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This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
CAPG (Capping Actin Protein, Gelsolin Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is GSN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 18266911 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IBA | 21873635 |
GO:0019904 | protein domain specific binding | IPI | 18266911 |
GO:0044877 | protein-containing complex binding | IDA | 18266911 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001726 | ruffle | IEA | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005634 | nucleus | IEA,IDA | 18266911 |
GO:0005654 | nucleoplasm | IDA | 18938132 |
GO:0005730 | nucleolus | IDA | 18938132 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007417 | central nervous system development | IBA | 21873635 |
GO:0008154 | actin polymerization or depolymerization | IBA | 21873635 |
GO:0022617 | NOT extracellular matrix disassembly | IMP | 24236012 |
GO:0030031 | cell projection assembly | IBA | 21873635 |
GO:0051014 | actin filament severing | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CAPG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CAPG 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Capg 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Capg 30 |
|
||
Cow (Bos Taurus) |
Mammalia | CAPG 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CAPG 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CAPG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CAPG 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CAPG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | capg 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | capgb 30 31 |
|
OneToMany | |
capga 31 |
|
OneToMany | |||
wufb14e07 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | K06A4.3 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6001 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
684549 | Not Provided: not provided | 85,401,227(-) | C/A | NONSENSE | |
731207 | Benign: not provided | 85,398,769(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
747161 | Benign: not provided | 85,398,051(-) | G/A | SYNONYMOUS_VARIANT | |
785969 | Benign: not provided | 85,401,547(-) | TG/T | FRAMESHIFT_VARIANT | |
rs11539103 | - | p.Arg198Trp |
No disorders were found for CAPG Gene.