Aliases for CARD19 Gene

Aliases for CARD19 Gene

  • Caspase Recruitment Domain Family Member 19 2 3 5
  • BinCARD 2 3 4
  • Caspase Recruitment Domain-Containing Protein 19 3 4
  • Bcl10-Interacting Protein With CARD 2 3
  • Bcl10-Interacting CARD Protein 3 4
  • C9orf89 3 4
  • Caspase Recruitment Domain Family, Member 19 2
  • Chromosome 9 Open Reading Frame 89 2
  • BA370F5.1 2
  • MGC11115 2
  • CARD19 5

External Ids for CARD19 Gene

Previous HGNC Symbols for CARD19 Gene

  • C9orf89

Summaries for CARD19 Gene

GeneCards Summary for CARD19 Gene

CARD19 (Caspase Recruitment Domain Family Member 19) is a Protein Coding gene. Diseases associated with CARD19 include Cystadenofibroma.

UniProtKB/Swiss-Prot Summary for CARD19 Gene

  • Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Additional gene information for CARD19 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CARD19 Gene

Genomics for CARD19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CARD19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARD19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CARD19

Genomic Locations for CARD19 Gene

Genomic Locations for CARD19 Gene
chr9:93,096,217-93,113,283
(GRCh38/hg38)
Size:
17,067 bases
Orientation:
Plus strand
chr9:95,858,450-95,875,565
(GRCh37/hg19)
Size:
17,116 bases
Orientation:
Plus strand

Genomic View for CARD19 Gene

Genes around CARD19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD19 Gene

Proteins for CARD19 Gene

  • Protein details for CARD19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW7-CAR19_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 19
    Protein Accession:
    Q96LW7
    Secondary Accessions:
    • Q5BJH8
    • Q9BSY2

    Protein attributes for CARD19 Gene

    Size:
    228 amino acids
    Molecular mass:
    25589 Da
    Quaternary structure:
    • Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).
    Miscellaneous:
    • [Isoform 2]: Appears to be the dominant isoform in peripheral blood cell fractions. Contains a transmembrane helix.

    Three dimensional structures from OCA and Proteopedia for CARD19 Gene

    Alternative splice isoforms for CARD19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD19 Gene

Post-translational modifications for CARD19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD19 Gene

No data available for DME Specific Peptides for CARD19 Gene

Domains & Families for CARD19 Gene

Gene Families for CARD19 Gene

Protein Domains for CARD19 Gene

InterPro:
Blocks:
  • CARD interaction domain
ProtoNet:

Suggested Antigen Peptide Sequences for CARD19 Gene

GenScript: Design optimal peptide antigens:
  • Bcl10-interacting CARD protein (BINCA_HUMAN)
genes like me logo Genes that share domains with CARD19: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CARD19 Gene

Function for CARD19 Gene

Molecular function for CARD19 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Phenotypes From GWAS Catalog for CARD19 Gene

Gene Ontology (GO) - Molecular Function for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050700 CARD domain binding NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view
genes like me logo Genes that share phenotypes with CARD19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CARD19

CRISPR Products

miRNA for CARD19 Gene

miRTarBase miRNAs that target CARD19

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CARD19 Gene

Localization for CARD19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD19 Gene

[Isoform 1]: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
[Isoform 2]: Endoplasmic reticulum membrane. Single-pass membrane protein. Mitochondrion membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD19 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
endoplasmic reticulum 3
golgi apparatus 2
plasma membrane 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15637807
GO:0005739 mitochondrion IBA,IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view

Pathways & Interactions for CARD19 Gene

PathCards logo

SuperPathways for CARD19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CARD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling NAS 15637807
genes like me logo Genes that share ontologies with CARD19: view

No data available for Pathways by source and SIGNOR curated interactions for CARD19 Gene

Drugs & Compounds for CARD19 Gene

No Compound Related Data Available

Transcripts for CARD19 Gene

mRNA/cDNA for CARD19 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD19

Alternative Splicing Database (ASD) splice patterns (SP) for CARD19 Gene

No ASD Table

Relevant External Links for CARD19 Gene

GeneLoc Exon Structure for
CARD19

Expression for CARD19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CARD19

mRNA Expression by UniProt/SwissProt for CARD19 Gene:

Q96LW7-CAR19_HUMAN
Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.

Evidence on tissue expression from TISSUES for CARD19 Gene

  • Skin(4.3)
  • Blood(4.3)
  • Liver(4.1)
  • Nervous system(2.6)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD19 Gene

Orthologs for CARD19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD19 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia 1110007C09Rik 30 31
  • 87.43 (n)
OneToOne
Card19 17
Cow
(Bos Taurus)
Mammalia C9orf89 31
  • 87 (a)
OneToOne
C8H9orf89 30
  • 84.34 (n)
Chimpanzee
(Pan troglodytes)
Mammalia C9H9orf89 30
  • 86.7 (n)
C9orf89 31
  • 43 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1306058 30
  • 85.82 (n)
Dog
(Canis familiaris)
Mammalia C9orf89 31
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C9orf89 31
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C9orf89 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C12H9ORF89 30
  • 61.42 (n)
C9orf89 31
  • 55 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C9orf89 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.11132 30
Zebrafish
(Danio rerio)
Actinopterygii LOC557314 30
  • 52.79 (n)
C11H9orf89 31
  • 37 (a)
OneToOne
Species where no ortholog for CARD19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CARD19 Gene

ENSEMBL:
Gene Tree for CARD19 (if available)
TreeFam:
Gene Tree for CARD19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CARD19: view image

Paralogs for CARD19 Gene

No data available for Paralogs for CARD19 Gene

Variants for CARD19 Gene

Additional dbSNP identifiers (rs#s) for CARD19 Gene

Structural Variations from Database of Genomic Variants (DGV) for CARD19 Gene

Variant ID Type Subtype PubMed ID
nsv1133736 CNV deletion 24896259
nsv526296 CNV loss 19592680

Variation tolerance for CARD19 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CARD19 Gene

Disorders for CARD19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CARD19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cystadenofibroma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CARD19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CARD19 Gene

Publications for CARD19 Gene

  1. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. (PMID: 15637807) Woo HN … Jung YK (FEBS letters 2004) 2 3 4 23
  2. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. (PMID: 23633586) Chen KE … Martin J (Acta crystallographica. Section D, Biological crystallography 2013) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CARD19 Gene

Sources for CARD19 Gene