CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008] See more...

Aliases for CAPZA1 Gene

Aliases for CAPZA1 Gene

  • Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1 2 3 5
  • Capping Protein (Actin Filament) Muscle Z-Line, Alpha 1 2 3
  • Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1 2 3
  • F-Actin-Capping Protein Subunit Alpha-1 3 4
  • CapZ Alpha-1 3 4
  • CAPPA1 3
  • CAPZA1 5
  • Cap Z 3
  • CAPZ 3
  • CAZ1 3

External Ids for CAPZA1 Gene

Previous GeneCards Identifiers for CAPZA1 Gene

  • GC01P113584
  • GC01P112047
  • GC01P112263
  • GC01P112461
  • GC01P112873
  • GC01P112963
  • GC01P113161
  • GC01P111020

Summaries for CAPZA1 Gene

Entrez Gene Summary for CAPZA1 Gene

  • CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPZA1 Gene

CAPZA1 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA2.

UniProtKB/Swiss-Prot Summary for CAPZA1 Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.

Gene Wiki entry for CAPZA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPZA1 Gene

Genomics for CAPZA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAPZA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPZA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPZA1

Top Transcription factor binding sites by QIAGEN in the CAPZA1 gene promoter:
  • AML1a
  • c-Myb
  • GATA-3
  • GR
  • GR-alpha
  • GR-beta
  • Pax-5
  • POU6F1 (c2)
  • STAT5A

Genomic Locations for CAPZA1 Gene

Genomic Locations for CAPZA1 Gene
chr1:112,619,775-112,671,616
(GRCh38/hg38)
Size:
51,842 bases
Orientation:
Plus strand
chr1:113,161,795-113,214,241
(GRCh37/hg19)
Size:
52,447 bases
Orientation:
Plus strand

Genomic View for CAPZA1 Gene

Genes around CAPZA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZA1 Gene

Proteins for CAPZA1 Gene

  • Protein details for CAPZA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52907-CAZA1_HUMAN
    Recommended name:
    F-actin-capping protein subunit alpha-1
    Protein Accession:
    P52907
    Secondary Accessions:
    • Q53FQ6
    • Q6FHD5

    Protein attributes for CAPZA1 Gene

    Size:
    286 amino acids
    Molecular mass:
    32923 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with S100B. Interacts with SH3BP1; recruits CAPZA1 to forming cell junctions (PubMed:22891260). Interacts with CD2AP (PubMed:22891260). Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).

    Three dimensional structures from OCA and Proteopedia for CAPZA1 Gene

neXtProt entry for CAPZA1 Gene

Post-translational modifications for CAPZA1 Gene

  • Ubiquitination at Lys19, Lys97, Lys118, Lys133, Lys166, Lys178, and Lys226
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPZA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPZA1 Gene

Domains & Families for CAPZA1 Gene

Gene Families for CAPZA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAPZA1 Gene

InterPro:
Blocks:
  • F-actin capping protein, alpha subunit
ProtoNet:

Suggested Antigen Peptide Sequences for CAPZA1 Gene

GenScript: Design optimal peptide antigens:
  • CapZ alpha-1 (CAZA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52907

UniProtKB/Swiss-Prot:

CAZA1_HUMAN :
  • Belongs to the F-actin-capping protein alpha subunit family.
Family:
  • Belongs to the F-actin-capping protein alpha subunit family.
genes like me logo Genes that share domains with CAPZA1: view

Function for CAPZA1 Gene

Molecular function for CAPZA1 Gene

UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.

Phenotypes From GWAS Catalog for CAPZA1 Gene

Gene Ontology (GO) - Molecular Function for CAPZA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 7665558
GO:0005515 protein binding IPI 22891260
GO:0045296 cadherin binding HDA 25468996
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with CAPZA1: view

Phenotypes for CAPZA1 Gene

genes like me logo Genes that share phenotypes with CAPZA1: view

Animal Model Products

CRISPR Products

miRNA for CAPZA1 Gene

miRTarBase miRNAs that target CAPZA1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPZA1 Gene

Localization for CAPZA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPZA1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPZA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CAPZA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0008290 F-actin capping protein complex IBA 21873635
genes like me logo Genes that share ontologies with CAPZA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAPZA1 Gene

