This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in ... See more...

Aliases for CAPZA3 Gene

Aliases for CAPZA3 Gene

  • Capping Actin Protein Of Muscle Z-Line Subunit Alpha 3 2 3 5
  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 3 2 3
  • Capping Actin Protein Of Muscle Z-Line Alpha Subunit 3 2 3
  • F-Actin-Capping Protein Subunit Alpha-3 3 4
  • Germ Cell-Specific Protein 3 3 4
  • CapZ Alpha-3 3 4
  • CP-Alpha-3 3 4
  • CAPPA3 2 3
  • Gsg3 2 3
  • Testis Tissue Sperm-Binding Protein Li 73n 3
  • F-Actin Capping Protein Alpha-3 Subunit 3
  • Epididymis Secretory Protein Li 86 3
  • HEL-S-86 3
  • CAPZA3 5
  • CAPAA3 4
  • GSG3 4

External Ids for CAPZA3 Gene

Previous GeneCards Identifiers for CAPZA3 Gene

  • GC12P018782
  • GC12P018891
  • GC12P018660

Summaries for CAPZA3 Gene

Entrez Gene Summary for CAPZA3 Gene

  • This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA3 Gene

CAPZA3 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 3) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and MAPK Erk Pathway. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot Summary for CAPZA3 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

Additional gene information for CAPZA3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPZA3 Gene

Genomics for CAPZA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAPZA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J018738 Promoter 0.5 EPDnew 600.7 -0.1 -87 0.1 ATF7 CREB1 CAPZA3 PLCZ1 lnc-RERGL-6 ENSG00000255648 RERGL
GH12J018697 Enhancer 0.8 Ensembl ENCODE 27.5 -40.8 -40818 0.6 IKZF1 JUND DPF2 TCF12 EP300 CEBPB FOS NCOR1 TAL1 ATF3 CAPZA3 PLCZ1 PSMC1P9 lnc-RERGL-5 RERGL PIK3C2G
GH12J018797 Enhancer 0.7 Ensembl ENCODE 18.5 +60.3 60281 1.6 SOX13 ZBTB26 SOX5 MAX RAD51 ARID3A USF2 ZNF384 HNF1A CAPZA3 PLCZ1 lnc-CAPZA3-3 LOC102724227 piR-58674 PLEKHA5
GH12J018747 Enhancer 0.6 Ensembl ENCODE 20.1 +10.8 10759 3.4 NR2F2 BHLHE40 JUND KDM1A HLF CAPZA3 ENSG00000255648 LOC102724227 PLEKHA5
GH12J018700 Enhancer 0.6 Ensembl ENCODE 21.1 -37.5 -37519 0.4 JUND CEBPB FOS lnc-RERGL-5 CAPZA3 PLCZ1 PSMC1P9 RERGL PIK3C2G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPZA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPZA3

Top Transcription factor binding sites by QIAGEN in the CAPZA3 gene promoter:
  • AML1a
  • Cdc5
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA5
  • HSF1 (long)
  • HSF1short
  • NF-AT
  • Nkx2-2

Genomic Locations for CAPZA3 Gene

Genomic Locations for CAPZA3 Gene
chr12:18,738,119-18,739,188
(GRCh38/hg38)
Size:
1,070 bases
Orientation:
Plus strand
chr12:18,891,045-18,892,122
(GRCh37/hg19)
Size:
1,078 bases
Orientation:
Plus strand

Genomic View for CAPZA3 Gene

Genes around CAPZA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA3 Gene

Proteins for CAPZA3 Gene

  • Protein details for CAPZA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KX2-CAZA3_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-3
    Protein Accession:
    Q96KX2
    Secondary Accessions:
    • Q969J0

    Protein attributes for CAPZA3 Gene

    Size:
    299 amino acids
    Molecular mass:
    35025 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5.

neXtProt entry for CAPZA3 Gene

Post-translational modifications for CAPZA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPZA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPZA3 Gene

Domains & Families for CAPZA3 Gene

Gene Families for CAPZA3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAPZA3 Gene

InterPro:
Blocks:
  • F-actin capping protein, alpha subunit
ProtoNet:

Suggested Antigen Peptide Sequences for CAPZA3 Gene

GenScript: Design optimal peptide antigens:
  • Germ cell-specific protein 3 (CAZA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KX2

UniProtKB/Swiss-Prot:

