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The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BC... See more...
Aliases for CARD10 Gene
Aliases for CARD10 Gene
External Ids for CARD10 Gene
- HGNC: 16422
- Entrez Gene: 29775
- Ensembl: ENSG00000100065
- OMIM: 607209
- UniProtKB: Q9BWT7
Previous GeneCards Identifiers for CARD10 Gene
- GC22M034500
- GC22M036129
- GC22M036210
- GC22M037886
- GC22M020852
- GC22M037491
- GC22M038419
- GC22M042757
- GC22M042874
- GC22M042867
- GC22M044545
- GC22M038808
- GC22M039928
- GC22M040616
- GC22M041058
- GC22M041458
- GC22M041870
- GC22M042300
- GC22M042652
Summaries for CARD10 Gene
-
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CARD10 Gene
CARD10 (Caspase Recruitment Domain Family Member 10) is a Protein Coding gene. Diseases associated with CARD10 include Glaucoma, Primary Open Angle and Autoimmune Hepatitis Type 1. Among its related pathways are NF-KappaB Family Pathway and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD11.
UniProtKB/Swiss-Prot Summary for CARD10 Gene
-
Activates NF-kappa-B via BCL10 and IKK.
Additional gene information for CARD10 Gene
- HGNC(16422)
- Entrez Gene(29775)
- Ensembl(ENSG00000100065)
- OMIM(607209)
- UniProtKB(Q9BWT7)
- Open Targets Platform(ENSG00000100065)
- Monarch Initiative
- Search for CARD10 at DataMed
- Search for CARD10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CARD10 Gene
Genomics for CARD10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CARD10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CARD10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CARD10
- Top Transcription factor binding sites by QIAGEN in the CARD10 gene promoter:
-
- c-Ets-1
- GR
- GR-alpha
- GR-beta
- HEN1
- NF-E2
- NF-E2 p45
- Olf-1
- Pax-3
- ZID
Genomic Locations for CARD10 Gene
Genomic Locations for CARD10 Gene
- chr22:37,490,362-37,519,542
- (GRCh38/hg38)
- Size:
- 29,181 bases
- Orientation:
- Minus strand
- chr22:37,886,400-37,915,549
- (GRCh37/hg19)
- Size:
- 29,150 bases
- Orientation:
- Minus strand
Genomic View for CARD10 Gene
Genes around CARD10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by HGNC
- 22q13.1 by Entrez Gene
- 22q13.1 by Ensembl
CARD10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CARD10 Gene
Proteins for CARD10 Gene
-
Protein details for CARD10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BWT7-CAR10_HUMAN
- Recommended name:
- Caspase recruitment domain-containing protein 10
- Protein Accession:
- Q9BWT7
- Q14CQ8
- Q5TFG6
- Q8NC81
- Q9UGR5
- Q9UGR6
- Q9Y3H0
Protein attributes for CARD10 Gene
- Size:
- 1032 amino acids
- Molecular mass:
- 115931 Da
- Quaternary structure:
-
- CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).
Protein Expression for CARD10 Gene
Post-translational modifications for CARD10 Gene
Other Protein References for CARD10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CARD10 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CARD10
- Novus Biologicals Antibodies for CARD10
- Invitrogen Antibodies for CARD10 (AFLGC-CARD10)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CARD10
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CARD10
- Origene Custom Protein Services for CARD10
- antibodies-online: Show 4 available CARD10 Proteins ranked by validation data
- Compare Top CARD10 Proteins
-
Quality Products:
-
Abcam proteins for CARD10
No data available for DME Specific Peptides for CARD10 Gene
Domains & Families for CARD10 Gene
Gene Families for CARD10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CARD10 Gene
- InterPro:
- Blocks:
-
- CARD interaction domain
- ProtoNet:
Suggested Antigen Peptide Sequences for CARD10 Gene
- GenScript: Design optimal peptide antigens:
-
- Caspase recruitment domain family, member 10 (B0QYC3_HUMAN)
- CARD-containing MAGUK protein 3 (CAR10_HUMAN)
- Caspase recruitment domain family, member 10 (Q17RA1_HUMAN)
- cDNA FLJ90425 fis, clone NT2RP3000444 (Q8NC81_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CARD10 Gene
Function for CARD10 Gene
Molecular function for CARD10 Gene
- UniProtKB/Swiss-Prot Function:
- Activates NF-kappa-B via BCL10 and IKK.
Phenotypes From GWAS Catalog for CARD10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11259443 |
| GO:0030159 | receptor signaling complex scaffold activity | NAS | 11259443 |
| GO:0050700 | CARD domain binding | IBA | 21873635 |
Phenotypes for CARD10 Gene
- MGI mutant phenotypes for CARD10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CARD10:
Animal Models for CARD10 Gene
- MGI Knock Outs for CARD10:
-
- Card10 Card10<tm1Xlin>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CARD10 - Select products 50% OFF >
- * CARD10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CARD10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARD10
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARD10
miRNA for CARD10 Gene
- miRTarBase miRNAs that target CARD10
-
- hsa-miR-103a-3p (MIRT027101)
- hsa-miR-24-3p (MIRT030440)
- hsa-miR-16-5p (MIRT031650)
- hsa-miR-146a-5p (MIRT053495)
- hsa-miR-6763-5p (MIRT479963)
- hsa-miR-3150a-3p (MIRT479964)
- hsa-miR-491-5p (MIRT479965)
- hsa-miR-4449 (MIRT479966)
- hsa-miR-92a-2-5p (MIRT479967)
- hsa-miR-6825-5p (MIRT479968)
- hsa-miR-939-5p (MIRT479969)
- hsa-miR-1343-5p (MIRT479970)
- hsa-miR-3175 (MIRT479971)
- hsa-miR-4745-5p (MIRT479972)
- hsa-miR-4481 (MIRT479973)
- hsa-miR-5008-5p (MIRT479974)
- hsa-miR-6730-5p (MIRT479975)
- hsa-miR-4532 (MIRT479976)
- hsa-miR-1247-3p (MIRT479977)
- hsa-miR-6840-3p (MIRT479978)
- hsa-miR-6501-3p (MIRT479979)
- hsa-miR-5697 (MIRT479980)
- hsa-miR-6873-5p (MIRT479981)
- hsa-miR-2278 (MIRT479982)
- hsa-miR-3664-5p (MIRT479983)
- hsa-miR-15b-5p (MIRT479984)
- hsa-miR-195-5p (MIRT479985)
- hsa-miR-6838-5p (MIRT479986)
- hsa-miR-497-5p (MIRT479987)
- hsa-miR-15a-5p (MIRT479988)
- hsa-miR-424-5p (MIRT479989)
- hsa-miR-181b-5p (MIRT733675)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARD10
- Browse OriGene Inhibitory RNA Products For CARD10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD10
Clone Products
- Applied Biological Materials (abm): Clones for CARD10 - Select products 50% OFF >
- * CARD10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CARD10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARD10
Cell Line Products
-
Horizon Cell Lines for CARD10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD10 Gene
Localization for CARD10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CARD10 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Cytosol (2)
- Intermediate filaments (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,NAS | 11259443 |
| GO:0032449 | CBM complex | NAS | 15125833 |
Pathways & Interactions for CARD10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NF-kappa B signaling pathway | ||
| 2 | GPCR Pathway |
GPCR Pathway
.62
|
|
| 3 | NF-KappaB Family Pathway |
NF-KappaB Family Pathway
.72
|
|
| 4 | IL-2 Pathway |
PI3K Signaling in B-Lymphocyte
.35
|
|
| 5 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
|
|
Pathways by source for CARD10 Gene
1 KEGG pathway for CARD10 Gene
4 Qiagen pathways for CARD10 Gene
- GPCR Pathway
- NF-KappaB Family Pathway
- PI3K Signaling in B-Lymphocyte
- PKC-Theta Pathway
Interacting Proteins for CARD10 Gene
Selected Interacting proteins:
Q9BWT7-CAR10_HUMAN
ENSP00000384570
for CARD10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CARD10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | IDA | 11259443 |
| GO:0042981 | regulation of apoptotic process | IEA | -- |
| GO:0065003 | protein-containing complex assembly | NAS | 11259443 |
| GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | IMP | 24863965 |
| GO:1900182 | positive regulation of protein localization to nucleus | IMP | 24863965 |
No data available for SIGNOR curated interactions for CARD10 Gene
Transcripts for CARD10 Gene
mRNA/cDNA for CARD10 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000488141 2169 nts (view in UCSC)
- ENST00000403299 4113 nts (view in UCSC)
- ENST00000467812 1910 nts (view in UCSC)
- ENST00000406271 3127 nts (view in UCSC)
- ENST00000251973 4111 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CARD10 - Select products 50% OFF >
- * CARD10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CARD10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARD10
-
Santa Cruz Biotechnology (SCBT) CRISPR for CARD10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARD10
- Browse OriGene Inhibitory RNA Products For CARD10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD10
Clone Products
- Applied Biological Materials (abm): Clones for CARD10 - Select products 50% OFF >
- * CARD10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CARD10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARD10
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 19 | ^ | 20a | · | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | - | ||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: |
Relevant External Links for CARD10 Gene
- GeneLoc Exon Structure for
- CARD10
Expression for CARD10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
This gene is overexpressed in Plasma (68.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARD10 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CARD10
SOURCE GeneReport for Unigene cluster for CARD10 Gene:
Hs.57973mRNA Expression by UniProt/SwissProt for CARD10 Gene:
Q9BWT7-CAR10_HUMAN
