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Aliases for CARD19 Gene

Aliases for CARD19 Gene

  • Caspase Recruitment Domain Family Member 19 2 3 5
  • Bcl10-Interacting Protein With CARD 2 3
  • Bcl10-Interacting CARD Protein 3 4
  • C9orf89 3 4
  • BinCARD 3 4
  • Caspase Recruitment Domain-Containing Protein 19 3
  • Caspase Recruitment Domain Family, Member 19 2
  • Chromosome 9 Open Reading Frame 89 2

External Ids for CARD19 Gene

Previous HGNC Symbols for CARD19 Gene

  • C9orf89

Summaries for CARD19 Gene

GeneCards Summary for CARD19 Gene

CARD19 (Caspase Recruitment Domain Family Member 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CARD19 Gene

  • Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Additional gene information for CARD19 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD19 Gene

Genomics for CARD19 Gene

GeneHancer (GH) Regulatory Elements for CARD19 Gene

Promoters and enhancers for CARD19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J093090 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 673.5 -0.5 -460 9.5 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B CARD19 LOC101927993 NINJ1 PHF2 LINC00475 NOL8 IARS ZNF484 SUSD3 IPPK
GH09J093125 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.6 +34.4 34443 10.1 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 NINJ1 CARD19 LOC101927993 SUSD3 IPPK PHF2
GH09J093056 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.3 -34.6 -34595 9.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B IRF4 YY1 ZNF766 ZNF207 SUSD3 FGD3 NOL8 CARD19 PHF2 LOC101927993 MTND4P15 LINC00475 IARS FAM120AOS
GH09J093110 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +17.7 17698 6.5 PKNOX1 MLX ZFP64 ARID4B DMAP1 SLC30A9 ZNF766 SP5 NFYC ZHX2 NINJ1 CARD19 SUSD3 NOL8 IPPK WNK2 FGD3 PHF2 FAM120A
GH09J093118 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18 +24.1 24078 3.2 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 NINJ1 CARD19 SUSD3 IPPK PHF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARD19 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CARD19 Gene

Genomic Locations for CARD19 Gene
chr9:93,096,129-93,113,283
(GRCh38/hg38)
Size:
17,155 bases
Orientation:
Plus strand
chr9:95,858,450-95,875,565
(GRCh37/hg19)
Size:
17,116 bases
Orientation:
Plus strand

Genomic View for CARD19 Gene

Genes around CARD19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD19 Gene

Proteins for CARD19 Gene

  • Protein details for CARD19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW7-CAR19_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 19
    Protein Accession:
    Q96LW7
    Secondary Accessions:
    • Q5BJH8
    • Q9BSY2

    Protein attributes for CARD19 Gene

    Size:
    228 amino acids
    Molecular mass:
    25589 Da
    Quaternary structure:
    • Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).

    Three dimensional structures from OCA and Proteopedia for CARD19 Gene

    Alternative splice isoforms for CARD19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD19 Gene

Post-translational modifications for CARD19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD19 Gene

No data available for DME Specific Peptides for CARD19 Gene

Domains & Families for CARD19 Gene

Gene Families for CARD19 Gene

Protein Domains for CARD19 Gene

Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CARD19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARD19: view

No data available for UniProtKB/Swiss-Prot for CARD19 Gene

Function for CARD19 Gene

Molecular function for CARD19 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Gene Ontology (GO) - Molecular Function for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15637807
GO:0050700 CARD domain binding NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view
genes like me logo Genes that share phenotypes with CARD19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CARD19

miRNA for CARD19 Gene

miRTarBase miRNAs that target CARD19

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARD19 Gene

Localization for CARD19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD19 Gene

Isoform 1: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD19 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
endoplasmic reticulum 3
golgi apparatus 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15637807
GO:0005739 mitochondrion IDA,IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view

Pathways & Interactions for CARD19 Gene

SuperPathways for CARD19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view

No data available for Pathways by source and SIGNOR curated interactions for CARD19 Gene

Drugs & Compounds for CARD19 Gene

No Compound Related Data Available

Transcripts for CARD19 Gene

mRNA/cDNA for CARD19 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD19 Gene

No ASD Table

Relevant External Links for CARD19 Gene

GeneLoc Exon Structure for
CARD19
ECgene alternative splicing isoforms for
CARD19

Expression for CARD19 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARD19 Gene:

CARD19

mRNA Expression by UniProt/SwissProt for CARD19 Gene:

Q96LW7-CAR19_HUMAN
Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.

Evidence on tissue expression from TISSUES for CARD19 Gene

  • Skin(4.2)
  • Blood(4.1)
  • Liver(4.1)
  • Nervous system(2.3)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD19 Gene

Orthologs for CARD19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD19 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia 1110007C09Rik 34 33
  • 87.43 (n)
OneToOne
Card19 16
cow
(Bos Taurus)
Mammalia C9orf89 34
  • 87 (a)
OneToOne
C8H9orf89 33
  • 84.34 (n)
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf89 33
  • 86.7 (n)
C9orf89 34
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306058 33
  • 85.82 (n)
dog
(Canis familiaris)
Mammalia C9orf89 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf89 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf89 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12H9ORF89 33
  • 61.42 (n)
C9orf89 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf89 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11132 33
zebrafish
(Danio rerio)
Actinopterygii LOC557314 33
  • 52.79 (n)
C11H9orf89 34
  • 37 (a)
OneToOne
Species where no ortholog for CARD19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD19 Gene

ENSEMBL:
Gene Tree for CARD19 (if available)
TreeFam:
Gene Tree for CARD19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CARD19: view image

Paralogs for CARD19 Gene

No data available for Paralogs for CARD19 Gene

Variants for CARD19 Gene

Sequence variations from dbSNP and Humsavar for CARD19 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000044111 -- 93,094,774(+) G/C upstream_transcript_variant
rs1000057693 -- 93,100,725(+) C/T intron_variant
rs1000109637 -- 93,100,946(+) A/G intron_variant
rs1000331921 -- 93,094,986(+) G/C upstream_transcript_variant
rs1000389585 -- 93,099,710(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CARD19 Gene

Variant ID Type Subtype PubMed ID
nsv1133736 CNV deletion 24896259
nsv526296 CNV loss 19592680

Variation tolerance for CARD19 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD19 Gene

Disorders for CARD19 Gene

No disorders were found for CARD19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD19 Gene

Publications for CARD19 Gene

  1. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. (PMID: 15637807) Woo HN … Jung YK (FEBS letters 2004) 2 3 4 22 58
  2. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. (PMID: 23633586) Chen KE … Martin J (Acta crystallographica. Section D, Biological crystallography 2013) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CARD19 Gene

Sources for CARD19 Gene

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