Aliases for CARD8 Gene
Aliases for CARD8 Gene
External Ids for CARD8 Gene
- HGNC: 17057
- Entrez Gene: 22900
- Ensembl: ENSG00000105483
- OMIM: 609051
- UniProtKB: Q9Y2G2
Previous GeneCards Identifiers for CARD8 Gene
- GC19M053403
- GC19M052918
- GC19M048711
- GC19M045093
Summaries for CARD8 Gene
-
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for CARD8 Gene
CARD8 (Caspase Recruitment Domain Family Member 8) is a Protein Coding gene. Diseases associated with CARD8 include Cervical Adenitis and Masters-Allen Syndrome. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway and NOD-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NACHT domain binding.
UniProtKB/Swiss-Prot for CARD8 Gene
-
Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Additional gene information for CARD8 Gene
- Monarch Initiative
- Search for CARD8 at DataMed
- Search for CARD8 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD8 Gene
Genomics for CARD8 Gene
GeneHancer (GH) Regulatory Elements for CARD8 Gene
Promoters and enhancers for CARD8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CARD8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CARD8 gene promoter:
-
- E47
- GATA-1
- ITF-2
- Tal-1
- Tal-1beta
Genomic Locations for CARD8 Gene
Genomic Locations for CARD8 Gene
- chr19:48,180,770-48,256,277
- (GRCh38/hg38)
- Size:
- 75,508 bases
- Orientation:
- Minus strand
- chr19:48,684,027-48,759,203
- (GRCh37/hg19)
- Size:
- 75,177 bases
- Orientation:
- Minus strand
Genomic View for CARD8 Gene
Genes around CARD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
CARD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CARD8 Gene
Proteins for CARD8 Gene
-
Protein details for CARD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2G2-CARD8_HUMAN
- Recommended name:
- Caspase recruitment domain-containing protein 8
- Protein Accession:
- Q9Y2G2
- B5KVR6
- B7Z496
- B7Z4A2
- E9PEM7
- G3XAM9
- Q6PGP8
- Q96P82
Protein attributes for CARD8 Gene
- Size:
- 431 amino acids
- Molecular mass:
- 48933 Da
- Quaternary structure:
-
- May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain.
- SequenceCaution:
-
- Sequence=BAA76799.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for CARD8 Gene
Post-translational modifications for CARD8 Gene
Other Protein References for CARD8 Gene
- ENSEMBL proteins:
-
- ENSP00000428662
- ENSP00000428862
- ENSP00000427727
- ENSP00000427922
- ENSP00000430747
- ENSP00000430495
- ENSP00000499211
- ENSP00000430836
- ENSP00000429741
- ENSP00000391248
- ENSP00000430178
- ENSP00000428736
- ENSP00000375767
- ENSP00000428883
- ENSP00000427858
- ENSP00000430567
- ENSP00000430460
- ENSP00000428975
- ENSP00000430108
- ENSP00000429839
- ENSP00000429362
- ENSP00000430057
- REFSEQ proteins:
-
- XP_006723154.1
- NP_001338716.1
- XP_006723169.1
- XP_006723159.1
- XP_011524946.1
- NP_001338721.1
- NP_001338711.1
- XP_024307193.1
- XP_011524949.1
- XP_016881972.1
- XP_024307189.1
- XP_016881987.1
- XP_016881977.1
- XP_011524943.1
- XP_016881974.1
- XP_011524950.1
- XP_006723161.1
- NP_001338717.1
- XP_006723172.1
- NP_001171830.1
- NP_001352879.1
- XP_006723167.1
- XP_006723157.1
- NP_055774.2
- XP_011524948.1
- XP_024307191.1
- XP_024307192.1
- XP_016881981.1
- XP_016881971.1
- XP_011524945.1
- NP_001338712.1
- XP_016881976.1
- XP_011524952.1
- NP_001338715.1
- XP_006723160.1
- XP_006723170.1
- NP_001171832.1
- XP_016881988.1
- XP_006723165.1
- XP_006723155.1
- NP_001171831.1
- NP_001338718.1
- XP_006723156.1
- XP_016881973.1
- NP_001171829.1
- XP_024307190.1
- NP_001338720.1
- NP_001338713.1
- XP_006723173.1
- NP_001171833.1
- NP_001338719.1
Antibody Products
- Atlas Antibodies Anti-CARD8 Antibody (HPA043513) and Anti-CARD8 Antibody (HPA042071)
- Novus Biologicals Antibodies for CARD8
-
Abcam antibodies for CARD8
- Invitrogen Antibodies for CARD8 (AFLGC-CARD8)
-
Biorbyt antibodies for CARD8
-
Boster Bio Antibodies for CARD8
-
Custom Antibody ServicesProSci Antibodies for CARD8
-
Santa Cruz Biotechnology (SCBT) Antibodies for CARD8
Protein Products
