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Aliases for CAPN8 Gene
Aliases for CAPN8 Gene
External Ids for CAPN8 Gene
- HGNC: 1485
- NCBI Entrez Gene: 388743
- Ensembl: ENSG00000203697
- OMIM®: 618777
- UniProtKB/Swiss-Prot: A6NHC0
Previous GeneCards Identifiers for CAPN8 Gene
- GC02U990107
- GC01U901168
- GC01M221871
- GC01M221782
- GC01M223711
- GC01M194391
Summaries for CAPN8 Gene
GeneCards Summary for CAPN8 Gene
CAPN8 (Calpain 8) is a Protein Coding gene. Diseases associated with CAPN8 include Isovaleric Acidemia and Methylmalonic Aciduria And Homocystinuria, Cblc Type. Among its related pathways are Degradation of the extracellular matrix and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN2.
UniProtKB/Swiss-Prot Summary for CAPN8 Gene
-
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
-
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.
Additional gene information for CAPN8 Gene
- HGNC (1485)
- NCBI Entrez Gene (388743)
- Ensembl (ENSG00000203697)
- OMIM® (618777)
- UniProtKB/Swiss-Prot (A6NHC0)
- Open Targets Platform(ENSG00000203697)
- Search for CAPN8 at DataMed
- Search for CAPN8 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPN8 Gene
Genomics for CAPN8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CAPN8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAPN8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPN8
- Top Transcription factor binding sites by QIAGEN in the CAPN8 gene promoter:
-
- AP-1
- COMP1
- E47
- LyF-1
- Pax-4a
- POU2F1
- POU2F1a
- Tal-1
- Tal-1beta
Genomic Locations for CAPN8 Gene
Latest Assembly
- chr1:223,538,007-223,665,734
- (GRCh38/hg38)
- Size:
- 127,728 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:223,714,979-223,853,403
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 138,425 bases
- Orientation:
- Minus strand
- chr1:223,711,349-223,853,436
- (GRCh37/hg19 by Ensembl)
- Size:
- 142,088 bases
- Orientation:
- Minus strand
Genomic View for CAPN8 Gene
Genes around CAPN8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by HGNC
- 1q41 by Entrez Gene
- 1q41 by Ensembl
CAPN8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAPN8 Gene
Proteins for CAPN8 Gene
-
Protein details for CAPN8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NHC0-CAN8_HUMAN
- Recommended name:
- Calpain-8
- Protein Accession:
- A6NHC0
- B2RXL2
Protein attributes for CAPN8 Gene
- Size:
- 703 amino acids
- Molecular mass:
- 79144 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Monomer and homooligomer. Interacts with COPS1/GPS1, COPB1, EYA2, NME2, NME4 and TOMM70 (By similarity).
Protein Expression for CAPN8 Gene
Selected DME Specific Peptides for CAPN8 Gene
- A6NHC0:
-
- EICNLSPDSL
- RNPWGEVEW
- GATRTDI
- GSLLGCSI
- LGDCWLLA
- YAGIFHF
- LLEKAYAK
- NPQFKIRL
- YAGIFHFQFWQYGEWV
- EGFEDFTGG
- RLRNPWG
- RGSTAGGC
- RTDICQG
Post-translational modifications for CAPN8 Gene
- Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAPN8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for CAPN8
- Novus Biologicals Antibodies for CAPN8
- Invitrogen Antibodies for CAPN8 (AFLGC-CAPN8)
-
Biorbyt antibodies for CAPN8
-
Custom Antibody ServicesProSci Antibodies for CAPN8
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAPN8
Protein products for research
-
OriGene Purified Proteins for CAPN8
- Search Origene for MassSpec and Protein Over-expression Lysates for CAPN8
- Origene Custom Protein Services for CAPN8
- Novus Biologicals proteins for CAPN8
- antibodies-online: Show 3 available CAPN8 Proteins ranked by validation data
- Compare Top CAPN8 Proteins
-
Quality Products:
Assay products for research
Domains & Families for CAPN8 Gene
Gene Families for CAPN8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CAPN8 Gene
Suggested Antigen Peptide Sequences for CAPN8 Gene
- GenScript: Design optimal peptide antigens:
-
- Calpain 8 (A3QK36_HUMAN)
- Calpain 8 (A3QK37_HUMAN)
- Stomach-specific M-type calpain (CAN8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A6NHC0UniProtKB/Swiss-Prot:
CAN8_HUMAN :- The domain III mediates oligomerization.
- Belongs to the peptidase C2 family.
- Domain:
-
- The domain III mediates oligomerization.
- Family:
-
- Belongs to the peptidase C2 family.
Function for CAPN8 Gene
Molecular function for CAPN8 Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Broad endopeptidase specificity.; EC=3.4.22.53;.
