Aliases for CAPN6 Gene
Aliases for CAPN6 Gene
External Ids for CAPN6 Gene
- HGNC: 1483
- Entrez Gene: 827
- Ensembl: ENSG00000077274
- OMIM: 300146
- UniProtKB: Q9Y6Q1
Previous GeneCards Identifiers for CAPN6 Gene
- GC0XM105791
- GC0XM107635
- GC0XM108513
- GC0XM109252
- GC0XM110294
- GC0XM110374
- GC0XM110488
- GC0XM100116
Summaries for CAPN6 Gene
-
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
GeneCards Summary for CAPN6 Gene
CAPN6 (Calpain 6) is a Protein Coding gene. Diseases associated with CAPN6 include Leiomyosarcoma and Corneal Dystrophy, Posterior Polymorphous, 1. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include microtubule binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN5.
UniProtKB/Swiss-Prot for CAPN6 Gene
-
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
-
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN6 Gene
Genomics for CAPN6 Gene
GeneHancer (GH) Regulatory Elements for CAPN6 Gene
Promoters and enhancers for CAPN6 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ111269 | Promoter/Enhancer | 1 | EPDnew Ensembl ENCODE | 650.7 | +0.5 | 480 | 1.1 | PRDM10 | CAPN6 GC0XP111245 | |
| GH0XJ111268 | Enhancer | 0.2 | ENCODE | 650.7 | +1.8 | 1779 | 1 | CAPN6 CHRDL1 GC0XP111245 | ||
| GH0XJ111282 | Enhancer | 0.2 | ENCODE | 4.1 | -12.6 | -12562 | 2.2 | CHRDL1 CAPN6 GC0XP111369 | ||
| GH0XJ111284 | Enhancer | 0.6 | ENCODE | 0.4 | -14.2 | -14236 | 0.1 | GATAD2A FOXA2 RXRA MAX RAD21 FOXA1 YY1 SP1 HNF1A ATF3 | CAPN6 GC0XP111369 | |
| GH0XJ111255 | Enhancer | 0.5 | ENCODE | 0.4 | +15.1 | 15078 | 0.2 | ZNF316 MAFF MAFG EMSY MAFK | GC0XP111245 CAPN6 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CAPN6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CAPN6 Gene
Genomic Locations for CAPN6 Gene
- chrX:111,245,099-111,270,546
- (GRCh38/hg38)
- Size:
- 25,448 bases
- Orientation:
- Minus strand
- chrX:110,488,327-110,513,774
- (GRCh37/hg19)
Genomic View for CAPN6 Gene
Genes around CAPN6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq23 by Entrez Gene
- Xq23 by HGNC
- Xq23 by Ensembl
CAPN6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAPN6 Gene
Proteins for CAPN6 Gene
-
Protein details for CAPN6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6Q1-CAN6_HUMAN
- Recommended name:
- Calpain-6
- Protein Accession:
- Q9Y6Q1
- D3DUY7
- Q9UEQ1
- Q9UJA8
Protein attributes for CAPN6 Gene
- Size:
- 641 amino acids
- Molecular mass:
- 74576 Da
- Quaternary structure:
-
- Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).
Protein Expression for CAPN6 Gene
Post-translational modifications for CAPN6 Gene
Other Protein References for CAPN6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CAPN6
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-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for CAPN6
Protein Products
-
OriGene Purified Proteins for CAPN6
- Search Origene for MassSpec and Protein Over-expression Lysates for CAPN6
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- antibodies-online: Search results for 5 available Calpain 6 Proteins ranked by validation data
- Compare Top Calpain 6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CAPN6
Assay Products
- antibodies-online: Search results for 15 available Calpain 6 Elisa Kits ranked by validation data
- Compare Top Calpain 6 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CAPN6 Gene
Domains & Families for CAPN6 Gene
Gene Families for CAPN6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for CAPN6 Gene
Suggested Antigen Peptide Sequences for CAPN6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6Q1- Family:
-
- Belongs to the peptidase C2 family.
