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Aliases for CAPZA2 Gene

Aliases for CAPZA2 Gene

  • Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2 2 3 5
  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2 2 3
  • F-Actin Capping Protein Alpha-2 Subunit 2 3
  • CapZ Alpha-2 3 4
  • F-Actin-Capping Protein Subunit Alpha-2 3
  • CAPPA2 3
  • CAPZ 3

External Ids for CAPZA2 Gene

Previous GeneCards Identifiers for CAPZA2 Gene

  • GC07P114980
  • GC07P116043
  • GC07P116057
  • GC07P116096
  • GC07P116289
  • GC07P116451
  • GC07P110868

Summaries for CAPZA2 Gene

Entrez Gene Summary for CAPZA2 Gene

  • The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA2 Gene

CAPZA2 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

UniProtKB/Swiss-Prot for CAPZA2 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Gene Wiki entry for CAPZA2 Gene

Additional gene information for CAPZA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZA2 Gene

Genomics for CAPZA2 Gene

GeneHancer (GH) Regulatory Elements for CAPZA2 Gene

Promoters and enhancers for CAPZA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I116861 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.3 +52.3 52290 3.1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CAPZA2 ST7-AS1 LOC100418716
GH07I116809 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 552.9 +0.4 401 4.5 PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CAPZA2 MET CFTR LOC100418716
GH07I116780 Enhancer 1.2 Ensembl ENCODE dbSUPER 21 -29.3 -29348 3.3 CLOCK NFIB NEUROD1 MZF1 FEZF1 ZNF121 SCRT2 RCOR1 FOS USF2 MET CAPZA2 ENSG00000235427 CFTR GC07P116736
GH07I116869 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.6 +61.4 61405 6.1 HDAC1 PKNOX1 JUN ZFP64 ZNF507 ZKSCAN1 ARID2 PRDM10 ZNF600 ZNF10 CAPZA2 LOC100418716
GH07I116951 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 5.2 +143.1 143134 5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ST7-AS1 ENSG00000275359 ST7-OT4 ST7-OT3 ST7 ENSG00000273596 ENSG00000273571 ENSG00000277583 CAPZA2 ENSG00000276100
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAPZA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPZA2 gene promoter:

Genomic Locations for CAPZA2 Gene

Genomic Locations for CAPZA2 Gene
chr7:116,811,070-116,922,049
(GRCh38/hg38)
Size:
110,980 bases
Orientation:
Plus strand
chr7:116,451,124-116,562,103
(GRCh37/hg19)

Genomic View for CAPZA2 Gene

Genes around CAPZA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA2 Gene

Proteins for CAPZA2 Gene

  • Protein details for CAPZA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47755-CAZA2_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-2
    Protein Accession:
    P47755
    Secondary Accessions:
    • B4DG50

    Protein attributes for CAPZA2 Gene

    Size:
    286 amino acids
    Molecular mass:
    32949 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP.

    Alternative splice isoforms for CAPZA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPZA2 Gene

Post-translational modifications for CAPZA2 Gene

  • Ubiquitination at Lys19, Lys133, and posLast=226226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CAPZA2 Gene

Domains & Families for CAPZA2 Gene

Gene Families for CAPZA2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAPZA2 Gene

Graphical View of Domain Structure for InterPro Entry

P47755

UniProtKB/Swiss-Prot:

CAZA2_HUMAN :
  • Belongs to the F-actin-capping protein alpha subunit family.
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.
genes like me logo Genes that share domains with CAPZA2: view

Function for CAPZA2 Gene

Molecular function for CAPZA2 Gene

GENATLAS Biochemistry:
actin-capping protein Z,alpha 2 subunit,amplified in the glioblastoma
UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Phenotypes From GWAS Catalog for CAPZA2 Gene

Gene Ontology (GO) - Molecular Function for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAPZA2: view
genes like me logo Genes that share phenotypes with CAPZA2: view

Animal Models for CAPZA2 Gene

MGI Knock Outs for CAPZA2:

Animal Model Products

miRNA for CAPZA2 Gene

miRTarBase miRNAs that target CAPZA2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPZA2 Gene