Enzyme Numbers (IUBMB) for CAPN8 Gene
Phenotypes From GWAS Catalog for CAPN8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004198 | calcium-dependent cysteine-type endopeptidase activity | IEA,IBA | 21873635 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CAPN8 Gene
- MGI mutant phenotypes for CAPN8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CAPN8:
Animal Models for CAPN8 Gene
- MGI Knock Outs for CAPN8:
-
- Capn8 Capn8<tm1Hiso>
Animal Models for research
-
Taconic Biosciences Mouse Models for CAPN8
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CAPN8 - Starting at $85 >
- * CAPN8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CAPN8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPN8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPN8
miRNA for CAPN8 Gene
- miRTarBase miRNAs that target CAPN8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPN8
- Browse OriGene Inhibitory RNA Products For CAPN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN8
Clone products for research
- Applied Biological Materials (abm): Clones for CAPN8 - Starting at $45 >
- * CAPN8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CAPN8
- Addgene plasmids for CAPN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPN8
Cell Lines for research
-
Horizon Cell Lines for CAPN8
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN8 Gene
Localization for CAPN8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAPN8 Gene
- Cytoplasm. Golgi apparatus.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Nuclear membrane (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for CAPN8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Degradation of the extracellular matrix | ||
| 2 | Apoptosis Pathway | ||
Pathways by source for CAPN8 Gene
2 Reactome pathways for CAPN8 Gene
1 Tocris pathway for CAPN8 Gene
Interacting Proteins for CAPN8 Gene
GPS-Prot Interaction Network for CAPN8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA,IBA | 21873635 |
| GO:0007586 | digestion | IEA | -- |
No data available for SIGNOR curated interactions for CAPN8 Gene
Drugs & Compounds for CAPN8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Epoxomicin | Pharma | Proteasome inhibitor | 0 | |||
| MG-132 | Pharma | Proteasome inhibitor, Cell permeable, reversible | 0 | |||
| PSI | Pharma | Proteasome inhibitor | 0 | |||
| Calcium | Nutra | 6876 | ||||
| Calpeptin | Pharma | Ca2+-dependent protease,calpain inhibitor, Calpain and cathepsin L inhibitor | 0 |
(2) Tocris Compounds for CAPN8 Gene
(3) ApexBio Compounds for CAPN8 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Epoxomicin | Proteasome inhibitor | 134381-21-8 |
| MG-132 | Proteasome inhibitor, Cell permeable, reversible | 133407-82-6 |
| PSI | Proteasome inhibitor | 158442-41-2 |
Transcripts for CAPN8 Gene
mRNA/cDNA for CAPN8 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000366872 2387 nts (view in UCSC)
- ENST00000366873 2596 nts (view in UCSC)
- ENST00000442247 327 nts (view in UCSC)
- ENST00000465098 710 nts (view in UCSC)
- ENST00000467384 884 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CAPN8 - Starting at $85 >
- * CAPN8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CAPN8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPN8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPN8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPN8
- Browse OriGene Inhibitory RNA Products For CAPN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN8
Clone products for research
- Applied Biological Materials (abm): Clones for CAPN8 - Starting at $45 >
- * CAPN8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CAPN8
- Addgene plasmids for CAPN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPN8
Relevant External Links for CAPN8 Gene
- GeneLoc Exon Structure for
- CAPN8
Expression for CAPN8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CAPN8 Gene
This gene is overexpressed in Stomach (x18.7), Colon - Transverse (x7.9), Bladder (x6.4), and Lung (x5.2).
This gene is overexpressed in Stomach (56.6) and Testis (12.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAPN8 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPN8
SOURCE GeneReport for Unigene cluster for CAPN8 Gene:
Hs.291487mRNA Expression by UniProt/SwissProt for CAPN8 Gene:
A6NHC0-CAN8_HUMAN
Tissue specificity:
Stomach.
