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This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalia... See more...
Aliases for CAND1 Gene
Aliases for CAND1 Gene
External Ids for CAND1 Gene
- HGNC: 30688
- Entrez Gene: 55832
- Ensembl: ENSG00000111530
- OMIM: 607727
- UniProtKB: Q86VP6
Previous GeneCards Identifiers for CAND1 Gene
- GC12P065950
- GC12P067663
- GC12P064713
Summaries for CAND1 Gene
-
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
GeneCards Summary for CAND1 Gene
CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Familial Hypertension. Among its related pathways are Innate Immune System and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.
UniProtKB/Swiss-Prot Summary for CAND1 Gene
-
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAND1 Gene
Genomics for CAND1 Gene
GeneHancer (GH) Regulatory Elements for CAND1 Gene
Promoters and enhancers for CAND1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAND1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAND1
- Top Transcription factor binding sites by QIAGEN in the CAND1 gene promoter:
-
- AML1a
- ATF6
- c-Myb
- CUTL1
- HNF-4alpha1
- HNF-4alpha2
- Ik-3
- Pax-2
- Pax-2a
- Sox5
Genomic Locations for CAND1 Gene
Genomic Locations for CAND1 Gene
- chr12:67,269,281-67,319,953
- (GRCh38/hg38)
- Size:
- 50,673 bases
- Orientation:
- Plus strand
- chr12:67,663,061-67,713,731
- (GRCh37/hg19)
- Size:
- 50,671 bases
- Orientation:
- Plus strand
Genomic View for CAND1 Gene
Genes around CAND1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q14.3-q15 by HGNC
- 12q14.3-q15 by Entrez Gene
- 12q14.3 by Ensembl
CAND1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAND1 Gene
Proteins for CAND1 Gene
-
Protein details for CAND1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86VP6-CAND1_HUMAN
- Recommended name:
- Cullin-associated NEDD8-dissociated protein 1
- Protein Accession:
- Q86VP6
- B2RAU3
- O94918
- Q6PIY4
- Q8NDJ4
- Q96JZ9
- Q96T19
- Q9BTC4
- Q9H0G2
- Q9P0H7
- Q9UF85
Protein attributes for CAND1 Gene
- Size:
- 1230 amino acids
- Molecular mass:
- 136376 Da
- Quaternary structure:
-
- Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with DCUN1D3. Interacts with ERCC6 (PubMed:26030138).
- Miscellaneous:
-
- A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate' deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757).
- SequenceCaution:
-
- Sequence=BAA74852.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB55090.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for CAND1 Gene
Post-translational modifications for CAND1 Gene
Other Protein References for CAND1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-CAND1 monoclonal antibody, clone FQS25353(C)
- Creative Biolabs Recombinant Mouse Anti-Human CAND1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CAND1
- Novus Biologicals Antibodies for CAND1
- Invitrogen Antibodies for CAND1 (AFLGC-CAND1)
-
Boster Bio Antibodies for CAND1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAND1
- Sino Biological Antibodies for CAND1
Protein Products
-
OriGene Purified Proteins for CAND1
- Search Origene for MassSpec and Protein Over-expression Lysates for CAND1
- Origene Custom Protein Services for CAND1
-
Abcam proteins for CAND1
Assay Products
- antibodies-online: Show 7 available CAND1 Elisa Kits ranked by validation data
- Compare Top CAND1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CAND1 Gene
Domains & Families for CAND1 Gene
Gene Families for CAND1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CAND1 Gene
- Blocks:
-
- HEAT repeat
- TATA-binding protein interacting (TIP20)
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CAND1 Gene
- GenScript: Design optimal peptide antigens:
-
- p120 CAND1 (CAND1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86VP6- Family:
-
- Belongs to the CAND family.
Function for CAND1 Gene
Molecular function for CAND1 Gene
- UniProtKB/Swiss-Prot Function:
- Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
- UniProtKB/Swiss-Prot Induction:
- Repressed by miR-148a.
