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Aliases for CAPN7 Gene

Aliases for CAPN7 Gene

  • Calpain 7 2 3 5
  • Homolog Of Aspergillus Nidulans PALB 2 3
  • Calpain Like Protease 2 3
  • PalB Homolog 3 4
  • PALBH 3 4
  • EC 3.4.22.- 4
  • Calpain-7 3
  • CALPAIN7 3
  • PalBH 4

External Ids for CAPN7 Gene

Previous GeneCards Identifiers for CAPN7 Gene

  • GC03P015177
  • GC03P015222
  • GC03P015223
  • GC03P015233
  • GC03P015251
  • GC03P015269

Summaries for CAPN7 Gene

Entrez Gene Summary for CAPN7 Gene

  • Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN7 Gene

CAPN7 (Calpain 7) is a Protein Coding gene. Among its related pathways are Focal Adhesion and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and MIT domain binding. An important paralog of this gene is CAPN15.

UniProtKB/Swiss-Prot for CAPN7 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN7 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Additional gene information for CAPN7 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN7 Gene

Genomics for CAPN7 Gene

GeneHancer (GH) Regulatory Elements for CAPN7 Gene

Promoters and enhancers for CAPN7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J015205 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 681.7 +0.6 621 2.7 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 CAPN7 COL6A4P1 CCDC174 SH3BP5-AS1 NR2C2 HACL1 EAF1-AS1 SH3BP5
GH03J015204 Enhancer 0.7 ENCODE 650.7 -1.9 -1943 0.2 ATF1 FOXA2 SAP130 ARID4B CEBPG ETS1 TEAD3 FOXK2 SCRT2 ATF7 CAPN7 COL6A4P1 RPS3AP53
GH03J015097 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.6 -107.3 -107317 2.4 CLOCK MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 RBSN GC03M015152 NR2C2 CCDC174 SH3BP5-AS1 ENSG00000228242 CAPN7 XPC TMEM43 MRPS25
GH03J015600 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.4 +395.5 395476 2.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 HACL1 BTD CCDC174 NR2C2 SH3BP5-AS1 CAPN7 EAF1-AS1 COLQ
GH03J015267 Enhancer 1.4 Ensembl ENCODE dbSUPER 37 +64.9 64901 6.3 HDGF HNRNPUL1 PKNOX1 ARNT SIN3A IRF4 POLR2B CBX5 ZNF207 ZNF143 CCDC174 SH3BP5-AS1 CAPN7 NR2C2 RNU6-454P SH3BP5 COL6A4P1 RNU6-1024P RBSN FGD5-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPN7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPN7 gene promoter:
  • HTF
  • Pax-2a
  • Pax-2
  • YY1
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Cart-1

Genomic Locations for CAPN7 Gene

Genomic Locations for CAPN7 Gene
chr3:15,206,152-15,252,918
(GRCh38/hg38)
Size:
46,767 bases
Orientation:
Plus strand
chr3:15,247,659-15,294,425
(GRCh37/hg19)
Size:
46,767 bases
Orientation:
Plus strand

Genomic View for CAPN7 Gene

Genes around CAPN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN7 Gene

Proteins for CAPN7 Gene

  • Protein details for CAPN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W3-CAN7_HUMAN
    Recommended name:
    Calpain-7
    Protein Accession:
    Q9Y6W3

    Protein attributes for CAPN7 Gene

    Size:
    813 amino acids
    Molecular mass:
    92652 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPN7 Gene

neXtProt entry for CAPN7 Gene

Post-translational modifications for CAPN7 Gene

  • Ubiquitination at Lys503, Lys419, posLast=320320, posLast=217217, and Lys130
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CAPN7 Gene

Domains & Families for CAPN7 Gene

Gene Families for CAPN7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6W3

UniProtKB/Swiss-Prot:

CAN7_HUMAN :
  • Belongs to the peptidase C2 family.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN7: view

Function for CAPN7 Gene

Molecular function for CAPN7 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN7 Gene

Phenotypes From GWAS Catalog for CAPN7 Gene

Gene Ontology (GO) - Molecular Function for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 20849418
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA,IEA --
GO:0005515 protein binding IPI 20849418
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with CAPN7: view
genes like me logo Genes that share phenotypes with CAPN7: view

Animal Models for CAPN7 Gene

MGI Knock Outs for CAPN7:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN7

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN7 Gene

Localization for CAPN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 2

Gene Ontology (GO) - Cellular Components for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CAPN7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAPN7 Gene

Pathways & Interactions for CAPN7 Gene

genes like me logo Genes that share pathways with CAPN7: view

Pathways by source for CAPN7 Gene

Gene Ontology (GO) - Biological Process for CAPN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA --
GO:0010634 positive regulation of epithelial cell migration IDA 23855590
GO:0097264 self proteolysis IDA 20849418
genes like me logo Genes that share ontologies with CAPN7: view

No data available for SIGNOR curated interactions for CAPN7 Gene

Drugs & Compounds for CAPN7 Gene

(3) Drugs for CAPN7 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Calpeptin Pharma Ca2+-dependent protease,calpain inhibitor, Calpain and cathepsin L inhibitor 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(2) Tocris Compounds for CAPN7 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
genes like me logo Genes that share compounds with CAPN7: view

Transcripts for CAPN7 Gene

Unigene Clusters for CAPN7 Gene

Calpain 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a ·
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CAPN7 Gene

GeneLoc Exon Structure for
CAPN7
ECgene alternative splicing isoforms for
CAPN7

Expression for CAPN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPN7 Gene

This gene is overexpressed in Urine (42.4) and Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPN7 Gene



Protein tissue co-expression partners for CAPN7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN7 Gene:

CAPN7

SOURCE GeneReport for Unigene cluster for CAPN7 Gene:

Hs.595234

mRNA Expression by UniProt/SwissProt for CAPN7 Gene:

Q9Y6W3-CAN7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAPN7 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CAPN7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN7 Gene

Orthologs for CAPN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAPN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN7 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN7 34 33
  • 93.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CAPN7 34 33
  • 91.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Capn7 16 34 33
  • 89.79 (n)
rat
(Rattus norvegicus)
Mammalia Capn7 33
  • 89.09 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPN7 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves CAPN7 34 33
  • 79.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN7 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn7 33
  • 74.57 (n)
Str.14941 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15745 33
zebrafish
(Danio rerio)
Actinopterygii capn7 34 33
  • 70.52 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010834 33
  • 51.99 (n)
worm
(Caenorhabditis elegans)
Secernentea clp-2 34 35 33
  • 52.37 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM13 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00317 33
  • 42.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for CAPN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN7 Gene

ENSEMBL:
Gene Tree for CAPN7 (if available)
TreeFam:
Gene Tree for CAPN7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPN7: view image

Paralogs for CAPN7 Gene

Paralogs for CAPN7 Gene

genes like me logo Genes that share paralogs with CAPN7: view

Variants for CAPN7 Gene

Sequence variations from dbSNP and Humsavar for CAPN7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000067855 -- 15,223,995(+) G/A intron_variant
rs1000080514 -- 15,219,706(+) T/C intron_variant
rs1000120044 -- 15,223,779(+) G/A intron_variant
rs1000237992 -- 15,237,698(+) C/T intron_variant
rs1000290101 -- 15,231,474(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN7 Gene

Variant ID Type Subtype PubMed ID
esv2548358 CNV insertion 19546169
esv3595380 CNV loss 21293372
nsv1009775 CNV loss 25217958
nsv237085 CNV deletion 16902084
nsv428413 CNV gain 18775914
nsv525308 CNV loss 19592680

Variation tolerance for CAPN7 Gene

Residual Variation Intolerance Score: 4.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN7 Gene

Disorders for CAPN7 Gene

Additional Disease Information for CAPN7

No disorders were found for CAPN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN7 Gene

Publications for CAPN7 Gene

  1. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. (PMID: 11342116) Futai E … Maeda T (Biochimica et biophysica acta 2001) 3 4 22 58
  2. Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. (PMID: 10051333) Franz T … Dear TN (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 58
  3. New era of calpain research. Discovery of tissue-specific calpains. (PMID: 8163008) Sorimachi H … Suzuki K (FEBS letters 1994) 2 3 58
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for CAPN7 Gene

Sources for CAPN7 Gene

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