Tissue specificity:
Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
Evidence on tissue expression from TISSUES for CARD10 Gene
- Liver(4.4)
- Kidney(2.5)
- Heart(2.3)
- Spleen(2.2)
- Blood(2.2)
- Intestine(2.1)
- Lymph node(2.1)
- Nervous system(2.1)
- Muscle(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for CARD10
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD10 Gene
Orthologs for CARD10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CARD10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CARD10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CARD10 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Card10 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Card10 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CARD10 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CARD10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CARD10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CARD10 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | CARD10 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for CARD10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CARD10 Gene
- ENSEMBL:
- Gene Tree for CARD10 (if available)
- TreeFam:
- Gene Tree for CARD10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CARD10: view image
Paralogs for CARD10 Gene
Variants for CARD10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CARD10 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711084 | Benign: not provided | 37,504,279(-) | T/C | MISSENSE_VARIANT | |
| 716133 | Benign: not provided | 37,491,799(-) | G/A | SYNONYMOUS_VARIANT | |
| 741007 | Benign: not provided | 37,506,267(-) | C/T | SYNONYMOUS_VARIANT | |
| 777704 | Benign: not provided | 37,507,876(-) | C/T | MISSENSE_VARIANT | |
| 790775 | Benign: not provided | 37,507,871(-) | A/G | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1010487 | CNV | deletion | 20482838 |
| esv1582981 | CNV | deletion | 17803354 |
| esv2496764 | CNV | insertion | 19546169 |
| esv2724214 | CNV | deletion | 23290073 |
| esv2724215 | CNV | deletion | 23290073 |
| esv2724216 | CNV | deletion | 23290073 |
| esv3438 | CNV | loss | 18987735 |
| esv3558147 | CNV | deletion | 23714750 |
| esv5893 | CNV | loss | 19470904 |
| nsv1057617 | CNV | gain | 25217958 |
| nsv1151872 | CNV | deletion | 26484159 |
| nsv512657 | CNV | loss | 21212237 |
| nsv829203 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.40;
88.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CARD10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD10 Gene
Disorders for CARD10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glaucoma, primary open angle |
|
|
| autoimmune hepatitis type 1 |
|
|
| open-angle glaucoma |
|
|
| pityriasis rubra pilaris |
|
|
| lymphoma, mucosa-associated lymphoid type |
|
|
Search CARD10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CARD10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CARD10 Gene
Publications for CARD10 Gene
- Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PMID: 11356195) Gaide O … Tschopp J (FEBS letters 2001) 2 3 4
- Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. (PMID: 11259443) Wang L … Bertin J (The Journal of biological chemistry 2001) 2 3 4
- Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (PMID: 21307088) Khor CC … Aung T (Human molecular genetics 2011) 3 41
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
ExternalLinks
Products for CARD10 Gene
- Custom Antibody ServicesOriGene Antibodies for CARD10
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CARD10
- Origene Custom Protein Services for CARD10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CARD10
- Browse OriGene Inhibitory RNA Products For CARD10
- OriGene qPCR primer pairs for CARD10
- OriGene CRISPR knockouts for CARD10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CARD10
- Sino Biological Human cDNA Clone for CARD10
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CARD10
- Novus Biologicals proteins and lysates for CARD10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for CARD10
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for CARD10 (AFLGC-CARD10)
- VectorBuilder Custom and pre-made DNA vectors for CARD10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CARD10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CARD10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CARD10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CARD10
- antibodies-online: Show 20 available CARD10 Antibodies ranked by validation data
- Compare Top CARD10 Antibodies
- antibodies-online: Search results for available CARD10 related products ranked by validation data
- antibodies-online: Show 4 available CARD10 Proteins ranked by validation data
- Compare Top CARD10 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CARD10
- Search Santa Cruz Biotechnology (SCBT) for CARD10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CARD10
- Horizon Cell Lines for CARD10
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CARD10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CARD10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CARD10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD10
Sources for CARD10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB