Aliases for CAPZA1 Gene
Aliases for CAPZA1 Gene
External Ids for CAPZA1 Gene
- HGNC: 1488
- Entrez Gene: 829
- Ensembl: ENSG00000116489
- OMIM: 601580
- UniProtKB: P52907
Previous GeneCards Identifiers for CAPZA1 Gene
- GC01P113584
- GC01P112047
- GC01P112263
- GC01P112461
- GC01P112873
- GC01P112963
- GC01P113161
- GC01P111020
Summaries for CAPZA1 Gene
-
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPZA1 Gene
CAPZA1 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1) is a Protein Coding gene. Diseases associated with CAPZA1 include Autosomal Recessive Primary Microcephaly. Among its related pathways are Advanced glycosylation endproduct receptor signaling and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA2.
UniProtKB/Swiss-Prot for CAPZA1 Gene
-
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Additional gene information for CAPZA1 Gene
- Monarch Initiative
- Search for CAPZA1 at DataMed
- Search for CAPZA1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZA1 Gene
Genomics for CAPZA1 Gene
GeneHancer (GH) Regulatory Elements for CAPZA1 Gene
Promoters and enhancers for CAPZA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAPZA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CAPZA1 gene promoter:
-
- GATA-3
- POU6F1 (c2)
- AML1a
- c-Myb
- GR
- GR-alpha
- GR-beta
- STAT5A
- Pax-5
Regulatory Element Products
Genomic Locations for CAPZA1 Gene
Genomic Locations for CAPZA1 Gene
- chr1:112,619,173-112,671,619
- (GRCh38/hg38)
- Size:
- 52,447 bases
- Orientation:
- Plus strand
- chr1:113,161,795-113,214,241
- (GRCh37/hg19)
- Size:
- 52,447 bases
- Orientation:
- Plus strand
Genomic View for CAPZA1 Gene
Genes around CAPZA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by Entrez Gene
- 1p13.2 by HGNC
- 1p13.2 by Ensembl
CAPZA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAPZA1 Gene
Proteins for CAPZA1 Gene
-
Protein details for CAPZA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52907-CAZA1_HUMAN
- Recommended name:
- F-actin-capping protein subunit alpha-1
- Protein Accession:
- P52907
- Q53FQ6
- Q6FHD5
Protein attributes for CAPZA1 Gene
- Size:
- 286 amino acids
- Molecular mass:
- 32923 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with S100B. Interacts with SH3BP1; recruits CAPZA1 to forming cell junctions (PubMed:22891260). Interacts with CD2AP (PubMed:22891260).
Protein Expression for CAPZA1 Gene
Post-translational modifications for CAPZA1 Gene
Other Protein References for CAPZA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CAPZA1
-
Abcam antibodies for CAPZA1
- Invitrogen Antibodies for CAPZA1 (AFLGC-CAPZA1)
- GeneTex CAPZA1 Antibody for CAPZA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAPZA1
Protein Products
-
OriGene Purified Proteins for CAPZA1
- Search Origene for MassSpec and Protein Over-expression Lysates for CAPZA1
- Origene Custom Protein Services for CAPZA1
- Search GeneTex for Proteins for CAPZA1
-
Abcam proteins for CAPZA1
Assay Products
No data available for DME Specific Peptides for CAPZA1 Gene
Domains & Families for CAPZA1 Gene
Gene Families for CAPZA1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CAPZA1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CAPZA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P52907- Family:
-
- Belongs to the F-actin-capping protein alpha subunit family.
