This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-pro... See more...

Aliases for CARM1 Gene

Aliases for CARM1 Gene

  • Coactivator Associated Arginine Methyltransferase 1 2 3 5
  • PRMT4 2 3 4
  • Histone-Arginine Methyltransferase CARM1 3 4
  • Protein Arginine N-Methyltransferase 4 3 4
  • Coactivator-Associated Arginine Methyltransferase 1 4
  • EC 2.1.1.319 4
  • EC 2.1.1 51
  • CARM1 5

External Ids for CARM1 Gene

Previous GeneCards Identifiers for CARM1 Gene

  • GC19P011113
  • GC19P010827
  • GC19P010843
  • GC19P010982
  • GC19P010560

Summaries for CARM1 Gene

Entrez Gene Summary for CARM1 Gene

  • This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

GeneCards Summary for CARM1 Gene

CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with CARM1 include Otopalatodigital Syndrome, Type I and Spinal Muscular Atrophy. Among its related pathways are Organelle biogenesis and maintenance and Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT3.

UniProtKB/Swiss-Prot Summary for CARM1 Gene

  • Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

Additional gene information for CARM1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CARM1 Gene

Genomics for CARM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CARM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010870 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 604 +0.2 210 3.7 BRCA1 SP1 GATAD2A PRDM10 ZNF629 LEF1 CTCF ZNF692 BACH1 LARP7 CARM1 ZNF439 ZNF627 RAVER1 HNRNPA1P10 KRI1 ILF3 ZNF491 ZNF441 PRKCSH
GH19J010871 Enhancer 0.3 ENCODE dbSUPER 600.7 -2.0 -1976 0.1 CARM1 HIKESHIP2 C19orf38 lnc-TIMM29-1
GH19J010869 Enhancer 0.3 ENCODE dbSUPER 600.7 -1.8 -1753 0.1 CARM1 HIKESHIP2 C19orf38 lnc-TIMM29-1
GH19J010808 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.7 -57.1 -57065 11.6 CTCF ZBTB33 LEF1 IKZF1 KDM1A JUND MTA2 ZIC2 PKNOX1 REST KRI1 ILF3 TIMM29 ZNF441 PPAN ZNF627 C19orf38 FBXL12 EIF3G ILF3-DT
GH19J010889 Enhancer 1 Ensembl ENCODE dbSUPER 4.9 +20.0 19966 3.4 PRDM10 PRDM1 ZIC2 ZNF600 ZNF341 SCRT2 SP2 ESR1 POLR2A SCRT1 SMARCA4 ILF3-DT KEAP1 CARM1 RF00017-2812 RF00017-2813 YIPF2 lnc-TIMM29-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CARM1

Top Transcription factor binding sites by QIAGEN in the CARM1 gene promoter:
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CARM1 Gene

Genomic Locations for CARM1 Gene
chr19:10,871,553-10,923,078
(GRCh38/hg38)
Size:
51,526 bases
Orientation:
Plus strand
chr19:10,982,189-11,033,453
(GRCh37/hg19)
Size:
51,265 bases
Orientation:
Plus strand

Genomic View for CARM1 Gene

Genes around CARM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARM1 Gene

Proteins for CARM1 Gene

  • Protein details for CARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X55-CARM1_HUMAN
    Recommended name:
    Histone-arginine methyltransferase CARM1
    Protein Accession:
    Q86X55
    Secondary Accessions:
    • A6NN38

    Protein attributes for CARM1 Gene

    Size:
    608 amino acids
    Molecular mass:
    65854 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA.
    • (Microbial infection) Interacts with HTLV-1 protein Tax.

    Three dimensional structures from OCA and Proteopedia for CARM1 Gene

    Alternative splice isoforms for CARM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARM1 Gene

Selected DME Specific Peptides for CARM1 Gene

Q86X55:
  • DKIVLDVG
  • VLDVGCG
  • GCGSGIL

Post-translational modifications for CARM1 Gene

  • Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).
  • Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location in the cytosol.
  • Ubiquitination at Lys227 and Lys470
  • Modification sites at PhosphoSitePlus

Domains & Families for CARM1 Gene

Gene Families for CARM1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CARM1 Gene

Suggested Antigen Peptide Sequences for CARM1 Gene

GenScript: Design optimal peptide antigens:
  • Protein arginine N-methyltransferase 4 (CARM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86X55

UniProtKB/Swiss-Prot:

CARM1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with CARM1: view

Function for CARM1 Gene

Molecular function for CARM1 Gene

UniProtKB/Swiss-Prot Function:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence={ECO:0000269|PubMed:19405910};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18' (H3K18ac) H3 'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4.

Enzyme Numbers (IUBMB) for CARM1 Gene

Phenotypes From GWAS Catalog for CARM1 Gene

Gene Ontology (GO) - Molecular Function for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0003713 transcription coactivator activity ISS --
GO:0005515 protein binding IPI 16938873
GO:0008013 beta-catenin binding TAS 16344550
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with CARM1: view
genes like me logo Genes that share phenotypes with CARM1: view

Animal Models for CARM1 Gene

MGI Knock Outs for CARM1:
  • Carm1 Carm1<tm1b(EUCOMM)Hmgu>
  • Carm1 Carm1<tm1Mtb>

Animal Model Products

  • Taconic Biosciences Mouse Models for CARM1

CRISPR Products

miRNA for CARM1 Gene

miRTarBase miRNAs that target CARM1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARM1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARM1 Gene

Localization for CARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARM1 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARM1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15221992
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 15221992
GO:0005829 cytosol ISS --
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with CARM1: view

