This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in no... See more...

Aliases for CAPG Gene

Aliases for CAPG Gene

  • Capping Actin Protein, Gelsolin Like 2 3 5
  • MCP 2 3 4
  • Capping Protein (Actin Filament), Gelsolin-Like 2 3
  • Macrophage-Capping Protein 3 4
  • AFCP 3 4
  • Epididymis Secretory Protein Li 66 3
  • Actin-Regulatory Protein CAP-G 3
  • Actin Regulatory Protein CAP-G 4
  • Gelsolin-Like Capping Protein 3
  • Macrophage Capping Protein 2
  • HEL-S-66 3
  • CAPG 5

External Ids for CAPG Gene

Previous HGNC Symbols for CAPG Gene

  • AFCP

Previous GeneCards Identifiers for CAPG Gene

  • GC02M085517
  • GC02M085915
  • GC02M085579
  • GC02M085596
  • GC02M085533
  • GC02M085475
  • GC02M085621
  • GC02M085520

Summaries for CAPG Gene

Entrez Gene Summary for CAPG Gene

  • This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CAPG Gene

CAPG (Capping Actin Protein, Gelsolin Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is GSN.

UniProtKB/Swiss-Prot Summary for CAPG Gene

  • Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Gene Wiki entry for CAPG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAPG Gene

Genomics for CAPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAPG

Top Transcription factor binding sites by QIAGEN in the CAPG gene promoter:
  • AML1a
  • E47
  • GATA-1
  • GATA-2
  • GATA-3
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • Spz1

Genomic Locations for CAPG Gene

Genomic Locations for CAPG Gene
chr2:85,394,748-85,418,467
(GRCh38/hg38)
Size:
23,720 bases
Orientation:
Minus strand
chr2:85,621,871-85,645,555
(GRCh37/hg19)
Size:
23,685 bases
Orientation:
Minus strand

Genomic View for CAPG Gene

Genes around CAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPG Gene

Proteins for CAPG Gene

  • Protein details for CAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40121-CAPG_HUMAN
    Recommended name:
    Macrophage-capping protein
    Protein Accession:
    P40121
    Secondary Accessions:
    • B8ZZS7
    • D6W5K8
    • Q53SA7

    Protein attributes for CAPG Gene

    Size:
    348 amino acids
    Molecular mass:
    38499 Da
    Quaternary structure:
    • Interacts with NUP62 (PubMed:18266911). Interacts with NUTF2 and RAN; involved in CAPG nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for CAPG Gene

    Alternative splice isoforms for CAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPG Gene

Post-translational modifications for CAPG Gene

No data available for DME Specific Peptides for CAPG Gene

Domains & Families for CAPG Gene

Gene Families for CAPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAPG Gene

Suggested Antigen Peptide Sequences for CAPG Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51488, highly similar to Macrophage capping protein (B4DU58_HUMAN)
  • Actin regulatory protein CAP-G (CAPG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40121

UniProtKB/Swiss-Prot:

CAPG_HUMAN :
  • Belongs to the villin/gelsolin family.
Family:
  • Belongs to the villin/gelsolin family.
genes like me logo Genes that share domains with CAPG: view

Function for CAPG Gene

Molecular function for CAPG Gene

UniProtKB/Swiss-Prot Function:
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
GENATLAS Biochemistry:
CapG,macrophage capping protein (gelsolin/villin family of actin regulatory protein)

Phenotypes From GWAS Catalog for CAPG Gene

Gene Ontology (GO) - Molecular Function for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18266911
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA 21873635
GO:0019904 protein domain specific binding IPI 18266911
GO:0044877 protein-containing complex binding IDA 18266911
genes like me logo Genes that share ontologies with CAPG: view
genes like me logo Genes that share phenotypes with CAPG: view

Animal Models for CAPG Gene

MGI Knock Outs for CAPG:

Animal Model Products

CRISPR Products

miRNA for CAPG Gene

miRTarBase miRNAs that target CAPG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPG Gene

Localization for CAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPG Gene

Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250 UniProtKB:P24452}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPG gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4
cytosol 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IEA,IDA 18266911
GO:0005654 nucleoplasm IDA 18938132
GO:0005730 nucleolus IDA 18938132
genes like me logo Genes that share ontologies with CAPG: view

Pathways & Interactions for CAPG Gene

PathCards logo

SuperPathways for CAPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IBA 21873635
GO:0008154 actin polymerization or depolymerization IBA 21873635
GO:0022617 NOT extracellular matrix disassembly IMP 24236012
GO:0030031 cell projection assembly IBA 21873635
GO:0051014 actin filament severing IBA 21873635
genes like me logo Genes that share ontologies with CAPG: view

No data available for Pathways by source and SIGNOR curated interactions for CAPG Gene

Drugs & Compounds for CAPG Gene

(2) Drugs for CAPG Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 1073
Calcium Nutra 6556

(1) Additional Compounds for CAPG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CAPG: view

Transcripts for CAPG Gene

mRNA/cDNA for CAPG Gene

6 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAPG

Alternative Splicing Database (ASD) splice patterns (SP) for CAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9:

Relevant External Links for CAPG Gene

GeneLoc Exon Structure for
CAPG

Expression for CAPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPG Gene

This gene is overexpressed in Whole Blood (x9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPG Gene



Protein tissue co-expression partners for CAPG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAPG

SOURCE GeneReport for Unigene cluster for CAPG Gene:

Hs.516155

mRNA Expression by UniProt/SwissProt for CAPG Gene:

P40121-CAPG_HUMAN
Tissue specificity: Macrophages and macrophage-like cells.

Evidence on tissue expression from TISSUES for CAPG Gene

  • Skin(4.8)
  • Liver(4.5)
  • Bone marrow(4.4)
  • Lung(3.4)
  • Nervous system(3)
  • Intestine(2.6)
  • Lymph node(2.5)
  • Kidney(2.3)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CAPG: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPG Gene

Orthologs for CAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAPG 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAPG 30 31
  • 91.19 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Capg 30 17 31
  • 89.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Capg 30
  • 88.31 (n)
Cow
(Bos Taurus)
Mammalia CAPG 30 31
  • 87.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CAPG 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CAPG 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CAPG 30 31
  • 69.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAPG 31
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia capg 30
  • 55.33 (n)
Zebrafish
(Danio rerio)
Actinopterygii capgb 30 31
  • 61.86 (n)
OneToMany
capga 31
  • 55 (a)
OneToMany
wufb14e07 30
Worm
(Caenorhabditis elegans)
Secernentea K06A4.3 32
  • 34 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6001 31
  • 5 (a)
OneToMany
Species where no ortholog for CAPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAPG Gene

ENSEMBL:
Gene Tree for CAPG (if available)
TreeFam:
Gene Tree for CAPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPG: view image

Paralogs for CAPG Gene

Paralogs for CAPG Gene

(7) SIMAP similar genes for CAPG Gene using alignment to 4 proteins:

  • CAPG_HUMAN
  • B8ZZL6_HUMAN
  • E7ENU9_HUMAN
  • H7C0X8_HUMAN
genes like me logo Genes that share paralogs with CAPG: view

Variants for CAPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAPG Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
684549 Not Provided: not provided 85,401,227(-) C/A NONSENSE
731207 Benign: not provided 85,398,769(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
747161 Benign: not provided 85,398,051(-) G/A SYNONYMOUS_VARIANT
785969 Benign: not provided 85,401,547(-) TG/T FRAMESHIFT_VARIANT
rs11539103 - p.Arg198Trp

Additional dbSNP identifiers (rs#s) for CAPG Gene

Structural Variations from Database of Genomic Variants (DGV) for CAPG Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV gain 17160897
nsv834283 CNV loss 17160897

Variation tolerance for CAPG Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPG Gene

Human Gene Mutation Database (HGMD)
CAPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPG Gene

Disorders for CAPG Gene

Additional Disease Information for CAPG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPG Gene

Publications for CAPG Gene

  1. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. (PMID: 1322908) Dabiri GA … Southwick FS (The Journal of biological chemistry 1992) 2 3 4 23
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K … Gettemans J (Traffic (Copenhagen, Denmark) 2008) 3 4 23
  3. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. (PMID: 12754261) Pellieux C … Silacci P (The Journal of biological chemistry 2003) 2 3 23
  4. The human actin-regulatory protein cap G: gene structure and chromosome location. (PMID: 7851883) Mishra VS … Southwick FS (Genomics 1994) 3 4 23
  5. Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. (PMID: 19188659) Zhang R … Wan H (American journal of respiratory cell and molecular biology 2009) 3 23

Products for CAPG Gene

Sources for CAPG Gene