Aliases for CARM1 Gene
Aliases for CARM1 Gene
External Ids for CARM1 Gene
- HGNC: 23393
- Entrez Gene: 10498
- Ensembl: ENSG00000142453
- OMIM: 603934
- UniProtKB: Q86X55
Previous GeneCards Identifiers for CARM1 Gene
- GC19P011113
- GC19P010827
- GC19P010843
- GC19P010982
- GC19P010560
Summaries for CARM1 Gene
-
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
GeneCards Summary for CARM1 Gene
CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT3.
UniProtKB/Swiss-Prot for CARM1 Gene
-
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at Arg-17 (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at Arg-2142, which may loosen its interaction with NCOA2/GRIP1, and at Arg-580 and Arg-604 in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARM1 Gene
Genomics for CARM1 Gene
GeneHancer (GH) Regulatory Elements for CARM1 Gene
Promoters and enhancers for CARM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CARM1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CARM1 gene promoter:
Regulatory Element Products
Genomic Locations for CARM1 Gene
Genomic Locations for CARM1 Gene
- chr19:10,871,513-10,923,070
- (GRCh38/hg38)
- Size:
- 51,558 bases
- Orientation:
- Plus strand
- chr19:10,982,189-11,033,453
- (GRCh37/hg19)
Genomic View for CARM1 Gene
Genes around CARM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
CARM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CARM1 Gene
Proteins for CARM1 Gene
-
Protein details for CARM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86X55-CARM1_HUMAN
- Recommended name:
- Histone-arginine methyltransferase CARM1
- Protein Accession:
- Q86X55
- A6NN38
Protein attributes for CARM1 Gene
- Size:
- 608 amino acids
- Molecular mass:
- 65854 Da
- Quaternary structure:
-
- Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.
Three dimensional structures from OCA and Proteopedia for CARM1 Gene
Protein Expression for CARM1 Gene
Selected DME Specific Peptides for CARM1 Gene
- Q86X55:
-
- DKIVLDVG
- VLDVGCG
- GCGSGIL
Post-translational modifications for CARM1 Gene
- Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).
- Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location in the cytosol.
- Ubiquitination at posLast=227227 and posLast=470470
- Modification sites at PhosphoSitePlus
Other Protein References for CARM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CARM1 (Carm1)
-
Custom Antibody ServicesOriGene Antibodies for CARM1
- Novus Biologicals Antibodies for CARM1
-
Abcam antibodies for CARM1
- Invitrogen Antibodies for CARM1
- GeneTex CARM1 antibody for CARM1
-
Custom Antibody ServicesProSci Antibodies for CARM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CARM1
- Sino Biological Antibodies for CARM1
Protein Products
-
OriGene Purified Proteins for CARM1
- Search Origene for MassSpec and Protein Over-expression Lysates for CARM1
- Origene Custom Protein Services for CARM1
- Search GeneTex for Proteins for CARM1
-
Abcam proteins for CARM1
Assay Products
Domains & Families for CARM1 Gene
Gene Families for CARM1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CARM1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CARM1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86X55UniProtKB/Swiss-Prot:
CARM1_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Function for CARM1 Gene
Molecular function for CARM1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 Lys-18 (H3K18ac) H3 Lys-23 (H3K23ac) by EP300 and blocked by citrullination of H3 Arg-17 (H3R17ci) by PADI4.
- UniProtKB/Swiss-Prot Function:
- Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at Arg-17 (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at Arg-2142, which may loosen its interaction with NCOA2/GRIP1, and at Arg-580 and Arg-604 in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
Enzyme Numbers (IUBMB) for CARM1 Gene
Phenotypes From GWAS Catalog for CARM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001105 | RNA polymerase II transcription coactivator activity | IEA | -- |
| GO:0003713 | transcription coactivator activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 16938873 |
| GO:0008013 | beta-catenin binding | TAS | 16344550 |
| GO:0008168 | methyltransferase activity | IEA | -- |
Phenotypes for CARM1 Gene
- MGI mutant phenotypes for CARM1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CARM1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased Aire reporter expression
Animal Model Products
-
Taconic Biosciences Mouse Models for CARM1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CARM1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CARM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CARM1 gene
- Search ViGene Biosciences for CARM1
CRISPR Products
-
OriGene CRISPR knockouts for CARM1
- genomics-online: gRNA clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
- Applied Biological Materials CRISPR for CARM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARM1
- GenScript: Design CRISPR guide RNA sequences for CARM1
miRNA for CARM1 Gene
- miRTarBase miRNAs that target CARM1
-
- hsa-mir-92a-3p (MIRT049639)
- hsa-let-7e-5p (MIRT051469)
- hsa-mir-15a-5p (MIRT054424)
- hsa-mir-181a-5p (MIRT081041)
- hsa-mir-181b-5p (MIRT081042)
- hsa-mir-181c-5p (MIRT081043)
- hsa-mir-181d-5p (MIRT081049)
- hsa-mir-149-3p (MIRT149384)
- hsa-mir-1207-5p (MIRT149405)
- hsa-mir-1909-3p (MIRT149408)
- hsa-mir-4728-5p (MIRT149428)
- hsa-mir-4763-3p (MIRT149432)
- hsa-mir-6722-3p (MIRT149440)
- hsa-mir-6785-5p (MIRT149445)
- hsa-mir-6883-5p (MIRT149455)
- hsa-mir-27a-3p (MIRT149461)
- hsa-mir-27b-3p (MIRT149464)
- hsa-mir-1249-5p (MIRT149470)
- hsa-mir-3688-3p (MIRT149479)
