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Aliases for CAPN11 Gene

Aliases for CAPN11 Gene

  • Calpain 11 2 3 5
  • Calcium-Activated Neutral Proteinase 11 3 4
  • CANP 11 3 4
  • EC 56
  • EC 56
  • EC 3.4.22.- 4
  • Calpain-11 3
  • Calpain11 3
  • EC 3.4.22 56

External Ids for CAPN11 Gene

Previous GeneCards Identifiers for CAPN11 Gene

  • GC06P044128
  • GC06P044173
  • GC06P044235
  • GC06P043847

Summaries for CAPN11 Gene

Entrez Gene Summary for CAPN11 Gene

  • Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

GeneCards Summary for CAPN11 Gene

CAPN11 (Calpain 11) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN1.

UniProtKB/Swiss-Prot for CAPN11 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Tocris Summary for CAPN11 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Additional gene information for CAPN11 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN11 Gene

Genomics for CAPN11 Gene

GeneHancer (GH) Regulatory Elements for CAPN11 Gene

Promoters and enhancers for CAPN11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I044158 Promoter 0.7 EPDnew 550.8 0.0 -10 0.1 TRIM24 TRIM28 CAPN11 PIR60878
GH06I044255 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +102.1 102133 11.9 CLOCK ZFP64 DMAP1 YBX1 IRF4 E2F8 ZNF143 ZNF263 SP3 SSRP1 SLC35B2 ABCC10 RPL34P14 ZNF318 AARS2 NFKBIE RPS2P29 POLH GTPBP2 POLR1C
GH06I044200 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.8 +43.5 43492 3.4 ARNT SIN3A TCF12 FOS ATF7 SP5 NCOA1 PPARG ZNF592 SREBF1 SLC29A1 CAPN11 HSP90AB1 NFKBIE TMEM151B SLC35B2 MRPL14 TMEM63B MYMX RN7SL811P
GH06I044236 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +79.1 79093 2.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 GC06P044236 NFKBIE CAPN11 MRPL14 TMEM63B AARS2 SPATS1 RPL34P14 HSP90AB1 SLC29A1
GH06I044172 Enhancer 1.1 Ensembl ENCODE 18 +14.0 14033 1.1 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZNF48 GLIS2 CAPN11 SLC29A1 LOC105375072
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAPN11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPN11 gene promoter:

Genomic Locations for CAPN11 Gene

Genomic Locations for CAPN11 Gene
25,592 bases
Plus strand

Genomic View for CAPN11 Gene

Genes around CAPN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN11 Gene

Proteins for CAPN11 Gene

  • Protein details for CAPN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RA64
    • Q5T3G1
    • Q8N4R5

    Protein attributes for CAPN11 Gene

    739 amino acids
    Molecular mass:
    84423 Da
    Quaternary structure:
    • Heterodimer of a large (catalytic) and a small (regulatory) subunit.
    • Sequence=AAH33733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG36761.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB52137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CAPN11 Gene

Selected DME Specific Peptides for CAPN11 Gene


Post-translational modifications for CAPN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN11 Gene

Domains & Families for CAPN11 Gene

Gene Families for CAPN11 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CAPN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C2 family.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN11: view

Function for CAPN11 Gene

Molecular function for CAPN11 Gene

GENATLAS Biochemistry:
calpain 11,large polypeptide 11,calcium dependent,neutral cysteine proteinase,papain superfamily expressed in the testis
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Enzyme Numbers (IUBMB) for CAPN11 Gene

Phenotypes From GWAS Catalog for CAPN11 Gene

Gene Ontology (GO) - Molecular Function for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity TAS,IBA --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity TAS 10409436
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CAPN11: view
genes like me logo Genes that share phenotypes with CAPN11: view

Animal Models for CAPN11 Gene

MGI Knock Outs for CAPN11:

Animal Model Products

miRNA for CAPN11 Gene

miRTarBase miRNAs that target CAPN11

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN11 Gene

Localization for CAPN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN11 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN11 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with CAPN11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAPN11 Gene