- Atlas Antibodies PrEST Antigen CARD8 (APrEST82549) and PrEST Antigen CARD8 (APrEST82548)
-
OriGene Purified Proteins for CARD8
- Search Origene for MassSpec and Protein Over-expression Lysates for CARD8
- Origene Custom Protein Services for CARD8
-
Abcam proteins for CARD8
No data available for DME Specific Peptides for CARD8 Gene
Domains & Families for CARD8 Gene
Gene Families for CARD8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CARD8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CARD8 Gene
- GenScript: Design optimal peptide antigens:
-
- CARD8 isoform T60 (B5KVR6_HUMAN)
- CARD8 isoform T51 (B5KVR7_HUMAN)
- CARD8 isoform T47 (B5KVR8_HUMAN)
- cDNA FLJ60955, highly similar to Caspase recruitment domain-containing protein 8 (B7Z7N9_HUMAN)
- Tumor up-regulated CARD-containing antagonist of CASP9 (CARD8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CARD8 Gene
Function for CARD8 Gene
Molecular function for CARD8 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11551959 |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | 15030775 |
| GO:0032089 | NACHT domain binding | IPI | 15030775 |
| GO:0042803 | protein homodimerization activity | IDA | 15030775 |
| GO:0050700 | CARD domain binding | IPI | 11821383 |
Phenotypes for CARD8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CARD8
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CARD8 - Now 50% OFF >
- * CARD8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CARD8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CARD8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARD8
- genomics-online: gRNA clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARD8
miRNA for CARD8 Gene
- miRTarBase miRNAs that target CARD8
-
- hsa-mir-16-5p (MIRT000824)
- hsa-mir-15a-5p (MIRT000825)
- hsa-mir-375 (MIRT019890)
- hsa-mir-629-5p (MIRT053405)
- hsa-mir-4793-5p (MIRT235391)
- hsa-mir-4724-5p (MIRT452272)
- hsa-mir-6516-5p (MIRT452273)
- hsa-mir-455-3p (MIRT452274)
- hsa-mir-650 (MIRT452275)
- hsa-mir-3612 (MIRT452276)
- hsa-mir-6499-3p (MIRT452277)
- hsa-mir-6086 (MIRT452278)
- hsa-mir-2467-3p (MIRT452279)
- hsa-mir-377-5p (MIRT452280)
- hsa-mir-4487 (MIRT452281)
- hsa-mir-1827 (MIRT452282)
- hsa-mir-558 (MIRT452283)
- hsa-mir-3160-3p (MIRT452284)
- hsa-mir-665 (MIRT452285)
- hsa-mir-4257 (MIRT452286)
- hsa-mir-4459 (MIRT452287)
- hsa-mir-6511a-5p (MIRT452288)
- hsa-mir-1910-3p (MIRT452289)
- hsa-mir-4695-5p (MIRT452290)
- hsa-mir-6818-3p (MIRT683563)
- hsa-mir-548s (MIRT683564)
- hsa-mir-4684-5p (MIRT683565)
- hsa-mir-593-3p (MIRT683566)
- hsa-mir-6895-3p (MIRT683567)
- hsa-mir-3926 (MIRT683568)
- hsa-mir-3190-5p (MIRT683569)
- hsa-mir-5699-3p (MIRT683570)
- hsa-mir-4421 (MIRT683571)
- hsa-mir-8073 (MIRT683572)
- hsa-mir-221-5p (MIRT683573)
- hsa-mir-339-5p (MIRT683574)
- hsa-mir-4698 (MIRT683575)
- hsa-mir-10b-5p (MIRT683576)
- hsa-mir-10a-5p (MIRT683577)
- hsa-mir-6732-3p (MIRT683578)
- hsa-mir-522-3p (MIRT683579)
- hsa-mir-224-3p (MIRT683580)
- hsa-mir-548c-3p (MIRT683581)
- hsa-mir-6079 (MIRT690168)
- hsa-mir-7977 (MIRT690169)
- hsa-mir-3165 (MIRT690170)
- hsa-mir-6745 (MIRT690171)
- hsa-mir-363-5p (MIRT690172)
- hsa-mir-3202 (MIRT690173)
- hsa-mir-4533 (MIRT690174)
- hsa-mir-3656 (MIRT690175)
- hsa-mir-6087 (MIRT690176)
- hsa-mir-4493 (MIRT690177)
- hsa-mir-383-3p (MIRT690178)
- hsa-mir-194-5p (MIRT763465)
- hsa-mir-219a-1-3p (MIRT763906)
- hsa-mir-3613-3p (MIRT765977)
- hsa-mir-3672 (MIRT766580)
- hsa-mir-431-5p (MIRT768576)
- hsa-mir-4635 (MIRT770509)
- hsa-mir-4668-5p (MIRT770849)
- hsa-mir-4725-5p (MIRT771634)
- hsa-mir-4786-5p (MIRT772284)
- hsa-mir-4797-5p (MIRT772508)
- hsa-mir-555 (MIRT774652)
- hsa-mir-661 (MIRT777410)
- hsa-mir-6861-5p (MIRT780589)
- hsa-mir-6864-3p (MIRT780607)
- hsa-mir-769-5p (MIRT781957)
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CARD8
- Browse OriGene Inhibitory RNA Products For CARD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD8
- genomics-online: shRNA clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CARD8 - Now 50% OFF >
