Aliases for CAPN8 Gene
External Ids for CAPN8 Gene
Previous GeneCards Identifiers for CAPN8 Gene
GeneCards Summary for CAPN8 Gene
CAPN8 (Calpain 8) is a Protein Coding gene. Diseases associated with CAPN8 include Isovaleric Acidemia and Methylmalonic Aciduria And Homocystinuria, Cblc Type. Among its related pathways are Degradation of the extracellular matrix and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN2.
UniProtKB/Swiss-Prot Summary for CAPN8 Gene
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.