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Aliases for CAPG Gene

Aliases for CAPG Gene

  • Capping Actin Protein, Gelsolin Like 2 3 5
  • Capping Protein (Actin Filament), Gelsolin-Like 2 3
  • AFCP 3 4
  • MCP 3 4
  • Epididymis Secretory Protein Li 66 3
  • Actin-Regulatory Protein CAP-G 3
  • Actin Regulatory Protein CAP-G 4
  • Gelsolin-Like Capping Protein 3
  • Macrophage-Capping Protein 3
  • Macrophage Capping Protein 2
  • HEL-S-66 3

External Ids for CAPG Gene

Previous HGNC Symbols for CAPG Gene

  • AFCP

Previous GeneCards Identifiers for CAPG Gene

  • GC02M085517
  • GC02M085915
  • GC02M085579
  • GC02M085596
  • GC02M085533
  • GC02M085475
  • GC02M085621
  • GC02M085520

Summaries for CAPG Gene

Entrez Gene Summary for CAPG Gene

  • This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CAPG Gene

CAPG (Capping Actin Protein, Gelsolin Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is GSN.

UniProtKB/Swiss-Prot for CAPG Gene

  • Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Gene Wiki entry for CAPG Gene

Additional gene information for CAPG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPG Gene

Genomics for CAPG Gene

GeneHancer (GH) Regulatory Elements for CAPG Gene

Promoters and enhancers for CAPG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J085412 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 676.3 +4.5 4477 2.8 PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF766 FOS ZNF263 SP5 REST CAPG LOC105374841 SNORD94 RETSAT ELMOD3 TGOLN2 VAMP8 ENSG00000273196 GC02P085363
GH02J085417 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 677 -1.9 -1916 5.2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D CAPG SH2D6 SNORD94 ELMOD3 MAT2A TCF7L1 USP39 POLR1A GC02P085438 GC02P085363
GH02J085404 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 677 +10.1 10066 8 HDGF HDAC1 YY1 EGR1 RCOR1 IKZF2 RUNX3 EGR2 SMARCA5 ZNF362 CAPG RETSAT TGOLN2 KCMF1 LOC105374841 ENSG00000273196 GC02P085363
GH02J085323 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.3 +92.2 92158 5.6 MLX DMAP1 YY1 E2F8 ZNF143 SP3 PPARGC1A SSRP1 ZNF610 GLIS1 TGOLN2 RETSAT ELMOD3 LOC100996506 SNORD94 CAPG USP39 C2orf68 SH2D6 VAMP8
GH02J085536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.8 -121.3 -121293 6.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PARTICL PIR40998 MAT2A GC02M085541 PIR39955 USP39 SNORD94 C2orf68 LOC100996506 KDM3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAPG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAPG gene promoter:
  • E47
  • Spz1
  • AML1a
  • POU2F1a
  • POU2F1
  • PPAR-gamma1
  • PPAR-gamma2
  • GATA-1
  • GATA-2
  • GATA-3

Genomic Locations for CAPG Gene

Genomic Locations for CAPG Gene
chr2:85,394,748-85,418,467
(GRCh38/hg38)
Size:
23,720 bases
Orientation:
Minus strand
chr2:85,621,871-85,645,555
(GRCh37/hg19)
Size:
23,685 bases
Orientation:
Minus strand

Genomic View for CAPG Gene

Genes around CAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPG Gene

Proteins for CAPG Gene

  • Protein details for CAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40121-CAPG_HUMAN
    Recommended name:
    Macrophage-capping protein
    Protein Accession:
    P40121
    Secondary Accessions:
    • B8ZZS7
    • D6W5K8
    • Q53SA7

    Protein attributes for CAPG Gene

    Size:
    348 amino acids
    Molecular mass:
    38499 Da
    Quaternary structure:
    • Interacts with NUP62 (PubMed:18266911). Interacts with NUTF2 and RAN; involved in CAPG nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for CAPG Gene

    Alternative splice isoforms for CAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPG Gene

Post-translational modifications for CAPG Gene

Antibody Products

No data available for DME Specific Peptides for CAPG Gene

Domains & Families for CAPG Gene

Gene Families for CAPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAPG Gene

Suggested Antigen Peptide Sequences for CAPG Gene

Graphical View of Domain Structure for InterPro Entry

P40121

UniProtKB/Swiss-Prot:

CAPG_HUMAN :
  • Belongs to the villin/gelsolin family.
Family:
  • Belongs to the villin/gelsolin family.
genes like me logo Genes that share domains with CAPG: view

Function for CAPG Gene

Molecular function for CAPG Gene

UniProtKB/Swiss-Prot Function:
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
GENATLAS Biochemistry:
CapG,macrophage capping protein (gelsolin/villin family of actin regulatory protein)

Phenotypes From GWAS Catalog for CAPG Gene

Gene Ontology (GO) - Molecular Function for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18266911
GO:0019904 protein domain specific binding IPI 18266911
GO:0044877 protein-containing complex binding IDA 18266911
GO:0045296 cadherin binding IDA 25468996
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with CAPG: view
genes like me logo Genes that share phenotypes with CAPG: view

