The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This pro... See more...

Aliases for CARD9 Gene

Aliases for CARD9 Gene

  • Caspase Recruitment Domain Family Member 9 2 3 5
  • Caspase Recruitment Domain-Containing Protein 9 3 4
  • HCARD9 3 4
  • Caspase Recruitment Domain Family, Member 9 2
  • CANDF2 3

External Ids for CARD9 Gene

Previous GeneCards Identifiers for CARD9 Gene

  • GC09M130326
  • GC09M130947
  • GC09M132699
  • GC09M134615
  • GC09M136532
  • GC09M138373
  • GC09M138378
  • GC09M139259
  • GC09M108717

Summaries for CARD9 Gene

Entrez Gene Summary for CARD9 Gene

  • The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CARD9 Gene

CARD9 (Caspase Recruitment Domain Family Member 9) is a Protein Coding gene. Diseases associated with CARD9 include Candidiasis, Familial, 2 and Candidiasis. Among its related pathways are CLEC7A (Dectin-1) signaling and Nucleotide-binding Oligomerization Domain (NOD) pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and CARD domain binding. An important paralog of this gene is CARD11.

UniProtKB/Swiss-Prot Summary for CARD9 Gene

  • Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

Gene Wiki entry for CARD9 Gene

Additional gene information for CARD9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CARD9 Gene

Genomics for CARD9 Gene

GeneHancer (GH) Regulatory Elements for CARD9 Gene

Promoters and enhancers for CARD9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J136370 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.7 678 2.8 CTCF NRF1 POLR2G FOS ZNF10 ZIC2 ZNF263 ZBTB11 ZNF423 REST CARD9 INPP5E SNAPC4 SNHG7 ANAPC2 ENTR1 MAN1B1 SEC16A NDOR1 lnc-DNLZ-1
GH09J136358 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.8 +11.9 11948 5.7 RXRA HNRNPK EP300 CTCF MYC TCF12 POLR2G USF1 SP1 GTF2E2 DNLZ RABL6 INPP5E ANAPC2 ENTR1 SNHG7 MAN1B1 SNAPC4 SEC16A NPDC1
GH09J136398 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -26.1 -26140 3 HNRNPK ZBTB40 CTCF SIN3A POLR2G SP1 PHF8 ZFX ZNF10 ZIC2 SNAPC4 INPP5E DNLZ SEC16A ENTR1 ANAPC2 MAN1B1 SNHG7 NDOR1 CARD9
GH09J136408 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.6 -36.8 -36772 3.6 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 ZFX ENTR1 PMPCA piR-37148 piR-43062 INPP5E DNLZ SEC16A SNAPC4 GPSM1 CARD9
GH09J136403 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.7 -30.5 -30545 2.9 ZIC2 RELA MEF2C TRIM22 POLR2A BCL11A TCF12 CBFB POLR2G MEF2B lnc-SNAPC4-1 piR-46328-002 piR-48360 ENTR1 DNLZ INPP5E SNAPC4 SEC16A CARD9 GPSM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARD9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CARD9

Top Transcription factor binding sites by QIAGEN in the CARD9 gene promoter:
  • c-Ets-1
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • NRSF form 2
  • Pax-6
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)

Genomic Locations for CARD9 Gene

Genomic Locations for CARD9 Gene
chr9:136,361,903-136,373,681
(GRCh38/hg38)
Size:
11,779 bases
Orientation:
Minus strand
chr9:139,256,355-139,268,133
(GRCh37/hg19)
Size:
11,779 bases
Orientation:
Minus strand

Genomic View for CARD9 Gene

Genes around CARD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD9 Gene

Proteins for CARD9 Gene

  • Protein details for CARD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H257-CARD9_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 9
    Protein Accession:
    Q9H257
    Secondary Accessions:
    • Q5SXM5
    • Q5SXM6
    • Q9H854

    Protein attributes for CARD9 Gene

    Size:
    536 amino acids
    Molecular mass:
    62241 Da
    Quaternary structure:
    • Interacts with NOD2 (via NACHT domain) (PubMed:24960071). Interacts with RIPK2 (By similarity). Interacts with VHL; without leading to protein degradation (By similarity). Self-associates. Interacts (via CARD domain) with BCL10 (via CARD domain) (PubMed:11053425).
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for CARD9 Gene

    Alternative splice isoforms for CARD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD9 Gene

Post-translational modifications for CARD9 Gene

  • Phosphorylated at Thr-531 and Thr-533 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD9 Gene

No data available for DME Specific Peptides for CARD9 Gene

Domains & Families for CARD9 Gene

Gene Families for CARD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CARD9 Gene

Blocks:
  • CARD interaction domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CARD9 Gene

GenScript: Design optimal peptide antigens:
  • Caspase recruitment domain-containing protein 9 (CARD9_HUMAN)
  • cDNA FLJ76920, highly similar to Homo sapiens caspase recruitment domain family, member 9 (CARD9), mRNA (Q5SXM5_HUMAN)
genes like me logo Genes that share domains with CARD9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CARD9 Gene

Function for CARD9 Gene

Molecular function for CARD9 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

Phenotypes From GWAS Catalog for CARD9 Gene

Gene Ontology (GO) - Molecular Function for CARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22267217
GO:0019904 protein domain specific binding IEA --
GO:0042803 protein homodimerization activity IPI 11053425
GO:0050700 CARD domain binding IBA,IPI 11053425
genes like me logo Genes that share ontologies with CARD9: view
genes like me logo Genes that share phenotypes with CARD9: view

Human Phenotype Ontology for CARD9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CARD9 Gene

MGI Knock Outs for CARD9:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CARD9

