Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CARD6 Gene

Aliases for CARD6 Gene

  • Caspase Recruitment Domain Family Member 6 2 3 5
  • CARD-Containing Inhibitor Of Nod1 And Cardiak-Induced NF-KB Activation 3
  • Caspase Recruitment Domain-Containing Protein 6 3
  • Caspase Recruitment Domain Family, Member 6 2
  • Caspase Recruitment Domain Protein 6 3
  • CINCIN1 3

External Ids for CARD6 Gene

Previous GeneCards Identifiers for CARD6 Gene

  • GC05P041147
  • GC05P041933
  • GC05P040841
  • GC05P040886

Summaries for CARD6 Gene

Entrez Gene Summary for CARD6 Gene

  • This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]

GeneCards Summary for CARD6 Gene

CARD6 (Caspase Recruitment Domain Family Member 6) is a Protein Coding gene. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway and Toll-like Receptor Signaling Pathway. An important paralog of this gene is URGCP.

UniProtKB/Swiss-Prot for CARD6 Gene

  • May be involved in apoptosis.

Additional gene information for CARD6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD6 Gene

Genomics for CARD6 Gene

GeneHancer (GH) Regulatory Elements for CARD6 Gene

Promoters and enhancers for CARD6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J040840 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 672.7 +0.7 650 2 PKNOX1 FOXA2 FEZF1 ZNF2 YY1 ZNF766 ZNF213 FOS ATF7 REST CARD6 PRKAA1 PLCXD3 C7
GH05J040832 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.5 -6.7 -6705 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SNORD72 RPL37 GC05M040833 PRKAA1 CARD6 PLCXD3 TTC33
GH05J040754 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 17.5 -85.9 -85877 2.6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC TTC33 PRKAA1 CARD6 PTGER4 GC05M040716
GH05J040672 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -168.7 -168683 1 IKZF1 SPI1 CARD6 PRKAA1 PTGER4 ENSG00000199552 TTC33
GH05J040674 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.1 -158.8 -158768 15.8 ATF1 PKNOX1 SIN3A FEZF1 ZNF2 BRCA1 YY1 GLIS2 ARID2 ZNF143 PTGER4 CARD6 TTC33 PRKAA1 GC05M040716
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CARD6 gene promoter:
  • E47
  • ZID
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • HSF2
  • Ik-1
  • XBP-1

Genomic Locations for CARD6 Gene

Genomic Locations for CARD6 Gene
18,992 bases
Plus strand
18,990 bases
Plus strand

Genomic View for CARD6 Gene

Genes around CARD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD6 Gene

Proteins for CARD6 Gene

  • Protein details for CARD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q52LR2

    Protein attributes for CARD6 Gene

    1037 amino acids
    Molecular mass:
    116468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CARD6 Gene

Post-translational modifications for CARD6 Gene

  • Ubiquitination at Lys307
  • Modification sites at PhosphoSitePlus

Other Protein References for CARD6 Gene

No data available for DME Specific Peptides for CARD6 Gene

Domains & Families for CARD6 Gene

Gene Families for CARD6 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CARD6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARD6: view

No data available for UniProtKB/Swiss-Prot for CARD6 Gene

Function for CARD6 Gene

Molecular function for CARD6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in apoptosis.

Phenotypes From GWAS Catalog for CARD6 Gene

Gene Ontology (GO) - Molecular Function for CARD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16418290
genes like me logo Genes that share ontologies with CARD6: view
genes like me logo Genes that share phenotypes with CARD6: view

Animal Models for CARD6 Gene

MGI Knock Outs for CARD6:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD6 Gene

Localization for CARD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD6 gene
Compartment Confidence
cytosol 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Focal adhesion sites (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CARD6 Gene

Pathways & Interactions for CARD6 Gene

genes like me logo Genes that share pathways with CARD6: view

Pathways by source for CARD6 Gene

1 BioSystems pathway for CARD6 Gene
1 KEGG pathway for CARD6 Gene

Gene Ontology (GO) - Biological Process for CARD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CARD6: view

No data available for SIGNOR curated interactions for CARD6 Gene

Drugs & Compounds for CARD6 Gene

No Compound Related Data Available

Transcripts for CARD6 Gene

mRNA/cDNA for CARD6 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD6 Gene

Caspase recruitment domain family, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD6 Gene

No ASD Table

Relevant External Links for CARD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CARD6 Gene

This gene is overexpressed in Whole Blood (x9.4).

Protein differential expression in normal tissues from HIPED for CARD6 Gene

This gene is overexpressed in Blymphocyte (30.9), Peripheral blood mononuclear cells (22.5), and Tlymphocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARD6 Gene

Protein tissue co-expression partners for CARD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CARD6 Gene:


SOURCE GeneReport for Unigene cluster for CARD6 Gene:


Evidence on tissue expression from TISSUES for CARD6 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with CARD6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD6 Gene

Orthologs for CARD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARD6 34 33
  • 99.2 (n)
(Bos Taurus)
Mammalia CARD6 34 33
  • 81.43 (n)
(Canis familiaris)
Mammalia CARD6 34 33
  • 80.41 (n)
(Mus musculus)
Mammalia Card6 16 34 33
  • 70.92 (n)
(Rattus norvegicus)
Mammalia Card6 33
  • 70.84 (n)
(Monodelphis domestica)
Mammalia CARD6 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 2 (a)
(Danio rerio)
Actinopterygii BX005336.3 34
  • 11 (a)
si:dkey-204a24.11 34
  • 10 (a)
si:dkey-204a24.10 34
  • 9 (a)
si:dkey-202l22.6 34
  • 8 (a)
Species where no ortholog for CARD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD6 Gene

Gene Tree for CARD6 (if available)
Gene Tree for CARD6 (if available)
Evolutionary constrained regions (ECRs) for CARD6: view image

Paralogs for CARD6 Gene

Paralogs for CARD6 Gene

(1) SIMAP similar genes for CARD6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CARD6: view

Variants for CARD6 Gene

Sequence variations from dbSNP and Humsavar for CARD6 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000301987 -- 40,851,189(+) G/T intron_variant
rs1000315813 -- 40,843,895(+) A/G intron_variant
rs1000431972 -- 40,844,170(+) G/C intron_variant
rs1000523757 -- 40,848,845(+) A/T intron_variant
rs1000769698 -- 40,842,647(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CARD6 Gene

Variant ID Type Subtype PubMed ID
esv2665245 CNV deletion 23128226
esv2673909 CNV deletion 23128226
esv2730121 CNV deletion 23290073
nsv597877 CNV gain 21841781
nsv820142 CNV loss 19587683

Variation tolerance for CARD6 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD6 Gene

Disorders for CARD6 Gene

Additional Disease Information for CARD6

No disorders were found for CARD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD6 Gene

Publications for CARD6 Gene

  1. CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. (PMID: 12775719) Stehlik C … Reed JC (The Journal of biological chemistry 2003) 2 3 22 58
  2. Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers. (PMID: 20025480) Kim SS … Lee SH (Pathology 2010) 3 22 58
  3. CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. (PMID: 16582588) Dufner A … Mak TW (Cell cycle (Georgetown, Tex.) 2006) 3 22 58
  4. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. (PMID: 16418290) Dufner A … Mak TW (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 22 58
  5. NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis. (PMID: 26976200) Tervaniemi MH … Elomaa O (Scientific reports 2016) 3 58

Products for CARD6 Gene

Sources for CARD6 Gene

Loading form....