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This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
CAMP (Cathelicidin Antimicrobial Peptide) is a Protein Coding gene. Diseases associated with CAMP include Rosacea and Eczema Herpeticum. Among its related pathways are Tuberculosis and Sterol Regulatory Element-Binding Proteins (SREBP) signalling.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001530 | lipopolysaccharide binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 12759353 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0035580 | specific granule lumen | TAS | -- |
GO:0042581 | specific granule | IEA,IDA | 12759353 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | NOD-like receptor signaling pathway | ||
3 | Salivary secretion | ||
4 | Staphylococcus aureus infection | ||
5 | Tuberculosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
GO:0006952 | defense response | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | IEA | -- |
GO:0019730 | antimicrobial humoral response | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
6-Bnz-cAMP sodium salt | cAMP analog,PKA activator | 1135306-29-4 |
8-Bromo-cAMP, sodium salt | cAMP-analogue | 76939-46-3 |
cAMPS-Rp, triethylammonium salt | 151837-09-1 | |
cAMPS-Sp, triethylammonium salt | ||
Dibutyryl-cAMP, sodium salt | 16980-89-5 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CAMP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CATHL5 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
CATHL7 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
CATHL4 31 |
|
OneToMany | |||
CATHL6 31 |
|
OneToMany | |||
CATHL1 31 31 |
|
OneToMany | |||
CATHL2 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
CATHL3 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | CAMP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Camp 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Camp 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | CAMP 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
rosacea |
|
|
eczema herpeticum |
|
|
cellulitis |
|
|
mycobacterium marinum |
|
|
guttate psoriasis |
|
|