The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It i... See more...

Aliases for CASP3 Gene

Aliases for CASP3 Gene

  • Caspase 3 2 3 5
  • Caspase 3, Apoptosis-Related Cysteine Peptidase 2 3
  • Caspase 3, Apoptosis-Related Cysteine Protease 2 3
  • SREBP Cleavage Activity 1 3 4
  • Cysteine Protease CPP32 3 4
  • Protein Yama 3 4
  • EC 3.4.22.56 4 52
  • Caspase-3 3 4
  • Apopain 3 4
  • CASP-3 3 4
  • CPP-32 3 4
  • CPP32 3 4
  • SCA-1 3 4
  • PARP Cleavage Protease 3
  • Procaspase3 3
  • EC 3.4.22 52
  • CPP32B 3

External Ids for CASP3 Gene

Previous GeneCards Identifiers for CASP3 Gene

  • GC04M186576
  • GC04M186228
  • GC04M186133
  • GC04M186244
  • GC04M185924
  • GC04M185785
  • GC04M185548
  • GC04M181303

Summaries for CASP3 Gene

Entrez Gene Summary for CASP3 Gene

  • The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

GeneCards Summary for CASP3 Gene

CASP3 (Caspase 3) is a Protein Coding gene. Diseases associated with CASP3 include Helicobacter Pylori Infection and Fixed Drug Eruption. Among its related pathways are Amyotrophic lateral sclerosis (ALS) and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CASP7.

UniProtKB/Swiss-Prot Summary for CASP3 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Tocris Summary for CASP3 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP3 Gene

Additional gene information for CASP3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASP3 Gene

Genomics for CASP3 Gene

GeneHancer (GH) Regulatory Elements for CASP3 Gene

Promoters and enhancers for CASP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J184644 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.5 1512 6.4 ZBTB40 EP300 ZSCAN5C SIN3A POLR2G USF1 GTF2E2 PHF8 ZFX ZNF639 PRIMPOL CASP3 CENPU ACSL1 IRF2 LINC02365
GH04J184824 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.1 -175.5 -175492 4.4 NRF1 POLR2G ZFX EP300 ZIC2 POLR2A ZBTB26 RELA MEF2C MYC ACSL1 ENSG00000286256 LOC105377587 CASP3 MIR3945HG CENPU ENSG00000251139
GH04J184470 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +175.5 175528 6.7 FOXK2 ZBTB40 SIN3A NRF1 POLR2G NCOR1 PHF8 ZFX ZIC2 POLR2A IRF2 ENSG00000270426 ENSG00000271646 LINC02427-001 lnc-CASP3-7 CASP3 PRIMPOL ACSL1 LINC02427
GH04J184342 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +303.0 302979 8.9 FOXK2 ZBTB40 ZNF217 EP300 POLR2G USF1 SP1 NCOR1 SIX5 KDM6A LINC02363 IRF2 ENSG00000251878 CASP3 PRIMPOL CFAP97 ACSL1 RF00017-4473
GH04J184624 Enhancer 1 Ensembl ENCODE 20.9 +23.1 23085 3.7 FOXK2 POLR2G NCOR1 TEAD4 KDM6A TCF7 SKI TEAD1 TBX3 CTBP1 LINC02365 CASP3 PRIMPOL CENPU
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CASP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CASP3

Top Transcription factor binding sites by QIAGEN in the CASP3 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXO1
  • PPAR-alpha

Genomic Locations for CASP3 Gene

Genomic Locations for CASP3 Gene
chr4:184,627,696-184,649,509
(GRCh38/hg38)
Size:
21,814 bases
Orientation:
Minus strand
chr4:185,548,850-185,570,663
(GRCh37/hg19)
Size:
21,814 bases
Orientation:
Minus strand

Genomic View for CASP3 Gene

Genes around CASP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP3 Gene

Proteins for CASP3 Gene

  • Protein details for CASP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42574-CASP3_HUMAN
    Recommended name:
    Caspase-3
    Protein Accession:
    P42574
    Secondary Accessions:
    • A8K5M2
    • D3DP53
    • Q96AN1
    • Q96KP2