Function for CAPN6 Gene
Molecular function for CAPN6 Gene
- UniProtKB/Swiss-Prot Function:
- Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
- GENATLAS Biochemistry:
- calpain,class C,large polypeptide,likely lacking a protease activity,papain superfamily,nCL-3 type,expressed only in placenta,homolog to C elegans sex determination gene tra3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004198 | calcium-dependent cysteine-type endopeptidase activity | IBA,TAS | -- |
| GO:0008017 | microtubule binding | IEA,ISS | -- |
Phenotypes for CAPN6 Gene
- MGI mutant phenotypes for CAPN6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CAPN6:
-
- Synthetic lethal with imatinib mesylate
- Decreased viability in esophageal squamous lineage
- Decreased p24 protein expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Increased transferrin (TF) endocytosis
Animal Models for CAPN6 Gene
- MGI Knock Outs for CAPN6:
-
- Capn6 Capn6<tm1Hiso>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAPN6
-
CRISPR Products
-
OriGene CRISPR knockouts for CAPN6
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- genomics-online: gRNA clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
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-
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-
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miRNA for CAPN6 Gene
- miRTarBase miRNAs that target CAPN6
-
- hsa-mir-6833-3p (MIRT659885)
- hsa-mir-4768-5p (MIRT659886)
- hsa-mir-4452 (MIRT659887)
- hsa-mir-6509-5p (MIRT659888)
- hsa-mir-6873-3p (MIRT659889)
- hsa-mir-6802-5p (MIRT659890)
- hsa-mir-6800-5p (MIRT659891)
- hsa-mir-1255b-5p (MIRT659892)
- hsa-mir-1255a (MIRT659893)
- hsa-mir-6744-5p (MIRT659894)
- hsa-mir-6870-3p (MIRT659895)
- hsa-mir-5571-5p (MIRT659896)
- hsa-mir-4290 (MIRT725599)
- hsa-mir-4772-5p (MIRT725600)
- hsa-mir-383-5p (MIRT725601)
- hsa-mir-3667-3p (MIRT725602)
- hsa-mir-6734-3p (MIRT725603)
- hsa-mir-660-3p (MIRT725604)
- hsa-mir-5193 (MIRT725605)
- hsa-mir-4667-3p (MIRT725606)
- hsa-mir-5685 (MIRT725607)
- hsa-mir-4690-3p (MIRT725608)
- hsa-mir-4687-5p (MIRT725609)
- hsa-mir-670-3p (MIRT725610)
- hsa-mir-449a (MIRT732558)
miRNA Products
Inhibitory RNA Products
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- Overview of 100 available Calpain 6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CAPN6
- VectorBuilder custom plasmid, inducible vectors for CAPN6
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPN6
- Applied Biological Materials Clones for CAPN6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CAPN6
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN6 Gene
Localization for CAPN6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAPN6 Gene
- Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005819 | spindle | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for CAPN6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BMP Pathway |
.36
|
|
| 2 | Degradation of the extracellular matrix | ||
| 3 | Apoptosis Pathway | ||
| 4 | B Cell Receptor Signaling Pathway (sino) | ||
| 5 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||
Pathways by source for CAPN6 Gene
1 Sino Biological pathway for CAPN6 Gene
1 BioSystems pathway for CAPN6 Gene
2 Reactome pathways for CAPN6 Gene
1 Tocris pathway for CAPN6 Gene
5 Qiagen pathways for CAPN6 Gene
Interacting Proteins for CAPN6 Gene
GPS-Prot Interaction Network for CAPN6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001578 | microtubule bundle formation | ISS | -- |
| GO:0006508 | proteolysis | IBA | -- |
| GO:0051493 | regulation of cytoskeleton organization | ISS | -- |
No data available for SIGNOR curated interactions for CAPN6 Gene
Drugs & Compounds for CAPN6 Gene
(2) Tocris Compounds for CAPN6 Gene
Transcripts for CAPN6 Gene
mRNA/cDNA for CAPN6 Gene
- (162) Selected AceView cDNA sequences:
- (6) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000324068 3568 bps (uc004epc.3)
CRISPR Products
-
OriGene CRISPR knockouts for CAPN6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPN6
- genomics-online: gRNA clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
- Applied Biological Materials CRISPR for CAPN6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAPN6
- GenScript: Design CRISPR guide RNA sequences for CAPN6
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CAPN6
- Browse OriGene Inhibitory RNA Products For CAPN6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN6
- genomics-online: shRNA clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CAPN6
- VectorBuilder custom plasmid, inducible vectors for CAPN6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAPN6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPN6
- Applied Biological Materials Clones for CAPN6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for CAPN6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Hyoid Arch Muscles
- Limb Muscle Progenitor Cells Forelimb Myotome
- Muscle Progenitor Cells Mandibular Arch Muscles
- Bone (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Limb (Muscoskeletal System)
- Limb Bud
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Heart (Cardiovascular System)
- Heart Tube
- Cardiac Fibroblasts Myocardium
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Cartilage (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
mRNA differential expression in normal tissues according to GTEx for CAPN6 Gene
This gene is overexpressed in Uterus (x10.3).