Function for CAPZA1 Gene
Molecular function for CAPZA1 Gene
- UniProtKB/Swiss-Prot Function:
- F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Phenotypes From GWAS Catalog for CAPZA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 22891260 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for CAPZA1 Gene
- GenomeRNAi human phenotypes for CAPZA1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAPZA1
-
CRISPR Products
-
OriGene CRISPR knockouts for CAPZA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPZA1
- genomics-online: gRNA clones - Search results for 134 available CAPZA1 gene related products
- Overview of 134 available CAPZA1 gene related products
- Applied Biological Materials CRISPR for CAPZA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPZA1
- GenScript: Design CRISPR guide RNA sequences for CAPZA1
miRNA for CAPZA1 Gene
- miRTarBase miRNAs that target CAPZA1
-
- hsa-mir-7-5p (MIRT004060)
- hsa-mir-9-5p (MIRT021466)
- hsa-mir-140-3p (MIRT021670)
- hsa-mir-30c-5p (MIRT047861)
- hsa-mir-194-5p (MIRT058639)
- hsa-mir-802 (MIRT058640)
- hsa-mir-3935 (MIRT058645)
- hsa-mir-3646 (MIRT058654)
- hsa-mir-4274 (MIRT179542)
- hsa-mir-4419a (MIRT179543)
- hsa-mir-4434 (MIRT179544)
- hsa-mir-4510 (MIRT179545)
- hsa-mir-4516 (MIRT179546)
- hsa-mir-5703 (MIRT179547)
- hsa-mir-6127 (MIRT179548)
- hsa-mir-6129 (MIRT179549)
- hsa-mir-6130 (MIRT179550)
- hsa-mir-6133 (MIRT179551)
- hsa-mir-6760-5p (MIRT179552)
- hsa-mir-6770-5p (MIRT179553)
- hsa-mir-6873-5p (MIRT179554)
- hsa-mir-6878-5p (MIRT179555)
- hsa-mir-142-5p (MIRT179576)
- hsa-mir-559 (MIRT179577)
- hsa-mir-548b-5p (MIRT179578)
- hsa-mir-548a-5p (MIRT179579)
- hsa-mir-548c-5p (MIRT179580)
- hsa-mir-548d-5p (MIRT179581)
- hsa-mir-548j-5p (MIRT179582)
- hsa-mir-548k (MIRT179583)
- hsa-mir-548l (MIRT179584)
- hsa-mir-548h-5p (MIRT179585)
- hsa-mir-548i (MIRT179586)
- hsa-mir-548w (MIRT179587)
- hsa-mir-548y (MIRT179588)
- hsa-mir-548o-5p (MIRT179589)
- hsa-mir-548ab (MIRT179590)
- hsa-mir-548ad-5p (MIRT179591)
- hsa-mir-548ae-5p (MIRT179592)
- hsa-mir-548ak (MIRT179593)
- hsa-mir-548am-5p (MIRT179594)
- hsa-mir-4722-3p (MIRT179595)
- hsa-mir-4769-3p (MIRT179596)
- hsa-mir-548ap-5p (MIRT179597)
- hsa-mir-548aq-5p (MIRT179598)
- hsa-mir-548ar-5p (MIRT179599)
- hsa-mir-548as-5p (MIRT179600)
- hsa-mir-548au-5p (MIRT179601)
- hsa-mir-5590-5p (MIRT179602)
- hsa-mir-5590-3p (MIRT179603)
- hsa-mir-548av-5p (MIRT179604)
- hsa-mir-548ay-5p (MIRT179605)
- hsa-mir-6727-3p (MIRT179606)
- hsa-mir-6817-5p (MIRT179607)
- hsa-mir-8054 (MIRT179608)
- hsa-mir-548bb-5p (MIRT179609)
- hsa-mir-432-3p (MIRT179637)
- hsa-mir-4534 (MIRT179641)
- hsa-mir-8082 (MIRT179645)
- hsa-mir-330-3p (MIRT265188)
- hsa-mir-4635 (MIRT328294)
- hsa-mir-7843-3p (MIRT450436)
- hsa-mir-127-5p (MIRT450437)
- hsa-mir-1193 (MIRT450438)
- hsa-mir-6514-5p (MIRT450439)
- hsa-mir-9-3p (MIRT503010)
- hsa-mir-6747-3p (MIRT503011)
- hsa-mir-4422 (MIRT503012)
- hsa-mir-6835-3p (MIRT503013)
- hsa-mir-6885-3p (MIRT568211)
- hsa-mir-4519 (MIRT568212)
- hsa-mir-1277-3p (MIRT568213)
- hsa-mir-624-3p (MIRT568214)
- hsa-mir-3682-3p (MIRT704990)
- hsa-mir-4257 (MIRT704991)
- hsa-mir-6847-5p (MIRT704992)
- hsa-mir-1272 (MIRT704993)
- hsa-mir-1252-3p (MIRT704994)
- hsa-mir-1206 (MIRT761245)
- hsa-mir-1264 (MIRT761732)
- hsa-mir-1273g-5p (MIRT762012)
- hsa-mir-1290 (MIRT762281)
- hsa-mir-1297 (MIRT762376)
- hsa-mir-1-3p (MIRT762615)
- hsa-mir-143-5p (MIRT762667)
- hsa-mir-183-5p (MIRT763160)
- hsa-mir-1909-3p (MIRT763239)
- hsa-mir-203a-5p (MIRT763697)
- hsa-mir-206 (MIRT763730)
- hsa-mir-2355-5p (MIRT763992)
- hsa-mir-26a-5p (MIRT764291)
- hsa-mir-26b-5p (MIRT764308)
- hsa-mir-3167 (MIRT765206)
- hsa-mir-320e (MIRT765545)
- hsa-mir-3607-5p (MIRT765856)
- hsa-mir-3613-3p (MIRT765976)
- hsa-mir-3688-5p (MIRT766780)
- hsa-mir-3919 (MIRT767660)
- hsa-mir-3944-5p (MIRT767873)
- hsa-mir-4465 (MIRT769417)
- hsa-mir-5004-3p (MIRT772932)
- hsa-mir-548ac (MIRT774051)
- hsa-mir-548ae-3p (MIRT774068)
- hsa-mir-548ah-3p (MIRT774088)
