Aliases for CAPRIN2 Gene
External Ids for CAPRIN2 Gene
Previous HGNC Symbols for CAPRIN2 Gene
Previous GeneCards Identifiers for CAPRIN2 Gene
The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for CAPRIN2 Gene
CAPRIN2 (Caprin Family Member 2) is a Protein Coding gene. Diseases associated with CAPRIN2 include Axenfeld-Rieger Syndrome, Type 1 and Mixed Fibrolamellar Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include RNA binding and signaling receptor binding. An important paralog of this gene is CAPRIN1.
UniProtKB/Swiss-Prot Summary for CAPRIN2 Gene
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).