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The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] See more...
Aliases for CAPRIN2 Gene
Aliases for CAPRIN2 Gene
External Ids for CAPRIN2 Gene
- HGNC: 21259
- NCBI Entrez Gene: 65981
- Ensembl: ENSG00000110888
- OMIM®: 610375
- UniProtKB/Swiss-Prot: Q6IMN6
Previous HGNC Symbols for CAPRIN2 Gene
- C1QDC1
Previous GeneCards Identifiers for CAPRIN2 Gene
- GC12M030754
- GC12M030862
- GC12M030627
Summaries for CAPRIN2 Gene
-
The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for CAPRIN2 Gene
CAPRIN2 (Caprin Family Member 2) is a Protein Coding gene. Diseases associated with CAPRIN2 include Combined Oxidative Phosphorylation Deficiency 32 and Axenfeld-Rieger Syndrome, Type 1. Gene Ontology (GO) annotations related to this gene include RNA binding and signaling receptor binding. An important paralog of this gene is CAPRIN1.
UniProtKB/Swiss-Prot Summary for CAPRIN2 Gene
-
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).
Additional gene information for CAPRIN2 Gene
- HGNC (21259)
- NCBI Entrez Gene (65981)
- Ensembl (ENSG00000110888)
- OMIM® (610375)
- UniProtKB/Swiss-Prot (Q6IMN6)
- Open Targets Platform(ENSG00000110888)
- Search for CAPRIN2 at DataMed
- Search for CAPRIN2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPRIN2 Gene
Genomics for CAPRIN2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CAPRIN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAPRIN2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPRIN2
Genomic Locations for CAPRIN2 Gene
Latest Assembly
- chr12:30,709,552-30,754,951
- (GRCh38/hg38)
- Size:
- 45,400 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:30,862,487-30,907,885
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 45,399 bases
- Orientation:
- Minus strand
- chr12:30,862,486-30,907,885
- (GRCh37/hg19 by Ensembl)
- Size:
- 45,400 bases
- Orientation:
- Minus strand
Genomic View for CAPRIN2 Gene
Genes around CAPRIN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by HGNC
- 12p11.21 by Entrez Gene
- 12p11.21 by Ensembl
CAPRIN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAPRIN2 Gene
Proteins for CAPRIN2 Gene
-
Protein details for CAPRIN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6IMN6-CAPR2_HUMAN
- Recommended name:
- Caprin-2
- Protein Accession:
- Q6IMN6
- E4NKG2
- Q149P6
- Q149P7
- Q6IMN5
- Q7Z371
- Q8TE70
- Q8TE71
- Q96RN6
- Q9H667
- Q9HAL4
Protein attributes for CAPRIN2 Gene
- Size:
- 1127 amino acids
- Molecular mass:
- 125925 Da
- Quaternary structure:
-
- Homotrimer; via C1q domain (PubMed:25331957). Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587). Interacts with LRP5 (PubMed:18762581). Interacts with LRP6 (PubMed:18762581, PubMed:25331957).