Evidence on tissue expression from TISSUES for CAPN8 Gene
- Blood(4.2)
Primer products for research
-
OriGene qPCR primer pairs for CAPN8
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN8 Gene
Orthologs for CAPN8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Rat (Rattus norvegicus) |
Mammalia | Capn8 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Capn8 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CAPN8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MGC151839 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CAPN8 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CAPN8 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CAPN8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CAPN8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | capn8 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | capn8 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | clp-1 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4609 31 |
|
OneToMany |
- Species where no ortholog for CAPN8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CAPN8 Gene
- ENSEMBL:
- Gene Tree for CAPN8 (if available)
- TreeFam:
- Gene Tree for CAPN8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAPN8: view image
Paralogs for CAPN8 Gene
Paralogs for CAPN8 Gene
(15) SIMAP similar genes for CAPN8 Gene using alignment to 8 proteins:
- CAN8_HUMAN
- A3QK36_HUMAN
- A3QK37_HUMAN
- B1B153_HUMAN
- B1B154_HUMAN
- H0YDN4_HUMAN
- H0YEJ4_HUMAN
- H0YEQ4_HUMAN
Variants for CAPN8 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv47e201 | CNV | deletion | 23290073 |
| dgv48e201 | CNV | deletion | 23290073 |
| dgv49e201 | CNV | deletion | 23290073 |
| dgv50e201 | CNV | deletion | 23290073 |
| esv1388923 | CNV | deletion | 17803354 |
| esv1919956 | CNV | deletion | 18987734 |
| esv2723417 | CNV | deletion | 23290073 |
| esv2723473 | CNV | deletion | 23290073 |
| esv2723495 | CNV | deletion | 23290073 |
| esv2740896 | CNV | deletion | 23290073 |
| esv2741351 | CNV | deletion | 23290073 |
| esv2742948 | CNV | deletion | 23290073 |
| esv27704 | CNV | loss | 19812545 |
| esv34082 | CNV | loss | 18971310 |
| esv3414527 | CNV | duplication | 20981092 |
| esv3547344 | CNV | deletion | 23714750 |
| esv3575717 | CNV | gain | 25503493 |
| esv3588960 | CNV | gain | 21293372 |
| nsv1126229 | CNV | deletion | 24896259 |
| nsv474099 | CNV | novel sequence insertion | 20440878 |
| nsv475163 | CNV | novel sequence insertion | 20440878 |
| nsv475307 | CNV | novel sequence insertion | 20440878 |
| nsv477673 | CNV | novel sequence insertion | 20440878 |
| nsv478790 | CNV | novel sequence insertion | 20440878 |
| nsv479023 | CNV | novel sequence insertion | 20440878 |
| nsv479114 | CNV | novel sequence insertion | 20440878 |
| nsv479266 | CNV | novel sequence insertion | 20440878 |
| nsv479272 | CNV | novel sequence insertion | 20440878 |
| nsv479392 | CNV | novel sequence insertion | 20440878 |
| nsv479450 | CNV | novel sequence insertion | 20440878 |
| nsv479737 | CNV | novel sequence insertion | 20440878 |
| nsv479800 | CNV | novel sequence insertion | 20440878 |
| nsv479801 | CNV | novel sequence insertion | 20440878 |
| nsv479837 | CNV | novel sequence insertion | 20440878 |
| nsv480006 | CNV | novel sequence insertion | 20440878 |
| nsv480072 | CNV | novel sequence insertion | 20440878 |
| nsv480187 | CNV | novel sequence insertion | 20440878 |
| nsv480449 | CNV | novel sequence insertion | 20440878 |
| nsv481088 | CNV | novel sequence insertion | 20440878 |
| nsv481348 | CNV | novel sequence insertion | 20440878 |
| nsv481361 | CNV | novel sequence insertion | 20440878 |
| nsv481510 | CNV | novel sequence insertion | 20440878 |
| nsv821216 | CNV | deletion | 20802225 |
| nsv832681 | CNV | gain | 17160897 |
| nsv945310 | CNV | duplication | 23825009 |
Gene Damage Index Score:
23.52;
99.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAPN8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAPN8
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPN8 Gene
Disorders for CAPN8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| isovaleric acidemia |
|
|
| methylmalonic aciduria and homocystinuria, cblc type |
|
|
| canavan disease |
|
|
| ceroid lipofuscinosis, neuronal, 3 |
|
|
| myoclonic epilepsy associated with ragged-red fibers |
|
|
Search CAPN8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAPN8
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN8 Gene
Publications for CAPN8 Gene
- Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. (PMID: 11523006) Hata S … Suzuki K (Journal of molecular evolution 2001) 3 4
- Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier LD … Marra M (Genome research 1996) 2 3
- A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. (PMID: 7690035) Sorimachi H … Suzuki K (The Journal of biological chemistry 1993) 2 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations. (PMID: 28002826) D'Adamo CR … McArdle PF (Journal of nutrigenetics and nutrigenomics 2016) 3
ExternalLinks
Products for CAPN8 Gene
- Custom Antibody ServicesOriGene Antibodies for CAPN8
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CAPN8
- Search Origene for MassSpec and Protein Over-expression Lysates for CAPN8
- Origene Custom Protein Services for CAPN8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAPN8
- Browse OriGene Inhibitory RNA Products For CAPN8
- OriGene qPCR primer pairs for CAPN8
- OriGene CRISPR knockouts for CAPN8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CAPN8
- Sino Biological Human cDNA Clone for CAPN8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CAPN8
- Novus Biologicals proteins for CAPN8
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CAPN8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CAPN8 (AFLGC-CAPN8)
- ApexBio compounds for CAPN8
- VectorBuilder Custom and pre-made DNA vectors for CAPN8 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CAPN8 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CAPN8 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CAPN8 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CAPN8
- Addgene plasmids for CAPN8
- antibodies-online: Show 18 available CAPN8 Antibodies ranked by validation data
- Compare Top CAPN8 Antibodies
- antibodies-online: Search results for available CAPN8 related products ranked by validation data
- antibodies-online: Show 3 available CAPN8 Proteins ranked by validation data
- Compare Top CAPN8 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CAPN8
- Search Santa Cruz Biotechnology (SCBT) for CAPN8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAPN8
- Custom Antibody ServicesProSci Antibodies for CAPN8
- Search for CAPN8 Proteins at ProSci
- Horizon Cell Lines for CAPN8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPN8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CAPN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN8
- Biorbyt antibodies for CAPN8
Sources for CAPN8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
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