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Aliases for CAPN2 Gene

Aliases for CAPN2 Gene

  • Calpain 2 2 3 5
  • Calcium-Activated Neutral Proteinase 2 3 4
  • Calpain 2, (M/II) Large Subunit 2 3
  • Millimolar-Calpain 3 4
  • Calpain M-Type 3 4
  • EC 3.4.22.53 4 56
  • M-Calpain 3 4
  • CANP 2 3 4
  • CANPL2 3 4
  • Calpain 2, Large [Catalytic] Subunit 3
  • Calpain, Large Polypeptide L2 3
  • Calpain Large Polypeptide L2 4
  • Calpain-2 Catalytic Subunit 3
  • Calpain 2, Large Subunit 3
  • Calpain-2 Large Subunit 4
  • EC 3.4.22 56
  • CANPml 3
  • CANP2 3
  • MCANP 3

External Ids for CAPN2 Gene

Previous GeneCards Identifiers for CAPN2 Gene

  • GC01M222640
  • GC01M219933
  • GC01P220400
  • GC01P220874
  • GC01P220206
  • GC01P221966
  • GC01P223890
  • GC01P194501

Summaries for CAPN2 Gene

Entrez Gene Summary for CAPN2 Gene

  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CAPN2 Gene

CAPN2 (Calpain 2) is a Protein Coding gene. Diseases associated with CAPN2 include Alzheimer Disease. Among its related pathways are Integrin Pathway and Necroptosis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is CAPN1.

UniProtKB/Swiss-Prot for CAPN2 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at Arg-226 (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).

Tocris Summary for CAPN2 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Gene Wiki entry for CAPN2 Gene

Additional gene information for CAPN2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN2 Gene

Genomics for CAPN2 Gene

GeneHancer (GH) Regulatory Elements for CAPN2 Gene

Promoters and enhancers for CAPN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I223710 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 579.2 +14.7 14731 11.8 ZFP64 FEZF1 YY1 ZNF213 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 CAPN2 CICP5 NVL LOC100287497 TP53BP2 WDR26 CAPN8 GTF2IP20 FBXO28 RNU6-1248P
GH01I223698 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 563 -0.1 -72 5.1 HDGF PKNOX1 ATF1 SIN3A ZNF121 POLR2B ZNF766 GLIS2 ATF7 FOS CAPN2 CICP5 NVL LOC100287497 WDR26 CAPN8 GTF2IP20 LOC105373281 RNU6-1248P
GH01I223844 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.6 +144.2 144160 3.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 TP53BP2 GC01P223846 GC01P223847 CICP5 NVL LOC100287497 CAPN2 FBXO28 WDR26 CNIH4
GH01I223704 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 37 +5.5 5460 5.5 HDGF PKNOX1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105373281 CICP5 CAPN2 WDR26 LOC100287497 NVL CNIH4 CAPN8 FBXO28 AIDA
GH01I223722 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 30 +23.9 23882 6.1 HDGF SMAD1 ARNT SIN3A FEZF1 ZNF2 IRF4 ZNF143 FOS SP3 GC01P223725 TP53BP2 NVL CAPN2 CICP5 RNU6-1248P CAPN8 FBXO28 GC01M223727 LOC105373281
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAPN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPN2 gene promoter:

Genomic Locations for CAPN2 Gene

Genomic Locations for CAPN2 Gene
chr1:223,701,593-223,776,018
(GRCh38/hg38)
Size:
74,426 bases
Orientation:
Plus strand
chr1:223,889,295-223,963,720
(GRCh37/hg19)

Genomic View for CAPN2 Gene

Genes around CAPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN2 Gene

Proteins for CAPN2 Gene

  • Protein details for CAPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17655-CAN2_HUMAN
    Recommended name:
    Calpain-2 catalytic subunit
    Protein Accession:
    P17655
    Secondary Accessions:
    • A6NDG7
    • B7ZA96
    • E7ES58
    • Q16738
    • Q6PJT3
    • Q8WU26
    • Q9HBB1

    Protein attributes for CAPN2 Gene

    Size:
    700 amino acids
    Molecular mass:
    79995 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with CPEB3; this leads to cleavage of CPEB3.
    SequenceCaution:
    • Sequence=AAH07686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH11828.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPN2 Gene

    Alternative splice isoforms for CAPN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPN2 Gene

Selected DME Specific Peptides for CAPN2 Gene

P17655:
  • RNPWGEVEW
  • EDGEFWMSFSDFL
  • TFINLREVLNRFKLP
  • GSLLGCSI
  • LGDCWLLA
  • YEALSGG
  • LVKGHAY
  • FINLREV
  • LFQDPSFPA
  • VPSTFEPNK
  • YAGIFHFQFWQYGEWV
  • TAGGCRN
  • TTEGFEDFTGGIAEWYEL
  • GDFCIRVFSEKKADYQ
  • RTDICQG
  • DFLRHYSRLEICNLTPDTL
  • LEICNLTPD
  • DAEISAFEL
  • GELLFVHSAEGSEFWSALLEKAYAK
  • LIIDFDNFVRCL
  • IVARFAD
  • IKLEEEDED
  • GATRTDI
  • GQTNIHL
  • LWTKIQKYQKIYREIDVDRSGTMNSYEMR
  • YAGIFHF
  • GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP
  • LLEKAYAK
  • EGFEDFTGG
  • DMHTIGF
  • QKLVKGHAYSVTGAEEV
  • RGSTAGGC

Post-translational modifications for CAPN2 Gene

  • Ubiquitination at posLast=2626, Lys260, Lys476, and Lys674
  • Modification sites at PhosphoSitePlus

Other Protein References for CAPN2 Gene

Domains & Families for CAPN2 Gene

Gene Families for CAPN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN2 Gene

Graphical View of Domain Structure for InterPro Entry

P17655

UniProtKB/Swiss-Prot:

CAN2_HUMAN :
  • Belongs to the peptidase C2 family.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN2: view

Function for CAPN2 Gene

Molecular function for CAPN2 Gene

GENATLAS Biochemistry:
calpain,class A,large polypeptide L2,calcium dependent neutral cysteine proteinase,papain superfamily,m type
UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at Arg-226 (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).

Enzyme Numbers (IUBMB) for CAPN2 Gene

Phenotypes From GWAS Catalog for CAPN2 Gene

Gene Ontology (GO) - Molecular Function for CAPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity ISS,IDA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10639123
GO:0008092 cytoskeletal protein binding NAS 12150984
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with CAPN2: view
genes like me logo Genes that share phenotypes with CAPN2: view

Animal Models for CAPN2 Gene

MGI Knock Outs for CAPN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN2

miRNA for CAPN2 Gene

miRTarBase miRNAs that target CAPN2

Clone Products

  • Addgene plasmids for CAPN2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN2 Gene

Localization for CAPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN2 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 3
mitochondrion 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with CAPN2: view

Pathways & Interactions for CAPN2 Gene

genes like me logo Genes that share pathways with CAPN2: view

SIGNOR curated interactions for CAPN2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CAPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001824 blastocyst development IEA --
GO:0006508 proteolysis ISS --
GO:0007520 myoblast fusion IEA --
GO:0016540 protein autoprocessing IEA --
genes like me logo Genes that share ontologies with CAPN2: view

Drugs & Compounds for CAPN2 Gene

(18) Drugs for CAPN2 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Calpeptin Pharma Ca2+-dependent protease,calpain inhibitor, Calpain and cathepsin L inhibitor 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor 0
Calpain Inhibitor I, ALLN Pharma Calpain I/II/ B/L inhibitor 0

(12) Additional Compounds for CAPN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for CAPN2 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8

(6) ApexBio Compounds for CAPN2 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Calpain I/II inhibitor 123714-50-1
Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor 110044-82-1
Calpain Inhibitor II, ALLM Calpain inhibitor 136632-32-1
Calpeptin Ca2+-dependent protease,calpain inhibitor 117591-20-5
MDL 28170 Calpain and cathepsin B inhibitor, selective 88191-84-8
PD 151746 calpain inhibitor, cell-permeable 179461-52-0
genes like me logo Genes that share compounds with CAPN2: view