- SequenceCaution:
-
- Sequence=AAK83153.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CAPRIN2 Gene
Protein Expression for CAPRIN2 Gene
Post-translational modifications for CAPRIN2 Gene
Other Protein References for CAPRIN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006719207.1
- XP_006719210.1
- XP_016875340.1
- XP_016875343.1
- XP_016875349.1
- XP_016875351.1
- XP_016875352.1
- XP_016875353.1
- XP_016875354.1
- XP_024304913.1
- XP_024304914.1
- XP_024304915.1
- NP_001002259.1
- NP_001193785.1
- NP_001306771.1
- NP_001306772.1
- NP_001306773.1
- NP_001306774.1
- NP_001306775.1
- NP_001372427.1
- NP_001372428.1
- NP_001372429.1
- NP_001372430.1
- NP_001372431.1
- NP_001372432.1
- NP_001372433.1
- NP_001372434.1
- NP_001372435.1
- NP_001372436.1
- NP_001372437.1
- NP_001372438.1
- NP_001372439.1
- NP_001372440.1
- NP_001372441.1
- NP_001372442.1
- NP_001372443.1
- NP_001372444.1
- NP_001372445.1
- NP_001372447.1
- NP_001372448.1
- NP_001372449.1
- NP_001372450.1
- NP_001372451.1
- NP_001372452.1
- NP_001372453.1
- NP_001372454.1
- NP_001372455.1
- NP_001372456.1
- NP_001372457.1
- NP_001372458.1
- NP_001372460.1
- NP_001372461.1
- NP_001372462.1
- NP_001372463.1
- NP_001372464.1
- NP_001372466.1
- NP_001372467.1
- NP_001372468.1
- NP_001372469.1
- NP_001372470.1
- NP_001372471.1
- NP_001372472.1
- NP_001372473.1
- NP_001372474.1
- NP_001372475.1
- NP_001372476.1
- NP_001372477.1
- NP_001372478.1
- NP_001372479.1
- NP_001372480.1
- NP_001372481.1
- NP_001372482.1
- NP_001372483.1
- NP_001372486.1
- NP_001372488.1
- NP_076414.2
- NP_115532.3
Antibodies for research
- Novus Biologicals Antibodies for CAPRIN2
- Invitrogen Antibodies for CAPRIN2 (AFLGC-Caprin2)
-
Custom Antibody ServicesProSci Antibodies for CAPRIN2
- Sino Biological Antibodies for CAPRIN2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CAPRIN2
- Origene Custom Protein Services for CAPRIN2
- Novus Biologicals proteins for CAPRIN2
- antibodies-online: Show 3 available CAPRIN2 Proteins ranked by validation data
- Compare Top CAPRIN2 Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Show 3 available CAPRIN2 Elisa Kits ranked by validation data
- Compare Top CAPRIN2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CAPRIN2 Gene
Domains & Families for CAPRIN2 Gene
Gene Families for CAPRIN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CAPRIN2 Gene
- InterPro:
- Blocks:
-
- Complement C1q protein
- ProtoNet:
Suggested Antigen Peptide Sequences for CAPRIN2 Gene
- GenScript: Design optimal peptide antigens:
-
- RNA granule protein 140 (CAPR2_HUMAN)
- RNA granule protein 140 (E4NKG2_HUMAN)
- KIAA1873 protein (Q96JF4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6IMN6UniProtKB/Swiss-Prot:
CAPR2_HUMAN :- The C1q domain is essential for the function in Wnt signaling.
- Belongs to the caprin family.
- Domain:
-
- The C1q domain is essential for the function in Wnt signaling.
- Family:
-
- Belongs to the caprin family.
Function for CAPRIN2 Gene
Molecular function for CAPRIN2 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).
