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This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-pro... See more...
Aliases for CARM1 Gene
Aliases for CARM1 Gene
External Ids for CARM1 Gene
- HGNC: 23393
- NCBI Entrez Gene: 10498
- Ensembl: ENSG00000142453
- OMIM®: 603934
- UniProtKB/Swiss-Prot: Q86X55
Previous GeneCards Identifiers for CARM1 Gene
- GC19P011113
- GC19P010827
- GC19P010843
- GC19P010982
- GC19P010560
Summaries for CARM1 Gene
-
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
GeneCards Summary for CARM1 Gene
CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with CARM1 include Spinal Muscular Atrophy and Otopalatodigital Syndrome, Type I. Among its related pathways are Androgen receptor signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is PRMT2.
UniProtKB/Swiss-Prot Summary for CARM1 Gene
-
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
Additional gene information for CARM1 Gene
- HGNC (23393)
- NCBI Entrez Gene (10498)
- Ensembl (ENSG00000142453)
- OMIM® (603934)
- UniProtKB/Swiss-Prot (Q86X55)
- Open Targets Platform(ENSG00000142453)
- Search for CARM1 at DataMed
- Search for CARM1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CARM1 Gene
Genomics for CARM1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CARM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CARM1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CARM1
- Top Transcription factor binding sites by QIAGEN in the CARM1 gene promoter:
-
- CREB
- deltaCREB
- GR
- GR-alpha
- GR-beta
- HNF-4alpha1
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for CARM1 Gene
Latest Assembly
- chr19:10,871,553-10,923,078
- (GRCh38/hg38)
- Size:
- 51,526 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:10,982,229-11,033,751
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 51,523 bases
- Orientation:
- Plus strand
- chr19:10,982,189-11,033,453
- (GRCh37/hg19 by Ensembl)
- Size:
- 51,265 bases
- Orientation:
- Plus strand
Genomic View for CARM1 Gene
Genes around CARM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
CARM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CARM1 Gene
Proteins for CARM1 Gene
-
Protein details for CARM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86X55-CARM1_HUMAN
- Recommended name:
- Histone-arginine methyltransferase CARM1
- Protein Accession:
- Q86X55
- A6NN38
Protein attributes for CARM1 Gene
- Size:
- 608 amino acids
- Molecular mass:
- 65854 Da
- Quaternary structure:
-
- Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, TRIM24, CREBBP and CTNNB1. Identified in a complex containing CARM1, TRIM24 and NCOA2/GRIP1. Interacts with NCOA3/SRC3. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA.
- (Microbial infection) Interacts with HTLV-1 protein Tax.
Three dimensional structures from OCA and Proteopedia for CARM1 Gene
Protein Expression for CARM1 Gene
Selected DME Specific Peptides for CARM1 Gene
- Q86X55:
-
- DKIVLDVG
- VLDVGCG
- GCGSGIL
Post-translational modifications for CARM1 Gene
- Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).
- Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location in the cytosol.
-
Ubiquitination at Lys227 and Lys470
- NX_Q86X55 (NX_Q86X55-3)
- Modification sites at PhosphoSitePlus
Other Protein References for CARM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PRMT4 / CARM1 Antibody
- NSJ Bioreagents PRMT4 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CARM1
- Novus Biologicals Antibodies for CARM1
- Invitrogen Antibodies for CARM1 (AFLGC-Carm1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CARM1
- Sino Biological Antibodies for CARM1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CARM1
- Origene Custom Protein Services for CARM1
-
Abcam proteins for CARM1
Assay products for research
- antibodies-online: Show 6 available CARM1 Elisa Kits ranked by validation data
- Compare Top CARM1 Elisa Kits
-
Quality Products:
Domains & Families for CARM1 Gene
Gene Families for CARM1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for CARM1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CARM1 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein arginine N-methyltransferase 4 (CARM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86X55UniProtKB/Swiss-Prot:
CARM1_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Function for CARM1 Gene
Molecular function for CARM1 Gene
- UniProtKB/Swiss-Prot Function:
- Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319; Evidence={ECO:0000269|PubMed:19405910};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Methylation of H3R17 (H3R17me) by CARM1 is stimulated by preacetylation of H3 'Lys-18' (H3K18ac) H3 'Lys-23' (H3K23ac) by EP300 and blocked by citrullination of H3 'Arg-17' (H3R17ci) by PADI4.
Enzyme Numbers (IUBMB) for CARM1 Gene
Phenotypes From GWAS Catalog for CARM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0003713 | transcription coactivator activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 16938873 |
| GO:0008013 | beta-catenin binding | TAS | 16344550 |
| GO:0008168 | methyltransferase activity | IEA | -- |
Phenotypes for CARM1 Gene
- MGI mutant phenotypes for CARM1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CARM1:
-
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with Ras
- Decreased viability
- shRNA abundance <= 50%
- Reduced mammosphere formation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 25%
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased Aire reporter expression
Animal Models for CARM1 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for CARM1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CARM1 - Starting at $85 >
- * CARM1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CARM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARM1
miRNA for CARM1 Gene
- miRTarBase miRNAs that target CARM1
-
- mmu-miR-9-5p (MIRT015393)
- hsa-miR-92a-3p (MIRT049639)
- hsa-let-7e-5p (MIRT051469)
- hsa-miR-15a-5p (MIRT054424)
- hsa-miR-181a-5p (MIRT081041)
- hsa-miR-181b-5p (MIRT081042)
- hsa-miR-181c-5p (MIRT081043)
- hsa-miR-181d-5p (MIRT081049)
- hsa-miR-149-3p (MIRT149384)
- hsa-miR-1207-5p (MIRT149405)
- hsa-miR-1909-3p (MIRT149408)
- hsa-miR-4728-5p (MIRT149428)
- hsa-miR-4763-3p (MIRT149432)
- hsa-miR-6722-3p (MIRT149440)
- hsa-miR-6785-5p (MIRT149445)
- hsa-miR-6883-5p (MIRT149455)
- hsa-miR-27a-3p (MIRT149461)
- hsa-miR-27b-3p (MIRT149464)
- hsa-miR-1249-5p (MIRT149470)
- hsa-miR-3688-3p (MIRT149479)
- hsa-miR-5093 (MIRT149491)
- hsa-miR-6721-5p (MIRT149500)
- hsa-miR-6757-5p (MIRT149503)
- hsa-miR-6797-5p (MIRT149505)
- hsa-miR-7112-5p (MIRT149509)
- hsa-miR-223-3p (MIRT438169)
- hsa-miR-1245b-5p (MIRT736362)
- hsa-miR-1296-3p (MIRT737204)
- hsa-miR-184 (MIRT738187)
- hsa-miR-194-3p (MIRT738585)
- hsa-miR-3142 (MIRT740202)
- hsa-miR-4297 (MIRT743804)
- hsa-miR-5581-5p (MIRT750938)
- hsa-miR-6734-3p (MIRT754130)
- hsa-miR-6742-5p (MIRT754373)
- hsa-miR-128-1-5p (MIRT762131)
- hsa-miR-128-2-5p (MIRT762160)
- hsa-miR-15b-5p (MIRT762932)
- hsa-miR-16-5p (MIRT762942)
- hsa-miR-1827 (MIRT763026)
- hsa-miR-195-5p (MIRT763475)
- hsa-miR-3131 (MIRT764884)
- hsa-miR-424-5p (MIRT767954)
- hsa-miR-4283 (MIRT768370)
- hsa-miR-4436a (MIRT769106)
- hsa-miR-451b (MIRT769946)
- hsa-miR-4700-3p (MIRT771288)
- hsa-miR-497-5p (MIRT772805)
- hsa-miR-5000-3p (MIRT772893)
- hsa-miR-542-5p (MIRT773984)
- hsa-miR-611 (MIRT775781)
- hsa-miR-6777-5p (MIRT778787)
- hsa-miR-6808-5p (MIRT779651)
- hsa-miR-6838-5p (MIRT780089)
- hsa-miR-6877-5p (MIRT780760)
- hsa-miR-6889-5p (MIRT781128)
- hsa-miR-6893-5p (MIRT781184)
- hsa-miR-940 (MIRT782878)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARM1
- Browse OriGene Inhibitory RNA Products For CARM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARM1
Clone products for research
- Applied Biological Materials (abm): Clones for CARM1 - Starting at $45 >
- * CARM1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209145
- MG222283
- MR209145
- MR209145L3
- MR209145L4
- MR222283
- MR222283L1
- MR222283L2
- MR222283L3
- MR222283L4
- RC217483
- RC217483L1
- RC217483L2
- RC217483L3
- RC217483L4
- RG217483
- RR200050
- RR200050L3
- RR200050L4
- RR200051
- RR200051L3
- RR200051L4
- MR209145L3V
- MR209145L4V
- MR222283L1V
- MR222283L2V
- MR222283L3V
- MR222283L4V
- RC217483L1V
- RC217483L2V
- RC217483L3V
- RC217483L4V
- RR200050L3V
- RR200050L4V
- RR200051L3V
- RR200051L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CARM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARM1
Cell Lines for research
-
Horizon Cell Lines for CARM1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARM1 Gene
Localization for CARM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CARM1 Gene
- Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 15221992 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 15221992 |
| GO:0005829 | cytosol | ISS | -- |
Pathways & Interactions for CARM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Crosstalk Between CARM1 and ESRs
.39
|
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
|
| 4 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | ||
| 5 | Chromatin organization | ||
Pathways by source for CARM1 Gene
4 BioSystems pathways for CARM1 Gene
24 Reactome pathways for CARM1 Gene
1 KEGG pathway for CARM1 Gene
5 GeneGo (Thomson Reuters) pathways for CARM1 Gene
- Cell cycle ESR1 regulation of G1/S transition
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Immune response Function of MEF2 in T lymphocytes
- Transcription Ligand-dependent activation of the ESR1/SP pathway
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for CARM1 Gene