- * CARD8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CARD8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for CARD8
- RC211512
- RC211512L1
- RC211512L1V
- RC211512L2
- RC211512L2V
- RC211512L3
- RC211512L3V
- RC211512L4
- RC211512L4V
- RC229496
- RC229496L1
- RC229496L1V
- RC229496L2
- RC229496L2V
- RC229496L3
- RC229496L3V
- RC229496L4
- RC229496L4V
- RC229985
- RC229985L1
- RC229985L1V
- RC229985L2
- RC229985L2V
- RC229985L3
- RC229985L3V
- RC229985L4
- RC229985L4V
- RC229986
- RC229986L1
- RC229986L1V
- RC229986L2
- RC229986L2V
- RC229986L3
- RC229986L3V
- RC229986L4
- RC229986L4V
- RC230166
- RC230166L1
- RC230166L1V
- RC230166L2
- RC230166L2V
- RC230166L3
- RC230166L3V
- RC230166L4
- RC230166L4V
- RC230245
- RC230245L1
- RC230245L1V
- RC230245L2
- RC230245L2V
- RC230245L3
- RC230245L3V
- RC230245L4
- RC230245L4V
- RG211512
- RG229496
- RG229985
- RG229986
- RG230166
- RG230245
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARD8
Cell Line Products
-
Horizon Cell Lines for CARD8
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARD8 Gene
Localization for CARD8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CARD8 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 11551959 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 15030775 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0032991 | protein-containing complex | IDA | 11821383 |
Pathways & Interactions for CARD8 Gene
Pathways by source for CARD8 Gene
1 BioSystems pathway for CARD8 Gene
1 KEGG pathway for CARD8 Gene
Interacting Proteins for CARD8 Gene
Selected Interacting proteins:
Q9Y2G2-CARD8_HUMAN
ENSP00000375767
for CARD8 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for CARD8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IBA | 21873635 |
| GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | IMP | 11821383 |
| GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway | IDA | 11821383 |
| GO:0032088 | negative regulation of NF-kappaB transcription factor activity | IMP | 11821383 |
Drugs & Compounds for CARD8 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen CARD8 (APrEST82549) and PrEST Antigen CARD8 (APrEST82548)
Transcripts for CARD8 Gene
mRNA/cDNA for CARD8 Gene
- (17) REFSEQ mRNAs :
- (32) Additional mRNA sequences :
- (175) Selected AceView cDNA sequences:
- (31) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000600800 3203 bps (ENST00000600800.1)
- ENST00000518450 1363 bps (ENST00000518450.5)
- ENST00000517510 2016 bps (ENST00000517510.5)
- ENST00000518622 5233 bps (ENST00000518622.5)
- ENST00000651546 5610 bps
Unigene Clusters for CARD8 Gene
- Caspase recruitment domain family, member 8:
- Representative Sequences:
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CARD8 - Now 50% OFF >
- * CARD8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CARD8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CARD8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARD8
- genomics-online: gRNA clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARD8
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CARD8
- Browse OriGene Inhibitory RNA Products For CARD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD8
- genomics-online: shRNA clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CARD8 - Now 50% OFF >
- * CARD8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CARD8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for CARD8
- RC211512
- RC211512L1
- RC211512L1V
- RC211512L2
- RC211512L2V
- RC211512L3
- RC211512L3V
- RC211512L4
- RC211512L4V
- RC229496
- RC229496L1
- RC229496L1V
- RC229496L2
- RC229496L2V
- RC229496L3
- RC229496L3V
- RC229496L4
- RC229496L4V
- RC229985
- RC229985L1
- RC229985L1V
- RC229985L2
- RC229985L2V
- RC229985L3
- RC229985L3V
- RC229985L4
- RC229985L4V
- RC229986
- RC229986L1
- RC229986L1V
- RC229986L2
- RC229986L2V
- RC229986L3
- RC229986L3V
- RC229986L4
- RC229986L4V
- RC230166
- RC230166L1
- RC230166L1V
- RC230166L2
- RC230166L2V
- RC230166L3