Phenotypes From GWAS Catalog for CAPRIN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005102 | signaling receptor binding | IPI | 18762581 |
| GO:0005515 | protein binding | IPI | 18762581 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CAPRIN2 Gene
- MGI mutant phenotypes for CAPRIN2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CAPRIN2:
Animal Models for CAPRIN2 Gene
- MGI Knock Outs for CAPRIN2:
-
- Caprin2 Caprin2<tm2a(EUCOMM)Wtsi>
Animal Models for research
-
Taconic Biosciences Mouse Models for CAPRIN2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CAPRIN2 - Starting at $85 >
- * CAPRIN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CAPRIN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPRIN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPRIN2
miRNA for CAPRIN2 Gene
- miRTarBase miRNAs that target CAPRIN2
-
- hsa-miR-124-3p (MIRT002910)
- hsa-miR-340-5p (MIRT019554)
- hsa-miR-93-5p (MIRT027968)
- hsa-let-7f-5p (MIRT051382)
- hsa-miR-20a-5p (MIRT441010)
- hsa-miR-106b-5p (MIRT441012)
- hsa-miR-759 (MIRT479990)
- hsa-miR-555 (MIRT479991)
- hsa-miR-4477b (MIRT479992)
- hsa-miR-3159 (MIRT479993)
- hsa-miR-582-5p (MIRT479994)
- hsa-miR-338-5p (MIRT479995)
- hsa-miR-520e (MIRT479996)
- hsa-miR-520d-3p (MIRT479997)
- hsa-miR-520c-3p (MIRT479998)
- hsa-miR-520b (MIRT479999)
- hsa-miR-520a-3p (MIRT480000)
- hsa-miR-373-3p (MIRT480001)
- hsa-miR-372-3p (MIRT480002)
- hsa-miR-302e (MIRT480003)
- hsa-miR-302d-3p (MIRT480004)
- hsa-miR-302c-3p (MIRT480005)
- hsa-miR-302b-3p (MIRT480006)
- hsa-miR-302a-3p (MIRT480007)
- hsa-miR-519c-3p (MIRT480008)
- hsa-miR-519b-3p (MIRT480009)
- hsa-miR-519a-3p (MIRT480010)
- hsa-miR-541-5p (MIRT480011)
- hsa-miR-655-3p (MIRT480012)
- hsa-miR-374c-5p (MIRT480013)
- hsa-miR-130a-3p (MIRT480014)
- hsa-miR-130b-3p (MIRT480015)
- hsa-miR-301a-3p (MIRT480016)
- hsa-miR-301b-3p (MIRT480017)
- hsa-miR-3666 (MIRT480018)
- hsa-miR-4295 (MIRT480019)
- hsa-miR-454-3p (MIRT480020)
- hsa-miR-19a-3p (MIRT480021)
- hsa-miR-19b-3p (MIRT480022)
- hsa-miR-181c-5p (MIRT480023)
- hsa-miR-181d-5p (MIRT480024)
- hsa-miR-4262 (MIRT480025)
- hsa-miR-181a-5p (MIRT480026)
- hsa-miR-181b-5p (MIRT480027)
- hsa-miR-4473 (MIRT538707)
- hsa-miR-4671-3p (MIRT538708)
- hsa-miR-5590-3p (MIRT538709)
- hsa-miR-616-3p (MIRT538710)
- hsa-miR-142-5p (MIRT538711)
- hsa-miR-520f-3p (MIRT538712)
- hsa-miR-512-3p (MIRT538713)
- hsa-miR-499b-3p (MIRT538714)
- hsa-miR-499a-3p (MIRT538715)
- hsa-miR-4796-3p (MIRT538716)
- hsa-miR-548ah-5p (MIRT538717)
- hsa-miR-3609 (MIRT538718)
- hsa-miR-106a-5p (MIRT538719)
- hsa-miR-17-5p (MIRT538720)
- hsa-miR-526b-3p (MIRT538721)
- hsa-miR-519d-3p (MIRT538722)
- hsa-miR-20b-5p (MIRT538723)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPRIN2
- Browse OriGene Inhibitory RNA Products For CAPRIN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN2
Clone products for research
- Applied Biological Materials (abm): Clones for CAPRIN2 - Starting at $45 >
- * CAPRIN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204214
- MG220180
- MR204214
- MR204214L3
- MR204214L4
- MR220180
- MR220180L3
- MR220180L4
- MR231196
- RC212106
- RC212106L3
- RC212106L4
- RC224862
- RC224862L3
- RC224862L4
- RC224910
- RC224910L3
- RC224910L4
- RC235015
- RG212106
- RG224862
- RG224910
- RG235015
- MR204214L3V
- MR204214L4V
- MR220180L3V
- MR220180L4V
- RC212106L3V
- RC212106L4V
- RC224862L3V
- RC224862L4V
- RC224910L3V
- RC224910L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CAPRIN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPRIN2
Cell Lines for research
-
Horizon Cell Lines for CAPRIN2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPRIN2 Gene
Localization for CAPRIN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN2 Gene
- [Isoform 1]: Cytoplasm.
- [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.
