Aliases for CANT1 Gene
External Ids for CANT1 Gene
Previous GeneCards Identifiers for CANT1 Gene
This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
GeneCards Summary for CANT1 Gene
CANT1 (Calcium Activated Nucleotidase 1) is a Protein Coding gene. Diseases associated with CANT1 include Desbuquois Dysplasia 1 and Epiphyseal Dysplasia, Multiple, 7. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and pyrophosphatase activity.
UniProtKB/Swiss-Prot Summary for CANT1 Gene
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336).