Pathways & Interactions for CAPN11 Gene

genes like me logo Genes that share pathways with CAPN11: view

Pathways by source for CAPN11 Gene

Gene Ontology (GO) - Biological Process for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CAPN11: view

No data available for SIGNOR curated interactions for CAPN11 Gene

Drugs & Compounds for CAPN11 Gene

(2) Drugs for CAPN11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for CAPN11 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for CAPN11 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
genes like me logo Genes that share compounds with CAPN11: view

Transcripts for CAPN11 Gene

Unigene Clusters for CAPN11 Gene

Calpain 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25

Relevant External Links for CAPN11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPN11 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN11 Gene

This gene is overexpressed in Testis (x27.2).

Protein differential expression in normal tissues from HIPED for CAPN11 Gene

This gene is overexpressed in Liver (24.8), Spleen (12.7), Kidney (12.5), and Platelet (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN11 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAPN11 Gene:


SOURCE GeneReport for Unigene cluster for CAPN11 Gene:


mRNA Expression by UniProt/SwissProt for CAPN11 Gene:

Tissue specificity: Highest expression in testis.

Evidence on tissue expression from TISSUES for CAPN11 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CAPN11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN11 Gene

Orthologs for CAPN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAPN11 33 34
  • 98.83 (n)
(Bos Taurus)
Mammalia CAPN11 33 34
  • 84.16 (n)
(Canis familiaris)
Mammalia CAPN11 33 34
  • 84 (n)
(Mus musculus)
Mammalia Capn11 33 16 34
  • 79.6 (n)
(Rattus norvegicus)
Mammalia Capn11 33
  • 79.2 (n)
(Danio rerio)
Actinopterygii zgc:85932 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CalpA 35 34
  • 47 (a)
CalpB 35 34
  • 41 (a)
CalpC 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea clp-7 35 34
  • 43 (a)
clp-6 35 34
  • 40 (a)
clp-3 35 34
  • 36 (a)
clp-4 34
  • 31 (a)
clp-1 34
  • 30 (a)
Species where no ortholog for CAPN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAPN11 Gene

Gene Tree for CAPN11 (if available)
Gene Tree for CAPN11 (if available)

Paralogs for CAPN11 Gene

Paralogs for CAPN11 Gene

(14) SIMAP similar genes for CAPN11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN11: view

Variants for CAPN11 Gene

Sequence variations from dbSNP and Humsavar for CAPN11 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000074431 -- 44,163,764(+) C/T intron_variant
rs1000107415 -- 44,158,266(+) A/G upstream_transcript_variant
rs1000112673 -- 44,179,831(+) G/A intron_variant, non_coding_transcript_variant
rs1000122881 -- 44,163,911(+) C/T intron_variant
rs1000334511 -- 44,183,024(+) C/T genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN11 Gene

Variant ID Type Subtype PubMed ID
dgv1003e201 CNV deletion 23290073
dgv3506e59 CNV duplication 20981092
esv1158501 CNV deletion 17803354
esv1646210 CNV deletion 17803354
esv2292197 CNV deletion 18987734
esv2732004 CNV deletion 23290073
esv2732005 CNV deletion 23290073
esv2732007 CNV deletion 23290073
esv2732008 CNV deletion 23290073
esv2732009 CNV deletion 23290073
esv2732011 CNV deletion 23290073
esv3608825 CNV loss 21293372
esv3608826 CNV gain 21293372
nsv1110794 CNV insertion 24896259
nsv1135962 CNV deletion 24896259
nsv509132 CNV insertion 20534489
nsv510028 OTHER sequence alteration 20534489
nsv958346 CNV deletion 24416366

Variation tolerance for CAPN11 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPN11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN11 Gene

Disorders for CAPN11 Gene

Additional Disease Information for CAPN11

No disorders were found for CAPN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN11 Gene

Publications for CAPN11 Gene

  1. CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6. (PMID: 10409436) Dear TN … Boehm T (Genomics 1999) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  5. Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states. (PMID: 20093171) Macqueen DJ … Johnston IA (Gene 2010) 22 58

Products for CAPN11 Gene

Sources for CAPN11 Gene

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