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Aliases for CASC2 Gene

Subcategory (RNA class) for CASC2 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for CASC2 Gene

  • Cancer Susceptibility 2 (Non-Protein Coding) 2 3 5
  • Cancer Susceptibility Candidate 2 (Non-Protein Coding) 2 3
  • C10orf5 3 4
  • Cancer Susceptibility Candidate Gene 2 Protein Isoforms 1/2 4
  • Cancer Susceptibility Candidate Gene 2 Protein, Isoform 3 4
  • Chromosome 10 Open Reading Frame 5 2
  • Cancer Susceptibility Candidate 2 2

External Ids for CASC2 Gene

Previous HGNC Symbols for CASC2 Gene

  • C10orf5

Previous GeneCards Identifiers for CASC2 Gene

  • GC10P119470
  • GC10P119471
  • GC10P119796
  • GC10P113434

Summaries for CASC2 Gene

GeneCards Summary for CASC2 Gene

CASC2 (Cancer Susceptibility 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CASC2 include Endometrial Cancer.

UniProtKB/Swiss-Prot for CASC2 Gene

  • May act as a potential tumor suppressor.

Additional gene information for CASC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASC2 Gene

Genomics for CASC2 Gene

GeneHancer (GH) Regulatory Elements for CASC2 Gene

Promoters and enhancers for CASC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I118045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.7 +0.2 214 2.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF213 ZNF143 CASC2 RAB11FIP2 RPL17P36 ENSG00000231104
GH10I118034 Enhancer 0.6 Ensembl ENCODE 5.1 -10.6 -10609 1.6 MYC PRDM4 CASC2 RAB11FIP2 ENSG00000231104
GH10I118017 Enhancer 0.2 ENCODE 11.4 -28.4 -28403 0.8 ENSG00000231104 CASC2 RAB11FIP2
GH10I118168 Enhancer 0.2 ENCODE 8.6 +121.2 121220 0.3 CASC2 GC10P118108 LOC101927760
GH10I118031 Enhancer 0.2 ENCODE 7.3 -13.8 -13802 2.2 CASC2 ENSG00000231104 RAB11FIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CASC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CASC2 gene promoter:

Genomic Locations for CASC2 Gene

Genomic Locations for CASC2 Gene
chr10:118,046,279-118,210,153
(GRCh38/hg38)
Size:
163,875 bases
Orientation:
Plus strand
chr10:119,805,790-119,969,665
(GRCh37/hg19)

Genomic View for CASC2 Gene

Genes around CASC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC2 Gene

Proteins for CASC2 Gene

  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XLA1-CSC2A_HUMAN
    Recommended name:
    Protein CASC2, isoform 3
    Protein Accession:
    Q6XLA1
    Secondary Accessions:
    • D3DRC5

    Protein attributes for CASC2 Gene

    Size:
    102 amino acids
    Molecular mass:
    11902 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU53-CASC2_HUMAN
    Recommended name:
    Protein CASC2, isoforms 1/2
    Protein Accession:
    Q8IU53
    Secondary Accessions:
    • Q2M1K1
    • Q8IUI3

    Protein attributes for CASC2 Gene

    Size:
    76 amino acids
    Molecular mass:
    8607 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASC2 Gene

Post-translational modifications for CASC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC2 Gene

Domains & Families for CASC2 Gene

Protein Domains for CASC2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CASC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CASC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CASC2 Gene

Function for CASC2 Gene

Molecular function for CASC2 Gene

UniProtKB/Swiss-Prot Function:
May act as a potential tumor suppressor.
UniProtKB/Swiss-Prot Induction:
Down-regulated in endometrial and colorectal tumor samples.

