Aliases for CAPZA1 Gene
External Ids for CAPZA1 Gene
Previous GeneCards Identifiers for CAPZA1 Gene
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPZA1 Gene
CAPZA1 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA2.
UniProtKB/Swiss-Prot Summary for CAPZA1 Gene
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.