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Aliases for CAPRIN1 Gene

Aliases for CAPRIN1 Gene

  • Cell Cycle Associated Protein 1 2 3 5
  • GPI-Anchored Membrane Protein 1 2 3 4
  • Cytoplasmic Activation- And Proliferation-Associated Protein 1 3 4
  • Cytoplasmic Activation/Proliferation-Associated Protein-1 2 3
  • Membrane Component Chromosome 11 Surface Marker 1 3 4
  • GPI-Anchored Protein P137 3 4
  • RNA Granule Protein 105 3 4
  • GPI-P137 3 4
  • GPIP137 3 4
  • P137GPI 3 4
  • GPIAP1 3 4
  • RNG105 3 4
  • M11S1 3 4
  • Membrane Component, Chromosome 11, Surface Marker 1 2
  • Activation/Proliferation-Associated Protein 1 3
  • Cell Cycle-Associated Protein 1 4
  • Caprin 1 3
  • Caprin-1 3
  • GRIP137 3

External Ids for CAPRIN1 Gene

Previous HGNC Symbols for CAPRIN1 Gene

  • M11S1
  • GPIAP1

Previous GeneCards Identifiers for CAPRIN1 Gene

  • GC11P033769

Summaries for CAPRIN1 Gene

GeneCards Summary for CAPRIN1 Gene

CAPRIN1 (Cell Cycle Associated Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is CAPRIN2.

UniProtKB/Swiss-Prot for CAPRIN1 Gene

  • May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.

Gene Wiki entry for CAPRIN1 Gene

Additional gene information for CAPRIN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPRIN1 Gene

Genomics for CAPRIN1 Gene

GeneHancer (GH) Regulatory Elements for CAPRIN1 Gene

Promoters and enhancers for CAPRIN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J034050 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 669.9 +0.8 808 4.7 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 ZHX2 CAPRIN1 LOC101929918 CSTF3 NAT10 RPS24P15 GC11P034049
GH11J034051 Enhancer 0.5 ENCODE dbSUPER 650.7 -1.5 -1544 0 HMBOX1 GC11P034049 CAPRIN1 LOC101929918
GH11J034103 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.2 +53.8 53802 3.2 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 NAT10 CAPRIN1 ABTB2 RPS24P15 GC11P034062
GH11J034437 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14 +387.4 387396 3.1 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CAT ENSG00000254619 ENSG00000255169 FBXO3-DT ENSG00000255272 CAPRIN1 NAT10 ELF5
GH11J033255 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 -793.3 -793259 5.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 HIPK3 FBXO3-DT ENSG00000255272 ENSG00000255169 ENSG00000254619 NAT10 CAPRIN1 TCP11L1 QSER1 PIGCP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAPRIN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPRIN1 gene promoter:

Genomic Locations for CAPRIN1 Gene

Genomic Locations for CAPRIN1 Gene
chr11:34,051,617-34,102,610
(GRCh38/hg38)
Size:
50,994 bases
Orientation:
Plus strand
chr11:34,073,230-34,124,157
(GRCh37/hg19)

Genomic View for CAPRIN1 Gene

Genes around CAPRIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPRIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPRIN1 Gene

Proteins for CAPRIN1 Gene

  • Protein details for CAPRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14444-CAPR1_HUMAN
    Recommended name:
    Caprin-1
    Protein Accession:
    Q14444
    Secondary Accessions:
    • A6NMY7
    • D3DR06
    • Q15074
    • Q6IMN4
    • Q6IMN7
    • Q9BV09

    Protein attributes for CAPRIN1 Gene

    Size:
    709 amino acids
    Molecular mass:
    78366 Da
    Quaternary structure:
    • May form homomultimers (By similarity). Interacts with G3BP1; interaction is direct and takes place in cytoplasmic RNA granules (PubMed:17210633). Interacts with PQBP1 (PubMed:21933836).
    Miscellaneous:
    • Overexpression induces the formation of cytoplasmic stress granules and EIF2A phosphorylation through a mechanism that depends on its ability to bind mRNA.
    SequenceCaution:
    • Sequence=CAA61751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA88096.1; Type=Frameshift; Positions=11, 629; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPRIN1 Gene

    Alternative splice isoforms for CAPRIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPRIN1 Gene

Post-translational modifications for CAPRIN1 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at Lys147, Lys125, and posLast=110110
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPRIN1 Gene

No data available for DME Specific Peptides for CAPRIN1 Gene

Domains & Families for CAPRIN1 Gene

Gene Families for CAPRIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAPRIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAPRIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14444

UniProtKB/Swiss-Prot:

CAPR1_HUMAN :
  • Belongs to the caprin family.
Family:
  • Belongs to the caprin family.
genes like me logo Genes that share domains with CAPRIN1: view

Function for CAPRIN1 Gene

Molecular function for CAPRIN1 Gene

UniProtKB/Swiss-Prot Function:
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.

