This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament le... See more...

Aliases for CAPZB Gene

Aliases for CAPZB Gene

  • Capping Actin Protein Of Muscle Z-Line Subunit Beta 2 3 5
  • Capping Protein (Actin Filament) Muscle Z-Line, Beta 2 3
  • Capping Actin Protein Of Muscle Z-Line Beta Subunit 2 3
  • F-Actin-Capping Protein Subunit Beta 3 4
  • CapZ Beta 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • CAPPB 3
  • CAPZB 5
  • CAPB 3
  • CAPZ 3

External Ids for CAPZB Gene

Previous GeneCards Identifiers for CAPZB Gene

  • GC01M019225
  • GC01M018690
  • GC01M018811
  • GC01M019135
  • GC01M019134
  • GC01M019410
  • GC01M019537
  • GC01M019665
  • GC01M017911

Summaries for CAPZB Gene

Entrez Gene Summary for CAPZB Gene

  • This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

GeneCards Summary for CAPZB Gene

CAPZB (Capping Actin Protein Of Muscle Z-Line Subunit Beta) is a Protein Coding gene. Diseases associated with CAPZB include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Orofacial Cleft 15. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin binding and beta-tubulin binding.

UniProtKB/Swiss-Prot Summary for CAPZB Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Wiki entry for CAPZB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPZB Gene

Genomics for CAPZB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAPZB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPZB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPZB

Top Transcription factor binding sites by QIAGEN in the CAPZB gene promoter:
  • aMEF-2
  • AML1a
  • FAC1
  • Ik-2
  • Ik-3
  • MEF-2
  • MEF-2A
  • MZF-1
  • POU2F1
  • POU2F1a

Genomic Locations for CAPZB Gene

Genomic Locations for CAPZB Gene
chr1:19,338,775-19,485,539
(GRCh38/hg38)
Size:
146,765 bases
Orientation:
Minus strand
chr1:19,665,267-19,812,066
(GRCh37/hg19)
Size:
146,800 bases
Orientation:
Minus strand

Genomic View for CAPZB Gene

Genes around CAPZB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZB Gene

Proteins for CAPZB Gene

  • Protein details for CAPZB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47756-CAPZB_HUMAN
    Recommended name:
    F-actin-capping protein subunit beta
    Protein Accession:
    P47756
    Secondary Accessions:
    • Q32Q68
    • Q5U0L4
    • Q8TB49
    • Q9NUC4

    Protein attributes for CAPZB Gene

    Size:
    277 amino acids
    Molecular mass:
    31350 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 (PubMed:16678097). Interaction with RCSD1/CAPZIP (PubMed:15850461). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5 (PubMed:19922875). Interacts with ACTG1 (PubMed:28493397). Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).

    Alternative splice isoforms for CAPZB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPZB Gene

Post-translational modifications for CAPZB Gene

  • Ubiquitination at Lys57, Lys78, Lys95, Lys223, and Lys235
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CAPZB Gene

Domains & Families for CAPZB Gene

Gene Families for CAPZB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAPZB Gene

InterPro:
Blocks:
  • F-actin capping protein, beta subunit
ProtoNet:

Suggested Antigen Peptide Sequences for CAPZB Gene

GenScript: Design optimal peptide antigens:
  • Capping protein (Actin filament) muscle Z-line, beta (B1AK84_HUMAN)
  • cDNA FLJ43095 fis, clone CORDB2000541, highly similar to F-actin capping protein subunit beta (B1AK85_HUMAN)
  • Capping protein (Actin filament) muscle Z-line, beta (B1AK86_HUMAN)
  • Capping protein (Actin filament) muscle Z-line, beta (B1AP81_HUMAN)
  • Capping protein (Actin filament) muscle Z-line, beta (B1AP83_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47756

UniProtKB/Swiss-Prot:

CAPZB_HUMAN :
  • Belongs to the F-actin-capping protein beta subunit family.
Family:
  • Belongs to the F-actin-capping protein beta subunit family.
genes like me logo Genes that share domains with CAPZB: view

Function for CAPZB Gene

Molecular function for CAPZB Gene

UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.
GENATLAS Biochemistry:
actin-capping protein Z,beta subunit 1

Phenotypes From GWAS Catalog for CAPZB Gene

Gene Ontology (GO) - Molecular Function for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IDA 28493397
GO:0005515 protein binding IPI 28493397
GO:0045296 cadherin binding HDA 25468996
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with CAPZB: view
genes like me logo Genes that share phenotypes with CAPZB: view

Animal Models for CAPZB Gene

MGI Knock Outs for CAPZB:
  • Capzb Capzb<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CAPZB Gene

miRTarBase miRNAs that target CAPZB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPZB Gene

Localization for CAPZB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPZB Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPZB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 3
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA,TAS 16130169
GO:0005903 brush border IEA --
GO:0008290 F-actin capping protein complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with CAPZB: view

