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Aliases for CAPN15 Gene

Aliases for CAPN15 Gene

  • Calpain 15 2 3 5
  • Small Optic Lobes Homolog 3 4
  • SOLH 3 4
  • Small Optic Lobes (Drosophila) Homolog 2
  • Small Optic Lobes Homolog (Drosophila) 2
  • EC 3.4.22.- 4
  • Calpain-15 3

External Ids for CAPN15 Gene

Previous HGNC Symbols for CAPN15 Gene

  • SOLH

Previous GeneCards Identifiers for CAPN15 Gene

  • GC16P000578

Summaries for CAPN15 Gene

Entrez Gene Summary for CAPN15 Gene

  • This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAPN15 Gene

CAPN15 (Calpain 15) is a Protein Coding gene. Diseases associated with CAPN15 include Spastic Hemiplegia and Polyradiculopathy. Among its related pathways are Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and cysteine-type peptidase activity. An important paralog of this gene is CAPN10.

Additional gene information for CAPN15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN15 Gene

Genomics for CAPN15 Gene

GeneHancer (GH) Regulatory Elements for CAPN15 Gene

Promoters and enhancers for CAPN15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000523 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.2 +0.1 74 7.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 CAPN15 LINC00235 GC16M000522 ENSG00000261505 ENSG00000260051 UNKL UBE2I CHTF18 TELO2 NHLRC4
GH16J000396 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.8 -127.8 -127834 7.7 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 NME4 DECR2 WDR90 ENSG00000261505 WASH4P RHOT2 UBE2I WDR24 JMJD8 LUC7L
GH16J000137 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22.5 -389.5 -389455 2.3 HDGF SMAD1 ARID4B DMAP1 ZNF2 POLR2B ZNF213 ZNF207 ZNF143 SP3 NPRL3 LOC102723689 GC16P000503 WDR90 JMJD8 WASH4P RHOT2 CAPN15 WDR24 AXIN1
GH16J001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.7 +783.0 783037 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 ENSG00000261505 TELO2 ENSG00000260051 E4F1 TSC2 IFT140
GH16J000689 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.6 +162.5 162525 1.7 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A WDR24 ENSG00000261659 TELO2 ENSG00000261505 LUC7L WDR90 CRAMP1 ENSG00000260051 IFT140 ENSG00000268836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPN15 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CAPN15 Gene

Genomic Locations for CAPN15 Gene
26,920 bases
Plus strand
26,920 bases
Plus strand

Genomic View for CAPN15 Gene

Genes around CAPN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN15 Gene

Proteins for CAPN15 Gene

  • Protein details for CAPN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B1B1M4
    • Q2KHS2
    • Q8WTY9
    • Q9BUW0

    Protein attributes for CAPN15 Gene

    1086 amino acids
    Molecular mass:
    117314 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAPN15 Gene


neXtProt entry for CAPN15 Gene

Post-translational modifications for CAPN15 Gene

  • Ubiquitination at posLast=10661066, Lys1053, posLast=791791, Lys686, posLast=348348, and posLast=3232
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for CAPN15

No data available for DME Specific Peptides for CAPN15 Gene

Domains & Families for CAPN15 Gene

Gene Families for CAPN15 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C2 family.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN15: view

Function for CAPN15 Gene

Enzyme Numbers (IUBMB) for CAPN15 Gene

Phenotypes From GWAS Catalog for CAPN15 Gene

Gene Ontology (GO) - Molecular Function for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 9722942
GO:0004198 calcium-dependent cysteine-type endopeptidase activity TAS,IBA --
GO:0008233 peptidase activity TAS 9722942
GO:0008234 cysteine-type peptidase activity TAS 9722942
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CAPN15: view
genes like me logo Genes that share phenotypes with CAPN15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPN15

CRISPR Products

miRNA for CAPN15 Gene

miRTarBase miRNAs that target CAPN15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN15

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPN15 Gene

Localization for CAPN15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN15 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN15 Gene

Pathways & Interactions for CAPN15 Gene

genes like me logo Genes that share pathways with CAPN15: view

Pathways by source for CAPN15 Gene

Gene Ontology (GO) - Biological Process for CAPN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CAPN15: view

No data available for SIGNOR curated interactions for CAPN15 Gene

Drugs & Compounds for CAPN15 Gene

No Compound Related Data Available

Transcripts for CAPN15 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP5: -
SP8: -

Relevant External Links for CAPN15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN15 Gene

Protein differential expression in normal tissues from HIPED for CAPN15 Gene

This gene is overexpressed in Plasma (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPN15 Gene

Protein tissue co-expression partners for CAPN15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN15 Gene:


mRNA Expression by UniProt/SwissProt for CAPN15 Gene:

Tissue specificity: Widely expressed with higher expression in brain.

Evidence on tissue expression from TISSUES for CAPN15 Gene

  • Nervous system(4.5)
  • Lung(4.2)
  • Skin(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CAPN15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN15 Gene

Orthologs for CAPN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOLH 33
  • 98.36 (n)
(Canis familiaris)
Mammalia CAPN15 34 33
  • 87.55 (n)
(Bos Taurus)
Mammalia CAPN15 33
  • 86.32 (n)
  • 86 (a)
(Mus musculus)
Mammalia Capn15 16 34 33
  • 83.3 (n)
(Rattus norvegicus)
Mammalia Capn15 33
  • 83.2 (n)
(Ornithorhynchus anatinus)
Mammalia CAPN15 34
  • 73 (a)
(Monodelphis domestica)
Mammalia CAPN15 34
  • 70 (a)
(Gallus gallus)
Aves SOLH 33
  • 77.73 (n)
CAPN15 34
  • 76 (a)
(Anolis carolinensis)
Reptilia CAPN15 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capn15 33
  • 69.19 (n)
(Danio rerio)
Actinopterygii solh 33
  • 68.62 (n)
CAPN15 34
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta sol 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea CELE_T11A5.6 33
  • 44.75 (n)
T11A5.6 34
  • 32 (a)
W05G11.4 34
  • 31 (a)
W04A4.4 34
  • 24 (a)
F47F6.9 34
  • 24 (a)
H25P06.4 34
  • 21 (a)
Y53H1B.6 34
  • 21 (a)
F44F1.3 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3566 34
  • 43 (a)
Species where no ortholog for CAPN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN15 Gene

Gene Tree for CAPN15 (if available)
Gene Tree for CAPN15 (if available)
Evolutionary constrained regions (ECRs) for CAPN15: view image

Paralogs for CAPN15 Gene

Paralogs for CAPN15 Gene

genes like me logo Genes that share paralogs with CAPN15: view

Variants for CAPN15 Gene

Sequence variations from dbSNP and Humsavar for CAPN15 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000017955 -- 538,582(+) C/T 5_prime_UTR_variant, intron_variant
rs1000131289 -- 534,753(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000266655 -- 547,727(+) G/A coding_sequence_variant, missense_variant
rs1000328838 -- 525,884(+) C/T upstream_transcript_variant
rs1000404210 -- 526,273(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN15 Gene

Variant ID Type Subtype PubMed ID
esv1035948 CNV insertion 17803354
esv1954677 CNV deletion 18987734
esv2422427 CNV duplication 17116639
esv2750202 CNV deletion 23290073
esv2750203 CNV deletion 23290073
esv2750204 CNV deletion 23290073
esv2750205 CNV deletion 23290073
esv2750206 CNV deletion 23290073
esv3637578 CNV loss 21293372
nsv103268 CNV deletion 16902084
nsv1054426 CNV gain 25217958
nsv1071244 CNV deletion 25765185
nsv1129573 CNV tandem duplication 24896259
nsv1131100 CNV deletion 24896259
nsv1140036 CNV deletion 24896259
nsv1147699 CNV deletion 26484159
nsv1160325 CNV duplication 26073780
nsv457304 CNV gain 19166990
nsv471063 CNV loss 18288195
nsv471064 CNV gain 18288195
nsv526903 CNV loss 19592680
nsv528354 CNV loss 19592680
nsv570954 CNV loss 21841781
nsv570986 CNV loss 21841781
nsv570987 CNV loss 21841781
nsv570988 CNV gain 21841781
nsv833113 CNV loss 17160897
nsv833114 CNV gain+loss 17160897
nsv952898 CNV deletion 24416366

Variation tolerance for CAPN15 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPN15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN15 Gene

Disorders for CAPN15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CAPN15 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
spastic hemiplegia
  • congenital hemiplegia
spastic cerebral palsy
  • palsy, cerebral, spastic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CAPN15

genes like me logo Genes that share disorders with CAPN15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAPN15 Gene

Publications for CAPN15 Gene

  1. SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia). (PMID: 9722942) Kamei M … Campbell HD (Genomics 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CAPN15 Gene

Sources for CAPN15 Gene

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