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CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008] See more...
Aliases for CAPZA1 Gene
Aliases for CAPZA1 Gene
External Ids for CAPZA1 Gene
- HGNC: 1488
- Entrez Gene: 829
- Ensembl: ENSG00000116489
- OMIM: 601580
- UniProtKB: P52907
Previous GeneCards Identifiers for CAPZA1 Gene
- GC01P113584
- GC01P112047
- GC01P112263
- GC01P112461
- GC01P112873
- GC01P112963
- GC01P113161
- GC01P111020
Summaries for CAPZA1 Gene
-
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPZA1 Gene
CAPZA1 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA2.
UniProtKB/Swiss-Prot Summary for CAPZA1 Gene
-
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Additional gene information for CAPZA1 Gene
- HGNC(1488)
- Entrez Gene(829)
- Ensembl(ENSG00000116489)
- OMIM(601580)
- UniProtKB(P52907)
- Open Targets Platform(ENSG00000116489)
- Monarch Initiative
- Search for CAPZA1 at DataMed
- Search for CAPZA1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPZA1 Gene
Genomics for CAPZA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CAPZA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAPZA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPZA1
- Top Transcription factor binding sites by QIAGEN in the CAPZA1 gene promoter:
-
- AML1a
- c-Myb
- GATA-3
- GR
- GR-alpha
- GR-beta
- Pax-5
- POU6F1 (c2)
- STAT5A
Genomic Locations for CAPZA1 Gene
Genomic Locations for CAPZA1 Gene
- chr1:112,619,775-112,671,616
- (GRCh38/hg38)
- Size:
- 51,842 bases
- Orientation:
- Plus strand
- chr1:113,161,795-113,214,241
- (GRCh37/hg19)
- Size:
- 52,447 bases
- Orientation:
- Plus strand
Genomic View for CAPZA1 Gene
Genes around CAPZA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
CAPZA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAPZA1 Gene
Proteins for CAPZA1 Gene
-
Protein details for CAPZA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52907-CAZA1_HUMAN
- Recommended name:
- F-actin-capping protein subunit alpha-1
- Protein Accession:
- P52907
- Q53FQ6
- Q6FHD5
Protein attributes for CAPZA1 Gene
- Size:
- 286 amino acids
- Molecular mass:
- 32923 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with S100B. Interacts with SH3BP1; recruits CAPZA1 to forming cell junctions (PubMed:22891260). Interacts with CD2AP (PubMed:22891260). Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).
Protein Expression for CAPZA1 Gene
Post-translational modifications for CAPZA1 Gene
Other Protein References for CAPZA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CAPZA1 / CAPZ Alpha 1 Monoclonal Antibody
- G Biosciences Immunotag™ CAPZA1 Antibody
- Novus Biologicals Antibodies for CAPZA1
-
Abcam antibodies for CAPZA1
- Invitrogen Antibodies for CAPZA1 (AFLGC-CAPZA1)
-
Biorbyt antibodies for CAPZA1
-
Boster Bio Antibodies for CAPZA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAPZA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CAPZA1
- Origene Custom Protein Services for CAPZA1
-
Abcam proteins for CAPZA1
No data available for DME Specific Peptides for CAPZA1 Gene
Domains & Families for CAPZA1 Gene
Gene Families for CAPZA1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CAPZA1 Gene
- InterPro:
- Blocks:
-
- F-actin capping protein, alpha subunit
- ProtoNet:
Suggested Antigen Peptide Sequences for CAPZA1 Gene
- GenScript: Design optimal peptide antigens:
-
- CapZ alpha-1 (CAZA1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P52907- Family:
-
- Belongs to the F-actin-capping protein alpha subunit family.
