Aliases for CASC2 Gene

Subcategory (RNA class) for CASC2 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for CASC2 Gene

  • Cancer Susceptibility 2 2 3 5
  • Cancer Susceptibility Candidate 2 (Non-Protein Coding) 2 3
  • Cancer Susceptibility 2 (Non-Protein Coding) 2 3
  • C10orf5 3 4
  • CASC2 2 168
  • Cancer Susceptibility Candidate Gene 2 Protein Isoforms 1/2 4
  • Cancer Susceptibility Candidate Gene 2 Protein, Isoform 3 4
  • Chromosome 10 Open Reading Frame 5 2
  • Cancer Susceptibility Candidate 2 2
  • Protein CASC2, Isoforms 1/2 4
  • Protein CASC2, Isoform 3 4
  • HSALNG0080948 167
  • NONHSAG006966 92

External Ids for CASC2 Gene

Previous HGNC Symbols for CASC2 Gene

  • C10orf5

Previous GeneCards Identifiers for CASC2 Gene

  • GC10P119470
  • GC10P119471
  • GC10P119796
  • GC10P113434

Summaries for CASC2 Gene

GeneCards Summary for CASC2 Gene

CASC2 (Cancer Susceptibility 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with CASC2 include Thyroid Carcinoma and Astrocytoma.

UniProtKB/Swiss-Prot Summary for CASC2 Gene

Additional gene information for CASC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASC2 Gene

Genomics for CASC2 Gene

GeneHancer (GH) Regulatory Elements for CASC2 Gene

Promoters and enhancers for CASC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J118045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 505.6 +0.2 238 3.8 HNRNPK EP300 SIN3A NRF1 USF1 POLR2G SP1 PHF8 ZFX CTCF CASC2 NONHSAG006965.2 RAB11FIP2 RPL17P36 ENSG00000231104
GH10J118002 Enhancer 0.7 Ensembl 16.1 -42.8 -42772 1 ZSCAN5C MYC ATF2 TRIM24 CEBPB FOSL1 ZNF513 EP400 CEBPG ATF4 CASC2 RAB11FIP2 ENSG00000231104 LOC105378504
GH10J118020 Enhancer 0.5 Ensembl 16.1 -25.4 -25361 1 TEAD4 ZIC2 YY1 TCF12 EGR1 CTCF POLR2A SCRT2 CASC2 RAB11FIP2 ENSG00000231104 lnc-FAM204A-3
GH10J118017 Enhancer 0.6 Ensembl ENCODE 11.4 -28.0 -27961 1 TEAD4 YY1 CEBPB ENSG00000231104 CASC2 RAB11FIP2 lnc-FAM204A-3
GH10J118028 Enhancer 0.8 Ensembl ENCODE 7.3 -14.8 -14779 5 EP300 ARNT MEF2B NBN ELF1 NR2F1 NFATC3 TBX21 SMARCA4 ZNF217 CASC2 ENSG00000231104 lnc-FAM204A-3 RAB11FIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CASC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CASC2 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • CUTL1
  • E47
  • GATA-1
  • USF-1
  • USF1

Genomic Locations for CASC2 Gene

Genomic Locations for CASC2 Gene
chr10:118,045,862-118,216,096
(GRCh38/hg38)
Size:
170,235 bases
Orientation:
Plus strand
chr10:119,805,790-119,969,665
(GRCh37/hg19)
Size:
163,876 bases
Orientation:
Plus strand

Genomic View for CASC2 Gene

Genes around CASC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASC2 Gene

Proteins for CASC2 Gene

  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XLA1-CSC2A_HUMAN
    Recommended name:
    Protein CASC2, isoform 3
    Protein Accession:
    Q6XLA1
    Secondary Accessions:
    • D3DRC5

    Protein attributes for CASC2 Gene

    Size:
    102 amino acids
    Molecular mass:
    11902 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CASC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU53-CASC2_HUMAN
    Recommended name:
    Protein CASC2, isoforms 1/2
    Protein Accession:
    Q8IU53
    Secondary Accessions:
    • Q2M1K1
    • Q8IUI3

    Protein attributes for CASC2 Gene

    Size:
    76 amino acids
    Molecular mass:
    8607 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CASC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CASC2 Gene

Post-translational modifications for CASC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CASC2 Gene

Domains & Families for CASC2 Gene

Gene Families for CASC2 Gene

Protein Domains for CASC2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CASC2 Gene

GenScript: Design optimal peptide antigens:
  • Cancer susceptibility candidate gene 2 protein isoforms 1/2 (CASC2_HUMAN)
  • Cancer susceptibility candidate gene 2 protein, isoform 3 (CSC2A_HUMAN)
genes like me logo Genes that share domains with CASC2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CASC2 Gene

Function for CASC2 Gene

Molecular function for CASC2 Gene

UniProtKB/Swiss-Prot Function:
May act as a potential tumor suppressor.
UniProtKB/Swiss-Prot Induction:
Down-regulated in endometrial and colorectal tumor samples.

