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Aliases for CARD10 Gene

Aliases for CARD10 Gene

  • Caspase Recruitment Domain Family Member 10 2 3 5
  • CARD-Containing MAGUK Protein 3 3 4
  • Carma 3 3 4
  • CARMA3 3 4
  • Caspase Recruitment Domain-Containing Protein 10 3
  • Caspase Recruitment Domain Family, Member 10 2
  • Bcl10 Binding Protein And Activator Of NFKB 3
  • CARD-Containing MAGUK 3 Protein 3
  • BIMP1 3

External Ids for CARD10 Gene

Previous GeneCards Identifiers for CARD10 Gene

  • GC22M034500
  • GC22M036129
  • GC22M036210
  • GC22M037886
  • GC22M020852
  • GC22M037491
  • GC22M038419
  • GC22M038808
  • GC22M039928
  • GC22M040616
  • GC22M041058
  • GC22M041458
  • GC22M041870

Summaries for CARD10 Gene

Entrez Gene Summary for CARD10 Gene

  • The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CARD10 Gene

CARD10 (Caspase Recruitment Domain Family Member 10) is a Protein Coding gene. Diseases associated with CARD10 include Glaucoma, Primary Open Angle. Among its related pathways are NF-kappa B signaling pathway and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD11.

UniProtKB/Swiss-Prot for CARD10 Gene

  • Activates NF-kappa-B via BCL10 and IKK.

Gene Wiki entry for CARD10 Gene

Additional gene information for CARD10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CARD10 Gene

Genomics for CARD10 Gene

GeneHancer (GH) Regulatory Elements for CARD10 Gene

Promoters and enhancers for CARD10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J037517 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 656.5 +0.6 616 2.7 ARID4B DMAP1 ZNF48 GLIS2 SP3 RXRA SP5 SMARCA4 GLIS1 ETV4 CARD10 GC22P037518
GH22J037508 Enhancer 0.9 Ensembl ENCODE dbSUPER 52.5 +10.5 10538 1.5 KLF1 RXRA KLF9 ZBTB33 CARD10 GC22P037518 MFNG
GH22J038200 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.7 -683.8 -683846 5.9 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 POLR2B ZNF143 FOS MAFF ENSG00000228274 CBY1 ANKRD54 BAIAP2L2 CARD10 TMEM184B FAM227A PLA2G6
GH22J037182 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +332.7 332680 8.6 PKNOX1 CLOCK NEUROD1 SIN3A GLIS2 ZNF143 FOS SP3 RXRA NFYC C1QTNF6 EIF3D ENSG00000235237 TMPRSS6 ENSG00000231467 CYTH4 APOL4 CARD10 ENSG00000226233 ENSG00000229971
GH22J037511 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 +6.9 6875 2.4 ARID4B SIN3A FEZF1 ZNF48 ETS1 SLC30A9 GLIS2 ATF7 FOS MCM3 EIF3D TRIOBP DDX17 EIF3L CARD10 GC22P037518 MFNG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CARD10 gene promoter:
  • Olf-1
  • HEN1
  • GR-beta
  • GR-alpha
  • GR
  • ZID
  • c-Ets-1
  • Pax-3
  • NF-E2
  • NF-E2 p45

Genomic Locations for CARD10 Gene

Genomic Locations for CARD10 Gene
29,181 bases
Minus strand
29,150 bases
Minus strand

Genomic View for CARD10 Gene

Genes around CARD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD10 Gene

Proteins for CARD10 Gene

  • Protein details for CARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caspase recruitment domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q14CQ8
    • Q5TFG6
    • Q8NC81
    • Q9UGR5
    • Q9UGR6
    • Q9Y3H0

    Protein attributes for CARD10 Gene

    1032 amino acids
    Molecular mass:
    115931 Da
    Quaternary structure:
    • CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).

    Alternative splice isoforms for CARD10 Gene


neXtProt entry for CARD10 Gene

Post-translational modifications for CARD10 Gene

  • Ubiquitination at posLast=778778
  • Modification sites at PhosphoSitePlus

Other Protein References for CARD10 Gene

No data available for DME Specific Peptides for CARD10 Gene

Domains & Families for CARD10 Gene

Gene Families for CARD10 Gene

Protein Domains for CARD10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CARD10: view

No data available for UniProtKB/Swiss-Prot for CARD10 Gene

Function for CARD10 Gene

Molecular function for CARD10 Gene

UniProtKB/Swiss-Prot Function:
Activates NF-kappa-B via BCL10 and IKK.

Phenotypes From GWAS Catalog for CARD10 Gene

Gene Ontology (GO) - Molecular Function for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11259443
GO:0030159 receptor signaling complex scaffold activity NAS 11259443
genes like me logo Genes that share ontologies with CARD10: view
genes like me logo Genes that share phenotypes with CARD10: view

Animal Models for CARD10 Gene

MGI Knock Outs for CARD10:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD10 Gene

Localization for CARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD10 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11259443
GO:0032449 CBM complex NAS 15125833
genes like me logo Genes that share ontologies with CARD10: view

Pathways & Interactions for CARD10 Gene

genes like me logo Genes that share pathways with CARD10: view

Pathways by source for CARD10 Gene

Gene Ontology (GO) - Biological Process for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007250 activation of NF-kappaB-inducing kinase activity ISS 11259443
GO:0042981 regulation of apoptotic process IEA --
GO:0065003 protein-containing complex assembly NAS 11259443
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP 24863965
GO:1900182 positive regulation of protein localization to nucleus IMP 24863965
genes like me logo Genes that share ontologies with CARD10: view

No data available for SIGNOR curated interactions for CARD10 Gene

Drugs & Compounds for CARD10 Gene

No Compound Related Data Available

Transcripts for CARD10 Gene

mRNA/cDNA for CARD10 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CARD10 Gene

Caspase recruitment domain family, member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CARD10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP3: -
SP4: - - - -
SP7: - - -
SP9: -
SP11: -

ExUns: 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: -
SP2: -
SP8: -

Relevant External Links for CARD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CARD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CARD10 Gene

This gene is overexpressed in Plasma (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARD10 Gene

Protein tissue co-expression partners for CARD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CARD10 Gene:


SOURCE GeneReport for Unigene cluster for CARD10 Gene:


mRNA Expression by UniProt/SwissProt for CARD10 Gene:

Tissue specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Evidence on tissue expression from TISSUES for CARD10 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with CARD10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD10 Gene

Orthologs for CARD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CARD10 34 33
  • 99.19 (n)
(Bos Taurus)
Mammalia CARD10 34 33
  • 90.08 (n)
(Canis familiaris)
Mammalia CARD10 34 33
  • 90.04 (n)
(Mus musculus)
Mammalia Card10 16 34 33
  • 86.71 (n)
(Rattus norvegicus)
Mammalia Card10 33
  • 85.78 (n)
(Ornithorhynchus anatinus)
Mammalia CARD10 34
  • 74 (a)
(Monodelphis domestica)
Mammalia CARD10 34
  • 69 (a)
(Gallus gallus)
Aves CARD10 34 33
  • 71.14 (n)
(Anolis carolinensis)
Reptilia CARD10 34
  • 56 (a)
(Danio rerio)
Actinopterygii CARD10 34
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
Species where no ortholog for CARD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CARD10 Gene

Gene Tree for CARD10 (if available)
Gene Tree for CARD10 (if available)
Evolutionary constrained regions (ECRs) for CARD10: view image

Paralogs for CARD10 Gene

Paralogs for CARD10 Gene

(1) SIMAP similar genes for CARD10 Gene using alignment to 5 proteins:

  • Q17RA1_HUMAN
  • Q8NC81_HUMAN
genes like me logo Genes that share paralogs with CARD10: view

Variants for CARD10 Gene

Sequence variations from dbSNP and Humsavar for CARD10 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1057519378 risk-factor, Primary open angle glaucoma 37,516,037(-) C/A/T coding_sequence_variant, missense_variant
rs139006752 risk-factor, Primary open angle glaucoma 37,508,609(-) G/A coding_sequence_variant, missense_variant
rs200148764 risk-factor, Primary open angle glaucoma 37,508,568(-) C/T coding_sequence_variant, missense_variant
rs201794655 risk-factor, Primary open angle glaucoma 37,492,794(-) G/A coding_sequence_variant, missense_variant
rs750643216 risk-factor, Primary open angle glaucoma 37,506,365(-) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CARD10 Gene

Variant ID Type Subtype PubMed ID
esv1010487 CNV deletion 20482838
esv1582981 CNV deletion 17803354
esv2496764 CNV insertion 19546169
esv2724214 CNV deletion 23290073
esv2724215 CNV deletion 23290073
esv2724216 CNV deletion 23290073
esv3438 CNV loss 18987735
esv3558147 CNV deletion 23714750
esv5893 CNV loss 19470904
nsv1057617 CNV gain 25217958
nsv1151872 CNV deletion 26484159
nsv512657 CNV loss 21212237
nsv829203 CNV loss 20364138

Variation tolerance for CARD10 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.40; 88.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD10 Gene

Disorders for CARD10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CARD10 Gene - From: ClinVar and DISEASES

Disorder Aliases PubMed IDs
glaucoma, primary open angle
  • poag
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CARD10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CARD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CARD10 Gene

Publications for CARD10 Gene

  1. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PMID: 11356195) Gaide O … Tschopp J (FEBS letters 2001) 2 3 4 58
  2. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. (PMID: 11259443) Wang L … Bertin J (The Journal of biological chemistry 2001) 2 3 4 58
  3. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (PMID: 21307088) Khor CC … Aung T (Human molecular genetics 2011) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for CARD10 Gene

Sources for CARD10 Gene

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