- hsa-mir-548aj-3p (MIRT774115)
- hsa-mir-548am-3p (MIRT774138)
- hsa-mir-548aq-3p (MIRT774175)
- hsa-mir-548bb-3p (MIRT774281)
- hsa-mir-548d-3p (MIRT774359)
- hsa-mir-548h-3p (MIRT774400)
- hsa-mir-548j-3p (MIRT774422)
- hsa-mir-548x-3p (MIRT774560)
- hsa-mir-548z (MIRT774581)
- hsa-mir-6132 (MIRT775892)
- hsa-mir-613 (MIRT775979)
- hsa-mir-6516-3p (MIRT777047)
- hsa-mir-6716-5p (MIRT777702)
- hsa-mir-6722-3p (MIRT777828)
- hsa-mir-6836-5p (MIRT780057)
- hsa-mir-6853-3p (MIRT780466)
- hsa-mir-876-5p (MIRT782530)
- hsa-mir-891a-3p (MIRT782612)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPZA1
- Browse OriGene Inhibitory RNA Products For CAPZA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1
- genomics-online: shRNA clones - Search results for 134 available CAPZA1 gene related products
- Overview of 134 available CAPZA1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CAPZA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPZA1
- Applied Biological Materials Clones for CAPZA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CAPZA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPZA1 Gene
Localization for CAPZA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAPZA1 Gene
- Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | TAS | 16130169 |
| GO:0008290 | F-actin capping protein complex | IEA,TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAPZA1 Gene
Pathways & Interactions for CAPZA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Endocytosis | ||
| 3 | MAPK-Erk Pathway | ||
| 4 | Advanced glycosylation endproduct receptor signaling | ||
| 5 | Factors involved in megakaryocyte development and platelet production | ||
Pathways by source for CAPZA1 Gene
1 Sino Biological pathway for CAPZA1 Gene
1 KEGG pathway for CAPZA1 Gene
2 GeneGo (Thomson Reuters) pathways for CAPZA1 Gene
Interacting Proteins for CAPZA1 Gene
Selected Interacting proteins:
ENSP00000263168
P52907-CAZA1_HUMAN
for CAPZA1 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for CAPZA1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | -- |
| GO:0034329 | cell junction assembly | IMP | 22891260 |
| GO:0035722 | interleukin-12-mediated signaling pathway | TAS | -- |
Transcripts for CAPZA1 Gene
mRNA/cDNA for CAPZA1 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (528) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000263168 3020 bps (uc001ecj.2)
- ENST00000485542 739 bps (uc057jlb.1)
- ENST00000476936 867 bps (uc057jlc.1)
- ENST00000498626 650 bps (uc057jld.1)
- ENST00000466066 765 bps (uc057jlf.1)
Unigene Clusters for CAPZA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAPZA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPZA1
- genomics-online: gRNA clones - Search results for 134 available CAPZA1 gene related products
- Overview of 134 available CAPZA1 gene related products
- Applied Biological Materials CRISPR for CAPZA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPZA1
- GenScript: Design CRISPR guide RNA sequences for CAPZA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPZA1
- Browse OriGene Inhibitory RNA Products For CAPZA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1
- genomics-online: shRNA clones - Search results for 134 available CAPZA1 gene related products
- Overview of 134 available CAPZA1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CAPZA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPZA1
- Applied Biological Materials Clones for CAPZA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: |
Expression for CAPZA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocytes Anterior Neck Muscles
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Trunk Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Lumbar Vertebrae Column Muscles
-
Limb (Muscoskeletal System)
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
- Multinuclear Myocytes Hindlimb Dorsal Muscle
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Amnion (Extraembryonic Tissues)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CAPZA1 Gene
