Aliases for CARD10 Gene
External Ids for CARD10 Gene
Previous GeneCards Identifiers for CARD10 Gene
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CARD10 Gene
CARD10 (Caspase Recruitment Domain Family Member 10) is a Protein Coding gene. Diseases associated with CARD10 include Glaucoma, Primary Open Angle and Autoimmune Hepatitis Type 1. Among its related pathways are NF-KappaB Family Pathway and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD11.
UniProtKB/Swiss-Prot Summary for CARD10 Gene
Activates NF-kappa-B via BCL10 and IKK.