Aliases for CASP10 Gene
External Ids for CASP10 Gene
Previous GeneCards Identifiers for CASP10 Gene
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
GeneCards Summary for CASP10 Gene
CASP10 (Caspase 10) is a Protein Coding gene. Diseases associated with CASP10 include Autoimmune Lymphoproliferative Syndrome, Type Iia and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are Presenilin-Mediated Signaling and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and cysteine-type peptidase activity. An important paralog of this gene is CASP8.
UniProtKB/Swiss-Prot Summary for CASP10 Gene
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.
Isoform C is proteolytically inactive.
Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.