- RC230166L3V
- RC230166L4
- RC230166L4V
- RC230245
- RC230245L1
- RC230245L1V
- RC230245L2
- RC230245L2V
- RC230245L3
- RC230245L3V
- RC230245L4
- RC230245L4V
- RG211512
- RG229496
- RG229985
- RG229986
- RG230166
- RG230245
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARD8
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - |
| ExUns: | 17b | · | 17c | · | 17d | · | 17e | · | 17f |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: |
Expression for CARD8 Gene
mRNA differential expression in normal tissues according to GTEx for CARD8 Gene
This gene is overexpressed in Whole Blood (x7.1).
This gene is overexpressed in Colon muscle (18.9), Esophagus (17.5), and Peripheral blood mononuclear cells (16.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARD8 Gene
NURSA nuclear receptor signaling pathways regulating expression of CARD8 Gene:
CARD8SOURCE GeneReport for Unigene cluster for CARD8 Gene:
Hs.446146mRNA Expression by UniProt/SwissProt for CARD8 Gene:
Q9Y2G2-CARD8_HUMAN
Tissue specificity:
High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.
Evidence on tissue expression from TISSUES for CARD8 Gene
- Nervous system(4.5)
- Blood(4.4)
- Kidney(4.3)
- Eye(4.1)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for CARD8
-
OriGene qPCR primer pairs and template standards for CARD8
- genomics-online: primer clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD8 Gene
Orthologs for CARD8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CARD8 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CARD8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CARD8 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | NLRP1 35 |
|
OneToMany |
- Species where no ortholog for CARD8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CARD8 Gene
- ENSEMBL:
- Gene Tree for CARD8 (if available)
- TreeFam:
- Gene Tree for CARD8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CARD8: view image
Paralogs for CARD8 Gene
(3) SIMAP similar genes for CARD8 Gene using alignment to 15 proteins:
- CARD8_HUMAN
- B5KVR7_HUMAN
- B5KVR8_HUMAN
- B7Z7N9_HUMAN
- E5RFI5_HUMAN
- E5RFV9_HUMAN
- E5RGC9_HUMAN
- E5RGG3_HUMAN
- E5RHJ3_HUMAN
- E5RHZ3_HUMAN
- E5RIN1_HUMAN
- E5RJG3_HUMAN
- H0YB90_HUMAN
- H0YBW7_HUMAN
- I6L9C6_HUMAN
No data available for Paralogs for CARD8 Gene
Variants for CARD8 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs879255364 | uncertain-significance, not specified | 48,238,462(-) | C/T | 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs1000040692 | -- | 48,206,876(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000067163 | -- | 48,217,153(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000098382 | -- | 48,253,631(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000142189 | -- | 48,218,481(-) | C/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3613n100 | CNV | gain | 25217958 |
| dgv3614n100 | CNV | gain | 25217958 |
| dgv3615n100 | CNV | loss | 25217958 |
| dgv3616n100 | CNV | loss | 25217958 |
| esv2669487 | CNV | deletion | 23128226 |
| esv34181 | CNV | loss | 18971310 |
| esv3644579 | CNV | loss | 21293372 |
| esv8882 | OTHER | inversion | 19470904 |
| nsv1056459 | CNV | loss | 25217958 |
| nsv1057454 | CNV | loss | 25217958 |
| nsv1065106 | CNV | gain | 25217958 |
| nsv1065311 | CNV | gain | 25217958 |
| nsv458716 | CNV | loss | 19166990 |
| nsv458717 | CNV | loss | 19166990 |
| nsv469623 | CNV | loss | 16826518 |
| nsv517364 | CNV | gain+loss | 19592680 |
| nsv523716 | CNV | loss | 19592680 |
| nsv579902 | CNV | loss | 21841781 |
| nsv579903 | CNV | loss | 21841781 |
| nsv833854 | CNV | loss | 17160897 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.90;
67.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CARD8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD8 Gene
Disorders for CARD8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cervical adenitis |
|
|
| masters-allen syndrome |
|
|
| arteriosclerosis obliterans |
|
|
| pharyngitis |
|
|
| rheumatoid arthritis |
|
|
Search CARD8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CARD8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CARD8 Gene
Publications for CARD8 Gene
- TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. (PMID: 11408476) Pathan N … Reed JC (The Journal of biological chemistry 2001) 2 3 4 23 58
- Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. (PMID: 18212821) Bagnall RD … Mathew CG (European journal of human genetics : EJHG 2008) 3 4 23 58
- Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). (PMID: 18263599) Kastbom A … Söderkvist P (Rheumatology (Oxford, England) 2008) 3 23 45 58
- Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? (PMID: 18311798) Verma D … Särndahl E (Arthritis and rheumatism 2008) 3 23 45 58
- CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PMID: 11821383) Razmara M … Alnemri ES (The Journal of biological chemistry 2002) 3 4 23 58
ExternalLinks
Products for CARD8 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CARD8
- Search Origene for MassSpec and Protein Over-expression Lysates for CARD8
- Origene Custom Protein Services for CARD8
- Origene shrna and RNAi products in human, mouse, rat for CARD8
- Browse OriGene Inhibitory RNA Products For CARD8
- OriGene qPCR primer pairs for CARD8
- OriGene qPCR primer pairs and template standards for CARD8
- OriGene CRISPR knockouts for CARD8
- OriGene ORF clones in human for CARD8
- RC211512
- RC211512L1
- RC211512L1V
- RC211512L2
- RC211512L2V
- RC211512L3
- RC211512L3V
- RC211512L4
- RC211512L4V
- RC229496
- RC229496L1
- RC229496L1V
- RC229496L2
- RC229496L2V
- RC229496L3
- RC229496L3V
- RC229496L4
- RC229496L4V
- RC229985
- RC229985L1
- RC229985L1V
- RC229985L2
- RC229985L2V
- RC229985L3
- RC229985L3V
- RC229985L4
- RC229985L4V
- RC229986
- RC229986L1
- RC229986L1V
- RC229986L2
- RC229986L2V
- RC229986L3
- RC229986L3V
- RC229986L4
- RC229986L4V
- RC230166
- RC230166L1
- RC230166L1V
- RC230166L2
- RC230166L2V
- RC230166L3
- RC230166L3V
- RC230166L4
- RC230166L4V
- RC230245
- RC230245L1
- RC230245L1V
- RC230245L2
- RC230245L2V
- RC230245L3
- RC230245L3V
- RC230245L4
- RC230245L4V
- RG211512
- RG229496
- RG229985
- RG229986
- RG230166
- RG230245
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CARD8
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CARD8
- Novus Biologicals proteins and lysates for CARD8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CARD8
- Abcam proteins for CARD8
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CARD8 (AFLGC-CARD8)
- Cyagen custom Knockout/knockin (KOKI) mouse models for CARD8
- antibodies-online: Search results for 82 available CARD8 Antibodies ranked by validation data
- Compare Top CARD8 Antibodies
- antibodies-online: Search results for available CARD8 related products ranked by validation data
- antibodies-online: Search results for 5 available CARD8 Proteins ranked by validation data
- Compare Top CARD8 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CARD8
- Search Santa Cruz Biotechnology (SCBT) for CARD8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CARD8
- Custom Antibody ServicesProSci Antibodies for CARD8
- Search for CARD8 Proteins at ProSci
- Horizon Cell Lines for CARD8
- genomics-online: cdna clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
- orf clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
- genomics-online: gRNA clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
- genomics-online: primer clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
- genomics-online: shRNA clones - Search results for 63 available CARD8 gene related products
- Overview of 63 available CARD8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARD8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARD8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CARD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD8
- Boster Bio Antibodies for CARD8
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for CARD8
Sources for CARD8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind