This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active... See more...

Aliases for CASP10 Gene

Aliases for CASP10 Gene

  • Caspase 10 2 3 5
  • FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2 3 4
  • Caspase 10, Apoptosis-Related Cysteine Protease 2 3
  • ICE-Like Apoptotic Protease 4 3 4
  • Caspase-10 3 4
  • CASP-10 3 4
  • FLICE2 3 4
  • MCH4 3 4
  • Caspase 10, Apoptosis-Related Cysteine Peptidase 2
  • Caspase 10 Apoptosis-Related Cysteine Peptidase 3
  • Interleukin-1B-Converting Enzyme 2 3
  • Apoptotic Protease MCH-4 3
  • Apoptotic Protease Mch-4 4
  • FADD-Like ICE2 3
  • EC 3.4.22.63 4
  • ALPS2 3

External Ids for CASP10 Gene

Previous GeneCards Identifiers for CASP10 Gene

  • GC02P200264
  • GC02P200772
  • GC02P202011
  • GC02P202250
  • GC02P202223
  • GC02P201873
  • GC02P201756
  • GC02P202047
  • GC02P193898

Summaries for CASP10 Gene

Entrez Gene Summary for CASP10 Gene

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for CASP10 Gene

CASP10 (Caspase 10) is a Protein Coding gene. Diseases associated with CASP10 include Autoimmune Lymphoproliferative Syndrome, Type Iia and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are Direct p53 effectors and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and cysteine-type peptidase activity. An important paralog of this gene is CASP8.

UniProtKB/Swiss-Prot Summary for CASP10 Gene

  • Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.
  • Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.
  • Isoform C is proteolytically inactive.

Tocris Summary for CASP10 Gene

  • Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Gene Wiki entry for CASP10 Gene

Additional gene information for CASP10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASP10 Gene

Genomics for CASP10 Gene

GeneHancer (GH) Regulatory Elements for CASP10 Gene

Promoters and enhancers for CASP10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CASP10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CASP10

Top Transcription factor binding sites by QIAGEN in the CASP10 gene promoter:
  • AP-1
  • NF-kappaB1
  • p53

Genomic Locations for CASP10 Gene

Genomic Locations for CASP10 Gene
chr2:201,182,881-201,229,406
(GRCh38/hg38)
Size:
46,526 bases
Orientation:
Plus strand
chr2:202,047,604-202,094,129
(GRCh37/hg19)
Size:
46,526 bases
Orientation:
Plus strand

Genomic View for CASP10 Gene

Genes around CASP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASP10 Gene

Proteins for CASP10 Gene

  • Protein details for CASP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92851-CASPA_HUMAN
    Recommended name:
    Caspase-10
    Protein Accession:
    Q92851
    Secondary Accessions:
    • Q68HC0
    • Q6KF62
    • Q6KF63
    • Q8IUP5
    • Q8WYQ8
    • Q99845
    • Q9Y2U6
    • Q9Y2U7

    Protein attributes for CASP10 Gene

    Size:
    521 amino acids
    Molecular mass:
    58951 Da
    Quaternary structure:
    • Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Interacts with RFFL and RNF34; negatively regulate CASP10 through proteasomal degradation. Interacts with RIOK3.
    Miscellaneous:
    • [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CASP10 Gene

neXtProt entry for CASP10 Gene

Post-translational modifications for CASP10 Gene

  • Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
  • Ubiquitination at Lys192 and Lys271
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CASP10 Gene

Domains & Families for CASP10 Gene

Gene Families for CASP10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CASP10 Gene

Suggested Antigen Peptide Sequences for CASP10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61090, highly similar to Caspase-10 (EC 3.4.22.-) (B4E3T5_HUMAN)
  • ICE-like apoptotic protease 4 (CASPA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92851

UniProtKB/Swiss-Prot:

CASPA_HUMAN :
  • Belongs to the peptidase C14A family.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CASP10: view

Function for CASP10 Gene

Molecular function for CASP10 Gene

UniProtKB/Swiss-Prot Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.
UniProtKB/Swiss-Prot Function:
Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.
UniProtKB/Swiss-Prot Function:
Isoform C is proteolytically inactive.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp- -Gly.; EC=3.4.22.63;.
GENATLAS Biochemistry:
caspase 10,cysteine containing aspartate-specific protease,expressed in fetal lung,kidney,skeletal muscle,stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli,recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis,homolog to C elegans cell death gene Ced-3

Enzyme Numbers (IUBMB) for CASP10 Gene

Phenotypes From GWAS Catalog for CASP10 Gene

Gene Ontology (GO) - Molecular Function for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 16920334
GO:0005515 protein binding IEA,IPI 12884866
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CASP10: view
genes like me logo Genes that share phenotypes with CASP10: view

Human Phenotype Ontology for CASP10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CASP10 Gene

Localization for CASP10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASP10 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0031265 CD95 death-inducing signaling complex IDA 11717445
GO:0097342 ripoptosome IDA 21737330
genes like me logo Genes that share ontologies with CASP10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CASP10 Gene

Pathways & Interactions for CASP10 Gene

PathCards logo

SuperPathways for CASP10 Gene

SuperPathway Contained pathways
1 Apoptosis Modulation and Signaling
.41
.35
.31
2 Apoptosis and survival Caspase cascade
.44
.44
3 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
4 TNFR1 Pathway
.52
.46
.42
.35
5 p53 Signaling
.44
genes like me logo Genes that share pathways with CASP10: view

Pathways by source for CASP10 Gene

4 GeneGo (Thomson Reuters) pathways for CASP10 Gene
  • Apoptosis and survival Apoptotic TNF-family pathways
  • Apoptosis and survival Caspase cascade
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival TNFR1 signaling pathway
2 R&D Systems pathways for CASP10 Gene
2 Tocris pathways for CASP10 Gene
16 Qiagen pathways for CASP10 Gene
  • 14-3-3 Induced Apoptosis
  • Apoptosis through Death Receptors
  • Caspase Cascade
  • Ceramide Pathway
  • DHA Signaling
3 GeneTex pathways for CASP10 Gene

SIGNOR curated interactions for CASP10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CASP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process IBA 21873635
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA 21873635
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with CASP10: view

Drugs & Compounds for CASP10 Gene

(7) Drugs for CASP10 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3311
Apoptosis Activator 2 Pharma Indoledione caspase activator, cell-permeable, Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis 0
PETCM Pharma Activator Caspase-3 activator, Activator of caspase-3 0

(1) Additional Compounds for CASP10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PAC 1
315183-21-2

(4) Tocris Compounds for CASP10 Gene

Compound Action Cas Number
Apoptosis Activator 2 Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis 79183-19-0
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 15663-27-1
PAC 1 Activator of procaspase-3; pro-apoptotic 315183-21-2
PETCM Activator of caspase-3 10129-56-3
genes like me logo Genes that share compounds with CASP10: view

Transcripts for CASP10 Gene

mRNA/cDNA for CASP10 Gene

7 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CASP10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10:
SP11: -

ExUns: 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CASP10 Gene

GeneLoc Exon Structure for
CASP10

Expression for CASP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CASP10 Gene

This gene is overexpressed in Whole Blood (x6.3) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for CASP10 Gene

This gene is overexpressed in Plasma (40.8) and Cervix (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CASP10 Gene



Protein tissue co-expression partners for CASP10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASP10

SOURCE GeneReport for Unigene cluster for CASP10 Gene:

Hs.5353

mRNA Expression by UniProt/SwissProt for CASP10 Gene:

Q92851-CASPA_HUMAN
Tissue specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Evidence on tissue expression from TISSUES for CASP10 Gene

  • Blood(4.4)
  • Spleen(4.4)
  • Nervous system(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CASP10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • head
Thorax:
  • lung
Abdomen:
  • kidney
  • liver
  • spleen
  • stomach
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • red blood cell
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with CASP10: view

Orthologs for CASP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CASP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CASP10 31 30
  • 99.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CASP10 31 30
  • 81 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CASP10 31
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CASP10 31
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CASP10 31 30
  • 55.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CASP10 31
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia casp10 30
  • 53.88 (n)
zebrafish
(Danio rerio)
Actinopterygii casp8l2 31 30
  • 47.51 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dcp-1 31
  • 29 (a)
ManyToMany
Ice 31
  • 28 (a)
ManyToMany
decay 31
  • 28 (a)
ManyToMany
Species where no ortholog for CASP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASP10 Gene

ENSEMBL:
Gene Tree for CASP10 (if available)
TreeFam:
Gene Tree for CASP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CASP10: view image

Paralogs for CASP10 Gene

(1) SIMAP similar genes for CASP10 Gene using alignment to 2 proteins:

  • CASPA_HUMAN
  • B4E3T5_HUMAN
genes like me logo Genes that share paralogs with CASP10: view

Variants for CASP10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CASP10 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
642131 Uncertain Significance: Autoimmune lymphoproliferative syndrome type 2; Autoimmune lymphoproliferative syndrome, type 2A 201,195,880(+) G/A MISSENSE_VARIANT
643723 Conflicting Interpretations: Autoimmune lymphoproliferative syndrome; Autoimmune lymphoproliferative syndrome type 2; Autoimmune lymphoproliferative syndrome, type 2A 201,209,468(+) G/A MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
644332 Uncertain Significance: Autoimmune lymphoproliferative syndrome type 2; Autoimmune lymphoproliferative syndrome, type 2A 201,185,976(+) G/T MISSENSE_VARIANT
652716 Uncertain Significance: Autoimmune lymphoproliferative syndrome type 2; Autoimmune lymphoproliferative syndrome, type 2A 201,209,295(+) C/A MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
653604 Uncertain Significance: Autoimmune lymphoproliferative syndrome type 2; Autoimmune lymphoproliferative syndrome, type 2A 201,195,884(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CASP10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CASP10 Gene

Variant ID Type Subtype PubMed ID
esv3593974 CNV loss 21293372
nsv1160898 CNV deletion 26073780
nsv584160 CNV loss 21841781
nsv821874 CNV loss 20364138
nsv961547 CNV duplication 23825009

Variation tolerance for CASP10 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CASP10 Gene

Human Gene Mutation Database (HGMD)
CASP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASP10 Gene

Disorders for CASP10 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CASP10 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CASPA_HUMAN
  • Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269 PubMed:10412980}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. {ECO:0000269 PubMed:12010812}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:11973654}. Note=The gene represented in this entry is involved in disease pathogenesis.

Additional Disease Information for CASP10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CASP10: view

No data available for Genatlas for CASP10 Gene

Publications for CASP10 Gene

  1. Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas. (PMID: 19900088) Kim MS … Lee SH (Pathology 2009) 3 4 23 41 54
  2. Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma. (PMID: 18563783) Li C … Wei Q (Human mutation 2008) 3 4 23 41 54
  3. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (PMID: 8755496) Fernandes-Alnemri T … Alnemri ES (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 23 54
  4. Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas. (PMID: 20025484) Oh JE … Yoo NJ (Pathology 2010) 3 4 23 54
  5. Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma. (PMID: 17071630) Lan Q … Rothman N (Carcinogenesis 2007) 3 23 41 54

Products for CASP10 Gene