    Protein attributes for CASP3 Gene

    Size:
    277 amino acids
    Molecular mass:
    31608 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for CASP3 Gene

neXtProt entry for CASP3 Gene

Selected DME Specific Peptides for CASP3 Gene

P42574:
  • SYKMDYPEMG
  • GSWFIQSLCAMLK
  • MHILTRVNRKVA
  • PGYYSWR
  • GSWFIQSLC
  • CIIINNKNFHKSTGM
  • IIQACRG
  • GTDVDAANLRETF
  • EDHSKRSSF
  • IQACRGTELD
  • IPVEADFLYAYST
  • SVDSKSI
  • CVLLSHG
  • CIIINNKNF

Post-translational modifications for CASP3 Gene

  • Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
  • S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
  • Ubiquitination at Lys229
  • Modification sites at PhosphoSitePlus

Antibody Products

Assay Products

Domains & Families for CASP3 Gene

Gene Families for CASP3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CASP3 Gene

Blocks:
  • Caspase-1, p20
  • Interleukin-1B converting enzyme signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CASP3 Gene

GenScript: Design optimal peptide antigens:
  • SREBP cleavage activity 1 (CASP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42574

UniProtKB/Swiss-Prot:

CASP3_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP3: view

Function for CASP3 Gene

Molecular function for CASP3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp- - with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.; EC=3.4.22.56;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by isatin sulfonamides.
GENATLAS Biochemistry:
caspase 3,effector,cysteine containing aspartate-specific protease CPP32,activated by CASP9,cleaving specifically CDKN1A,alpha-fodrin (SPTAN1), gelsolin (GSN),stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,promoting CD95/APO1/fas mediated apoptosis,homolog to C elegans Ced-3 and mammalian interleukin 1 beta convertase (IL1BC),including two isoforms alpha and beta

Enzyme Numbers (IUBMB) for CASP3 Gene

Phenotypes From GWAS Catalog for CASP3 Gene

Gene Ontology (GO) - Molecular Function for CASP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0004197 cysteine-type endopeptidase activity IDA,IEA 16920334
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA --
GO:0005123 death receptor binding IEA --
genes like me logo Genes that share ontologies with CASP3: view
genes like me logo Genes that share phenotypes with CASP3: view

Animal Models for CASP3 Gene

MGI Knock Outs for CASP3:

Animal Model Products

Clone Products

  • Addgene plasmids for CASP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CASP3 Gene

Localization for CASP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
mitochondrion 4
cytoskeleton 3
endoplasmic reticulum 3
lysosome 3
peroxisome 2
endosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CASP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17167422
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0031264 death-inducing signaling complex IEA --
genes like me logo Genes that share ontologies with CASP3: view

Pathways & Interactions for CASP3 Gene

genes like me logo Genes that share pathways with CASP3: view

Pathways by source for CASP3 Gene

10 GeneGo (Thomson Reuters) pathways for CASP3 Gene
  • Apoptosis and survival Apoptotic TNF-family pathways
  • Apoptosis and survival Caspase cascade
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival NGF signaling pathway
2 R&D Systems pathways for CASP3 Gene
2 Tocris pathways for CASP3 Gene
43 Qiagen pathways for CASP3 Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Apoptosis through Death Receptors
  • Apoptotic Pathways Triggered By HIV1
1 Cell Signaling Technology pathway for CASP3 Gene
2 GeneTex pathways for CASP3 Gene

SIGNOR curated interactions for CASP3 Gene

Gene Ontology (GO) - Biological Process for CASP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001554 luteolysis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001782 B cell homeostasis IEA --
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006508 proteolysis IDA,IEA 12888622
genes like me logo Genes that share ontologies with CASP3: view

Drugs & Compounds for CASP3 Gene

(94) Drugs for CASP3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3311
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, inhibitor, downregulator 1440
glycyrrhizin Approved, Experimental Pharma Inhibition, Inhibitor, Target, antagonist 26
Minocycline Approved, Investigational Pharma Target, negative modulator 222
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate Experimental Pharma Target 0