Gene Ontology (GO) - Molecular Function for CASC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CASC2: view

Phenotypes for CASC2 Gene

genes like me logo Genes that share phenotypes with CASC2: view

Animal Model Products

miRNA for CASC2 Gene

miRTarBase miRNAs that target CASC2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CASC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASC2 Gene

Localization for CASC2 Gene

Gene Ontology (GO) - Cellular Components for CASC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CASC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CASC2 Gene

Pathways & Interactions for CASC2 Gene

SuperPathways for CASC2 Gene

No Data Available

Interacting Proteins for CASC2 Gene

Gene Ontology (GO) - Biological Process for CASC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002357 defense response to tumor cell IDA 28621238
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 28621238
GO:0043409 negative regulation of MAPK cascade IDA 28621238
genes like me logo Genes that share ontologies with CASC2: view

No data available for Pathways by source and SIGNOR curated interactions for CASC2 Gene

Drugs & Compounds for CASC2 Gene

No Compound Related Data Available

Transcripts for CASC2 Gene

Unigene Clusters for CASC2 Gene

Cancer susceptibility candidate 2 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CASC2

Alternative Splicing Database (ASD) splice patterns (SP) for CASC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2:
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for CASC2 Gene

GeneLoc Exon Structure for
CASC2
ECgene alternative splicing isoforms for
CASC2

Expression for CASC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CASC2 Gene

mRNA differential expression in normal tissues according to GTEx for CASC2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of CASC2 Gene:

CASC2

SOURCE GeneReport for Unigene cluster for CASC2 Gene:

Hs.89387

mRNA Expression by UniProt/SwissProt for CASC2 Gene:

Q6XLA1-CSC2A_HUMAN
Tissue specificity: Expressed in normal and neoplastic endometrial tissues.
genes like me logo Genes that share expression patterns with CASC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASC2 Gene

Orthologs for CASC2 Gene

Evolution for CASC2 Gene

ENSEMBL:
Gene Tree for CASC2 (if available)
TreeFam:
Gene Tree for CASC2 (if available)

No data available for Orthologs for CASC2 Gene

Paralogs for CASC2 Gene

No data available for Paralogs for CASC2 Gene

Variants for CASC2 Gene

Sequence variations from dbSNP and Humsavar for CASC2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
VAR_039469 Some patients with endometrial cancer p.Pro8Ser
rs1000010883 -- 118,120,568(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000011013 -- 118,058,071(+) T/C intron_variant
rs1000029385 -- 118,102,357(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000087634 -- 118,047,804(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CASC2 Gene

Variant ID Type Subtype PubMed ID
esv1096716 CNV insertion 17803354
esv1289381 CNV insertion 17803354
esv1538733 CNV insertion 17803354
esv1573329 CNV insertion 17803354
esv2580643 CNV deletion 19546169
esv2741484 CNV deletion 23290073
esv2741495 CNV deletion 23290073
esv2741506 CNV deletion 23290073
esv2741517 CNV deletion 23290073
nsv1047815 CNV gain 25217958
nsv1113339 CNV deletion 24896259
nsv1120230 CNV tandem duplication 24896259
nsv7566 CNV deletion 18451855
nsv7567 CNV insertion 18451855
nsv819998 CNV loss 19587683
nsv951860 CNV duplication 24416366
nsv958495 CNV insertion 24416366

Additional Variant Information for CASC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC2 Gene

Disorders for CASC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CASC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search CASC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CASC2

genes like me logo Genes that share disorders with CASC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASC2 Gene

Publications for CASC2 Gene

  1. Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. (PMID: 15024726) Baldinu P … Palmieri G (Human mutation 2004) 3 4 22 58
  2. CASC2a gene is down-regulated in endometrial cancer. (PMID: 17352238) Baldinu P … Palmieri G (Anticancer research 2007) 4 22 58
  3. LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway. (PMID: 28121023) Liao Y … Cheng L (Journal of cellular biochemistry 2017) 3 58
  4. Down-regulation of lncRNA CASC2 promotes cell proliferation and metastasis of bladder cancer by activation of the Wnt/β-catenin signaling pathway. (PMID: 28199978) Pei Z … Zeng J (Oncotarget 2017) 3 58
  5. CASC2c as an unfavorable prognosis factor interacts with miR-101 to mediate astrocytoma tumorigenesis. (PMID: 28252647) Liu C … Wu M (Cell death & disease 2017) 3 58

Products for CASC2 Gene

  • Addgene plasmids for CASC2

Sources for CASC2 Gene

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