Phenotypes From GWAS Catalog for CAPRIN1 Gene

Gene Ontology (GO) - Molecular Function for CAPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 20696395
genes like me logo Genes that share ontologies with CAPRIN1: view
genes like me logo Genes that share phenotypes with CAPRIN1: view

Animal Models for CAPRIN1 Gene

MGI Knock Outs for CAPRIN1:

Animal Model Products

CRISPR Products

miRNA for CAPRIN1 Gene

miRTarBase miRNAs that target CAPRIN1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPRIN1 Gene

Localization for CAPRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN1 Gene

Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPRIN1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CAPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane TAS 7657653
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with CAPRIN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAPRIN1 Gene

Pathways & Interactions for CAPRIN1 Gene

SuperPathways for CAPRIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation ISS --
GO:0030154 cell differentiation IEA --
GO:0050775 positive regulation of dendrite morphogenesis ISS --
GO:0061003 positive regulation of dendritic spine morphogenesis ISS --
genes like me logo Genes that share ontologies with CAPRIN1: view

No data available for Pathways by source and SIGNOR curated interactions for CAPRIN1 Gene

Drugs & Compounds for CAPRIN1 Gene

No Compound Related Data Available

Transcripts for CAPRIN1 Gene

mRNA/cDNA for CAPRIN1 Gene

Unigene Clusters for CAPRIN1 Gene

Cell cycle associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPRIN1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - -
SP8:
SP9: - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - -
SP15:

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CAPRIN1 Gene

GeneLoc Exon Structure for
CAPRIN1
ECgene alternative splicing isoforms for
CAPRIN1

Expression for CAPRIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPRIN1 Gene

This gene is overexpressed in Bone marrow stromal cell (10.0) and Nasal epithelium (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPRIN1 Gene



Protein tissue co-expression partners for CAPRIN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPRIN1 Gene:

CAPRIN1

SOURCE GeneReport for Unigene cluster for CAPRIN1 Gene:

Hs.471818

mRNA Expression by UniProt/SwissProt for CAPRIN1 Gene:

Q14444-CAPR1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAPRIN1 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Intestine(4.6)
  • Liver(4.4)
  • Lung(3.6)
  • Skin(3.1)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with CAPRIN1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPRIN1 Gene

Orthologs for CAPRIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPRIN1 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CAPRIN1 34 33
  • 95.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CAPRIN1 34 33
  • 94.93 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Caprin1 33
  • 91.94 (n)
mouse
(Mus musculus)
Mammalia Caprin1 16 34 33
  • 91.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAPRIN1 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPRIN1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPRIN1 34 33
  • 83.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPRIN1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia caprin1 33
  • 73.04 (n)
Str.6417 33
African clawed frog
(Xenopus laevis)
Amphibia m11s1-prov 33
zebrafish
(Danio rerio)
Actinopterygii caprin1b 34 33
  • 66.61 (n)
OneToMany
caprin1a 34
  • 57 (a)
OneToMany
Dr.941 33
fruit fly
(Drosophila melanogaster)
Insecta Capr 34
  • 18 (a)
OneToMany
Species where no ortholog for CAPRIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPRIN1 Gene

ENSEMBL:
Gene Tree for CAPRIN1 (if available)
TreeFam:
Gene Tree for CAPRIN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPRIN1: view image

Paralogs for CAPRIN1 Gene

(2) SIMAP similar genes for CAPRIN1 Gene using alignment to 4 proteins:

  • CAPR1_HUMAN
  • E9PLA9_HUMAN
  • E9PP31_HUMAN
  • G3V153_HUMAN
genes like me logo Genes that share paralogs with CAPRIN1: view

Variants for CAPRIN1 Gene

Sequence variations from dbSNP and Humsavar for CAPRIN1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000013866 -- 34,052,248(+) C/CCC genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000069736 -- 34,074,872(+) A/G intron_variant
rs1000088953 -- 34,052,115(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000096011 -- 34,089,304(+) A/G intron_variant
rs1000231493 -- 34,057,002(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPRIN1 Gene

Variant ID Type Subtype PubMed ID
esv2744334 CNV deletion 23290073
esv3547573 CNV deletion 23714750
esv3625904 CNV loss 21293372
esv3625905 CNV loss 21293372
esv3625906 CNV gain 21293372
nsv1070442 CNV deletion 25765185
nsv1152966 CNV deletion 26484159

Variation tolerance for CAPRIN1 Gene

Residual Variation Intolerance Score: 5.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPRIN1 Gene

Human Gene Mutation Database (HGMD)
CAPRIN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPRIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN1 Gene

Disorders for CAPRIN1 Gene

Additional Disease Information for CAPRIN1

No disorders were found for CAPRIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPRIN1 Gene

Publications for CAPRIN1 Gene

  1. Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs. (PMID: 17210633) Solomon S … Schrader JW (Molecular and cellular biology 2007) 2 3 4 22 58
  2. Absence of caprin-1 results in defects in cellular proliferation. (PMID: 16177067) Wang B … Schrader JW (Journal of immunology (Baltimore, Md. : 1950) 2005) 2 3 22 58
  3. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B … Schrader JW (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4 58
  4. The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse. (PMID: 8786113) Gessler M … Luzio JP (Genomics 1996) 3 4 22 58
  5. Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells. (PMID: 7657653) Ellis JA … Luzio JP (The Journal of biological chemistry 1995) 2 3 4 58

Products for CAPRIN1 Gene

Sources for CAPRIN1 Gene

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