Phenotypes From GWAS Catalog for CAND1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12504025 |
| GO:0017025 | TBP-class protein binding | IEA | -- |
Phenotypes for CAND1 Gene
- MGI mutant phenotypes for CAND1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CAND1:
-
- Increased transcriptional activity
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAND1 - Select products 50% OFF >
- * CAND1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CAND1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CAND1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAND1
- genomics-online: gRNA clones - Search for available CAND1 gRNA products
- Overview of 108 available CAND1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAND1
miRNA for CAND1 Gene
- miRTarBase miRNAs that target CAND1
-
- hsa-mir-1-3p (MIRT001378)
- hsa-mir-1301-3p (MIRT036016)
- hsa-mir-1296-5p (MIRT036143)
- hsa-mir-425-5p (MIRT039318)
- hsa-mir-195-5p (MIRT044866)
- hsa-mir-186-5p (MIRT045132)
- hsa-mir-1185-1-3p (MIRT441018)
- hsa-mir-136-3p (MIRT441019)
- hsa-mir-539-3p (MIRT441020)
- hsa-mir-1185-2-3p (MIRT441021)
- hsa-mir-580-3p (MIRT444098)
- hsa-mir-215-5p (MIRT444099)
- hsa-mir-192-5p (MIRT444100)
- hsa-mir-6770-5p (MIRT444101)
- hsa-mir-1253 (MIRT444102)
- hsa-mir-6759-3p (MIRT444103)
- hsa-mir-3910 (MIRT444104)
- hsa-mir-548an (MIRT444105)
- hsa-mir-1304-5p (MIRT480048)
- hsa-mir-7856-5p (MIRT480049)
- hsa-mir-4477b (MIRT480050)
- hsa-mir-7151-3p (MIRT480051)
- hsa-mir-6077 (MIRT480052)
- hsa-mir-5095 (MIRT480053)
- hsa-mir-3975 (MIRT480054)
- hsa-mir-548v (MIRT480055)
- hsa-mir-3670 (MIRT480056)
- hsa-mir-3663-3p (MIRT480057)
- hsa-mir-4302 (MIRT480058)
- hsa-mir-4719 (MIRT480059)
- hsa-mir-556-5p (MIRT480060)
- hsa-mir-4700-3p (MIRT480061)
- hsa-mir-590-3p (MIRT480062)
- hsa-mir-651-3p (MIRT480063)
- hsa-mir-1252-3p (MIRT480064)
- hsa-mir-29c-3p (MIRT480065)
- hsa-mir-29b-3p (MIRT480066)
- hsa-mir-29a-3p (MIRT480067)
- hsa-mir-139-5p (MIRT480068)
- hsa-mir-203a-3p (MIRT480069)
- hsa-mir-557 (MIRT503014)
- hsa-mir-507 (MIRT503015)
- hsa-mir-511-5p (MIRT503016)
- hsa-mir-4266 (MIRT503017)
- hsa-mir-6830-3p (MIRT503018)
- hsa-mir-7157-5p (MIRT503019)
- hsa-mir-4310 (MIRT503020)
- hsa-mir-4307 (MIRT503021)
- hsa-mir-6888-5p (MIRT503022)
- hsa-mir-7844-5p (MIRT503023)
- hsa-mir-30c-5p (MIRT503024)
- hsa-mir-30d-5p (MIRT503025)
- hsa-mir-30b-5p (MIRT503026)
- hsa-mir-30e-5p (MIRT503027)
- hsa-mir-30a-5p (MIRT503028)
- hsa-mir-6739-3p (MIRT669212)
- hsa-mir-374a-3p (MIRT669213)
- hsa-mir-4677-5p (MIRT669214)
- hsa-mir-7156-5p (MIRT669215)
- hsa-mir-4273 (MIRT669216)
- hsa-mir-6878-3p (MIRT669217)
- hsa-mir-22-5p (MIRT669218)
- hsa-mir-2116-5p (MIRT669219)
- hsa-mir-6744-3p (MIRT669220)
- hsa-mir-4312 (MIRT669221)
- hsa-mir-4757-5p (MIRT669222)
- hsa-mir-212-5p (MIRT669223)
- hsa-mir-487a-3p (MIRT669224)
- hsa-mir-154-3p (MIRT669225)
- hsa-mir-1247-3p (MIRT761521)
- hsa-mir-1827 (MIRT763024)
- hsa-mir-1910-3p (MIRT763269)
- hsa-mir-2467-3p (MIRT764072)
- hsa-mir-3612 (MIRT765891)
- hsa-mir-377-5p (MIRT767365)
- hsa-mir-4257 (MIRT768110)
- hsa-mir-4537 (MIRT770132)
- hsa-mir-455-3p (MIRT770281)
- hsa-mir-6086 (MIRT775496)
- hsa-mir-6499-3p (MIRT776215)
- hsa-mir-650 (MIRT776649)
- hsa-mir-6511a-5p (MIRT776767)
- hsa-mir-6516-5p (MIRT777078)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAND1
- Browse OriGene Inhibitory RNA Products For CAND1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAND1
- genomics-online: shRNA clones - Search for available CAND1 shRNA products
- Overview of 108 available CAND1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CAND1 - Select products 50% OFF >
- * CAND1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CAND1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for CAND1
- Addgene plasmids for CAND1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAND1
- genomics-online: cdna clones - Search for available CAND1 CDNA products
- Overview of 108 available CAND1 gene related products
- orf clones - Search for available CAND1 ORF products
- Overview of 108 available CAND1 gene related products
Cell Line Products
-
Horizon Cell Lines for CAND1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAND1 Gene
Localization for CAND1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAND1 Gene
- Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (4)
- Golgi apparatus (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 12609982 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IBA,IDA | 10581176 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
Pathways & Interactions for CAND1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Mesodermal Commitment Pathway | ||
Pathways by source for CAND1 Gene
1 BioSystems pathway for CAND1 Gene
3 Reactome pathways for CAND1 Gene
Interacting Proteins for CAND1 Gene
Selected Interacting proteins:
Q86VP6-CAND1_HUMAN
ENSP00000442318
for CAND1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CAND1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006879 | cellular iron ion homeostasis | TAS | -- |
| GO:0010265 | SCF complex assembly | IDA,IEA | 15537541 |
| GO:0016567 | protein ubiquitination | IDA,IBA | 12609982 |
| GO:0030154 | cell differentiation | IDA | 10581176 |
| GO:0043086 | negative regulation of catalytic activity | IDA | 12609982 |
No data available for SIGNOR curated interactions for CAND1 Gene
Transcripts for CAND1 Gene
mRNA/cDNA for CAND1 Gene
- 4 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000535146 560 bps (ENST00000535146.1)
- ENST00000539109 433 bps (ENST00000539109.1)
- ENST00000539434 772 bps (ENST00000539434.1)
- ENST00000540319 2786 bps (ENST00000540319.5)
- ENST00000540525 527 bps (ENST00000540525.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAND1 - Select products 50% OFF >
- * CAND1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CAND1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CAND1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAND1
- genomics-online: gRNA clones - Search for available CAND1 gRNA products
- Overview of 108 available CAND1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAND1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAND1
- Browse OriGene Inhibitory RNA Products For CAND1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAND1
- genomics-online: shRNA clones - Search for available CAND1 shRNA products
- Overview of 108 available CAND1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CAND1 - Select products 50% OFF >
- * CAND1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CAND1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for CAND1
- Addgene plasmids for CAND1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAND1
- genomics-online: cdna clones - Search for available CAND1 CDNA products
- Overview of 108 available CAND1 gene related products
- orf clones - Search for available CAND1 ORF products
- Overview of 108 available CAND1 gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for CAND1 Gene
- GeneLoc Exon Structure for
- CAND1
Expression for CAND1 Gene
This gene is overexpressed in Bone (14.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAND1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAND1
SOURCE GeneReport for Unigene cluster for CAND1 Gene:
Hs.546407Evidence on tissue expression from TISSUES for CAND1 Gene
- Nervous system(4.9)
- Liver(4.4)
- Adrenal gland(4.3)
- Heart(2.4)
Primer Products
-
OriGene qPCR primer pairs for CAND1
-
OriGene qPCR primer pairs and template standards for CAND1
- genomics-online: primer clones - Search for available CAND1 Primer products
- Overview of 108 available CAND1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAND1 Gene
Orthologs for CAND1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAND1 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CAND1 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAND1 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CAND1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CAND1 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cand1 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Cand1 17 31 30 |
|
||
| chicken (Gallus gallus) |
Aves | CAND1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CAND1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cand1 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cand1 31 30 |
|
OneToOne | |
| wufa93g07 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009970 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cand1 31 30 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cand-1 31 30 |
|
OneToMany | |
| corn (Zea mays) |
Liliopsida | Zm.6443 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for CAND1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CAND1 Gene
- ENSEMBL:
- Gene Tree for CAND1 (if available)
- TreeFam:
- Gene Tree for CAND1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAND1: view image
Paralogs for CAND1 Gene
Variants for CAND1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAND1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921038 | Uncertain Significance: Malignant tumor of prostate | 67,297,652(+) | G/A | MISSENSE_VARIANT | |
| rs12580996 | - | p.Val803Ala | |||
| rs17854618 | - | p.Ala952Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv857e59 | CNV | tandem duplication | 20981092 |
| esv3341682 | CNV | duplication | 20981092 |
| esv3407176 | CNV | duplication | 20981092 |
| esv3580303 | CNV | loss | 25503493 |
| esv3629822 | CNV | loss | 21293372 |
| esv3629823 | CNV | loss | 21293372 |
| esv3629825 | CNV | loss | 21293372 |
| esv8315 | CNV | gain | 19470904 |
| nsv1054111 | CNV | gain | 25217958 |
| nsv1142141 | CNV | tandem duplication | 24896259 |
| nsv1152456 | CNV | insertion | 26484159 |
| nsv525023 | CNV | loss | 19592680 |
| nsv559212 | CNV | gain | 21841781 |
| nsv756 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
2.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.67;
31.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAND1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAND1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAND1 Gene
Disorders for CAND1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial hypertension |
|
|
Search CAND1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAND1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CAND1 Gene
Publications for CAND1 Gene
- TIP120A associates with cullins and modulates ubiquitin ligase activity. (PMID: 12609982) Min KW … Yoon JB (The Journal of biological chemistry 2003) 3 4 23 54
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
- Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. (PMID: 26030138) Nicolai S … Proietti-De-Santis L (PloS one 2015) 3 4 54
- SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). (PMID: 25349211) Huang G … Singh B (The Journal of biological chemistry 2014) 3 4 54
- Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PMID: 23453757) Pierce NW … Deshaies RJ (Cell 2013) 3 4 54
ExternalLinks
Products for CAND1 Gene
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Sources for CAND1 Gene
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