Pathways & Interactions for CARM1 Gene

genes like me logo Genes that share pathways with CARM1: view

Pathways by source for CARM1 Gene

1 KEGG pathway for CARM1 Gene
5 GeneGo (Thomson Reuters) pathways for CARM1 Gene
  • Cell cycle ESR1 regulation of G1/S transition
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Immune response Function of MEF2 in T lymphocytes
  • Transcription Ligand-dependent activation of the ESR1/SP pathway
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for CARM1 Gene
  • Crosstalk Between CARM1 and ESRs
  • Nuclear Receptor Activation by Vitamin-A
1 Cell Signaling Technology pathway for CARM1 Gene
1 GeneTex pathway for CARM1 Gene

SIGNOR curated interactions for CARM1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation IEA --
GO:0006325 chromatin organization IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006479 protein methylation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CARM1: view

Drugs & Compounds for CARM1 Gene

(8) Drugs for CARM1 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0
BMS PYRAZOLE INHIBITOR 7F Pharma 0
COMPOUND 17F [PMID:19632837] Pharma 0

(3) Additional Compounds for CARM1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with CARM1: view

Transcripts for CARM1 Gene

mRNA/cDNA for CARM1 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARM1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7:
SP8: - -
SP9: -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CARM1 Gene

GeneLoc Exon Structure for
CARM1

Expression for CARM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CARM1 Gene

mRNA differential expression in normal tissues according to GTEx for CARM1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for CARM1 Gene

This gene is overexpressed in Breast (10.3) and Uterus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARM1 Gene



Protein tissue co-expression partners for CARM1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CARM1

SOURCE GeneReport for Unigene cluster for CARM1 Gene:

Hs.323213

mRNA Expression by UniProt/SwissProt for CARM1 Gene:

Q86X55-CARM1_HUMAN
Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.

Evidence on tissue expression from TISSUES for CARM1 Gene

  • Nervous system(4.7)
  • Skin(4.5)
  • Muscle(3.5)
  • Kidney(2.6)
  • Intestine(2.5)
  • Lung(2.4)
  • Blood(2.4)
  • Liver(2.4)
  • Heart(2.3)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with CARM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARM1 Gene

Orthologs for CARM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CARM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CARM1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CARM1 30 31
  • 93.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Carm1 30
  • 91.14 (n)
Cow
(Bos Taurus)
Mammalia CARM1 30 31
  • 91.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Carm1 30 17 31
  • 90.51 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CARM1 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CARM1 31
  • 85 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CARM1 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia carm1 30
  • 77.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9644 30
Zebrafish
(Danio rerio)
Actinopterygii carm1 30 31
  • 77.14 (n)
OneToOne
btg1 30
African malaria mosquito
(Anopheles gambiae)
Insecta CARM1_ANOGA 30
  • 64.43 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Art4 30 31
  • 60.64 (n)
OneToOne
CG5358 32
  • 59 (a)
CG16840 32
  • 37 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 31
  • 33 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PRMT4B 30
  • 52.93 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0671700 30
  • 53.45 (n)
Os.10778 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5717 31
  • 60 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2441 30
Species where no ortholog for CARM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CARM1 Gene

ENSEMBL:
Gene Tree for CARM1 (if available)
TreeFam:
Gene Tree for CARM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CARM1: view image

Paralogs for CARM1 Gene

Paralogs for CARM1 Gene

(4) SIMAP similar genes for CARM1 Gene using alignment to 7 proteins:

  • CARM1_HUMAN
  • K7EIQ8_HUMAN
  • K7EK20_HUMAN
  • K7EPK1_HUMAN
  • K7EQA8_HUMAN
  • K7EQB9_HUMAN
  • K7ERM3_HUMAN

Pseudogenes.org Pseudogenes for CARM1 Gene

genes like me logo Genes that share paralogs with CARM1: view

Variants for CARM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CARM1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
777443 Likely Benign: not provided 10,921,652(+) G/A SYNONYMOUS_VARIANT
783826 Benign: not provided 10,913,885(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CARM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CARM1 Gene

Variant ID Type Subtype PubMed ID
esv3583244 CNV loss 25503493
nsv1144864 CNV deletion 24896259
nsv1160584 CNV deletion 26073780
nsv474981 CNV novel sequence insertion 20440878
nsv833748 CNV loss 17160897
nsv833749 CNV loss 17160897

Variation tolerance for CARM1 Gene

Residual Variation Intolerance Score: 8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARM1 Gene

Human Gene Mutation Database (HGMD)
CARM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARM1 Gene

Disorders for CARM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CARM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
otopalatodigital syndrome, type i
  • cranioorodigital syndrome
spinal muscular atrophy
  • progressive muscular atrophy
- elite association - COSMIC cancer census association via MalaCards
Search CARM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CARM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CARM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CARM1 Gene

Publications for CARM1 Gene

  1. Biochemical control of CARM1 enzymatic activity by phosphorylation. (PMID: 19843527) Feng Q … O'Malley BW (The Journal of biological chemistry 2009) 3 4 23
  2. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 41
  3. Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax. (PMID: 17005681) Jeong SJ … Brady JN (Journal of virology 2006) 3 4 23
  4. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PMID: 16497732) Miao F … Natarajan R (Molecular endocrinology (Baltimore, Md.) 2006) 3 4 23
  5. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. (PMID: 15731352) Lee YH … Stallcup MR (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23

Products for CARM1 Gene

Sources for CARM1 Gene