- Crosstalk Between CARM1 and ESRs
- Nuclear Receptor Activation by Vitamin-A
1 Cell Signaling Technology pathway for CARM1 Gene
1 GeneTex pathway for CARM1 Gene
Interacting Proteins for CARM1 Gene
Selected Interacting proteins:
Q86X55-CARM1_HUMAN
ENSP00000325690
for CARM1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CARM1
SIGNOR curated interactions for CARM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
Drugs & Compounds for CARM1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
Transcripts for CARM1 Gene
mRNA/cDNA for CARM1 Gene
- 3 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000327064 3295 nts (view in UCSC)
- ENST00000344150 2722 nts (view in UCSC)
- ENST00000586221 2766 nts (view in UCSC)
- ENST00000586298 674 nts (view in UCSC)
- ENST00000586508 1050 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CARM1 - Starting at $85 >
- * CARM1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CARM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARM1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARM1
- Browse OriGene Inhibitory RNA Products For CARM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARM1
Clone products for research
- Applied Biological Materials (abm): Clones for CARM1 - Starting at $45 >
- * CARM1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209145
- MG222283
- MR209145
- MR209145L3
- MR209145L4
- MR222283
- MR222283L1
- MR222283L2
- MR222283L3
- MR222283L4
- RC217483
- RC217483L1
- RC217483L2
- RC217483L3
- RC217483L4
- RG217483
- RR200050
- RR200050L3
- RR200050L4
- RR200051
- RR200051L3
- RR200051L4
- MR209145L3V
- MR209145L4V
- MR222283L1V
- MR222283L2V
- MR222283L3V
- MR222283L4V
- RC217483L1V
- RC217483L2V
- RC217483L3V
- RC217483L4V
- RR200050L3V
- RR200050L4V
- RR200051L3V
- RR200051L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CARM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARM1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
| ExUns: | 16b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Relevant External Links for CARM1 Gene
- GeneLoc Exon Structure for
- CARM1
Expression for CARM1 Gene
mRNA differential expression in normal tissues according to GTEx for CARM1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Breast (10.3) and Uterus (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARM1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CARM1
SOURCE GeneReport for Unigene cluster for CARM1 Gene:
Hs.323213mRNA Expression by UniProt/SwissProt for CARM1 Gene:
Q86X55-CARM1_HUMAN
Tissue specificity:
Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
Evidence on tissue expression from TISSUES for CARM1 Gene
- Nervous system(4.7)
- Skin(4.5)
- Muscle(3.4)
- Kidney(2.4)
- Intestine(2.4)
- Lung(2.3)
- Blood(2.2)
- Heart(2.2)
- Liver(2.2)
- Thyroid gland(2.1)
- Lymph node(2)
Primer products for research
-
OriGene qPCR primer pairs for CARM1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARM1 Gene
Orthologs for CARM1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CARM1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CARM1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Carm1 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | CARM1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Carm1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CARM1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CARM1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CARM1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | carm1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9644 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | carm1 30 31 |
|
OneToOne | |
| btg1 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | CARM1_ANOGA 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Art4 30 31 |
|
OneToOne | |
| CG5358 32 |
|
|
|||
| CG16840 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HMT1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PRMT4B 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os07g0671700 30 |
|
||
| Os.10778 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5717 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2441 30 |
|
- Species where no ortholog for CARM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CARM1 Gene
- ENSEMBL:
- Gene Tree for CARM1 (if available)
- TreeFam:
- Gene Tree for CARM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CARM1: view image
Paralogs for CARM1 Gene
(4) SIMAP similar genes for CARM1 Gene using alignment to 7 proteins:
- CARM1_HUMAN
- K7EIQ8_HUMAN
- K7EK20_HUMAN
- K7EPK1_HUMAN
- K7EQA8_HUMAN
- K7EQB9_HUMAN
- K7ERM3_HUMAN
Pseudogenes.org Pseudogenes for CARM1 Gene
Variants for CARM1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CARM1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 992650 | Uncertain Significance: not provided | 10,908,054(+) |
A/T NM_199141.2(CARM1):c.362A>T (p.Tyr121Phe) |
MISSENSE | |
| rs114556688 | Benign: not provided | 10,913,885(+) |
G/A NM_199141.2(CARM1):c.678G>A (p.Val226=) |
SYNONYMOUS | |
| rs149968022 | Likely Benign: not provided | 10,921,652(+) |
G/A NM_199141.2(CARM1):c.1722G>A (p.Thr574=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3583244 | CNV | loss | 25503493 |
| nsv1144864 | CNV | deletion | 24896259 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv474981 | CNV | novel sequence insertion | 20440878 |
| nsv833748 | CNV | loss | 17160897 |
| nsv833749 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.26;
40.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CARM1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARM1 Gene
Disorders for CARM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinal muscular atrophy |
|
|
| otopalatodigital syndrome, type i |
|
|
| breast cancer |
|
|
Search CARM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CARM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CARM1 Gene
Publications for CARM1 Gene
- Biochemical control of CARM1 enzymatic activity by phosphorylation. (PMID: 19843527) Feng Q … O'Malley BW (The Journal of biological chemistry 2009) 3 4 23
- Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 23 41
- Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax. (PMID: 17005681) Jeong SJ … Brady JN (Journal of virology 2006) 3 4 23
- Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PMID: 16497732) Miao F … Natarajan R (Molecular endocrinology (Baltimore, Md.) 2006) 3 4 23
- Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. (PMID: 15731352) Lee YH … Stallcup MR (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
ExternalLinks
Products for CARM1 Gene
- Custom Antibody ServicesOriGene Antibodies for CARM1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARM1
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- OriGene qPCR primer pairs for CARM1
- OriGene CRISPR knockouts for CARM1
- MG209145
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- MR209145
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- MR222283L1
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- RC217483
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- RR200050
- RR200050L3
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- RR200050L3V
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- RR200051L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CARM1
- Sino Biological Human cDNA Clone for CARM1
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- Sino Biological Antibodies for CARM1
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- Browse Antibodies
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for CARM1
- Browse Antibodies
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- Find your target
- Browse Primary Antibodies
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- Taconic Biosciences Mouse Models for CARM1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CARM1 (AFLGC-Carm1)
- VectorBuilder Custom and pre-made DNA vectors for CARM1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CARM1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CARM1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CARM1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CARM1
- antibodies-online: Show 55 available CARM1 Antibodies ranked by validation data
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- antibodies-online: Show 6 available CARM1 Elisa Kits ranked by validation data
- Compare Top CARM1 Elisa Kits
- Quality Products:
- antibodies-online: Show 7 available CARM1 Proteins ranked by validation data
- Compare Top CARM1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CARM1
- Search Santa Cruz Biotechnology (SCBT) for CARM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CARM1
- Horizon Cell Lines for CARM1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARM1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CARM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARM1
Sources for CARM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
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- (80) MaxQB
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- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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- (94) GeneReviews
- (95) GeneTex
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- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
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- (104) diseasecard
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- (163) LncBase
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- (165) LNCipedia
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- (176) snoDB
- (177) MirGeneDB