOT AIM2 inflammasome complex IBA --
genes like me logo Genes that share ontologies with CASP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CASP5 Gene

Pathways & Interactions for CASP5 Gene

genes like me logo Genes that share pathways with CASP5: view

Pathways by source for CASP5 Gene

3 Sino Biological pathways for CASP5 Gene
1 GeneTex pathway for CASP5 Gene
1 BioSystems pathway for CASP5 Gene
1 KEGG pathway for CASP5 Gene
1 R&D Systems pathway for CASP5 Gene
1 Cell Signaling Technology pathway for CASP5 Gene

Gene Ontology (GO) - Biological Process for CASP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS,IEA --
GO:0006915 apoptotic process TAS 7797592
GO:0021762 substantia nigra development IEP,HEP 22926577
GO:0042981 regulation of apoptotic process IEA --
GO:0050727 regulation of inflammatory response IBA --
genes like me logo Genes that share ontologies with CASP5: view

No data available for SIGNOR curated interactions for CASP5 Gene

Drugs & Compounds for CASP5 Gene

(8) Drugs for CASP5 Gene - From: ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Z-WEHD-FMK Pharma Inhibition, Inhibitor Caspase 5 inhibitor,potent,cell-permeable and irreversible 0
Caspase Inhibitor Set I Pharma Caspase Inhibitors 0
Q-VD(OMe)-OPh Pharma Pan-caspase inhibitor 0
Z-FA-FMK Pharma Cysteine proteases inhibitor 0
z-VAD-fmk Pharma Cell-permeable, irreversible pan-caspase inhibitor 0

(2) Additional Compounds for CASP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for CASP5 Gene

Compound Action Cas Number
Apoptosis Activator 2 Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis 79183-19-0
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 15663-27-1
PAC 1 Activator of procaspase-3; pro-apoptotic 315183-21-2
PETCM Activator of caspase-3 10129-56-3

(5) ApexBio Compounds for CASP5 Gene

Compound Action Cas Number
Caspase Inhibitor Set I Caspase Inhibitors
Q-VD(OMe)-OPh Pan-caspase inhibitor
Z-FA-FMK Cysteine proteases inhibitor
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2
Z-WEHD-FMK Caspase 5 inhibitor,potent,cell-permeable and irreversible 210345-00-9
genes like me logo Genes that share compounds with CASP5: view

Drug Products

Transcripts for CASP5 Gene

mRNA/cDNA for CASP5 Gene

Unigene Clusters for CASP5 Gene

Caspase 5, apoptosis-related cysteine peptidase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP5 Gene

No ASD Table

Relevant External Links for CASP5 Gene

GeneLoc Exon Structure for
CASP5
ECgene alternative splicing isoforms for
CASP5

Expression for CASP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP5 Gene

This gene is overexpressed in Whole Blood (x23.7), Colon - Transverse (x11.3), and Small Intestine - Terminal Ileum (x8.9).

Protein differential expression in normal tissues from HIPED for CASP5 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CASP5 Gene



Protein tissue co-expression partners for CASP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASP5 Gene:

CASP5

SOURCE GeneReport for Unigene cluster for CASP5 Gene:

Hs.213327

mRNA Expression by UniProt/SwissProt for CASP5 Gene:

P51878-CASP5_HUMAN
Tissue specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for CASP5 Gene

  • Intestine(4.4)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with CASP5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP5 Gene

Orthologs for CASP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP5 33 34
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia CASP13 34
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Casp4 34
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CASP4 34
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii caspb 34
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Nc 34
  • 16 (a)
ManyToMany
Dredd 34
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea csp-1 34
  • 15 (a)
ManyToMany
Species where no ortholog for CASP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CASP5 Gene

ENSEMBL:
Gene Tree for CASP5 (if available)
TreeFam:
Gene Tree for CASP5 (if available)

Paralogs for CASP5 Gene

Paralogs for CASP5 Gene

(6) SIMAP similar genes for CASP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CASP5: view

Variants for CASP5 Gene

Sequence variations from dbSNP and Humsavar for CASP5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000142979 -- 104,997,655(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000144673 -- 105,001,060(-) C/T intron_variant
rs1000216970 -- 105,015,955(-) G/C intron_variant
rs1000235164 -- 105,003,734(-) T/A/C intron_variant
rs1000278217 -- 105,021,438(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CASP5 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV gain 17911159
nsv1038877 CNV gain 25217958
nsv1041081 CNV loss 25217958
nsv1046098 CNV loss 25217958
nsv1052674 CNV loss 25217958
nsv1153818 CNV duplication 26484159
nsv468862 CNV gain 19166990
nsv556218 CNV gain 21841781
nsv556219 CNV loss 21841781

Variation tolerance for CASP5 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CASP5 Gene

Human Gene Mutation Database (HGMD)
CASP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP5 Gene

Disorders for CASP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CASP5 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
cowpox
  • yaba
- elite association - COSMIC cancer census association via MalaCards
Search CASP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CASP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CASP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASP5 Gene

Publications for CASP5 Gene

  1. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. (PMID: 7797592) Munday NA … Nicholson DW (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PMID: 19270026) Quaye L … Gayther SA (Human molecular genetics 2009) 3 22 44 58
  3. Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants. (PMID: 16893518) Eckhart L … Tschachler E (Biochemical and biophysical research communications 2006) 3 4 22 58
  4. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y … Chen DS (Pharmacogenomics 2006) 3 22 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CASP5 Gene

Sources for CASP5 Gene

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