CAPN10 Gene (Protein Coding)

Calpain 10

GC02P240586
GIFtS:
42
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, ... See more...

Aliases for CAPN10 Gene

Aliases for CAPN10 Gene

  • Calpain 10 2 3 5
  • Calcium-Activated Neutral Proteinase 10 3 4
  • Calpain-10 3 4
  • Calpain-Like Protease CAPN10 3
  • EC 3.4.22.- 4
  • KIAA1845 4
  • CANP 10 4
  • CANP10 3
  • NIDDM1 3
  • CAPN10 5

External Ids for CAPN10 Gene

Previous GeneCards Identifiers for CAPN10 Gene

  • GC02M239919
  • GC02M240764
  • GC02P241545
  • GC02P241846
  • GC02P241246
  • GC02P241174
  • GC02P233282
  • GC02P241526

Summaries for CAPN10 Gene

Entrez Gene Summary for CAPN10 Gene

  • Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for CAPN10 Gene

CAPN10 (Calpain 10) is a Protein Coding gene. Diseases associated with CAPN10 include Type 1 Diabetes Mellitus 2 and Polycystic Ovary Syndrome. Among its related pathways are Degradation of the extracellular matrix and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include cytoskeletal protein binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN3.

UniProtKB/Swiss-Prot Summary for CAPN10 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Tocris Summary for CAPN10 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Gene Wiki entry for CAPN10 Gene

Additional gene information for CAPN10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPN10 Gene

Genomics for CAPN10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CAPN10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPN10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPN10

Top Transcription factor binding sites by QIAGEN in the CAPN10 gene promoter:
  • STAT3

Genomic Locations for CAPN10 Gene

Latest Assembly
chr2:240,586,734-240,617,705
(GRCh38/hg38)
Size:
30,972 bases
Orientation:
Plus strand

Previous Assembly
chr2:241,526,151-241,538,521
(GRCh37/hg19 by Entrez Gene)
Size:
12,371 bases
Orientation:
Plus strand

chr2:241,526,133-241,557,122
(GRCh37/hg19 by Ensembl)
Size:
30,990 bases
Orientation:
Plus strand

Genomic View for CAPN10 Gene

Genes around CAPN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CAPN10 Gene

Proteins for CAPN10 Gene

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  • Protein details for CAPN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC96-CAN10_HUMAN
    Recommended name:
    Calpain-10
    Protein Accession:
    Q9HC96
    Secondary Accessions:
    • A8MVS7
    • Q4ZFV1
    • Q8NCD4
    • Q96IG4
    • Q96JI2
    • Q9HC89
    • Q9HC90
    • Q9HC91
    • Q9HC92
    • Q9HC93
    • Q9HC94
    • Q9HC95

    Protein attributes for CAPN10 Gene

    Size:
    672 amino acids
    Molecular mass:
    74952 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47474.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform B]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform D]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform E]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform F]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CAPN10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPN10 Gene

Protein Expression for CAPN10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CAPN10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAPN10 Gene

Domains & Families for CAPN10 Gene

Gene Families for CAPN10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CAPN10 Gene

InterPro:
Blocks:
  • Calpain cysteine protease (C2) family signature

Suggested Antigen Peptide Sequences for CAPN10 Gene

GenScript: Design optimal peptide antigens:
  • Calcium-activated neutral proteinase 10 (CAN10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HC96

UniProtKB/Swiss-Prot:

CAN10_HUMAN :
  • Belongs to the peptidase C2 family.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN10: view

Function for CAPN10 Gene

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  6. Cell Lines for research

Molecular function for CAPN10 Gene

UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Enzyme Numbers (IUBMB) for CAPN10 Gene

Phenotypes From GWAS Catalog for CAPN10 Gene

Gene Ontology (GO) - Molecular Function for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA,IMP 15044459
GO:0005515 protein binding IPI 32814053
GO:0008092 cytoskeletal protein binding ISS --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with CAPN10: view
genes like me logo Genes that share phenotypes with CAPN10: view

Animal Models for CAPN10 Gene

MGI Knock Outs for CAPN10:

