The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] See more...

Aliases for CAPRIN2 Gene

Aliases for CAPRIN2 Gene

  • Caprin Family Member 2 2 3 5
  • Cytoplasmic Activation/Proliferation-Associated Protein 2 3 4
  • Gastric Cancer Multidrug Resistance-Associated Protein 3 4
  • C1q Domain-Containing Protein 1 3 4
  • RNA Granule Protein 140 3 4
  • Caprin-2 3 4
  • C1QDC1 3 4
  • RNG140 3 4
  • EEG1 3 4
  • C1q Domain Containing 1 2
  • Protein EEG-1 4
  • KIAA1873 4
  • EEG-1 3

External Ids for CAPRIN2 Gene

Previous HGNC Symbols for CAPRIN2 Gene

  • C1QDC1

Previous GeneCards Identifiers for CAPRIN2 Gene

  • GC12M030754
  • GC12M030862
  • GC12M030627

Summaries for CAPRIN2 Gene

Entrez Gene Summary for CAPRIN2 Gene

  • The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for CAPRIN2 Gene

CAPRIN2 (Caprin Family Member 2) is a Protein Coding gene. Diseases associated with CAPRIN2 include Axenfeld-Rieger Syndrome, Type 1 and Mixed Fibrolamellar Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include RNA binding and signaling receptor binding. An important paralog of this gene is CAPRIN1.

UniProtKB/Swiss-Prot Summary for CAPRIN2 Gene

  • Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).

Gene Wiki entry for CAPRIN2 Gene

Additional gene information for CAPRIN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPRIN2 Gene

Genomics for CAPRIN2 Gene

GeneHancer (GH) Regulatory Elements for CAPRIN2 Gene

Promoters and enhancers for CAPRIN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J030753 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 517.3 +68.5 68487 3.1 HNRNPK ZBTB40 EP300 CTCF NRF1 TCF12 POLR2G USF1 SP1 PHF8 CAPRIN2 ENSG00000246331 LOC645485 LINC00941 HSALNG0090147 DDX11 IPO8 SINHCAF ENSG00000177340 ENSG00000256984
GH12J030821 Promoter/Enhancer 1.4 EPDnew ENCODE CraniofacialAtlas 500.7 +0.4 449 1.8 CTCF EZH2 YY1 POLR2A ZBTB33 MAX HNRNPL RXRA SUZ12 CHD2 CAPRIN2 lnc-CAPRIN2-1 LINC00941 piR-48759-056 ENSG00000285517
GH12J030751 Promoter 0.3 EPDnew 500.2 +72.1 72122 0.1 CAPRIN2 HSALNG0090147 ENSG00000285870
GH12J030735 Promoter 0.3 EPDnew 500.2 +88.2 88153 0.1 CAPRIN2 IPO8 HSALNG0090147 ENSG00000285870
GH12J031726 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 29.4 -907.9 -907863 9.1 EP300 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 POLR2G USF1 SP1 AMN1 ENSG00000276900 lnc-AMN1-1 piR-61945-095 CAPRIN2 BICD1 DDX11-AS1 DNM1L ENSG00000252204 AK4P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPRIN2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPRIN2

Genomic Locations for CAPRIN2 Gene

Genomic Locations for CAPRIN2 Gene
chr12:30,709,552-30,823,235
(GRCh38/hg38)
Size:
113,684 bases
Orientation:
Minus strand
chr12:30,862,486-30,907,885
(GRCh37/hg19)
Size:
45,400 bases
Orientation:
Minus strand

Genomic View for CAPRIN2 Gene

Genes around CAPRIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPRIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPRIN2 Gene

Proteins for CAPRIN2 Gene

  • Protein details for CAPRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMN6-CAPR2_HUMAN
    Recommended name:
    Caprin-2
    Protein Accession:
    Q6IMN6
    Secondary Accessions:
    • E4NKG2
    • Q149P6
    • Q149P7
    • Q6IMN5
    • Q7Z371
    • Q8TE70
    • Q8TE71
    • Q96RN6
    • Q9H667
    • Q9HAL4

    Protein attributes for CAPRIN2 Gene

    Size:
    1127 amino acids
    Molecular mass:
    125925 Da
    Quaternary structure:
    • Homotrimer; via C1q domain (PubMed:25331957). Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587). Interacts with LRP5 (PubMed:18762581). Interacts with LRP6 (PubMed:18762581, PubMed:25331957).
    SequenceCaution:
    • Sequence=AAK83153.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPRIN2 Gene

    Alternative splice isoforms for CAPRIN2 Gene

neXtProt entry for CAPRIN2 Gene

Post-translational modifications for CAPRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPRIN2 Gene

Domains & Families for CAPRIN2 Gene

Gene Families for CAPRIN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAPRIN2 Gene

Blocks:
  • Complement C1q protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAPRIN2 Gene

GenScript: Design optimal peptide antigens:
  • RNA granule protein 140 (CAPR2_HUMAN)
  • RNA granule protein 140 (E4NKG2_HUMAN)
  • KIAA1873 protein (Q96JF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IMN6

UniProtKB/Swiss-Prot:

CAPR2_HUMAN :
  • The C1q domain is essential for the function in Wnt signaling.
  • Belongs to the caprin family.
Domain:
  • The C1q domain is essential for the function in Wnt signaling.
Family:
  • Belongs to the caprin family.
genes like me logo Genes that share domains with CAPRIN2: view

Function for CAPRIN2 Gene

Molecular function for CAPRIN2 Gene

UniProtKB/Swiss-Prot Function:
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).