CAZA3_HUMAN :
  • Belongs to the F-actin-capping protein alpha subunit family.
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.
genes like me logo Genes that share domains with CAPZA3: view

Function for CAPZA3 Gene

Molecular function for CAPZA3 Gene

UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

Phenotypes From GWAS Catalog for CAPZA3 Gene

Gene Ontology (GO) - Molecular Function for CAPZA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with CAPZA3: view
genes like me logo Genes that share phenotypes with CAPZA3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPZA3 Gene

Localization for CAPZA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPZA3 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 3
mitochondrion 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CAPZA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0008290 F-actin capping protein complex IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CAPZA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CAPZA3 Gene

Pathways & Interactions for CAPZA3 Gene

PathCards logo

SuperPathways for CAPZA3 Gene

SuperPathway Contained pathways
1 Endocytosis
2 MAPK Erk Pathway
3 Cell cycle_Spindle assembly and chromosome separation
-
4 Cytoskeleton remodeling Neurofilaments
.32
genes like me logo Genes that share pathways with CAPZA3: view

Pathways by source for CAPZA3 Gene

1 Sino Biological pathway for CAPZA3 Gene
1 KEGG pathway for CAPZA3 Gene
2 GeneGo (Thomson Reuters) pathways for CAPZA3 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling Neurofilaments

Gene Ontology (GO) - Biological Process for CAPZA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007286 spermatid development IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0030036 actin cytoskeleton organization IBA 21873635
GO:0051016 barbed-end actin filament capping IBA 21873635
genes like me logo Genes that share ontologies with CAPZA3: view

No data available for SIGNOR curated interactions for CAPZA3 Gene

Drugs & Compounds for CAPZA3 Gene

No Compound Related Data Available

Transcripts for CAPZA3 Gene

mRNA/cDNA for CAPZA3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA3

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA3 Gene

No ASD Table

Relevant External Links for CAPZA3 Gene

GeneLoc Exon Structure for
CAPZA3

Expression for CAPZA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPZA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPZA3 Gene

This gene is overexpressed in Testis (x50.8).

Protein differential expression in normal tissues from HIPED for CAPZA3 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAPZA3 Gene



Protein tissue co-expression partners for CAPZA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPZA3

SOURCE GeneReport for Unigene cluster for CAPZA3 Gene:

Hs.131288

mRNA Expression by UniProt/SwissProt for CAPZA3 Gene:

Q96KX2-CAZA3_HUMAN
Tissue specificity: Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region.
genes like me logo Genes that share expression patterns with CAPZA3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZA3 Gene

Orthologs for CAPZA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPZA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAPZA3 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAPZA3 30 31
  • 92.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CAPZA3 30 31
  • 88.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Capza3 30 17 31
  • 84.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Capza3 30
  • 84.39 (n)
Oppossum
(Monodelphis domestica)
Mammalia CAPZA3 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CAPZA3 30 31
  • 54.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAPZA3 31
  • 39 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii capza1a 31
  • 34 (a)
OneToMany
capza1b 31
  • 34 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta cpa 31
  • 31 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cap-1 31
  • 28 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8055 31
  • 29 (a)
OneToMany
Species where no ortholog for CAPZA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CAPZA3 Gene

ENSEMBL:
Gene Tree for CAPZA3 (if available)
TreeFam:
Gene Tree for CAPZA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPZA3: view image

Paralogs for CAPZA3 Gene

Paralogs for CAPZA3 Gene

(2) SIMAP similar genes for CAPZA3 Gene using alignment to 1 proteins:

  • CAZA3_HUMAN
genes like me logo Genes that share paralogs with CAPZA3: view

Variants for CAPZA3 Gene

Additional dbSNP identifiers (rs#s) for CAPZA3 Gene

Variation tolerance for CAPZA3 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPZA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPZA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CAPZA3 Gene

Disorders for CAPZA3 Gene

Additional Disease Information for CAPZA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CAPZA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZA3 Gene

Publications for CAPZA3 Gene

  1. Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3). (PMID: 12029070) Miyagawa Y … Nishimune Y (Molecular human reproduction 2002) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Genome-wide association study of the five-factor model of personality in young Korean women. (PMID: 23903073) Kim HN … Kim HL (Journal of human genetics 2013) 3

Products for CAPZA3 Gene

  • Signalway Proteins for CAPZA3

Sources for CAPZA3 Gene