Function for CAPZA1 Gene
Molecular function for CAPZA1 Gene
- UniProtKB/Swiss-Prot Function:
- F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Phenotypes From GWAS Catalog for CAPZA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | TAS | 7665558 |
| GO:0005515 | protein binding | IPI | 22891260 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
| GO:0051015 | actin filament binding | IBA | 21873635 |
Phenotypes for CAPZA1 Gene
- GenomeRNAi human phenotypes for CAPZA1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAPZA1 - Select products 50% OFF >
- * CAPZA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CAPZA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPZA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPZA1
miRNA for CAPZA1 Gene
- miRTarBase miRNAs that target CAPZA1
-
- hsa-miR-7-5p (MIRT004060)
- hsa-miR-9-5p (MIRT021466)
- hsa-miR-140-3p (MIRT021670)
- hsa-miR-30c-5p (MIRT047861)
- hsa-miR-194-5p (MIRT058639)
- hsa-miR-802 (MIRT058640)
- hsa-miR-3935 (MIRT058645)
- hsa-miR-3646 (MIRT058654)
- hsa-miR-4274 (MIRT179542)
- hsa-miR-4419a (MIRT179543)
- hsa-miR-4434 (MIRT179544)
- hsa-miR-4510 (MIRT179545)
- hsa-miR-4516 (MIRT179546)
- hsa-miR-5703 (MIRT179547)
- hsa-miR-6127 (MIRT179548)
- hsa-miR-6129 (MIRT179549)
- hsa-miR-6130 (MIRT179550)
- hsa-miR-6133 (MIRT179551)
- hsa-miR-6760-5p (MIRT179552)
- hsa-miR-6770-5p (MIRT179553)
- hsa-miR-6873-5p (MIRT179554)
- hsa-miR-6878-5p (MIRT179555)
- hsa-miR-142-5p (MIRT179576)
- hsa-miR-559 (MIRT179577)
- hsa-miR-548b-5p (MIRT179578)
- hsa-miR-548a-5p (MIRT179579)
- hsa-miR-548c-5p (MIRT179580)
- hsa-miR-548d-5p (MIRT179581)
- hsa-miR-548j-5p (MIRT179582)
- hsa-miR-548k (MIRT179583)
- hsa-miR-548l (MIRT179584)
- hsa-miR-548h-5p (MIRT179585)
- hsa-miR-548i (MIRT179586)
- hsa-miR-548w (MIRT179587)
- hsa-miR-548y (MIRT179588)
- hsa-miR-548o-5p (MIRT179589)
- hsa-miR-548ab (MIRT179590)
- hsa-miR-548ad-5p (MIRT179591)
- hsa-miR-548ae-5p (MIRT179592)
- hsa-miR-548ak (MIRT179593)
- hsa-miR-548am-5p (MIRT179594)
- hsa-miR-4722-3p (MIRT179595)
- hsa-miR-4769-3p (MIRT179596)
- hsa-miR-548ap-5p (MIRT179597)
- hsa-miR-548aq-5p (MIRT179598)
- hsa-miR-548ar-5p (MIRT179599)
- hsa-miR-548as-5p (MIRT179600)
- hsa-miR-548au-5p (MIRT179601)
- hsa-miR-5590-5p (MIRT179602)
- hsa-miR-5590-3p (MIRT179603)
- hsa-miR-548av-5p (MIRT179604)
- hsa-miR-548ay-5p (MIRT179605)
- hsa-miR-6727-3p (MIRT179606)
- hsa-miR-6817-5p (MIRT179607)
- hsa-miR-8054 (MIRT179608)
- hsa-miR-548bb-5p (MIRT179609)
- hsa-miR-432-3p (MIRT179637)
- hsa-miR-4534 (MIRT179641)
- hsa-miR-8082 (MIRT179645)
- hsa-miR-330-3p (MIRT265188)
- hsa-miR-4635 (MIRT328294)
- hsa-miR-7843-3p (MIRT450436)
- hsa-miR-127-5p (MIRT450437)
- hsa-miR-1193 (MIRT450438)
- hsa-miR-6514-5p (MIRT450439)
- hsa-miR-9-3p (MIRT503010)
- hsa-miR-6747-3p (MIRT503011)
- hsa-miR-4422 (MIRT503012)
- hsa-miR-6835-3p (MIRT503013)
- hsa-miR-6885-3p (MIRT568211)
- hsa-miR-4519 (MIRT568212)
- hsa-miR-1277-3p (MIRT568213)
- hsa-miR-624-3p (MIRT568214)
- mmu-miR-377-3p (MIRT584477)
- mmu-miR-362-3p (MIRT584478)
- mmu-miR-329-3p (MIRT584479)
- mmu-miR-875-5p (MIRT584480)
- mmu-miR-3474 (MIRT584481)
- hsa-miR-3682-3p (MIRT704990)
- hsa-miR-4257 (MIRT704991)
- hsa-miR-6847-5p (MIRT704992)
- hsa-miR-1272 (MIRT704993)
- hsa-miR-1252-3p (MIRT704994)
- hsa-miR-1206 (MIRT761245)
- hsa-miR-1264 (MIRT761732)
- hsa-miR-1273g-5p (MIRT762012)
- hsa-miR-1290 (MIRT762281)
- hsa-miR-1297 (MIRT762376)
- hsa-miR-1-3p (MIRT762615)
- hsa-miR-143-5p (MIRT762667)
- hsa-miR-183-5p (MIRT763160)
- hsa-miR-1909-3p (MIRT763239)
- hsa-miR-203a-5p (MIRT763697)
- hsa-miR-206 (MIRT763730)
- hsa-miR-2355-5p (MIRT763992)
- hsa-miR-26a-5p (MIRT764291)
- hsa-miR-26b-5p (MIRT764308)
- hsa-miR-3167 (MIRT765206)
- hsa-miR-320e (MIRT765545)
- hsa-miR-3607-5p (MIRT765856)
- hsa-miR-3613-3p (MIRT765976)
- hsa-miR-3688-5p (MIRT766780)
- hsa-miR-3919 (MIRT767660)
- hsa-miR-3944-5p (MIRT767873)
- hsa-miR-4465 (MIRT769417)
- hsa-miR-5004-3p (MIRT772932)
- hsa-miR-548ac (MIRT774051)
- hsa-miR-548ae-3p (MIRT774068)
- hsa-miR-548ah-3p (MIRT774088)
- hsa-miR-548aj-3p (MIRT774115)
- hsa-miR-548am-3p (MIRT774138)
- hsa-miR-548aq-3p (MIRT774175)
- hsa-miR-548bb-3p (MIRT774281)
- hsa-miR-548d-3p (MIRT774359)
- hsa-miR-548h-3p (MIRT774400)
- hsa-miR-548j-3p (MIRT774422)
- hsa-miR-548x-3p (MIRT774560)
- hsa-miR-548z (MIRT774581)
- hsa-miR-6132 (MIRT775892)
- hsa-miR-613 (MIRT775979)
- hsa-miR-6516-3p (MIRT777047)
- hsa-miR-6716-5p (MIRT777702)
- hsa-miR-6722-3p (MIRT777828)
- hsa-miR-6836-5p (MIRT780057)
- hsa-miR-6853-3p (MIRT780466)
- hsa-miR-876-5p (MIRT782530)
- hsa-miR-891a-3p (MIRT782612)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPZA1
- Browse OriGene Inhibitory RNA Products For CAPZA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1
Clone Products
- Applied Biological Materials (abm): Clones for CAPZA1 - Select products 50% OFF >
- * CAPZA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CAPZA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPZA1
Cell Line Products
-
Horizon Cell Lines for CAPZA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPZA1 Gene
Localization for CAPZA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAPZA1 Gene
- Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | TAS | 16130169 |
| GO:0008290 | F-actin capping protein complex | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAPZA1 Gene
Pathways & Interactions for CAPZA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Endocytosis | ||
| 3 | MAPK Erk Pathway | ||
| 4 | Advanced glycosylation endproduct receptor signaling | ||
| 5 | Factors involved in megakaryocyte development and platelet production | ||
Pathways by source for CAPZA1 Gene
1 Sino Biological pathway for CAPZA1 Gene
1 KEGG pathway for CAPZA1 Gene
2 GeneGo (Thomson Reuters) pathways for CAPZA1 Gene
- Cell cycle_Spindle assembly and chromosome separation
- Cytoskeleton remodeling Neurofilaments
Interacting Proteins for CAPZA1 Gene
Selected Interacting proteins:
P52907-CAZA1_HUMAN
ENSP00000263168
for CAPZA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CAPZA1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | -- |
| GO:0030036 | actin cytoskeleton organization | IBA | 21873635 |
| GO:0034329 | cell junction assembly | IMP | 22891260 |
Transcripts for CAPZA1 Gene
mRNA/cDNA for CAPZA1 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263168 2358 nts (view in UCSC)
- ENST00000485542 739 nts (view in UCSC)
- ENST00000476936 867 nts (view in UCSC)
- ENST00000498626 650 nts (view in UCSC)
- ENST00000466066 765 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAPZA1 - Select products 50% OFF >
- * CAPZA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CAPZA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPZA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPZA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPZA1
- Browse OriGene Inhibitory RNA Products For CAPZA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1
Clone Products
- Applied Biological Materials (abm): Clones for CAPZA1 - Select products 50% OFF >
- * CAPZA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CAPZA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPZA1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for CAPZA1 Gene
- GeneLoc Exon Structure for
- CAPZA1
Expression for CAPZA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocytes Anterior Neck Muscles
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Trunk Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Lumbar Vertebrae Column Muscles
-
Limb (Muscoskeletal System)
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
- Multinuclear Myocytes Hindlimb Dorsal Muscle
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Amnion (Extraembryonic Tissues)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CAPZA1 Gene
This gene is overexpressed in Whole Blood (x6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPZA1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPZA1
SOURCE GeneReport for Unigene cluster for CAPZA1 Gene:
Hs.744974Evidence on tissue expression from TISSUES for CAPZA1 Gene
- Blood(4.7)
- Stomach(4.5)
- Liver(4.4)
- Nervous system(3.9)
- Skin(3.3)
- Lung(2.6)
- Intestine(2.6)
- Kidney(2.5)
- Lymph node(2.4)
- Bone marrow(2.2)
- Spleen(2.2)
- Muscle(2.2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for CAPZA1
-
OriGene qPCR primer pairs and template standards for CAPZA1
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPZA1 Gene
Orthologs for CAPZA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CAPZA1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CAPZA1 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | CAPZA1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Capza1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Capza1 30 17 31 |
|
OneToMany | |
| 4933400A11Rik 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | CAPZA1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CAPZA1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CAPZA1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | capza1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | capza1a 30 |