Phenotypes From GWAS Catalog for CASC2 Gene

Gene Ontology (GO) - Molecular Function for CASC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CASC2: view
genes like me logo Genes that share phenotypes with CASC2: view

miRNA for CASC2 Gene

miRTarBase miRNAs that target CASC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASC2 Gene

Localization for CASC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASC2 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CASC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CASC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CASC2 Gene

Pathways & Interactions for CASC2 Gene

PathCards logo

SuperPathways for CASC2 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for CASC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002357 defense response to tumor cell IDA 28621238
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 28621238
GO:0043409 negative regulation of MAPK cascade IDA 28621238
genes like me logo Genes that share ontologies with CASC2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CASC2 Gene

Drugs & Compounds for CASC2 Gene

No Compound Related Data Available

Transcripts for CASC2 Gene

mRNA/cDNA for CASC2 Gene

32 RNACentral transcripts :
5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
10 NONCODE transcripts :
21 LncBook transcripts :
23 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for CASC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2:
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for CASC2 Gene

GeneLoc Exon Structure for
CASC2

Expression for CASC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CASC2 Gene

mRNA differential expression in normal tissues according to GTEx for CASC2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASC2

SOURCE GeneReport for Unigene cluster for CASC2 Gene:

Hs.89387

mRNA Expression by UniProt/SwissProt for CASC2 Gene:

Q6XLA1-CSC2A_HUMAN
Tissue specificity: Expressed in normal and neoplastic endometrial tissues.
genes like me logo Genes that share expression patterns with CASC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASC2 Gene

Orthologs for CASC2 Gene

Evolution for CASC2 Gene

ENSEMBL:
Gene Tree for CASC2 (if available)
TreeFam:
Gene Tree for CASC2 (if available)

No data available for Orthologs for CASC2 Gene

Paralogs for CASC2 Gene

No data available for Paralogs for CASC2 Gene

Variants for CASC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CASC2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
VAR_039469 Some patients with endometrial cancer p.Pro8Ser

Additional dbSNP identifiers (rs#s) for CASC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CASC2 Gene

Variant ID Type Subtype PubMed ID
esv1096716 CNV insertion 17803354
esv1289381 CNV insertion 17803354
esv1538733 CNV insertion 17803354
esv1573329 CNV insertion 17803354
esv2580643 CNV deletion 19546169
esv2741484 CNV deletion 23290073
esv2741495 CNV deletion 23290073
esv2741506 CNV deletion 23290073
esv2741517 CNV deletion 23290073
nsv1047815 CNV gain 25217958
nsv1113339 CNV deletion 24896259
nsv1120230 CNV tandem duplication 24896259
nsv7566 CNV deletion 18451855
nsv7567 CNV insertion 18451855
nsv819998 CNV loss 19587683
nsv951860 CNV duplication 24416366
nsv958495 CNV insertion 24416366

Additional Variant Information for CASC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CASC2 Gene

Disorders for CASC2 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CASC2 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thyroid carcinoma
  • thyroid cancer
astrocytoma
  • astrocytic tumor
endometrial cancer
  • endometrial cancer, familial
malignant glioma
  • glial cell tumor
glioma
- elite association - COSMIC cancer census association via MalaCards
Search CASC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CASC2

genes like me logo Genes that share disorders with CASC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASC2 Gene

Publications for CASC2 Gene

  1. Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. (PMID: 15024726) Baldinu P … Palmieri G (Human mutation 2004) 3 4 23 54
  2. LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway. (PMID: 28121023) Liao Y … Cheng L (Journal of cellular biochemistry 2017) 2 3 54
  3. Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. (PMID: 25446261) Wang P … Xue YX (Cellular signalling 2015) 2 3 54
  4. CASC2a gene is down-regulated in endometrial cancer. (PMID: 17352238) Baldinu P … Palmieri G (Anticancer research 2007) 4 23 54
  5. Berberine Promotes Apoptosis of Colorectal Cancer via Regulation of the Long Non-Coding RNA (lncRNA) Cancer Susceptibility Candidate 2 (CASC2)/AU-Binding Factor 1 (AUF1)/B-Cell CLL/Lymphoma 2 (Bcl-2) Axis. (PMID: 30681073) Dai W … Wang X (Medical science monitor : international medical journal of experimental and clinical research 2019) 3 54

Products for CASC2 Gene

Sources for CASC2 Gene