Localization for CAPZA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPZA2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005903 brush border IEA --
GO:0008290 F-actin capping protein complex IEA --
GO:0015629 actin cytoskeleton TAS 9331217
genes like me logo Genes that share ontologies with CAPZA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPZA2 Gene

Pathways & Interactions for CAPZA2 Gene

genes like me logo Genes that share pathways with CAPZA2: view

Pathways by source for CAPZA2 Gene

Gene Ontology (GO) - Biological Process for CAPZA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9331217
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006928 movement of cell or subcellular component TAS 9331217
GO:0007596 blood coagulation TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with CAPZA2: view

No data available for SIGNOR curated interactions for CAPZA2 Gene

Drugs & Compounds for CAPZA2 Gene

(1) Drugs for CAPZA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CAPZA2: view

Transcripts for CAPZA2 Gene

Unigene Clusters for CAPZA2 Gene

Capping protein (actin filament) muscle Z-line, alpha 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6: - -

Relevant External Links for CAPZA2 Gene

GeneLoc Exon Structure for
CAPZA2
ECgene alternative splicing isoforms for
CAPZA2

Expression for CAPZA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPZA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPZA2 Gene



Protein tissue co-expression partners for CAPZA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPZA2 Gene:

CAPZA2

SOURCE GeneReport for Unigene cluster for CAPZA2 Gene:

Hs.446123

Evidence on tissue expression from TISSUES for CAPZA2 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Liver(4.4)
  • Blood(4.3)
  • Eye(4.2)
  • Pancreas(4.2)
  • Intestine(3.4)
  • Lung(3)
  • Heart(2.3)
  • Spleen(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CAPZA2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZA2 Gene

Orthologs for CAPZA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPZA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPZA2 33 34
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPZA2 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPZA2 33 34
  • 95.92 (n)
cow
(Bos Taurus)
Mammalia CAPZA2 33 34
  • 95.1 (n)
mouse
(Mus musculus)
Mammalia Capza2 33 16 34
  • 93.82 (n)
rat
(Rattus norvegicus)
Mammalia Capza2 33
  • 93.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAPZA2 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPZA2 33 34
  • 89.98 (n)
lizard
(Anolis carolinensis)
Reptilia CAPZA2 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capza2 33
  • 83.22 (n)
Str.10827 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21413 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11052 33
fruit fly
(Drosophila melanogaster)
Insecta CG10540 35
  • 61 (a)
cpa 34
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cap-1 35 34
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 33 34 36
  • 46.35 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13453g 33
  • 45.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR007C 33
  • 44.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8055 34
  • 52 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03911 33
  • 45.57 (n)
Species where no ortholog for CAPZA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CAPZA2 Gene

ENSEMBL:
Gene Tree for CAPZA2 (if available)
TreeFam:
Gene Tree for CAPZA2 (if available)

Paralogs for CAPZA2 Gene

Paralogs for CAPZA2 Gene

(2) SIMAP similar genes for CAPZA2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CAPZA2 Gene

genes like me logo Genes that share paralogs with CAPZA2: view

Variants for CAPZA2 Gene

Sequence variations from dbSNP and Humsavar for CAPZA2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000062727 -- 116,867,651(+) TCGGCTCACTGCA/ intron_variant
rs1000098302 -- 116,918,625(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000118673 -- 116,886,682(+) C/A intron_variant
rs1000152473 -- 116,868,627(+) G/A intron_variant
rs1000253332 -- 116,900,804(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPZA2 Gene

Variant ID Type Subtype PubMed ID
dgv1324e214 CNV gain 21293372
esv3576422 CNV gain 25503493
esv3891196 CNV gain 25118596
nsv7405 OTHER inversion 18451855
nsv831107 CNV gain 17160897

Variation tolerance for CAPZA2 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPZA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPZA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZA2 Gene

Disorders for CAPZA2 Gene

Additional Disease Information for CAPZA2

No disorders were found for CAPZA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZA2 Gene

Publications for CAPZA2 Gene

  1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella EA … Casella JF (The Journal of biological chemistry 1995) 3 4 22 58
  2. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. (PMID: 15850461) Eyers CE … Cohen P (The Biochemical journal 2005) 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for CAPZA2 Gene

Sources for CAPZA2 Gene

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