This gene is overexpressed in Placenta (65.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAPN6 Gene
NURSA nuclear receptor signaling pathways regulating expression of CAPN6 Gene:
CAPN6SOURCE GeneReport for Unigene cluster for CAPN6 Gene:
Hs.496593mRNA Expression by UniProt/SwissProt for CAPN6 Gene:
Q9Y6Q1-CAN6_HUMAN
Tissue specificity:
Expressed only in placenta.
Evidence on tissue expression from TISSUES for CAPN6 Gene
- Muscle(2.7)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CAPN6
-
OriGene qPCR primer pairs for CAPN6
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN6 Gene
Orthologs for CAPN6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAPN6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CAPN6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CAPN6 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Capn6 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Capn6 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAPN6 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CAPN6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAPN6 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CAPN6 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CR847986.1 34 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tra-3 34 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3869 34 |
|
OneToMany |
- Species where no ortholog for CAPN6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for CAPN6 Gene
- ENSEMBL:
- Gene Tree for CAPN6 (if available)
- TreeFam:
- Gene Tree for CAPN6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAPN6: view image
Paralogs for CAPN6 Gene
Variants for CAPN6 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921059 | uncertain-significance, Malignant tumor of prostate | 111,246,746(-) | C/T | coding_sequence_variant, missense_variant | |
| VAR_036048 | A colorectal cancer sample | p.Gly358Arg | |||
| rs1000035503 | -- | 111,252,231(-) | C/T | intron_variant | |
| rs1000272602 | -- | 111,264,211(-) | C/T | intron_variant | |
| rs1000286130 | -- | 111,260,643(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3361732 | OTHER | inversion | 20981092 |
Residual Variation Intolerance Score:
10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.40;
77.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAPN6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAPN6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN6 Gene
Disorders for CAPN6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leiomyosarcoma |
|
|
| corneal dystrophy, posterior polymorphous, 1 |
|
|
Search CAPN6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAPN6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN6 Gene
Publications for CAPN6 Gene
- A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. (PMID: 9339374) Dear N … Boehm T (Genomics 1997) 2 3 4 22 58
- Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. (PMID: 17210638) Tonami K … Kurihara H (Molecular and cellular biology 2007) 3 4 22 58
- Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. (PMID: 9503024) Matena K … Dear N (Genomics 1998) 2 3 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Family-based association study for bipolar affective disorder. (PMID: 20414141) Secolin R … Lopes-Cendes I (Psychiatric genetics 2010) 3 44 58
Products for CAPN6 Gene
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- Browse Lysates
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- VectorBuilder custom plasmid, inducible vectors for CAPN6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAPN6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available Calpain 6 related products ranked by validation data
- antibodies-online: Search results for 15 available Calpain 6 Elisa Kits ranked by validation data
- Compare Top Calpain 6 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 5 available Calpain 6 Proteins ranked by validation data
- Compare Top Calpain 6 Proteins
- Quality Products:
- GeneTex CAPN6 Antibody for CAPN6
- Search GeneTex for Proteins for CAPN6
- Santa Cruz Biotechnology (SCBT) Antibodies for CAPN6
- Search Santa Cruz Biotechnology (SCBT) for CAPN6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAPN6
- Custom Antibody ServicesProSci Antibodies for CAPN6
- Search for CAPN6 Proteins at ProSci
- Horizon Cell Lines for CAPN6
- genomics-online: cdna clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
- orf clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
- genomics-online: gRNA clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
- genomics-online: primer clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
- genomics-online: shRNA clones - Search results for 100 available Calpain 6 gene related products
- Overview of 100 available Calpain 6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAPN6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAPN6
- GeneCopoeia miRNA 3'UTR Target clone products for CAPN6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN6
Sources for CAPN6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio