Aliases for CARS1 Gene
External Ids for CARS1 Gene
Previous HGNC Symbols for CARS1 Gene
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
GeneCards Summary for CARS1 Gene
CARS1 (Cysteinyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with CARS1 include Microcephaly, Developmental Delay, And Brittle Hair Syndrome and Inflammatory Myofibroblastic Tumor. Among its related pathways are tRNA Aminoacylation and Gene Expression. An important paralog of this gene is CARS2.