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Aliases for CAND2 Gene

Aliases for CAND2 Gene

  • Cullin Associated And Neddylation Dissociated 2 (Putative) 2 3 5
  • Cullin-Associated And Neddylation-Dissociated Protein 2 3 4
  • TBP-Interacting Protein Of 120 KDa B 3 4
  • Epididymis Tissue Protein Li 169 3 4
  • TBP-Interacting Protein 120B 3 4
  • TBP Interacting Protein 2 3
  • P120 CAND2 3 4
  • TIP120B 3 4
  • Cullin-Associated And Neddylation-Dissociated 2 (Putative) 2
  • Cullin-Associated NEDD8-Dissociated Protein 2 3
  • KIAA0667 4
  • Tp120b 3

External Ids for CAND2 Gene

Summaries for CAND2 Gene

GeneCards Summary for CAND2 Gene

CAND2 (Cullin Associated And Neddylation Dissociated 2 (Putative)) is a Protein Coding gene. Diseases associated with CAND2 include Esophageal Atresia/Tracheoesophageal Fistula. Gene Ontology (GO) annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND1.

UniProtKB/Swiss-Prot for CAND2 Gene

  • Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

Additional gene information for CAND2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAND2 Gene

Genomics for CAND2 Gene

GeneHancer (GH) Regulatory Elements for CAND2 Gene

Promoters and enhancers for CAND2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J012795 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 686.1 +1.8 1815 4.7 ATF1 SIN3A FEZF1 YY1 GTF3C2 ZNF121 POLR2B GLIS2 KLF7 ATF7 CAND2 TAMM41 MKRN2 TSEN2 TMEM40 ENSG00000272263
GH03J012757 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 21.2 -37.1 -37070 3.8 PKNOX1 KLF17 MZF1 BATF ZBTB7B ZNF335 GLIS2 ZNF213 ZNF366 FOS TMEM40 CAND2 TAMM41 MKRN2 VGLL4 CRIP1P1
GH03J012749 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.6 -44.4 -44410 5 HDAC1 PKNOX1 SIN3A BATF IRF4 RFX5 YY1 SCRT2 FOS BCLAF1 CAND2 MKRN2 KRT18P17 TMEM40 CRIP1P1
GH03J012700 Enhancer 0.8 Ensembl ENCODE 17.7 -93.7 -93745 3.5 SCRT1 JUN MAX CEBPB FOSL1 JUND CTBP1 GATA3 HMBOX1 RCOR1 CAND2 MKRN2 KRT18P17 ENSG00000272263 CRIP1P1 TMEM40
GH03J012962 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.4 +170.5 170498 8.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IQSEC1 TSEN2 ENSG00000250939 RPL32 SNORA7A CAND2 PIR41577 GC03M014578 GC03P013041
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAND2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAND2 gene promoter:
  • MRF-2
  • FOXD1
  • deltaCREB
  • CREB
  • c-Jun
  • ATF-2
  • Pax-2
  • Pax-2a
  • RFX1
  • En-1

Genomic Locations for CAND2 Gene

Genomic Locations for CAND2 Gene
75,445 bases
Plus strand
75,445 bases
Plus strand

Genomic View for CAND2 Gene

Genes around CAND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAND2 Gene

Proteins for CAND2 Gene

  • Protein details for CAND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cullin-associated NEDD8-dissociated protein 2
    Protein Accession:
    Secondary Accessions:
    • B9EGM9
    • E9KL24

    Protein attributes for CAND2 Gene

    1236 amino acids
    Molecular mass:
    135256 Da
    Quaternary structure:
    • Binds TBP, CNOT3 and UBE3C.
    • Sequence=AAI36593.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CAND2 Gene


neXtProt entry for CAND2 Gene

Post-translational modifications for CAND2 Gene

Antibody Products

  • Abcam antibodies for CAND2
  • Boster Bio Antibodies for CAND2
  • Santa Cruz Biotechnology (SCBT) Antibodies for CAND2

No data available for DME Specific Peptides for CAND2 Gene

Domains & Families for CAND2 Gene

Gene Families for CAND2 Gene

Protein Domains for CAND2 Gene

Suggested Antigen Peptide Sequences for CAND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CAND family.
  • Belongs to the CAND family.
genes like me logo Genes that share domains with CAND2: view

Function for CAND2 Gene

Molecular function for CAND2 Gene

UniProtKB/Swiss-Prot Function:
Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

Phenotypes From GWAS Catalog for CAND2 Gene

Gene Ontology (GO) - Molecular Function for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12207886
GO:0017025 TBP-class protein binding IEA --
genes like me logo Genes that share ontologies with CAND2: view
genes like me logo Genes that share phenotypes with CAND2: view

Animal Models for CAND2 Gene

MGI Knock Outs for CAND2:
  • Cand2 Cand2<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for CAND2 Gene

miRTarBase miRNAs that target CAND2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAND2 Gene

Localization for CAND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAND2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAND2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 12692129
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with CAND2: view

Pathways & Interactions for CAND2 Gene

SuperPathways for CAND2 Gene

No Data Available

SIGNOR curated interactions for CAND2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010265 SCF complex assembly IBA --
GO:0016567 protein ubiquitination IBA --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with CAND2: view

No data available for Pathways by source for CAND2 Gene

Drugs & Compounds for CAND2 Gene

No Compound Related Data Available

Transcripts for CAND2 Gene

mRNA/cDNA for CAND2 Gene

Unigene Clusters for CAND2 Gene

Cullin-associated and neddylation-dissociated 2 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAND2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP3: -
SP4: - -

Relevant External Links for CAND2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAND2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAND2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAND2 Gene

This gene is overexpressed in Muscle - Skeletal (x17.7).

Protein differential expression in normal tissues from HIPED for CAND2 Gene

This gene is overexpressed in Fetal ovary (9.0), Testis (8.6), and Fetal testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAND2 Gene

Protein tissue co-expression partners for CAND2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAND2 Gene:


SOURCE GeneReport for Unigene cluster for CAND2 Gene:


mRNA Expression by UniProt/SwissProt for CAND2 Gene:

Tissue specificity: Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for CAND2 Gene

  • Nervous system(4.4)
  • Muscle(3)
  • Lung(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CAND2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAND2 Gene

Orthologs for CAND2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAND2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAND2 34 33
  • 99.35 (n)
(Canis familiaris)
Mammalia CAND2 34 33
  • 89.97 (n)
(Bos Taurus)
Mammalia CAND2 34 33
  • 87.46 (n)
(Mus musculus)
Mammalia Cand2 16 34 33
  • 85.86 (n)
(Rattus norvegicus)
Mammalia Cand2 33
  • 85.67 (n)
(Monodelphis domestica)
Mammalia CAND2 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia CAND2 34
  • 47 (a)
(Gallus gallus)
Aves CAND2 34
  • 68 (a)
(Anolis carolinensis)
Reptilia CAND2 34
  • 64 (a)
(Danio rerio)
Actinopterygii cand2 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cand1 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea cand-1 34
  • 33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08875 33
  • 46.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for CAND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAND2 Gene

Gene Tree for CAND2 (if available)
Gene Tree for CAND2 (if available)
Evolutionary constrained regions (ECRs) for CAND2: view image

Paralogs for CAND2 Gene

Paralogs for CAND2 Gene

(1) SIMAP similar genes for CAND2 Gene using alignment to 3 proteins:

  • C9JH00_HUMAN
genes like me logo Genes that share paralogs with CAND2: view

Variants for CAND2 Gene

Sequence variations from dbSNP and Humsavar for CAND2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000253727 -- 12,826,462(+) G/A intron_variant
rs1000300230 -- 12,832,517(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000300696 -- 12,810,689(+) A/G intron_variant
rs1000354316 -- 12,831,670(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000374868 -- 12,794,681(+) TTTTTTTTTTTTTTTTTTTTT/TTTTTTTTT/TTTTTTTTTTTTTTTTTTTT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CAND2 Gene

Variant ID Type Subtype PubMed ID
dgv763e201 CNV deletion 23290073
dgv850e199 CNV deletion 23128226
esv2751977 CNV gain 17911159
esv3893663 CNV gain 25118596
nsv1112379 CNV deletion 24896259
nsv1127940 CNV deletion 24896259
nsv1147269 CNV deletion 26484159
nsv460435 CNV loss 19166990
nsv589714 CNV loss 21841781
nsv589715 CNV loss 21841781
nsv589716 CNV loss 21841781
nsv7351 OTHER inversion 18451855
nsv965144 CNV duplication 23825009

Variation tolerance for CAND2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.43; 97.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAND2 Gene

Disorders for CAND2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAND2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esophageal atresia/tracheoesophageal fistula
  • esophageal atresia with or without tracheoesophageal fistula
- elite association - COSMIC cancer census association via MalaCards
Search CAND2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAND2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CAND2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAND2 Gene

Publications for CAND2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4 58
  3. Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot. (PMID: 19159115) Shyy W … Morcuende JA (Clinical orthopaedics and related research 2009) 3 44 58
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  5. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PMID: 12692129) You J … Pickart CM (The Journal of biological chemistry 2003) 3 22 58

Products for CAND2 Gene

Sources for CAND2 Gene

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