Phenotypes From GWAS Catalog for CAPRIN2 Gene

Gene Ontology (GO) - Molecular Function for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005102 signaling receptor binding IPI 18762581
GO:0005515 protein binding IPI 18762581
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CAPRIN2: view

Phenotypes for CAPRIN2 Gene

genes like me logo Genes that share phenotypes with CAPRIN2: view

Animal Models for CAPRIN2 Gene

MGI Knock Outs for CAPRIN2:
  • Caprin2 Caprin2<tm2a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPRIN2

CRISPR Products

miRNA for CAPRIN2 Gene

miRTarBase miRNAs that target CAPRIN2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPRIN2 Gene

Localization for CAPRIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN2 Gene

[Isoform 1]: Cytoplasm.
[Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.
[Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.
Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPRIN2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 3
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 14593112
GO:0005739 mitochondrion IDA,IEA 14593112
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CAPRIN2: view

Pathways & Interactions for CAPRIN2 Gene

PathCards logo

SuperPathways for CAPRIN2 Gene

No Data Available

SIGNOR curated interactions for CAPRIN2 Gene

Activates:

Gene Ontology (GO) - Biological Process for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA 14593112
GO:0032092 positive regulation of protein binding IDA 18762581
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 18762581
genes like me logo Genes that share ontologies with CAPRIN2: view

No data available for Pathways by source for CAPRIN2 Gene

Drugs & Compounds for CAPRIN2 Gene

No Compound Related Data Available

Transcripts for CAPRIN2 Gene

mRNA/cDNA for CAPRIN2 Gene

9 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19: - - - - - - - -
SP20: - - - - - - -
SP21:
SP22: -
SP23: - - - -
SP24:
SP25: - - -

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: -
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - -
SP15: - -
SP16: - - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21: - - - - - - - -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for CAPRIN2 Gene

GeneLoc Exon Structure for
CAPRIN2

Expression for CAPRIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPRIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPRIN2 Gene

This gene is overexpressed in Plasma (53.1) and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPRIN2 Gene



Protein tissue co-expression partners for CAPRIN2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPRIN2

SOURCE GeneReport for Unigene cluster for CAPRIN2 Gene:

Hs.234355

mRNA Expression by UniProt/SwissProt for CAPRIN2 Gene:

Q6IMN6-CAPR2_HUMAN
Tissue specificity: Detected in all tissues tested with highest levels of expression in brain and spleen.

Evidence on tissue expression from TISSUES for CAPRIN2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with CAPRIN2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPRIN2 Gene

Orthologs for CAPRIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPRIN2 31 30
  • 99.65 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPRIN2 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPRIN2 31 30
  • 93.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CAPRIN2 31 30
  • 93.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Caprin2 17 31 30
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia Caprin2 30
  • 82.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPRIN2 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPRIN2 31 30
  • 73.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPRIN2 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia caprin2 30
  • 59.25 (n)
Str.17842 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.3769 30
zebrafish
(Danio rerio)
Actinopterygii caprin2 31 30
  • 52.89 (n)
OneToOne
wufj80b02 30
fruit fly
(Drosophila melanogaster)
Insecta Capr 31
  • 20 (a)
OneToMany
Species where no ortholog for CAPRIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPRIN2 Gene

ENSEMBL:
Gene Tree for CAPRIN2 (if available)
TreeFam:
Gene Tree for CAPRIN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPRIN2: view image

Paralogs for CAPRIN2 Gene

Paralogs for CAPRIN2 Gene

(7) SIMAP similar genes for CAPRIN2 Gene using alignment to 12 proteins:

  • CAPR2_HUMAN
  • F5GXI7_HUMAN
  • F5GYA1_HUMAN
  • F5GZX3_HUMAN
  • F5H142_HUMAN
  • F5H5J8_HUMAN
  • F5H7T6_HUMAN
  • H0YGG3_HUMAN
  • H0YID4_HUMAN
  • H3BM22_HUMAN
  • H7BXN4_HUMAN
  • L8E8S3_HUMAN
genes like me logo Genes that share paralogs with CAPRIN2: view

Variants for CAPRIN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPRIN2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
779266 Benign: not provided 30,715,074(-) C/T SYNONYMOUS_VARIANT
785398 Benign: not provided 30,719,127(-) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT
785399 Benign: not provided 30,731,402(-) A/G INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT
786224 Benign: not provided 30,713,872(-) A/G SYNONYMOUS_VARIANT
788433 Benign: not provided 30,723,254(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CAPRIN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPRIN2 Gene

Variant ID Type Subtype PubMed ID
esv2745706 CNV deletion 23290073
esv3629022 CNV loss 21293372
nsv832361 CNV loss 17160897

Variation tolerance for CAPRIN2 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPRIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPRIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Disorders for CAPRIN2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CAPRIN2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CAPRIN2

genes like me logo Genes that share disorders with CAPRIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPRIN2 Gene

Publications for CAPRIN2 Gene

  1. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B … Schrader JW (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4 54
  2. Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation. (PMID: 27821587) Wang X … Li L (The Journal of biological chemistry 2016) 3 4 54
  3. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling. (PMID: 25331957) Miao H … Li L (The Journal of biological chemistry 2014) 3 4 54
  4. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. (PMID: 20516077) Shiina N … Tokunaga M (The Journal of biological chemistry 2010) 3 4 54
  5. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. (PMID: 18762581) Ding Y … Li L (The Journal of cell biology 2008) 3 4 54

Products for CAPRIN2 Gene

Sources for CAPRIN2 Gene