Aliases for CAPNS2 Gene
External Ids for CAPNS2 Gene
Previous GeneCards Identifiers for CAPNS2 Gene
GeneCards Summary for CAPNS2 Gene
CAPNS2 (Calpain Small Subunit 2) is a Protein Coding gene. Among its related pathways are Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPNS1.
UniProtKB/Swiss-Prot for CAPNS2 Gene
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.