Animal Models for CAPG Gene

MGI Knock Outs for CAPG:

Animal Model Products

miRNA for CAPG Gene

miRTarBase miRNAs that target CAPG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPG Gene

Localization for CAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPG Gene

Nucleus. Cytoplasm. Secreted. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Redistributes throughout the cytoplasm during mitosis and is excluded from regions containing chromosomes (By similarity). {ECO:0000250 UniProtKB:P24452, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPG gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 18266911
GO:0005654 nucleoplasm IDA 18938132
GO:0005730 nucleolus IDA 18938132
GO:0005737 cytoplasm IDA,IEA 18266911
genes like me logo Genes that share ontologies with CAPG: view

Pathways & Interactions for CAPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022617 NOT extracellular matrix disassembly IMP 24236012
GO:0051016 barbed-end actin filament capping IEA --
GO:0051693 actin filament capping IEA --
GO:0065003 protein-containing complex assembly NAS 1322908
GO:0071803 NOT positive regulation of podosome assembly IMP 24236012
genes like me logo Genes that share ontologies with CAPG: view

No data available for Pathways by source and SIGNOR curated interactions for CAPG Gene

Drugs & Compounds for CAPG Gene

(2) Drugs for CAPG Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 965

(1) Additional Compounds for CAPG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CAPG: view

Transcripts for CAPG Gene

Unigene Clusters for CAPG Gene

Capping protein (actin filament), gelsolin-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9:

Relevant External Links for CAPG Gene

GeneLoc Exon Structure for
CAPG
ECgene alternative splicing isoforms for
CAPG

Expression for CAPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPG Gene

This gene is overexpressed in Whole Blood (x9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAPG Gene



Protein tissue co-expression partners for CAPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPG Gene:

CAPG

SOURCE GeneReport for Unigene cluster for CAPG Gene:

Hs.516155

mRNA Expression by UniProt/SwissProt for CAPG Gene:

P40121-CAPG_HUMAN
Tissue specificity: Macrophages and macrophage-like cells.

Evidence on tissue expression from TISSUES for CAPG Gene

  • Skin(4.8)
  • Bone marrow(4.4)
  • Liver(4.4)
  • Lung(3.4)
  • Nervous system(2.5)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CAPG: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPG Gene

Orthologs for CAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPG 34 33
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CAPG 34 33
  • 91.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Capg 16 34 33
  • 89.37 (n)
rat
(Rattus norvegicus)
Mammalia Capg 33
  • 88.31 (n)
cow
(Bos Taurus)
Mammalia CAPG 34 33
  • 87.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPG 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPG 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPG 34 33
  • 69.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPG 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capg 33
  • 55.33 (n)
zebrafish
(Danio rerio)
Actinopterygii capgb 34 33
  • 61.86 (n)
OneToMany
capga 34
  • 55 (a)
OneToMany
wufb14e07 33
worm
(Caenorhabditis elegans)
Secernentea K06A4.3 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6001 34
  • 5 (a)
OneToMany
Species where no ortholog for CAPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPG Gene

ENSEMBL:
Gene Tree for CAPG (if available)
TreeFam:
Gene Tree for CAPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAPG: view image

Paralogs for CAPG Gene

Paralogs for CAPG Gene

(7) SIMAP similar genes for CAPG Gene using alignment to 4 proteins:

  • CAPG_HUMAN
  • B8ZZL6_HUMAN
  • E7ENU9_HUMAN
  • H7C0X8_HUMAN
genes like me logo Genes that share paralogs with CAPG: view

Variants for CAPG Gene

Sequence variations from dbSNP and Humsavar for CAPG Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000123860 -- 85,412,532(-) AATAATAATA/AATAATA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000170206 -- 85,407,953(-) G/A intron_variant
rs1000201222 -- 85,407,521(-) T/C intron_variant
rs1000344355 -- 85,398,034(-) A/G coding_sequence_variant, missense_variant
rs1000526352 -- 85,409,524(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAPG Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV gain 17160897
nsv834283 CNV loss 17160897

Variation tolerance for CAPG Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAPG Gene

Human Gene Mutation Database (HGMD)
CAPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPG Gene

Disorders for CAPG Gene

Additional Disease Information for CAPG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPG Gene

Publications for CAPG Gene

  1. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. (PMID: 1322908) Dabiri GA … Southwick FS (The Journal of biological chemistry 1992) 2 3 4 22 58
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K … Gettemans J (Traffic (Copenhagen, Denmark) 2008) 3 4 22 58
  3. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. (PMID: 12754261) Pellieux C … Silacci P (The Journal of biological chemistry 2003) 2 3 22 58
  4. The human actin-regulatory protein cap G: gene structure and chromosome location. (PMID: 7851883) Mishra VS … Southwick FS (Genomics 1994) 3 4 22 58
  5. Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. (PMID: 19188659) Zhang R … Wan H (American journal of respiratory cell and molecular biology 2009) 3 22 58

Products for CAPG Gene

Sources for CAPG Gene

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