(70) Additional Compounds for CASP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PAC 1
315183-21-2

(4) Tocris Compounds for CASP3 Gene

Compound Action Cas Number
Apoptosis Activator 2 Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis 79183-19-0
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 15663-27-1
PAC 1 Activator of procaspase-3; pro-apoptotic 315183-21-2
PETCM Activator of caspase-3 10129-56-3

(19) ApexBio Compounds for CASP3 Gene

Compound Action Cas Number
Apoptosis Activator 2 Indoledione caspase activator, cell-permeable 79183-19-0
Apoptosis Inhibitor Associate with caspase-3 inhibition 54135-60-3
AZ 10417808 Caspase-3 inhibitor,selective non-peptide 331645-84-2
Boc-D-FMK Pan-caspase inhibitor 187389-53-3, 634911-80-1
Caspase Inhibitor Set I Caspase Inhibitors
Caspase-3/7 Inhibitor I Caspase-3/7 inhibitor 220509-74-0
Cisplatin Inhibits DNA synthesis,chemotherapy drug 15663-27-1
Emricasan 254750-02-2
Gambogic Acid Caspase activator and apoptosis inducer 2752-65-0
Ivachtin Caspase-3 inhibitor 745046-84-8
PAC-1 Procaspase-3 activator 315183-21-2
PETCM Caspase-3 activator 10129-56-3
Q-VD(OMe)-OPh Pan-caspase inhibitor
Q-VD-OPh hydrate Cell-permeable, irreversible pan-caspase inhibitor 1135695-98-5
Tasisulam 519055-62-0
Z-DEVD-FMK Caspase-3 inhibitor 210344-95-9
Z-DQMD-FMK Caspase-3 inhibitor,cell-permeable
Z-FA-FMK Cysteine proteases inhibitor
Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2
genes like me logo Genes that share compounds with CASP3: view

Drug Products

Transcripts for CASP3 Gene

mRNA/cDNA for CASP3 Gene

9 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for CASP3

Alternative Splicing Database (ASD) splice patterns (SP) for CASP3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for CASP3 Gene

GeneLoc Exon Structure for
CASP3

Expression for CASP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CASP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2) and Nasal epithelium (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CASP3 Gene



Protein tissue co-expression partners for CASP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASP3

SOURCE GeneReport for Unigene cluster for CASP3 Gene:

Hs.141125

mRNA Expression by UniProt/SwissProt for CASP3 Gene:

P42574-CASP3_HUMAN
Tissue specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Evidence on tissue expression from TISSUES for CASP3 Gene

  • Blood(4.7)
  • Nervous system(4.6)
  • Heart(3.5)
  • Intestine(3.5)
  • Lung(3.5)
  • Liver(3.4)
  • Muscle(3.4)
  • Kidney(3.2)
  • Adrenal gland(3)
  • Eye(3)
  • Skin(3)
  • Stomach(2.9)
  • Bone marrow(2.8)
  • Pancreas(2.8)
  • Lymph node(2.7)
  • Spleen(2.6)
  • Bone(2.3)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with CASP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP3 Gene

Orthologs for CASP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP3 31 30
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CASP3 31 30
  • 89.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CASP3 31 30
  • 86.3 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Casp3 30
  • 84.84 (n)
mouse
(Mus musculus)
Mammalia Casp3 17 31 30
  • 83.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CASP3 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP3 31 30
  • 70.76 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp3 30
  • 66.67 (n)
zebrafish
(Danio rerio)
Actinopterygii casp3a 31
  • 55 (a)
OneToMany
casp3b 31
  • 53 (a)
OneToMany
casp3 30
African malaria mosquito
(Anopheles gambiae)
Insecta CASPS8 30
  • 45.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ice 31 32
  • 32 (a)
ManyToMany
Dcp-1 31 32
  • 30 (a)
ManyToMany
decay 31 32
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for CASP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP3 Gene

ENSEMBL:
Gene Tree for CASP3 (if available)
TreeFam:
Gene Tree for CASP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CASP3: view image

Paralogs for CASP3 Gene

Paralogs for CASP3 Gene