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Aliases for CAPN14 Gene

Aliases for CAPN14 Gene

  • Calpain 14 2 3 5
  • Calcium-Activated Neutral Proteinase 14 3 4
  • CANP 14 3 4
  • EC 3.4.22.- 4
  • Calpain-14 3

External Ids for CAPN14 Gene

Previous GeneCards Identifiers for CAPN14 Gene

  • GC02U990305
  • GC02M031370
  • GC02M031249

Summaries for CAPN14 Gene

Entrez Gene Summary for CAPN14 Gene

  • Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]

GeneCards Summary for CAPN14 Gene

CAPN14 (Calpain 14) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN11.

UniProtKB/Swiss-Prot for CAPN14 Gene

  • Calcium-regulated non-lysosomal thiol-protease.

Tocris Summary for CAPN14 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Additional gene information for CAPN14 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN14 Gene

Genomics for CAPN14 Gene

GeneHancer (GH) Regulatory Elements for CAPN14 Gene

Promoters and enhancers for CAPN14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J031233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.7 -673 2.6 SIN3A YY1 ETS1 ZNF213 ZNF143 FOS RUNX3 SP3 YY2 REST EHD3 CAPN14 PIR36197
GH02J031323 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 -90.5 -90505 1 IRF2 FOXA2 BATF ZNF316 NFATC1 ATF7 NFE2 FOSL2 FOS IKZF2 EHD3 CAPN14 GC02P031291 PIR52882 GC02M031380
GH02J031268 Enhancer 0.7 ENCODE dbSUPER 12.8 -36.6 -36628 3.5 JUND HCFC1 RXRA POLR2A ZNF143 NR2F2 ETS1 EHD3 CAPN14 PIR43580 RPL21P70
GH02J031281 Enhancer 0.7 ENCODE dbSUPER 12.1 -48.5 -48483 2 SRF GATA3 JUND JUN FOS EHD3 GALNT14 CAPN14 RPL21P70 PIR43580
GH02J031216 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +15.4 15351 4.1 HDGF PKNOX1 BACH1 PAX8 EBF1 BATF ZIC2 IRF4 EED ETV6 GALNT14 ENSG00000234579 CAPN14 RNA5SP90 GC02P031184
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPN14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPN14 gene promoter:
  • STAT3
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • Lmo2
  • AML1a
  • AP-4
  • ISGF-3
  • C/EBPalpha
  • SRF (504 AA)

Genomic Locations for CAPN14 Gene

Genomic Locations for CAPN14 Gene
60,916 bases
Minus strand
60,803 bases
Minus strand

Genomic View for CAPN14 Gene

Genes around CAPN14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN14 Gene

Proteins for CAPN14 Gene

  • Protein details for CAPN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KRU9

    Protein attributes for CAPN14 Gene

    684 amino acids
    Molecular mass:
    79568 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAPN14 Gene


neXtProt entry for CAPN14 Gene

Post-translational modifications for CAPN14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN14 Gene

No data available for DME Specific Peptides for CAPN14 Gene

Domains & Families for CAPN14 Gene

Gene Families for CAPN14 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C2 family.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN14: view

Function for CAPN14 Gene

Molecular function for CAPN14 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease.

Enzyme Numbers (IUBMB) for CAPN14 Gene

Phenotypes From GWAS Catalog for CAPN14 Gene

Gene Ontology (GO) - Molecular Function for CAPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CAPN14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN14

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAPN14 Gene

Localization for CAPN14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN14 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CAPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CAPN14 Gene

Pathways & Interactions for CAPN14 Gene

genes like me logo Genes that share pathways with CAPN14: view

Pathways by source for CAPN14 Gene

1 Tocris pathway for CAPN14 Gene

Gene Ontology (GO) - Biological Process for CAPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CAPN14: view

No data available for SIGNOR curated interactions for CAPN14 Gene

Drugs & Compounds for CAPN14 Gene

(3) Drugs for CAPN14 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Calpeptin Pharma Ca2+-dependent protease,calpain inhibitor, Calpain and cathepsin L inhibitor 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(2) Tocris Compounds for CAPN14 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
genes like me logo Genes that share compounds with CAPN14: view

Transcripts for CAPN14 Gene

mRNA/cDNA for CAPN14 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAPN14 Gene

Calpain 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN14

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN14 Gene

No ASD Table

Relevant External Links for CAPN14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPN14 Gene

This gene is overexpressed in Esophagus - Mucosa (x47.8).

Protein differential expression in normal tissues from HIPED for CAPN14 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAPN14 Gene

Protein tissue co-expression partners for CAPN14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAPN14 Gene:


SOURCE GeneReport for Unigene cluster for CAPN14 Gene:


mRNA Expression by UniProt/SwissProt for CAPN14 Gene:

Tissue specificity: Not expressed in tissues tested.
genes like me logo Genes that share expression patterns with CAPN14: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN14 Gene

Orthologs for CAPN14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAPN14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAPN14 34 33
  • 99.42 (n)
(Bos Taurus)
Mammalia CAPN14 34 33
  • 85.38 (n)
(Canis familiaris)
Mammalia CAPN14 34 33
  • 84.84 (n)
(Monodelphis domestica)
Mammalia CAPN14 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia CAPN14 34
  • 53 (a)
(Gallus gallus)
Aves CAPN14 34 33
  • 66.92 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
-- 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia capn14 33
  • 61.08 (n)
(Danio rerio)
Actinopterygii si:ch211-202f3.4 34
  • 38 (a)
zgc:162184 34
  • 38 (a)
zgc:136872 34
  • 37 (a)
si:ch211-202f3.3 34
  • 33 (a)
Species where no ortholog for CAPN14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPN14 Gene

Gene Tree for CAPN14 (if available)
Gene Tree for CAPN14 (if available)
Evolutionary constrained regions (ECRs) for CAPN14: view image

Paralogs for CAPN14 Gene

Paralogs for CAPN14 Gene

(9) SIMAP similar genes for CAPN14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAPN14: view

Variants for CAPN14 Gene

Sequence variations from dbSNP and Humsavar for CAPN14 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000022165 -- 31,177,956(-) A/G intron_variant
rs1000053213 -- 31,177,718(-) C/G intron_variant
rs1000088910 -- 31,220,308(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000145610 -- 31,209,998(-) C/T intron_variant
rs1000372712 -- 31,225,200(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN14 Gene

Variant ID Type Subtype PubMed ID
dgv3746n100 CNV loss 25217958
esv1010164 CNV gain 20482838
esv24497 CNV loss 19812545
esv3583708 CNV loss 25503493
esv3891692 CNV gain 25118596
nsv523787 CNV loss 19592680
nsv581268 CNV loss 21841781

Variation tolerance for CAPN14 Gene

Gene Damage Index Score: 16.45; 97.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPN14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN14 Gene

Disorders for CAPN14 Gene

Additional Disease Information for CAPN14

No disorders were found for CAPN14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN14 Gene

Publications for CAPN14 Gene

  1. Identification and characterization of two novel calpain large subunit genes. (PMID: 11675017) Dear TN … Boehm T (Gene 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Calpain-14 and its association with eosinophilic esophagitis. (PMID: 28131390) Litosh VA … Rothenberg ME (The Journal of allergy and clinical immunology 2017) 3 58
  4. GWAS identifies four novel eosinophilic esophagitis loci. (PMID: 25407941) Sleiman PM … Hakonarson H (Nature communications 2014) 3 58
  5. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan LC … Rothenberg ME (Nature genetics 2014) 3 58

Products for CAPN14 Gene

Sources for CAPN14 Gene

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