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This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Familial Hypertension. Among its related pathways are Innate Immune System and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12504025 |
GO:0017025 | TBP-class protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | IDA | 12609982 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA,IDA | 10581176 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Mesodermal Commitment Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006879 | cellular iron ion homeostasis | TAS | -- |
GO:0010265 | SCF complex assembly | IEA,IDA | 15537541 |
GO:0016567 | protein ubiquitination | IBA,IDA | 12609982 |
GO:0030154 | cell differentiation | IDA | 10581176 |
GO:0043086 | negative regulation of catalytic activity | IDA | 12609982 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CAND1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CAND1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CAND1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CAND1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CAND1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cand1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cand1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CAND1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CAND1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cand1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cand1 30 31 |
|
OneToOne | |
wufa93g07 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009970 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cand1 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cand-1 30 31 |
|
OneToMany | |
Corn (Zea mays) |
Liliopsida | Zm.6443 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193921038 | Uncertain Significance: Malignant tumor of prostate | 67,297,652(+) | G/A | MISSENSE_VARIANT | |
rs12580996 | - | p.Val803Ala | |||
rs17854618 | - | p.Ala952Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv857e59 | CNV | tandem duplication | 20981092 |
esv3341682 | CNV | duplication | 20981092 |
esv3407176 | CNV | duplication | 20981092 |
esv3580303 | CNV | loss | 25503493 |
esv3629822 | CNV | loss | 21293372 |
esv3629823 | CNV | loss | 21293372 |
esv3629825 | CNV | loss | 21293372 |
esv8315 | CNV | gain | 19470904 |
nsv1054111 | CNV | gain | 25217958 |
nsv1142141 | CNV | tandem duplication | 24896259 |
nsv1152456 | CNV | insertion | 26484159 |
nsv525023 | CNV | loss | 19592680 |
nsv559212 | CNV | gain | 21841781 |
nsv756 | CNV | deletion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial hypertension |
|
|