Animal Models for research

  • Taconic Biosciences Mouse Models for CAPN10

miRNA for CAPN10 Gene

miRTarBase miRNAs that target CAPN10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN10 Gene

Localization for CAPN10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPN10 gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 4
nucleus 3
extracellular 2
endoplasmic reticulum 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IDA 16790502
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with CAPN10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAPN10 Gene

Pathways & Interactions for CAPN10 Gene

PathCards logo

SuperPathways for CAPN10 Gene

SuperPathway Contained pathways
1 DREAM Repression and Dynorphin Expression
nNOS Signaling in Skeletal Muscle
.37
Caspase Cascade
.36
Calpain Protease Regulates Cellular Mechanics
.31
2 Degradation of the extracellular matrix
Degradation of the extracellular matrix
.38
Extracellular matrix organization
.38
3 Apoptosis Pathway
Apoptosis Pathway
.45
4 ERK Signaling
ERK Signaling
.61
5 Integrin Pathway
FAK1 Signaling
.67
genes like me logo Genes that share pathways with CAPN10: view

Pathways by source for CAPN10 Gene

1 BioSystems pathway for CAPN10 Gene
1 Tocris pathway for CAPN10 Gene
5 Qiagen pathways for CAPN10 Gene
  • Calpain Protease Regulates Cellular Mechanics
  • Caspase Cascade
  • ERK Signaling
  • FAK1 Signaling
  • nNOS Signaling in Skeletal Muscle

SIGNOR curated interactions for CAPN10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IMP 15044459
GO:0006921 cellular component disassembly involved in execution phase of apoptosis IC --
GO:0031532 actin cytoskeleton reorganization ISS 12974673
GO:0032024 positive regulation of insulin secretion IMP 15471947
GO:0032388 positive regulation of intracellular transport ISS 12974673
genes like me logo Genes that share ontologies with CAPN10: view

Drugs & Compounds for CAPN10 Gene

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  1. Drug products for research

(9) Drugs for CAPN10 Gene - From: PharmGKB, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 2304
Tacrolimus Approved, Investigational Pharma 1328
Calcium Nutra 6959
Calpeptin Pharma Ca2+-dependent protease,calpain inhibitor, Calpain and cathepsin L inhibitor 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(3) Additional Compounds for CAPN10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for CAPN10 Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
genes like me logo Genes that share compounds with CAPN10: view

Transcripts for CAPN10 Gene

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mRNA/cDNA for CAPN10 Gene

8 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPN10

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - -
SP15:
SP16: -
SP17:

ExUns: 16c ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11: - -
SP12: -
SP13: - - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CAPN10 Gene

GeneLoc Exon Structure for
CAPN10

Expression for CAPN10 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPN10 Gene

mRNA expression in normal human tissues for CAPN10 Gene
mRNA expression by BioGPS for CAPN10 GenemRNA expression by GTEx for CAPN10 Gene

Protein differential expression in normal tissues from HIPED for CAPN10 Gene

This gene is overexpressed in Serum (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAPN10 Gene



Protein tissue co-expression partners for CAPN10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPN10

SOURCE GeneReport for Unigene cluster for CAPN10 Gene:

Hs.728234

mRNA Expression by UniProt/SwissProt for CAPN10 Gene:

Q9HC96-CAN10_HUMAN
Tissue specificity: Detected in primary skeletal muscle cells (at protein level). Ubiquitous.

Evidence on tissue expression from TISSUES for CAPN10 Gene

  • Nervous system(4.8)
  • Skin(4.6)
  • Lung(4)
  • Pancreas(3.5)
  • Intestine(3.1)
  • Eye(2.8)
  • Liver(2.5)
  • Bone(2.5)
  • Blood(2.5)
  • Kidney(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CAPN10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPN10 Gene