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CARD9 Gene

Localization for CARD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD9 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
endosome 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 11053425
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0032991 protein-containing complex IDA 22267217
genes like me logo Genes that share ontologies with CARD9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CARD9 Gene

Pathways & Interactions for CARD9 Gene

genes like me logo Genes that share pathways with CARD9: view

SIGNOR curated interactions for CARD9 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0009620 response to fungus IEA --
GO:0032494 response to peptidoglycan IEA --
genes like me logo Genes that share ontologies with CARD9: view

Drugs & Compounds for CARD9 Gene

No Compound Related Data Available

Transcripts for CARD9 Gene

mRNA/cDNA for CARD9 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CARD9

Alternative Splicing Database (ASD) splice patterns (SP) for CARD9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6: -
SP7: -
SP8:
SP9:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CARD9 Gene

GeneLoc Exon Structure for
CARD9

Expression for CARD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CARD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARD9 Gene

This gene is overexpressed in Whole Blood (x6.5) and Spleen (x5.9).

Protein differential expression in normal tissues from HIPED for CARD9 Gene

This gene is overexpressed in Pancreas (39.9), Peripheral blood mononuclear cells (7.2), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CARD9 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CARD9

SOURCE GeneReport for Unigene cluster for CARD9 Gene:

Hs.694071

mRNA Expression by UniProt/SwissProt for CARD9 Gene:

Q9H257-CARD9_HUMAN
Tissue specificity: Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.

Evidence on tissue expression from TISSUES for CARD9 Gene

  • Blood(4.4)
  • Muscle(4.3)
  • Spleen(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD9 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with CARD9: view

No data available for Protein tissue co-expression partners for CARD9 Gene

Orthologs for CARD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CARD9 31 30
  • 99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CARD9 31 30
  • 87.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CARD9 31 30
  • 85.88 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Card9 30
  • 85.23 (n)
mouse
(Mus musculus)
Mammalia Card9 17 31 30
  • 84.55 (n)
oppossum
(Monodelphis domestica)
Mammalia CARD9 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CARD9 31
  • 8 (a)
OneToOne
chicken
(Gallus gallus)
Aves CARD9 31 30
  • 67.48 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia card9 30
  • 63.92 (n)
zebrafish
(Danio rerio)
Actinopterygii card9 31 30
  • 56.25 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 17 (a)
OneToMany
Species where no ortholog for CARD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD9 Gene

ENSEMBL:
Gene Tree for CARD9 (if available)
TreeFam:
Gene Tree for CARD9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CARD9: view image

Paralogs for CARD9 Gene

Paralogs for CARD9 Gene

(1) SIMAP similar genes for CARD9 Gene using alignment to 1 proteins:

  • CARD9_HUMAN
genes like me logo Genes that share paralogs with CARD9: view

Variants for CARD9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CARD9 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
636956 Likely Pathogenic: not provided 136,371,375(-) A/G MISSENSE_VARIANT
636957 Conflicting Interpretations: not provided 136,366,816(-) G/A SYNONYMOUS_VARIANT
642602 Uncertain Significance: Candidiasis, familial, 2 136,370,550(-) C/T MISSENSE_VARIANT
645815 Uncertain Significance: Candidiasis, familial, 2 136,370,384(-) C/A MISSENSE_VARIANT
646086 Uncertain Significance: Candidiasis, familial, 2 136,370,989(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CARD9 Gene

Structural Variations from Database of Genomic Variants (DGV) for CARD9 Gene

Variant ID Type Subtype PubMed ID
esv2759720 CNV loss 17122850
nsv1046074 CNV gain 25217958
nsv469918 CNV loss 18288195
nsv509333 CNV insertion 20534489
nsv615962 CNV loss 21841781
nsv6764 CNV deletion 18451855
nsv825173 CNV gain 20364138
nsv831760 CNV loss 17160897
nsv951202 CNV deletion 24416366

Variation tolerance for CARD9 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.21; 80.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD9 Gene

Human Gene Mutation Database (HGMD)
CARD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD9 Gene

Disorders for CARD9 Gene

MalaCards: The human disease database

(39) MalaCards diseases for CARD9 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 2
  • candf2
candidiasis
  • disseminated candidiasis
dermatophytosis
  • tinea
phaeohyphomycosis
  • infection by dematiacious fungi
endophthalmitis
- elite association - COSMIC cancer census association via MalaCards
Search CARD9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CARD9_HUMAN
  • Candidiasis, familial, 2 (CANDF2) [MIM:212050]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:19864672, ECO:0000269 PubMed:23335372, ECO:0000269 PubMed:24131138}. Note=The disease is caused by mutations affecting the gene represented in this entry. Defects induce reduced numbers of CD4(+) Th17 lymphocytes as well as a lack of monocyte-derived cytokines in response to Candida strains. Neutrophils show a selective Candida albicans killing defect with abnormal ultrastructural phagolysosomes and outgrowth of hyphae (PubMed:23335372). {ECO:0000269 PubMed:23335372}.

Additional Disease Information for CARD9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CARD9: view

No data available for Genatlas for CARD9 Gene

Publications for CARD9 Gene

  1. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. (PMID: 11053425) Bertin J … Alnemri ES (The Journal of biological chemistry 2000) 2 3 4 54
  2. Deep dermatophytosis and inherited CARD9 deficiency. (PMID: 24131138) Lanternier F … Puel A (The New England journal of medicine 2013) 3 4 54
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 41 54
  4. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (PMID: 21743469) Evans DM … Wellcome Trust Case Control Consortium 2 (WTCCC2) (Nature genetics 2011) 3 41 54
  5. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 41 54

Products for CARD9 Gene

Sources for CARD9 Gene