Pathways & Interactions for CAPZA1 Gene

genes like me logo Genes that share pathways with CAPZA1: view

Pathways by source for CAPZA1 Gene

1 KEGG pathway for CAPZA1 Gene
2 GeneGo (Thomson Reuters) pathways for CAPZA1 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling Neurofilaments

SIGNOR curated interactions for CAPZA1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CAPZA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007596 blood coagulation TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0030036 actin cytoskeleton organization IBA 21873635
GO:0034329 cell junction assembly IMP 22891260
genes like me logo Genes that share ontologies with CAPZA1: view

Drugs & Compounds for CAPZA1 Gene

No Compound Related Data Available

Transcripts for CAPZA1 Gene

mRNA/cDNA for CAPZA1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for CAPZA1 Gene

GeneLoc Exon Structure for
CAPZA1

Expression for CAPZA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPZA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPZA1 Gene

This gene is overexpressed in Whole Blood (x6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPZA1 Gene



Protein tissue co-expression partners for CAPZA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPZA1

SOURCE GeneReport for Unigene cluster for CAPZA1 Gene:

Hs.744974

Evidence on tissue expression from TISSUES for CAPZA1 Gene

  • Blood(4.7)
  • Stomach(4.5)
  • Liver(4.4)
  • Nervous system(3.9)
  • Skin(3.3)
  • Lung(2.6)
  • Intestine(2.6)
  • Kidney(2.5)
  • Lymph node(2.4)
  • Bone marrow(2.2)
  • Spleen(2.2)
  • Muscle(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with CAPZA1: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZA1 Gene

Orthologs for CAPZA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPZA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAPZA1 30 31
  • 97.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAPZA1 30
  • 96.62 (n)
-- 31
  • 94 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CAPZA1 30 31
  • 95.92 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Capza1 30
  • 93.12 (n)
Mouse
(Mus musculus)
Mammalia Capza1 30 17 31
  • 92.42 (n)
OneToMany
4933400A11Rik 31
  • 68 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia CAPZA1 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CAPZA1 30 31
  • 84.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAPZA1 31
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia capza1 30
  • 78.55 (n)
Zebrafish
(Danio rerio)
Actinopterygii capza1a 30
  • 75.99 (n)
wufa19e05 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG10540 32
  • 64 (a)
cpa 30 31
  • 61.13 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006141 30
  • 59.74 (n)
Worm
(Caenorhabditis elegans)
Secernentea cap-1 30 31 32
  • 57.51 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP1 31
  • 28 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G05520 30
  • 47.52 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0414800 30
  • 49.06 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8055 31
  • 55 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2607 30
Species where no ortholog for CAPZA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAPZA1 Gene

ENSEMBL:
Gene Tree for CAPZA1 (if available)
TreeFam:
Gene Tree for CAPZA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPZA1: view image

Paralogs for CAPZA1 Gene

Paralogs for CAPZA1 Gene

(2) SIMAP similar genes for CAPZA1 Gene using alignment to 1 proteins:

  • CAZA1_HUMAN
genes like me logo Genes that share paralogs with CAPZA1: view

Variants for CAPZA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPZA1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs555597264 - p.Ser219Leu

Additional dbSNP identifiers (rs#s) for CAPZA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPZA1 Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV gain+loss 19812545
esv3310239 CNV mobile element insertion 20981092
esv3356260 CNV insertion 20981092
esv3587216 CNV loss 21293372
nsv159055 CNV deletion 16902084
nsv946142 CNV duplication 23825009

Variation tolerance for CAPZA1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPZA1 Gene

Human Gene Mutation Database (HGMD)
CAPZA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPZA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZA1 Gene

Disorders for CAPZA1 Gene

Additional Disease Information for CAPZA1

No disorders were found for CAPZA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZA1 Gene

Publications for CAPZA1 Gene

  1. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. (PMID: 30361697) Jung YS … Park JI (Nature cell biology 2018) 3 4
  2. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. (PMID: 22891260) Elbediwy A … Balda MS (The Journal of cell biology 2012) 3 4
  3. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N … He J (Nature genetics 2011) 3 41
  4. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PMID: 19922875) Derivery E … Gautreau A (Developmental cell 2009) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for CAPZA1 Gene

Sources for CAPZA1 Gene