- [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.
- Cell membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| plasma membrane | 3 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Centrosome (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 14593112 |
| GO:0005739 | mitochondrion | IEA,IDA | 14593112 |
| GO:0005813 | centrosome | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for CAPRIN2 Gene
Interacting Proteins for CAPRIN2 Gene
Selected Interacting proteins:
Q6IMN6-CAPR2_HUMAN
ENSP00000298892
for CAPRIN2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CAPRIN2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017148 | negative regulation of translation | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0030308 | negative regulation of cell growth | IDA | 14593112 |
| GO:0032092 | positive regulation of protein binding | IDA | 18762581 |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | IDA | 18762581 |
No data available for Pathways by source for CAPRIN2 Gene
Transcripts for CAPRIN2 Gene
mRNA/cDNA for CAPRIN2 Gene
- 65 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000298892 4334 nts (view in UCSC)
- ENST00000395805 4156 nts (view in UCSC)
- ENST00000417045 3535 nts (view in UCSC)
- ENST00000433722 3012 nts (view in UCSC)
- ENST00000454014 4398 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CAPRIN2 - Starting at $85 >
- * CAPRIN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CAPRIN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPRIN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPRIN2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPRIN2
- Browse OriGene Inhibitory RNA Products For CAPRIN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN2
Clone products for research
- Applied Biological Materials (abm): Clones for CAPRIN2 - Starting at $45 >
- * CAPRIN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204214
- MG220180
- MR204214
- MR204214L3
- MR204214L4
- MR220180
- MR220180L3
- MR220180L4
- MR231196
- RC212106
- RC212106L3
- RC212106L4
- RC224862
- RC224862L3
- RC224862L4
- RC224910
- RC224910L3
- RC224910L4
- RC235015
- RG212106
- RG224862
- RG224910
- RG235015
- MR204214L3V
- MR204214L4V
- MR220180L3V
- MR220180L4V
- RC212106L3V
- RC212106L4V
- RC224862L3V
- RC224862L4V
- RC224910L3V
- RC224910L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CAPRIN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPRIN2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP25: | - | - | - |
| ExUns: | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | · | 20d | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | · | 26c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
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Relevant External Links for CAPRIN2 Gene
- GeneLoc Exon Structure for
- CAPRIN2
Expression for CAPRIN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Plasma (53.1) and Fetal ovary (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPRIN2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPRIN2
SOURCE GeneReport for Unigene cluster for CAPRIN2 Gene:
Hs.234355mRNA Expression by UniProt/SwissProt for CAPRIN2 Gene:
Q6IMN6-CAPR2_HUMAN
Tissue specificity:
Detected in all tissues tested with highest levels of expression in brain and spleen.
Evidence on tissue expression from TISSUES for CAPRIN2 Gene
- Nervous system(4.8)
Primer products for research
-
OriGene qPCR primer pairs for CAPRIN2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPRIN2 Gene
Orthologs for CAPRIN2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CAPRIN2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CAPRIN2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CAPRIN2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CAPRIN2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Caprin2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Caprin2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CAPRIN2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CAPRIN2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CAPRIN2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | caprin2 30 |
|
||
| Str.17842 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3769 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | caprin2 30 31 |
|
OneToOne | |
| wufj80b02 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Capr 31 |
|
OneToMany |
- Species where no ortholog for CAPRIN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CAPRIN2 Gene
- ENSEMBL:
- Gene Tree for CAPRIN2 (if available)
- TreeFam:
- Gene Tree for CAPRIN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAPRIN2: view image
Paralogs for CAPRIN2 Gene
(7) SIMAP similar genes for CAPRIN2 Gene using alignment to 12 proteins:
- CAPR2_HUMAN
- F5GXI7_HUMAN
- F5GYA1_HUMAN
- F5GZX3_HUMAN
- F5H142_HUMAN
- F5H5J8_HUMAN
- F5H7T6_HUMAN
- H0YGG3_HUMAN
- H0YID4_HUMAN
- H3BM22_HUMAN
- H7BXN4_HUMAN
- L8E8S3_HUMAN
Variants for CAPRIN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPRIN2 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 932666 | Likely Benign: not provided | 30,731,389(-) |
T/G NM_023925.4(CAPRIN2):c.1014A>C (p.Ser338=) |
SYNONYMOUS | |
| rs111738878 | Benign: not provided | 30,723,254(-) |
G/A NM_001002259.2(CAPRIN2):c.2043+5C>T |
INTRON | |
| rs114776731 | Benign: not provided | 30,726,098(-) |
A/G NM_001002259.2(CAPRIN2):c.1783-10T>C |
INTRON | |
| rs3213895 | Benign: not provided | 30,713,872(-) |
A/G NM_001002259.2(CAPRIN2):c.2664T>C (p.Tyr888=) |
SYNONYMOUS | |
| rs34087421 | Benign: not provided | 30,719,127(-) |
A/G NM_001002259.2(CAPRIN2):c.2247T>C (p.Ser749=) |
SYNONYMOUS_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745706 | CNV | deletion | 23290073 |
| esv3629022 | CNV | loss | 21293372 |
| nsv832361 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.58;
65.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAPRIN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAPRIN2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN2 Gene
Disorders for CAPRIN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| combined oxidative phosphorylation deficiency 32 |
|
|
| axenfeld-rieger syndrome, type 1 |
|
|
| cone-rod dystrophy 2 |
|
|
Search CAPRIN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAPRIN2
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CAPRIN2 Gene
Publications for CAPRIN2 Gene
- Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B … Schrader JW (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4
- Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation. (PMID: 27821587) Wang X … Li L (The Journal of biological chemistry 2016) 3 4
- Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling. (PMID: 25331957) Miao H … Li L (The Journal of biological chemistry 2014) 3 4
- RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. (PMID: 20516077) Shiina N … Tokunaga M (The Journal of biological chemistry 2010) 3 4
- Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. (PMID: 18762581) Ding Y … Li L (The Journal of cell biology 2008) 3 4
ExternalLinks
Products for CAPRIN2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CAPRIN2
- Origene Custom Protein Services for CAPRIN2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPRIN2
- Browse OriGene Inhibitory RNA Products For CAPRIN2
- OriGene qPCR primer pairs for CAPRIN2
- OriGene CRISPR knockouts for CAPRIN2
- MG204214
- MG220180
- MR204214
- MR204214L3
- MR204214L4
- MR220180
- MR220180L3
- MR220180L4
- MR231196
- RC212106
- RC212106L3
- RC212106L4
- RC224862
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- RC224910
- RC224910L3
- RC224910L4
- RC235015
- RG212106
- RG224862
- RG224910
- RG235015
- MR204214L3V
- MR204214L4V
- MR220180L3V
- MR220180L4V
- RC212106L3V
- RC212106L4V
- RC224862L3V
- RC224862L4V
- RC224910L3V
- RC224910L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CAPRIN2
- Sino Biological Human cDNA Clone for CAPRIN2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CAPRIN2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CAPRIN2
- Novus Biologicals proteins for CAPRIN2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CAPRIN2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CAPRIN2 (AFLGC-Caprin2)
- VectorBuilder Custom and pre-made DNA vectors for CAPRIN2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CAPRIN2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CAPRIN2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CAPRIN2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CAPRIN2
- antibodies-online: Show 3 available CAPRIN2 Antibodies ranked by validation data
- Compare Top CAPRIN2 Antibodies
- antibodies-online: Show 3 available CAPRIN2 Elisa Kits ranked by validation data
- Compare Top CAPRIN2 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available CAPRIN2 Proteins ranked by validation data
- Compare Top CAPRIN2 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for CAPRIN2
- Search for CAPRIN2 Proteins at ProSci
- Horizon Cell Lines for CAPRIN2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPRIN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPRIN2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CAPRIN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN2
Sources for CAPRIN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB