Aliases for CAPSL Gene

Aliases for CAPSL Gene

  • Calcyphosine Like 2 3 5
  • Calcyphosin-Like Protein 3 4
  • Calcyphosine-Like 2
  • MGC26610 2
  • CAPSL 5

External Ids for CAPSL Gene

Previous GeneCards Identifiers for CAPSL Gene

  • GC05M035941
  • GC05M035854

Summaries for CAPSL Gene

GeneCards Summary for CAPSL Gene

CAPSL (Calcyphosine Like) is a Protein Coding gene. Diseases associated with CAPSL include Lipomatosis, Multiple Symmetric. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CAPS.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPSL Gene

Genomics for CAPSL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAPSL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPSL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPSL

Top Transcription factor binding sites by QIAGEN in the CAPSL gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • FOXF2

Genomic Locations for CAPSL Gene

Genomic Locations for CAPSL Gene
chr5:35,904,288-35,938,779
(GRCh38/hg38)
Size:
34,492 bases
Orientation:
Minus strand
chr5:35,904,397-35,938,881
(GRCh37/hg19)
Size:
34,485 bases
Orientation:
Minus strand

Genomic View for CAPSL Gene

Genes around CAPSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPSL Gene

Proteins for CAPSL Gene

  • Protein details for CAPSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWF8-CAPSL_HUMAN
    Recommended name:
    Calcyphosin-like protein
    Protein Accession:
    Q8WWF8

    Protein attributes for CAPSL Gene

    Size:
    208 amino acids
    Molecular mass:
    24229 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17586.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for CAPSL Gene

Post-translational modifications for CAPSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPSL Gene

Domains & Families for CAPSL Gene

Gene Families for CAPSL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAPSL Gene

Suggested Antigen Peptide Sequences for CAPSL Gene

GenScript: Design optimal peptide antigens:
  • Calcyphosin-like protein (CAPSL_HUMAN)
genes like me logo Genes that share domains with CAPSL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CAPSL Gene

Function for CAPSL Gene

Phenotypes From GWAS Catalog for CAPSL Gene

Gene Ontology (GO) - Molecular Function for CAPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CAPSL: view
genes like me logo Genes that share phenotypes with CAPSL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPSL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPSL Gene

Localization for CAPSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPSL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPSL gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CAPSL: view

Pathways & Interactions for CAPSL Gene

PathCards logo

SuperPathways for CAPSL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPSL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CAPSL Gene

Drugs & Compounds for CAPSL Gene

No Compound Related Data Available

Transcripts for CAPSL Gene

mRNA/cDNA for CAPSL Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPSL

Alternative Splicing Database (ASD) splice patterns (SP) for CAPSL Gene

No ASD Table

Relevant External Links for CAPSL Gene

GeneLoc Exon Structure for
CAPSL

Expression for CAPSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPSL Gene

This gene is overexpressed in Pituitary (x9.2), Fallopian Tube (x7.6), Testis (x6.8), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for CAPSL Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAPSL Gene



Protein tissue co-expression partners for CAPSL Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPSL

SOURCE GeneReport for Unigene cluster for CAPSL Gene:

Hs.55150
genes like me logo Genes that share expression patterns with CAPSL: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPSL Gene

Orthologs for CAPSL Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPSL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAPSL 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAPSL 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CAPSL 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CAPSL 31
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CAPSL 30 31
  • 90.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Capsl 30 17 31
  • 89.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Capsl 30
  • 89.26 (n)
Chicken
(Gallus gallus)
Aves CAPSL 30 31
  • 79.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAPSL 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia capsl 30
  • 74.75 (n)
Str.19315 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18844 30
Zebrafish
(Danio rerio)
Actinopterygii capslb 30 31
  • 71.63 (n)
OneToOne
wufj05b10 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG10126 30 31
  • 56.29 (n)
ManyToMany
CG31345 31
  • 46 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007666 30
  • 55.93 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 64 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1998 30
Species where no ortholog for CAPSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CAPSL Gene

ENSEMBL:
Gene Tree for CAPSL (if available)
TreeFam:
Gene Tree for CAPSL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPSL: view image

Paralogs for CAPSL Gene

Paralogs for CAPSL Gene

(6) SIMAP similar genes for CAPSL Gene using alignment to 3 proteins:

  • CAPSL_HUMAN
  • D6RF97_HUMAN
  • D6RHD7_HUMAN
genes like me logo Genes that share paralogs with CAPSL: view

Variants for CAPSL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPSL Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
787282 Benign: not provided 35,904,571(-) T/C MISSENSE_VARIANT
rs1345826 - p.Met201Val
rs1445898 - p.Arg85Gln

Additional dbSNP identifiers (rs#s) for CAPSL Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPSL Gene

Variant ID Type Subtype PubMed ID
esv3604707 CNV gain 21293372
nsv471011 CNV gain 18288195
nsv4794 CNV deletion 18451855
nsv483069 CNV gain 15286789
nsv830261 CNV gain 17160897

Variation tolerance for CAPSL Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPSL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPSL Gene

Disorders for CAPSL Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAPSL Gene - From: DISEASES

Disorder Aliases PubMed IDs
lipomatosis, multiple symmetric
  • msl
- elite association - COSMIC cancer census association via MalaCards
Search CAPSL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAPSL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CAPSL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPSL Gene

Publications for CAPSL Gene

  1. Study of the association between the CAPSL-IL7R locus and type 1 diabetes. (PMID: 18563381) Santiago JL … Urcelay E (Diabetologia 2008) 3 41
  2. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd JA … Clayton DG (Nature genetics 2007) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3

Products for CAPSL Gene

Sources for CAPSL Gene