- hsa-mir-5093 (MIRT149491)
- hsa-mir-6721-5p (MIRT149500)
- hsa-mir-6757-5p (MIRT149503)
- hsa-mir-6797-5p (MIRT149505)
- hsa-mir-7112-5p (MIRT149509)
- hsa-mir-223-3p (MIRT438169)
- hsa-mir-1245b-5p (MIRT736362)
- hsa-mir-1296-3p (MIRT737204)
- hsa-mir-184 (MIRT738187)
- hsa-mir-194-3p (MIRT738585)
- hsa-mir-3142 (MIRT740202)
- hsa-mir-4297 (MIRT743804)
- hsa-mir-5581-5p (MIRT750938)
- hsa-mir-6734-3p (MIRT754130)
- hsa-mir-6742-5p (MIRT754373)
- hsa-mir-128-1-5p (MIRT762131)
- hsa-mir-128-2-5p (MIRT762160)
- hsa-mir-15b-5p (MIRT762932)
- hsa-mir-16-5p (MIRT762942)
- hsa-mir-1827 (MIRT763026)
- hsa-mir-195-5p (MIRT763475)
- hsa-mir-3131 (MIRT764884)
- hsa-mir-424-5p (MIRT767954)
- hsa-mir-4283 (MIRT768370)
- hsa-mir-4436a (MIRT769106)
- hsa-mir-451b (MIRT769946)
- hsa-mir-4700-3p (MIRT771288)
- hsa-mir-497-5p (MIRT772805)
- hsa-mir-5000-3p (MIRT772893)
- hsa-mir-542-5p (MIRT773984)
- hsa-mir-611 (MIRT775781)
- hsa-mir-6777-5p (MIRT778787)
- hsa-mir-6808-5p (MIRT779651)
- hsa-mir-6838-5p (MIRT780089)
- hsa-mir-6877-5p (MIRT780760)
- hsa-mir-6889-5p (MIRT781128)
- hsa-mir-6893-5p (MIRT781184)
- hsa-mir-940 (MIRT782878)
miRNA Products
- Search ViGene Biosciences for CARM1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARM1
- Browse OriGene Inhibitory RNA Products For CARM1
- genomics-online: shRNA clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CARM1 gene
Clone Products
- Sino Biological Human cDNA Clone for CARM1
- VectorBuilder custom plasmid, inducible vectors for CARM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CARM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CARM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CARM1
-
ViGene Biosciences adenoviral particle packaged cDNA for CARM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CARM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CARM1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARM1 Gene
Localization for CARM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CARM1 Gene
- Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 15221992 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 15221992 |
| GO:0005829 | cytosol | IBA,ISS | -- |
| GO:0043234 | protein complex | IEA | -- |
Pathways & Interactions for CARM1 Gene
Pathways by source for CARM1 Gene
1 GeneTex pathway for CARM1 Gene
4 BioSystems pathways for CARM1 Gene
24 Reactome pathways for CARM1 Gene
1 KEGG pathway for CARM1 Gene
5 GeneGo (Thomson Reuters) pathways for CARM1 Gene
- Cell cycle ESR1 regulation of G1/S transition
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Immune response Function of MEF2 in T lymphocytes
- Transcription Ligand-dependent activation of the ESR1/SP pathway
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for CARM1 Gene
1 Cell Signaling Technology pathway for CARM1 Gene
Interacting Proteins for CARM1 Gene
Selected Interacting proteins:
Q86X55-CARM1_HUMAN
ENSP00000325690
for CARM1 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003420 | regulation of growth plate cartilage chondrocyte proliferation | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | ISS,IBA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0006479 | protein methylation | IEA | -- |
Drugs & Compounds for CARM1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
29908-03-0 |
Transcripts for CARM1 Gene
mRNA/cDNA for CARM1 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (311) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CARM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CARM1
- genomics-online: gRNA clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
- Applied Biological Materials CRISPR for CARM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARM1
- GenScript: Design CRISPR guide RNA sequences for CARM1
miRNA Products
- Search ViGene Biosciences for CARM1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARM1
- Browse OriGene Inhibitory RNA Products For CARM1
- genomics-online: shRNA clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CARM1 gene
Clone Products
- Sino Biological Human cDNA Clone for CARM1
- VectorBuilder custom plasmid, inducible vectors for CARM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CARM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CARM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
| ExUns: | 16b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Expression for CARM1 Gene
mRNA differential expression in normal tissues according to GTEx for CARM1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Breast (10.3) and Uterus (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CARM1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CARM1 Gene:
CARM1SOURCE GeneReport for Unigene cluster for CARM1 Gene:
Hs.323213mRNA Expression by UniProt/SwissProt for CARM1 Gene:
Q86X55-CARM1_HUMAN
Tissue specificity:
Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
Evidence on tissue expression from TISSUES for CARM1 Gene
- Nervous system(4.5)
- Skin(4.2)
- Muscle(3)
Primer Products
-
OriGene qPCR primer pairs for CARM1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARM1 Gene
Orthologs for CARM1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CARM1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CARM1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Carm1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CARM1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Carm1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CARM1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CARM1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CARM1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | carm1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9644 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | carm1 33 34 |