Pathways & Interactions for CAPZB Gene

genes like me logo Genes that share pathways with CAPZB: view

Pathways by source for CAPZB Gene

1 Sino Biological pathway for CAPZB Gene
1 KEGG pathway for CAPZB Gene
2 GeneGo (Thomson Reuters) pathways for CAPZB Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling Neurofilaments

Gene Ontology (GO) - Biological Process for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007596 blood coagulation TAS --
GO:0008154 actin polymerization or depolymerization IEA --
genes like me logo Genes that share ontologies with CAPZB: view

No data available for SIGNOR curated interactions for CAPZB Gene

Drugs & Compounds for CAPZB Gene

No Compound Related Data Available

Transcripts for CAPZB Gene

mRNA/cDNA for CAPZB Gene

5 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZB

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: -
SP11: - -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CAPZB Gene

GeneLoc Exon Structure for
CAPZB

Expression for CAPZB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPZB Gene

mRNA differential expression in normal tissues according to GTEx for CAPZB Gene

This gene is overexpressed in Whole Blood (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPZB Gene



Protein tissue co-expression partners for CAPZB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPZB

SOURCE GeneReport for Unigene cluster for CAPZB Gene:

Hs.432760

Evidence on tissue expression from TISSUES for CAPZB Gene

  • Nervous system(4.9)
  • Blood(4.7)
  • Eye(4.5)
  • Liver(4.5)
  • Lung(4.1)
  • Skin(4)
  • Intestine(4)
  • Muscle(3.2)
  • Pancreas(3)
  • Thyroid gland(2.9)
  • Heart(2.8)
  • Kidney(2.8)
  • Spleen(2.7)
  • Bone marrow(2.2)
  • Lymph node(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with CAPZB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZB Gene

Orthologs for CAPZB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPZB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAPZB 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAPZB 30 31
  • 93.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Capzb 30
  • 92.87 (n)
Cow
(Bos Taurus)
Mammalia CAPZB 30 31
  • 92.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Capzb 30 17 31
  • 92.14 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CAPZB 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CAPZB 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CAPZB 30 31
  • 88.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAPZB 31
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia capzb-prov 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.6774 30
Zebrafish
(Danio rerio)
Actinopterygii capzb 30 31
  • 79.38 (n)
OneToOne
wufk65f06 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11173 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007864 30
  • 72.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta cpb 30 31 32
  • 70.9 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cap-2 30 31 32
  • 62.52 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADL101C 30
  • 54.05 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP2 30 31 33
  • 51.84 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04225g 30
  • 50.32 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G71790 30
  • 56.84 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0381200 30
  • 58.33 (n)
Os.15764 30
Corn
(Zea mays)
Liliopsida Zm.12180 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6107 31
  • 73 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU07471 30
  • 58.49 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes acp2 30
  • 53.17 (n)
Species where no ortholog for CAPZB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAPZB Gene

ENSEMBL:
Gene Tree for CAPZB (if available)
TreeFam:
Gene Tree for CAPZB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPZB: view image

Paralogs for CAPZB Gene

No data available for Paralogs for CAPZB Gene

Variants for CAPZB Gene

Additional dbSNP identifiers (rs#s) for CAPZB Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPZB Gene

Variant ID Type Subtype PubMed ID
dgv21e212 CNV loss 25503493
dgv26e199 CNV deletion 23128226
esv2398290 CNV deletion 18987734
esv3553122 CNV deletion 23714750
esv3577761 CNV loss 25503493
esv3577762 CNV loss 25503493
esv3585397 CNV loss 21293372
esv3747 CNV loss 18987735
esv6224 CNV loss 19470904
nsv1014816 CNV loss 25217958
nsv1069009 CNV deletion 25765185
nsv1075274 CNV deletion 25765185
nsv1111049 CNV deletion 24896259
nsv1144333 CNV deletion 24896259
nsv471771 CNV loss 16327809
nsv5409 CNV insertion 18451855
nsv834358 CNV loss 17160897

Variation tolerance for CAPZB Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPZB Gene

Human Gene Mutation Database (HGMD)
CAPZB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPZB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPZB Gene

Disorders for CAPZB Gene

MalaCards: The human disease database

(3) MalaCards diseases for CAPZB Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CAPZB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAPZB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CAPZB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPZB Gene

Publications for CAPZB Gene

  1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella EA … Casella JF (The Journal of biological chemistry 1995) 3 4 23
  2. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. (PMID: 30361697) Jung YS … Park JI (Nature cell biology 2018) 3 4
  3. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. (PMID: 28493397) Rainger J … FitzPatrick DR (Human mutation 2017) 3 4
  4. Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. (PMID: 22494929) Rawal R … Homuth G (Human molecular genetics 2012) 3 41
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4

Products for CAPZB Gene

  • Signalway ELISA kits for CAPZB
  • Signalway Proteins for CAPZB

Sources for CAPZB Gene