The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BC... See more...

Aliases for CARD10 Gene

Aliases for CARD10 Gene

  • Caspase Recruitment Domain Family Member 10 2 3 5
  • CARMA3 2 3 4
  • Caspase Recruitment Domain-Containing Protein 10 3 4
  • CARD-Containing MAGUK Protein 3 3 4
  • Carma 3 3 4
  • BIMP1 2 3
  • Caspase Recruitment Domain Family, Member 10 2
  • Bcl10 Binding Protein And Activator Of NFKB 3
  • CARD-Containing MAGUK 3 Protein 3
  • CARD10 5

External Ids for CARD10 Gene

Previous GeneCards Identifiers for CARD10 Gene

  • GC22M034500
  • GC22M036129
  • GC22M036210
  • GC22M037886
  • GC22M020852
  • GC22M037491
  • GC22M038419
  • GC22M042757
  • GC22M042874
  • GC22M042867
  • GC22M044545
  • GC22M038808
  • GC22M039928
  • GC22M040616
  • GC22M041058
  • GC22M041458
  • GC22M041870
  • GC22M042300
  • GC22M042652

Summaries for CARD10 Gene

Entrez Gene Summary for CARD10 Gene

  • The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CARD10 Gene

CARD10 (Caspase Recruitment Domain Family Member 10) is a Protein Coding gene. Diseases associated with CARD10 include Glaucoma, Primary Open Angle and Autoimmune Hepatitis Type 1. Among its related pathways are NF-KappaB Family Pathway and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is CARD11.

UniProtKB/Swiss-Prot Summary for CARD10 Gene

Gene Wiki entry for CARD10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CARD10 Gene

Genomics for CARD10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CARD10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CARD10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CARD10

Top Transcription factor binding sites by QIAGEN in the CARD10 gene promoter:
  • c-Ets-1
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • NF-E2
  • NF-E2 p45
  • Olf-1
  • Pax-3
  • ZID

Genomic Locations for CARD10 Gene

Genomic Locations for CARD10 Gene
chr22:37,490,362-37,519,542
(GRCh38/hg38)
Size:
29,181 bases
Orientation:
Minus strand
chr22:37,886,400-37,915,549
(GRCh37/hg19)
Size:
29,150 bases
Orientation:
Minus strand

Genomic View for CARD10 Gene

Genes around CARD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CARD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CARD10 Gene

Proteins for CARD10 Gene

  • Protein details for CARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWT7-CAR10_HUMAN
    Recommended name:
    Caspase recruitment domain-containing protein 10
    Protein Accession:
    Q9BWT7
    Secondary Accessions:
    • Q14CQ8
    • Q5TFG6
    • Q8NC81
    • Q9UGR5
    • Q9UGR6
    • Q9Y3H0

    Protein attributes for CARD10 Gene

    Size:
    1032 amino acids
    Molecular mass:
    115931 Da
    Quaternary structure:
    • CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).

    Alternative splice isoforms for CARD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CARD10 Gene

Post-translational modifications for CARD10 Gene

  • Ubiquitination at Lys778
  • Modification sites at PhosphoSitePlus

Other Protein References for CARD10 Gene

No data available for DME Specific Peptides for CARD10 Gene

Domains & Families for CARD10 Gene

Gene Families for CARD10 Gene

Protein Domains for CARD10 Gene

InterPro:
Blocks:
  • CARD interaction domain
ProtoNet:

Suggested Antigen Peptide Sequences for CARD10 Gene

GenScript: Design optimal peptide antigens:
  • Caspase recruitment domain family, member 10 (B0QYC3_HUMAN)
  • CARD-containing MAGUK protein 3 (CAR10_HUMAN)
  • Caspase recruitment domain family, member 10 (Q17RA1_HUMAN)
  • cDNA FLJ90425 fis, clone NT2RP3000444 (Q8NC81_HUMAN)
genes like me logo Genes that share domains with CARD10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CARD10 Gene

Function for CARD10 Gene

Molecular function for CARD10 Gene

UniProtKB/Swiss-Prot Function:
Activates NF-kappa-B via BCL10 and IKK.

Phenotypes From GWAS Catalog for CARD10 Gene

Gene Ontology (GO) - Molecular Function for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11259443
GO:0030159 receptor signaling complex scaffold activity NAS 11259443
GO:0050700 CARD domain binding IBA 21873635
genes like me logo Genes that share ontologies with CARD10: view
genes like me logo Genes that share phenotypes with CARD10: view

Animal Models for CARD10 Gene

MGI Knock Outs for CARD10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CARD10 Gene

Localization for CARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CARD10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CARD10 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2
cytoskeleton 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,NAS 11259443
GO:0032449 CBM complex NAS 15125833
genes like me logo Genes that share ontologies with CARD10: view

Pathways & Interactions for CARD10 Gene

PathCards logo

SuperPathways for CARD10 Gene

SuperPathway Contained pathways
1 NF-kappa B signaling pathway
2 GPCR Pathway
.62
3 NF-KappaB Family Pathway
.72
4 IL-2 Pathway
.35
5 TCR Signaling (Qiagen)
.68
genes like me logo Genes that share pathways with CARD10: view

Pathways by source for CARD10 Gene

1 KEGG pathway for CARD10 Gene
4 Qiagen pathways for CARD10 Gene
  • GPCR Pathway
  • NF-KappaB Family Pathway
  • PI3K Signaling in B-Lymphocyte
  • PKC-Theta Pathway

Gene Ontology (GO) - Biological Process for CARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007250 activation of NF-kappaB-inducing kinase activity IDA 11259443
GO:0042981 regulation of apoptotic process IEA --
GO:0065003 protein-containing complex assembly NAS 11259443
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP 24863965
GO:1900182 positive regulation of protein localization to nucleus IMP 24863965
genes like me logo Genes that share ontologies with CARD10: view

No data available for SIGNOR curated interactions for CARD10 Gene

Drugs & Compounds for CARD10 Gene

No Compound Related Data Available

Transcripts for CARD10 Gene

mRNA/cDNA for CARD10 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CARD10

Alternative Splicing Database (ASD) splice patterns (SP) for CARD10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP2:
SP3: -
SP4: - - - -
SP5:
SP6:
SP7: - - -
SP8:
SP9: -
SP10:
SP11: -
SP12:

ExUns: 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CARD10 Gene

GeneLoc Exon Structure for
CARD10

Expression for CARD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CARD10 Gene

This gene is overexpressed in Plasma (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CARD10 Gene



Protein tissue co-expression partners for CARD10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CARD10

SOURCE GeneReport for Unigene cluster for CARD10 Gene:

Hs.57973

mRNA Expression by UniProt/SwissProt for CARD10 Gene:

Q9BWT7-CAR10_HUMAN
Tissue specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Evidence on tissue expression from TISSUES for CARD10 Gene

  • Liver(4.4)
  • Kidney(2.5)
  • Heart(2.3)
  • Spleen(2.2)
  • Blood(2.2)
  • Intestine(2.1)
  • Lymph node(2.1)
  • Nervous system(2.1)
  • Muscle(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with CARD10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CARD10 Gene

Orthologs for CARD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CARD10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CARD10 30 31
  • 99.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CARD10 30 31
  • 90.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CARD10 30 31
  • 90.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Card10 30 17 31
  • 86.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Card10 30
  • 85.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CARD10 31
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CARD10 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CARD10 30 31
  • 71.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CARD10 31
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CARD10 31
  • 46 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToMany
Species where no ortholog for CARD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CARD10 Gene

ENSEMBL:
Gene Tree for CARD10 (if available)
TreeFam:
Gene Tree for CARD10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CARD10: view image

Paralogs for CARD10 Gene

Paralogs for CARD10 Gene

(1) SIMAP similar genes for CARD10 Gene using alignment to 5 proteins:

  • CAR10_HUMAN
  • B0QYC3_HUMAN
  • B0QYC4_HUMAN
  • Q17RA1_HUMAN
  • Q8NC81_HUMAN
genes like me logo Genes that share paralogs with CARD10: view

Variants for CARD10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CARD10 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
711084 Benign: not provided 37,504,279(-) T/C MISSENSE_VARIANT
716133 Benign: not provided 37,491,799(-) G/A SYNONYMOUS_VARIANT
741007 Benign: not provided 37,506,267(-) C/T SYNONYMOUS_VARIANT
777704 Benign: not provided 37,507,876(-) C/T MISSENSE_VARIANT
790775 Benign: not provided 37,507,871(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CARD10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CARD10 Gene

Variant ID Type Subtype PubMed ID
esv1010487 CNV deletion 20482838
esv1582981 CNV deletion 17803354
esv2496764 CNV insertion 19546169
esv2724214 CNV deletion 23290073
esv2724215 CNV deletion 23290073
esv2724216 CNV deletion 23290073
esv3438 CNV loss 18987735
esv3558147 CNV deletion 23714750
esv5893 CNV loss 19470904
nsv1057617 CNV gain 25217958
nsv1151872 CNV deletion 26484159
nsv512657 CNV loss 21212237
nsv829203 CNV loss 20364138

Variation tolerance for CARD10 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.40; 88.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CARD10 Gene

Human Gene Mutation Database (HGMD)
CARD10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CARD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CARD10 Gene

Disorders for CARD10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CARD10 Gene - From: ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CARD10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CARD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CARD10 Gene

Publications for CARD10 Gene

  1. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. (PMID: 11356195) Gaide O … Tschopp J (FEBS letters 2001) 2 3 4
  2. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. (PMID: 11259443) Wang L … Bertin J (The Journal of biological chemistry 2001) 2 3 4
  3. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (PMID: 21307088) Khor CC … Aung T (Human molecular genetics 2011) 3 41
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41

Products for CARD10 Gene

Sources for CARD10 Gene