|
||
| btg1 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | CARM1_ANOGA 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Art4 33 34 |
|
||
| CG5358 35 |
|
|
|||
| CG16840 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HMT1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PRMT4B 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0671700 33 |
|
||
| Os.10778 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5717 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2441 33 |
|
- Species where no ortholog for CARM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CARM1 Gene
(4) SIMAP similar genes for CARM1 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for CARM1 Gene
Variants for CARM1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004367 | -- | 10,877,923(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000022008 | -- | 10,892,978(+) | A/C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000077821 | -- | 10,881,048(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000105798 | -- | 10,918,954(+) | T/G | intron_variant | |
| rs1000235539 | -- | 10,880,867(+) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3583244 | CNV | loss | 25503493 |
| nsv1144864 | CNV | deletion | 24896259 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv474981 | CNV | novel sequence insertion | 20440878 |
| nsv833748 | CNV | loss | 17160897 |
| nsv833749 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.26;
40.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CARM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARM1 Gene
Disorders for CARM1 Gene
Additional Disease Information for CARM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CARM1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARM1 Gene
Publications for CARM1 Gene
- Biochemical control of CARM1 enzymatic activity by phosphorylation. (PMID: 19843527) Feng Q … O'Malley BW (The Journal of biological chemistry 2009) 3 4 22 58
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 44 58
- Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PMID: 16497732) Miao F … Natarajan R (Molecular endocrinology (Baltimore, Md.) 2006) 3 4 22 58
- Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax. (PMID: 17005681) Jeong SJ … Brady JN (Journal of virology 2006) 3 4 22 58
- Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. (PMID: 15731352) Lee YH … Stallcup MR (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
Products for CARM1 Gene
- R&D Systems Antibodies for CARM1 (Carm1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CARM1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CARM1
- Search Origene for MassSpec and Protein Over-expression Lysates for CARM1
- Origene Custom Protein Services for CARM1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARM1
- Browse OriGene Inhibitory RNA Products For CARM1
- OriGene qPCR primer pairs for CARM1
- OriGene CRISPR knockouts for CARM1
- OriGene ORF clones in human for CARM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CARM1
- GenScript: Next-day shipping of latest version cDNA ORF clones for CARM1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CARM1
- GenScript Custom Assay Services for CARM1
- GenScript Custom overexpressing Cell Line Services for CARM1
- GenScript: Design CRISPR guide RNA sequences for CARM1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CARM1
- Sino Biological Human cDNA Clone for CARM1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Sino Biological Antibodies for CARM1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CARM1
- Novus Biologicals lysates and proteins for CARM1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CARM1
- Abcam proteins for CARM1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for CARM1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CARM1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CARM1
- VectorBuilder custom plasmid, inducible vectors for CARM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CARM1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 202 available CARM1 Antibodies ranked by validation data
- Compare Top CARM1 Antibodies
- antibodies-online: Search results for 3 available CARM1 Elisa Kits ranked by validation data
- Compare Top CARM1 Elisa Kits
- antibodies-online: Search results for 7 available CARM1 Proteins ranked by validation data
- Compare Top CARM1 Proteins
- GeneTex CARM1 antibody for CARM1
- Search GeneTex for Proteins for CARM1
- ViGene Biosciences adenoviral particle packaged cDNA for CARM1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CARM1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CARM1 gene
- Search ViGene Biosciences for CARM1
- Santa Cruz Biotechnology (SCBT) Antibodies for CARM1
- Search Santa Cruz Biotechnology (SCBT) for CARM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CARM1
- Custom Antibody ServicesProSci Antibodies for CARM1
- Search for CARM1 Proteins at ProSci
- Horizon Cell Lines for CARM1
- genomics-online: cdna clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
- orf clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
- genomics-online: gRNA clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
- genomics-online: primer clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
- genomics-online: shRNA clones - Search results for 96 available CARM1 gene related products
- Overview of 96 available CARM1 gene related products
Sources for CARM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems