Aliases for CAPN14 Gene
External Ids for CAPN14 Gene
Previous GeneCards Identifiers for CAPN14 Gene
Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]
GeneCards Summary for CAPN14 Gene
CAPN14 (Calpain 14) is a Protein Coding gene. Diseases associated with CAPN14 include Esophagitis, Eosinophilic, 1. Among its related pathways are Apoptosis Pathway and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN11.
UniProtKB/Swiss-Prot for CAPN14 Gene
Calcium-regulated non-lysosomal thiol-protease.
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.