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Aliases for CARHSP1 Gene

Aliases for CARHSP1 Gene

  • Calcium Regulated Heat Stable Protein 1 2 3 5
  • Calcium-Regulated Heat-Stable Protein Of 24 KDa 3 4
  • Calcium Regulated Heat Stable Protein 1, 24kDa 2 3
  • CRHSP-24 3 4
  • Calcium Regulated Heat Stable Protein 1 (24kD) 2
  • Calcium-Regulated Heat-Stable Protein (24kD) 3
  • Calcium-Regulated Heat-Stable Protein 1 3
  • CRHSP24 3
  • CSDC1 3

External Ids for CARHSP1 Gene

Previous GeneCards Identifiers for CARHSP1 Gene

  • GC16M008750
  • GC16M009048
  • GC16M008914
  • GC16M008916
  • GC16M008857
  • GC16M008946
  • GC16M008867

Summaries for CARHSP1 Gene

GeneCards Summary for CARHSP1 Gene

CARHSP1 (Calcium Regulated Heat Stable Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA 3-UTR binding. An important paralog of this gene is CSDC2.

UniProtKB/Swiss-Prot for CARHSP1 Gene

  • Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Gene Wiki entry for CARHSP1 Gene

Additional gene information for CARHSP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARHSP1 Gene

Genomics for CARHSP1 Gene

GeneHancer (GH) Regulatory Elements for CARHSP1 Gene

Promoters and enhancers for CARHSP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J008858 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 663.2 +4.5 4484 11.2 CLOCK MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 SP3 CARHSP1 ENSG00000260276 PMM2 ENSG00000260349 C16orf72 ENSG00000261481 GC16P008857
GH16J008796 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19 +71.0 70986 3.1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 PMM2 TMEM186 CARHSP1 ENSG00000260276 RNU7-63P GC16M008818
GH16J009089 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.5 -223.3 -223347 5.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 C16orf72 PIR39735 GC16P009091 USP7 METTL22 ENSG00000260349 LINC01195 LINC01177 ENSG00000260058 ENSG00000260003
GH16J008847 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.9 +19.6 19556 3.5 MLX ARID4B ZNF48 YY1 TCF12 FOS NFKBIZ PAF1 RXRA SP5 ENSG00000260276 PIR57219 PIR52659 PIR38881 GC16M008839 ENSG00000260350 CARHSP1 PMM2
GH16J008890 Enhancer 1.1 FANTOM5 ENCODE 13.8 -23.6 -23616 3.7 PKNOX1 SMAD1 RB1 STAT5A BMI1 YBX1 BATF KLF5 IRF4 RAD21 CARHSP1 USP7 C16orf72 LOC101929989 GC16P008905
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARHSP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CARHSP1 gene promoter:
  • c-Ets-1
  • E47
  • ITF-2
  • Tal-1beta
  • Egr-3

Genomic Locations for CARHSP1 Gene

Genomic Locations for CARHSP1 Gene
16,071 bases
Minus strand
16,068 bases
Minus strand

Genomic View for CARHSP1 Gene

Genes around CARHSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARHSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARHSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARHSP1 Gene

Proteins for CARHSP1 Gene

  • Protein details for CARHSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-regulated heat-stable protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R4C3
    • D3DUF5
    • Q2YDX5
    • Q9BQ53

    Protein attributes for CARHSP1 Gene

    147 amino acids
    Molecular mass:
    15892 Da
    Quaternary structure:
    • Homodimer. Interacts with STYX (By similarity).

    Three dimensional structures from OCA and Proteopedia for CARHSP1 Gene

neXtProt entry for CARHSP1 Gene

Post-translational modifications for CARHSP1 Gene

  • Dephosphorylated by calcineurin in a Ca(2+) dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).
  • Ubiquitination at Lys64
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CARHSP1
  • Boster Bio Antibodies for CARHSP1

No data available for DME Specific Peptides for CARHSP1 Gene

Domains & Families for CARHSP1 Gene

Gene Families for CARHSP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CARHSP1 Gene

Suggested Antigen Peptide Sequences for CARHSP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARHSP1: view

No data available for UniProtKB/Swiss-Prot for CARHSP1 Gene

Function for CARHSP1 Gene

Molecular function for CARHSP1 Gene

UniProtKB/Swiss-Prot Function:
Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Phenotypes From GWAS Catalog for CARHSP1 Gene

Gene Ontology (GO) - Molecular Function for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding IDA 21078874
genes like me logo Genes that share ontologies with CARHSP1: view
genes like me logo Genes that share phenotypes with CARHSP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARHSP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARHSP1 Gene

Localization for CARHSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARHSP1 Gene

Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARHSP1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000177 colocalizes_with cytoplasmic exosome (RNase complex) ISS --
GO:0000932 P-body IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol ISS --
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with CARHSP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CARHSP1 Gene

Pathways & Interactions for CARHSP1 Gene

SuperPathways for CARHSP1 Gene

No Data Available

SIGNOR curated interactions for CARHSP1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CARHSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0035556 intracellular signal transduction TAS 9712905
GO:0043488 regulation of mRNA stability ISS,IBA --
genes like me logo Genes that share ontologies with CARHSP1: view

No data available for Pathways by source for CARHSP1 Gene

Drugs & Compounds for CARHSP1 Gene

No Compound Related Data Available

Transcripts for CARHSP1 Gene

Unigene Clusters for CARHSP1 Gene

Calcium regulated heat stable protein 1, 24kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARHSP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARHSP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP13: - - - - - - - -

Relevant External Links for CARHSP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARHSP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARHSP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARHSP1 Gene

Protein tissue co-expression partners for CARHSP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARHSP1 Gene:


SOURCE GeneReport for Unigene cluster for CARHSP1 Gene:


Evidence on tissue expression from TISSUES for CARHSP1 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Blood(4.2)
  • Eye(2.8)
genes like me logo Genes that share expression patterns with CARHSP1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARHSP1 Gene

Orthologs for CARHSP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CARHSP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARHSP1 34 33
  • 99.32 (n)
(Mus musculus)
Mammalia Gm9791 34
  • 95 (a)
Carhsp1 16 34 33
  • 89.14 (n)
(Canis familiaris)
Mammalia CARHSP1 34 33
  • 88.66 (n)
(Rattus norvegicus)
Mammalia Carhsp1 33
  • 88.21 (n)
(Bos Taurus)
Mammalia CARHSP1 34 33
  • 87.41 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 86 (a)
-- 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia CARHSP1 34
  • 70 (a)
(Gallus gallus)
Aves CARHSP1 34 33
  • 77.53 (n)
(Anolis carolinensis)
Reptilia CARHSP1 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia carhsp1 33
  • 72.18 (n)
Str.15423 33
African clawed frog
(Xenopus laevis)
Amphibia carhsp1-prov 33
(Danio rerio)
Actinopterygii carhsp1 34 33
  • 70.34 (n)
zgc65920 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10912 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005641 33
  • 60.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9705 34 33
  • 55.46 (n)
Species where no ortholog for CARHSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARHSP1 Gene

Gene Tree for CARHSP1 (if available)
Gene Tree for CARHSP1 (if available)
Evolutionary constrained regions (ECRs) for CARHSP1: view image

Paralogs for CARHSP1 Gene

Paralogs for CARHSP1 Gene

(1) SIMAP similar genes for CARHSP1 Gene using alignment to 8 proteins:

  • I3L3X8_HUMAN
genes like me logo Genes that share paralogs with CARHSP1: view

Variants for CARHSP1 Gene

Sequence variations from dbSNP and Humsavar for CARHSP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000037467 -- 8,869,291(-) G/A upstream_transcript_variant
rs1000247347 -- 8,853,685(-) A/G 3_prime_UTR_variant
rs1000345225 -- 8,859,616(-) G/A/C intron_variant
rs1000425285 -- 8,864,159(-) AT/ genic_upstream_transcript_variant, intron_variant
rs1000518554 -- 8,868,370(-) G/C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CARHSP1 Gene

Variant ID Type Subtype PubMed ID
dgv341n27 CNV gain 19166990
dgv4906n54 CNV gain 21841781
esv27013 CNV gain 19812545
esv2763129 CNV gain 21179565
nsv1036523 CNV gain 25217958
nsv1043528 CNV gain 25217958
nsv457394 CNV gain 19166990
nsv521109 CNV loss 19592680
nsv571424 CNV gain 21841781
nsv571428 CNV gain 21841781
nsv833135 CNV loss 17160897
nsv952916 CNV deletion 24416366

Variation tolerance for CARHSP1 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARHSP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARHSP1 Gene

Disorders for CARHSP1 Gene

Additional Disease Information for CARHSP1

No disorders were found for CARHSP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARHSP1 Gene

Publications for CARHSP1 Gene

  1. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. (PMID: 9712905) Groblewski GE … Williams JA (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL. (PMID: 15910284) Auld GC … Cohen P (The Biochemical journal 2005) 3 4 22 58
  3. Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response. (PMID: 21177848) Hou H … Rao Z (The Journal of biological chemistry 2011) 3 4 58
  4. CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. (PMID: 21078874) Pfeiffer JR … Brooks SA (Molecular and cellular biology 2011) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CARHSP1 Gene

Sources for CARHSP1 Gene

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