Drug Products

Transcripts for CAPN2 Gene

Unigene Clusters for CAPN2 Gene

Calpain 2, (m/II) large subunit:
Representative Sequences:

Clone Products

  • Addgene plasmids for CAPN2

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a ·
SP1: - - - - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:

ExUns: 19b · 19c ^ 20a · 20b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for CAPN2 Gene

GeneLoc Exon Structure for
CAPN2
ECgene alternative splicing isoforms for
CAPN2

Expression for CAPN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPN2 Gene

This gene is overexpressed in Breast (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPN2 Gene



Protein tissue co-expression partners for CAPN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN2 Gene:

CAPN2

SOURCE GeneReport for Unigene cluster for CAPN2 Gene:

Hs.350899

mRNA Expression by UniProt/SwissProt for CAPN2 Gene:

P17655-CAN2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAPN2 Gene

  • Pancreas(4.6)
  • Skin(4.6)
  • Nervous system(4.6)
  • Liver(4.5)
  • Lung(4.4)
  • Lymph node(4.3)
  • Blood(4.2)
  • Kidney(3.2)
  • Intestine(3)
  • Muscle(2.6)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CAPN2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN2 Gene

Orthologs for CAPN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN2 33 34
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia CAPN2 33 34
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Capn2 33
  • 88.1 (n)
mouse
(Mus musculus)
Mammalia Capn2 33 16 34
  • 87.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPN2 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN2 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN2 33 34
  • 86.37 (n)
chicken
(Gallus gallus)
Aves CAPN2 33 34
  • 77.95 (n)
lizard
(Anolis carolinensis)
Reptilia CAPN2 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn2.2 33
  • 71.44 (n)
Str.4897 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68474 33
zebrafish
(Danio rerio)
Actinopterygii CAPN2 (3 of 4) 34
  • 69 (a)
OneToMany
capn2a 34
  • 67 (a)
OneToMany
capn2l 33 34
  • 66.1 (n)
capn2b 34
  • 65 (a)
OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5054 33
fruit fly
(Drosophila melanogaster)
Insecta CalpA 35
  • 49 (a)
CalpB 35
  • 44 (a)
CalpC 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-7 35
  • 45 (a)
clp-6 35
  • 44 (a)
clp-3 35
  • 37 (a)
Species where no ortholog for CAPN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN2 Gene

ENSEMBL:
Gene Tree for CAPN2 (if available)
TreeFam:
Gene Tree for CAPN2 (if available)

Paralogs for CAPN2 Gene

Paralogs for CAPN2 Gene

(14) SIMAP similar genes for CAPN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CAPN2: view

Variants for CAPN2 Gene

Sequence variations from dbSNP and Humsavar for CAPN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000002729 -- 223,737,921(+) C/G intron_variant
rs1000032679 -- 223,772,387(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000058332 -- 223,729,584(+) G/T intron_variant
rs1000092672 -- 223,723,701(+) C/T intron_variant
rs1000114478 -- 223,700,729(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN2 Gene

Variant ID Type Subtype PubMed ID
esv2759000 CNV gain+loss 17122850
esv3307033 CNV mobile element insertion 20981092
esv3310267 CNV mobile element insertion 20981092
esv3402894 CNV insertion 20981092
esv34082 CNV loss 18971310
nsv1133940 CNV deletion 24896259
nsv437346 CNV loss 16327808
nsv4698 CNV insertion 18451855
nsv520609 CNV loss 19592680
nsv521758 CNV loss 19592680
nsv832681 CNV gain 17160897

Variation tolerance for CAPN2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.43; 92.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN2 Gene

Disorders for CAPN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAPN2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search CAPN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAPN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CAPN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN2 Gene

Publications for CAPN2 Gene

  1. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. (PMID: 10639123) Strobl S … Bode W (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 58
  2. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. (PMID: 2539381) Hata A … Suzuki K (The Journal of biological chemistry 1989) 2 3 4 58
  3. Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease. (PMID: 2852952) Imajoh S … Suzuki K (Biochemistry 1988) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58

Products for CAPN2 Gene

  • Addgene plasmids for CAPN2

Sources for CAPN2 Gene