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Aliases for CASC9 Gene

Subcategory (RNA class) for CASC9 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for CASC9 Gene

  • Cancer Susceptibility 9 2 3
  • Cancer Susceptibility 9 (Non-Protein Coding) 2 3 5
  • Cancer Susceptibility Candidate 9 (Non-Protein Coding) 2 3
  • Esophageal Squamous Cell Carcinoma Associated LncRNA-1 2 3
  • Long Intergenic Non-Protein Coding RNA 981 2 3
  • Esophageal Squamous Cell Carcinoma Sssociated LncRNA-1 3
  • ESCC-Associated LncRNA 3
  • LINC00981 3
  • ESCCAL-1 3
  • ESSCAL1 3

External Ids for CASC9 Gene

Previous GeneCards Identifiers for CASC9 Gene

  • GC08M076136

Summaries for CASC9 Gene

GeneCards Summary for CASC9 Gene

CASC9 (Cancer Susceptibility 9) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CASC9 include Squamous Cell Carcinoma and Esophageal Cancer.

Additional gene information for CASC9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC9 Gene

Genomics for CASC9 Gene

GeneHancer (GH) Regulatory Elements for CASC9 Gene

Promoters and enhancers for CASC9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J075324 Promoter 0.8 EPDnew 650.7 +0.5 541 0.1 L3MBTL2 SIN3A ZBTB26 YY1 ZBTB20 CASC9 GC08P075322 HNF4G
GH08J075218 Enhancer 0.7 ENCODE dbSUPER 4.9 +105.5 105537 2.4 SP1 NANOG ZNF366 ZNF26 POU5F1 REST EZH2 CASC9 GC08M075206 HIGD1AP6
GH08J075216 Enhancer 0.5 ENCODE dbSUPER 4.5 +107.5 107508 1.1 NANOG CASC9 GC08M075206 HIGD1AP6
GH08J075275 Enhancer 0.4 ENCODE 0.2 +49.4 49420 0.2 CTCF RAD21 HIGD1AP6 CASC9 GC08M075206
GH08J075223 Enhancer 0.2 dbSUPER 0.1 +100.6 100594 0.5 GC08M075206 HIGD1AP6 CASC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CASC9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CASC9 Gene

Genomic Locations for CASC9 Gene
chr8:75,223,117-75,324,741
(GRCh38/hg38)
Size:
101,625 bases
Orientation:
Minus strand
chr8:76,135,639-76,236,976
(GRCh37/hg19)

Genomic View for CASC9 Gene

Genes around CASC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC9 Gene

Function for CASC9 Gene

Phenotypes From GWAS Catalog for CASC9 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CASC9 Gene

Localization for CASC9 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CASC9 Gene

Pathways & Interactions for CASC9 Gene

SuperPathways for CASC9 Gene

No Data Available

Interacting Proteins for CASC9 Gene

Gene Ontology (GO) - Biological Process for CASC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CASC9 Gene

Drugs & Compounds for CASC9 Gene

No Compound Related Data Available

Transcripts for CASC9 Gene

mRNA/cDNA for CASC9 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(7) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for CASC9 Gene

No ASD Table

Relevant External Links for CASC9 Gene

GeneLoc Exon Structure for
CASC9
ECgene alternative splicing isoforms for
CASC9

Expression for CASC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASC9 Gene

mRNA differential expression in normal tissues according to GTEx for CASC9 Gene

This gene is overexpressed in Colon - Transverse (x12.3) and Bladder (x12.1).

NURSA nuclear receptor signaling pathways regulating expression of CASC9 Gene:

CASC9
genes like me logo Genes that share expression patterns with CASC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASC9 Gene

Orthologs for CASC9 Gene

Evolution for CASC9 Gene

ENSEMBL:
Gene Tree for CASC9 (if available)
TreeFam:
Gene Tree for CASC9 (if available)

No data available for Orthologs for CASC9 Gene

Paralogs for CASC9 Gene

No data available for Paralogs for CASC9 Gene

Variants for CASC9 Gene

Sequence variations from dbSNP and Humsavar for CASC9 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000011823 -- 75,277,075(-) G/C intron_variant, non_coding_transcript_variant
rs1000075642 -- 75,258,907(-) C/G intron_variant
rs1000332677 -- 75,271,270(-) A/C intron_variant
rs1000390668 -- 75,252,580(-) C/A intron_variant
rs1000462197 -- 75,228,394(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CASC9 Gene

Variant ID Type Subtype PubMed ID
dgv7242n100 CNV loss 25217958
esv1954762 CNV deletion 18987734
esv2628728 CNV deletion 19546169
esv2737188 CNV deletion 23290073
esv2737189 CNV deletion 23290073
esv2737190 CNV deletion 23290073
esv2737191 CNV deletion 23290073
esv3116050 CNV deletion 24192839
esv3576590 CNV gain 25503493
esv3891411 CNV loss 25118596
esv3891412 CNV gain 25118596
esv3891413 CNV loss 25118596
esv990823 CNV deletion 20482838
nsv1128427 CNV deletion 24896259
nsv397746 CNV deletion 16902084
nsv520966 CNV loss 19592680
nsv524725 CNV loss 19592680
nsv611561 CNV gain 21841781
nsv831356 CNV loss 17160897
nsv971668 CNV duplication 23825009

Additional Variant Information for CASC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC9 Gene

Disorders for CASC9 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CASC9 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
esophageal cancer
  • esophageal cancer, somatic
nasopharyngeal carcinoma
  • npca
lung cancer
  • lung cancer, susceptibility to
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CASC9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CASC9

genes like me logo Genes that share disorders with CASC9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASC9 Gene

Publications for CASC9 Gene

  1. Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2. (PMID: 28854977) Wu Y … Bai Y (Molecular cancer 2017) 2 3 58
  2. Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma. (PMID: 25885227) Hao Y … Cao W (BMC cancer 2015) 2 3 58
  3. The Long Noncoding RNA Cancer Susceptibility Candidate 9 Promotes Nasopharyngeal Carcinogenesis via Stabilizing HIF1α. (PMID: 28398871) Su X … Liu W (DNA and cell biology 2017) 3 58
  4. Silence of cancer susceptibility candidate 9 inhibits gastric cancer and reverses chemoresistance. (PMID: 28146436) Shang C … Huang B (Oncotarget 2017) 3 58
  5. The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer. (PMID: 27431358) Pan Z … Xu X (Cancer medicine 2016) 3 58

Products for CASC9 Gene

Sources for CASC9 Gene

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