|
||
| wufa19e05 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10540 32 |
|
|
|
| cpa 30 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006141 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | cap-1 30 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CAP1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G05520 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os07g0414800 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8055 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2607 30 |
|
- Species where no ortholog for CAPZA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CAPZA1 Gene
- ENSEMBL:
- Gene Tree for CAPZA1 (if available)
- TreeFam:
- Gene Tree for CAPZA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAPZA1: view image
Paralogs for CAPZA1 Gene
Pseudogenes.org Pseudogenes for CAPZA1 Gene
Variants for CAPZA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPZA1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs555597264 | - | p.Ser219Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv27061 | CNV | gain+loss | 19812545 |
| esv3310239 | CNV | mobile element insertion | 20981092 |
| esv3356260 | CNV | insertion | 20981092 |
| esv3587216 | CNV | loss | 21293372 |
| nsv159055 | CNV | deletion | 16902084 |
| nsv946142 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.47;
43.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAPZA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZA1 Gene
Disorders for CAPZA1 Gene
Additional Disease Information for CAPZA1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CAPZA1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZA1 Gene
Publications for CAPZA1 Gene
- Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. (PMID: 30361697) Jung YS … Park JI (Nature cell biology 2018) 3 4
- Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. (PMID: 22891260) Elbediwy A … Balda MS (The Journal of cell biology 2012) 3 4
- Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N … He J (Nature genetics 2011) 3 41
- The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PMID: 19922875) Derivery E … Gautreau A (Developmental cell 2009) 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
ExternalLinks
Products for CAPZA1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPZA1
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- OriGene qPCR primer pairs and template standards for CAPZA1
- OriGene CRISPR knockouts for CAPZA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CAPZA1
- Sino Biological Human cDNA Clone for CAPZA1
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- Novus Biologicals proteins and lysates for CAPZA1
- Browse Antibodies
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- Invitrogen Antibodies for CAPZA1 (AFLGC-CAPZA1)
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- VectorBuilder CRISPR vectors for CAPZA1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CAPZA1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CAPZA1
- antibodies-online: Show 23 available CAPZA1 Antibodies ranked by validation data
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- antibodies-online: Search results for available CAPZA1 related products ranked by validation data
- antibodies-online: Show 11 available CAPZA1 Proteins ranked by validation data
- Compare Top CAPZA1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CAPZA1
- Search Santa Cruz Biotechnology (SCBT) for CAPZA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAPZA1
- Horizon Cell Lines for CAPZA1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPZA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPZA1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CAPZA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPZA1
- Boster Bio Antibodies for CAPZA1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for CAPZA1
Sources for CAPZA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
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- (33) SGD
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- (36) Pseudogene
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- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
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- (84) COMPARTMENTS
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- (104) diseasecard
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- (154) Biorbyt
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