Aliases for CARD11 Gene
External Ids for CARD11 Gene
Previous GeneCards Identifiers for CARD11 Gene
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
GeneCards Summary for CARD11 Gene
CARD11 (Caspase Recruitment Domain Family Member 11) is a Protein Coding gene. Diseases associated with CARD11 include B-Cell Expansion With Nfkb And T-Cell Anergy and Immunodeficiency 11. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and TCR signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include guanylate kinase activity and CARD domain binding. An important paralog of this gene is CARD10.
UniProtKB/Swiss-Prot Summary for CARD11 Gene
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.