This gene is overexpressed in Whole Blood (x6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPZA1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CAPZA1 Gene:
CAPZA1SOURCE GeneReport for Unigene cluster for CAPZA1 Gene:
Hs.744974Evidence on tissue expression from TISSUES for CAPZA1 Gene
- Blood(4.6)
- Liver(4.3)
- Stomach(4.3)
- Nervous system(3.6)
- Skin(2.7)
- Lung(2.5)
- Intestine(2.4)
Primer Products
-
OriGene qPCR primer pairs for CAPZA1
-
OriGene qPCR primer pairs and template standards for CAPZA1
- genomics-online: primer clones - Search results for 134 available CAPZA1 gene related products
- Overview of 134 available CAPZA1 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZA1 Gene
Orthologs for CAPZA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAPZA1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CAPZA1 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | CAPZA1 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Capza1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Capza1 16 34 33 |
|
||
| 4933400A11Rik 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | CAPZA1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAPZA1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CAPZA1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | capza1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | capza1a 33 |
|
||
| wufa19e05 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10540 35 |
|
|
|
| cpa 34 33 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006141 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cap-1 34 35 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CAP1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G05520 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0414800 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8055 34 |
|
OneToMany | |
| Cin.2607 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2607 33 |
|
- Species where no ortholog for CAPZA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CAPZA1 Gene
- ENSEMBL:
- Gene Tree for CAPZA1 (if available)
- TreeFam:
- Gene Tree for CAPZA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAPZA1: view image
Paralogs for CAPZA1 Gene
Pseudogenes.org Pseudogenes for CAPZA1 Gene
Variants for CAPZA1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007271 | -- | 112,641,907(+) | T/A | intron_variant | |
| rs1000128397 | -- | 112,634,194(+) | T/C | intron_variant | |
| rs1000137429 | -- | 112,618,272(+) | T/A/C | upstream_transcript_variant | |
| rs1000212011 | -- | 112,649,572(+) | G/A | intron_variant | |
| rs1000228038 | -- | 112,641,491(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv27061 | CNV | gain+loss | 19812545 |
| esv3310239 | CNV | mobile element insertion | 20981092 |
| esv3356260 | CNV | insertion | 20981092 |
| esv3587216 | CNV | loss | 21293372 |
| nsv159055 | CNV | deletion | 16902084 |
| nsv946142 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.47;
43.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAPZA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZA1 Gene
Disorders for CAPZA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autosomal recessive primary microcephaly |
|
|
Search CAPZA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAPZA1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CAPZA1 Gene
Publications for CAPZA1 Gene
- Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. (PMID: 22891260) Elbediwy A … Balda MS (The Journal of cell biology 2012) 3 4 58
- Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N … He J (Nature genetics 2011) 3 44 58
- The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PMID: 19922875) Derivery E … Gautreau A (Developmental cell 2009) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for CAPZA1 Gene
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Sources for CAPZA1 Gene
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