Orthologs for CAPN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CAPN10 29 30
  • 98.31 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LOC789674 29
  • 85.03 (n)
CAPN10 30
  • 85 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CAPN10 29 30
  • 84.74 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Capn10 29
  • 82.56 (n)
Mouse
(Mus musculus)
 Mammalia Capn10 29 16 30
  • 82.41 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CAPN10 30
  • 73 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 72 (a)
 OneToMany
-- 30
  • 66 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves CAPN10 29
  • 65.55 (n)
Lizard
(Anolis carolinensis)
 Reptilia CAPN10 30
  • 54 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia capn10 29
  • 56.05 (n)
Zebrafish
(Danio rerio)
 Actinopterygii capn10 29 30
  • 57.69 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CalpC 30
  • 22 (a)
 OneToOne
Species where no ortholog for CAPN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CAPN10 Gene

ENSEMBL:
Gene Tree for CAPN10 (if available)
TreeFam:
Gene Tree for CAPN10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPN10: view image
Alliance of Genome Resources:
Additional Orthologs for CAPN10

Paralogs for CAPN10 Gene

Paralogs for CAPN10 Gene

(1) SIMAP similar genes for CAPN10 Gene using alignment to 4 proteins:

  • CAN10_HUMAN
  • B7WPF5_HUMAN
  • H7C251_HUMAN
  • H7C2P1_HUMAN
genes like me logo Genes that share paralogs with CAPN10: view

Variants for CAPN10 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPN10 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
771849 Benign: not provided 240,598,657(+) A/.
NM_023083.4(CAPN10):c.1996= (p.Ile666=) 		NO_SEQUENCE_ALTERATION
984988 Uncertain Significance: Inborn genetic diseases 240,591,007(+) G/A
NM_023083.4(CAPN10):c.466G>A (p.Ala156Thr) 		MISSENSE
984989 Pathogenic: Inborn genetic diseases 240,594,547(+) G/GAAGGGTGGAGCCA
NM_023083.4(CAPN10):c.837_858dup (p.Ala287fs) 		FRAMESHIFT
rs1009002311 Likely Benign: not provided 240,593,973(+) G/A
NM_023083.4(CAPN10):c.756G>A (p.Ala252=) 		SYNONYMOUS
rs114120181 Benign: not provided 240,597,889(+) T/C
NM_023083.4(CAPN10):c.1745T>C (p.Val582Ala) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CAPN10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CAPN10 Gene

Variant ID Type Subtype PubMed ID
esv2759119 CNV gain 17122850
nsv1001262 CNV gain 25217958
nsv470529 CNV loss 18288195
nsv834586 CNV loss 17160897
nsv955291 CNV deletion 24416366

Variation tolerance for CAPN10 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPN10 Gene

Human Gene Mutation Database (HGMD)
CAPN10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN10
Leiden Open Variation Database (LOVD)
CAPN10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN10 Gene

Disorders for CAPN10 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CAPN10 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 2
  • t1d2
polycystic ovary syndrome
  • multicystic ovaries
type 2 diabetes mellitus
  • t2d
diabetes mellitus
  • diabetes
hyperandrogenism
  • hyperandrogenization syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CAN10_HUMAN
  • Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:11017071, ECO:0000269 PubMed:16721485}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for CAPN10

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CAPN10: view

No data available for Genatlas for CAPN10 Gene

Publications for CAPN10 Gene

  1. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PMID: 11017071) Horikawa Y … Bell GI (Nature genetics 2000) 2 3 4 22 40 72
  2. A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes. (PMID: 16721485) Kang ES … Lee HC (Journal of human genetics 2006) 3 4 22 40
  3. Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects. (PMID: 15240652) Carlsson E … Ridderstråle M (The Journal of clinical endocrinology and metabolism 2004) 3 22 40 72
  4. Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients. (PMID: 14602801) Gonzalez A … Ruiz A (The Journal of clinical endocrinology and metabolism 2003) 3 22 40 72
  5. Comment: CAPN10 alleles are associated with polycystic ovary syndrome. (PMID: 12161543) Gonzalez A … Ruiz A (The Journal of clinical endocrinology and metabolism 2002) 3 22 40 72

ExternalLinks

View latest publications for CAPN10 gene in Mastermind

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Sources for CAPN10 Gene