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Aliases for CARD18 Gene

Aliases for CARD18 Gene

  • Caspase Recruitment Domain Family Member 18 2 3 5
  • Caspase-1 Inhibitor Iceberg 3 4
  • ICEBERG 3 4
  • Caspase Recruitment Domain-Containing Protein 18 3
  • Caspase Recruitment Domain Family, Member 18 2
  • ICEBERG Caspase-1 Inhibitor 3
  • Pseudo-ICE 3
  • UNQ5804 3

External Ids for CARD18 Gene

Previous GeneCards Identifiers for CARD18 Gene

  • GC11M104514
  • GC11M105008

Summaries for CARD18 Gene

GeneCards Summary for CARD18 Gene

CARD18 (Caspase Recruitment Domain Family Member 18) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD16.

UniProtKB/Swiss-Prot for CARD18 Gene

  • Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.

Additional gene information for CARD18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD18 Gene

Genomics for CARD18 Gene

GeneHancer (GH) Regulatory Elements for CARD18 Gene

Promoters and enhancers for CARD18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J105139 Promoter 0.5 EPDnew 650.7 0.0 -44 0.1 CARD18 LOC105369469
GH11J105099 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 8.7 +39.2 39169 2.5 CARD17 CARD16 CARD18 CASP1P3
GH11J105132 Enhancer 0.6 ENCODE 10.3 +6.4 6434 0.9 JUN MAX CEBPB EP300 RFX5 JUND STAT3 FOS TCF7L2 CARD17 CARD18 CASP1P1
GH11J105180 Enhancer 0.6 Ensembl ENCODE 9.9 -41.9 -41867 1.6 NFIC NFIB CARD18 GC11M105194 LOC105369469 LOC105369468
GH11J105145 Enhancer 0.5 ENCODE 0.4 -5.4 -5375 0.2 JUND JUN CEBPB FOS EP300 NFE2L2 CARD17 CARD18 LOC105369469
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CARD18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CARD18 gene promoter:

Genomic Locations for CARD18 Gene

Genomic Locations for CARD18 Gene
2,014 bases
Minus strand

Genomic View for CARD18 Gene

Genes around CARD18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD18 Gene

Proteins for CARD18 Gene

  • Protein details for CARD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • A2RRF8

    Protein attributes for CARD18 Gene

    90 amino acids
    Molecular mass:
    10138 Da
    Quaternary structure:
    • Interacts with pro-CASP1. Interacts with CARD8.

    Three dimensional structures from OCA and Proteopedia for CARD18 Gene

neXtProt entry for CARD18 Gene

Post-translational modifications for CARD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CARD18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CARD18 Gene

Domains & Families for CARD18 Gene

Gene Families for CARD18 Gene

Protein Domains for CARD18 Gene

Suggested Antigen Peptide Sequences for CARD18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARD18: view

No data available for UniProtKB/Swiss-Prot for CARD18 Gene

Function for CARD18 Gene

Molecular function for CARD18 Gene

UniProtKB/Swiss-Prot Function:
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for CARD18 Gene

Gene Ontology (GO) - Molecular Function for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 11536016
GO:0030414 peptidase inhibitor activity IEA --
GO:0050700 CARD domain binding IPI 11821383
genes like me logo Genes that share ontologies with CARD18: view
genes like me logo Genes that share phenotypes with CARD18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD18

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CARD18 Gene

Localization for CARD18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD18 gene
Compartment Confidence
cytosol 1

Gene Ontology (GO) - Cellular Components for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0032991 protein-containing complex IDA 11536016
GO:0072557 IPAF inflammasome complex IBA --
GO:0072559 NLRP3 inflammasome complex IBA --
GO:0097169 AIM2 inflammasome complex IBA --
genes like me logo Genes that share ontologies with CARD18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CARD18 Gene

Pathways & Interactions for CARD18 Gene

genes like me logo Genes that share pathways with CARD18: view

Pathways by source for CARD18 Gene

1 KEGG pathway for CARD18 Gene

Gene Ontology (GO) - Biological Process for CARD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IBA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA --
GO:0006954 inflammatory response NAS 11051551
GO:0010466 negative regulation of peptidase activity IEA --
GO:0032091 negative regulation of protein binding IDA 11536016
genes like me logo Genes that share ontologies with CARD18: view

No data available for SIGNOR curated interactions for CARD18 Gene

Drugs & Compounds for CARD18 Gene

No Compound Related Data Available

Transcripts for CARD18 Gene

mRNA/cDNA for CARD18 Gene

(18) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD18 Gene

Caspase recruitment domain family, member 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD18

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD18 Gene

No ASD Table

Relevant External Links for CARD18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARD18 Gene

mRNA differential expression in normal tissues according to GTEx for CARD18 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x29.6) and Skin - Sun Exposed (Lower leg) (x18.3).

Protein differential expression in normal tissues from HIPED for CARD18 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CARD18 Gene

Protein tissue co-expression partners for CARD18 Gene

NURSA nuclear receptor signaling pathways regulating expression of CARD18 Gene:


SOURCE GeneReport for Unigene cluster for CARD18 Gene:


mRNA Expression by UniProt/SwissProt for CARD18 Gene:

Tissue specificity: Primarily expressed in the heart and placenta.
genes like me logo Genes that share expression patterns with CARD18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD18 Gene

Orthologs for CARD18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CARD18 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
Species where no ortholog for CARD18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CARD18 Gene

Gene Tree for CARD18 (if available)
Gene Tree for CARD18 (if available)
Evolutionary constrained regions (ECRs) for CARD18: view image

Paralogs for CARD18 Gene

Paralogs for CARD18 Gene

(3) SIMAP similar genes for CARD18 Gene using alignment to 2 proteins:

  • G5EA35_HUMAN
genes like me logo Genes that share paralogs with CARD18: view

Variants for CARD18 Gene

Sequence variations from dbSNP and Humsavar for CARD18 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000874513 -- 105,140,865(-) C/T upstream_transcript_variant
rs1001531130 -- 105,137,565(-) G/A downstream_transcript_variant
rs1001930927 -- 105,141,415(-) A/T upstream_transcript_variant
rs1002171367 -- 105,137,876(-) A/G 3_prime_UTR_variant
rs1002380808 -- 105,140,457(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CARD18 Gene

Variant ID Type Subtype PubMed ID
esv2750978 CNV gain 17911159
nsv1038877 CNV gain 25217958
nsv1052674 CNV loss 25217958
nsv468862 CNV gain 19166990
nsv556218 CNV gain 21841781

Variation tolerance for CARD18 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD18 Gene

Disorders for CARD18 Gene

Additional Disease Information for CARD18

No disorders were found for CARD18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CARD18 Gene

Publications for CARD18 Gene

  1. ICEBERG: a novel inhibitor of interleukin-1beta generation. (PMID: 11051551) Humke EW … Dixit VM (Cell 2000) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. (PMID: 11821383) Razmara M … Alnemri ES (The Journal of biological chemistry 2002) 3 4 58
  4. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. (PMID: 11536016) Druilhe A … Alnemri ES (Cell death and differentiation 2001) 3 22 58
  5. The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus. (PMID: 28506683) Qin H … Tschachler E (Journal of dermatological science 2017) 3 58

Products for CARD18 Gene

Sources for CARD18 Gene

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