Aliases for CAPN5 Gene
External Ids for CAPN5 Gene
Previous HGNC Symbols for CAPN5 Gene
Previous GeneCards Identifiers for CAPN5 Gene
Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAPN5 Gene
CAPN5 (Calpain 5) is a Protein Coding gene. Diseases associated with CAPN5 include Vitreoretinopathy, Neovascular Inflammatory and Vitreoretinopathy. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN6.
UniProtKB/Swiss-Prot Summary for CAPN5 Gene
Calcium-regulated non-lysosomal thiol-protease.
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.