This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functi... See more...

Aliases for CAMP Gene

Aliases for CAMP Gene

  • Cathelicidin Antimicrobial Peptide 2 3 4 5
  • FALL39 2 3 4
  • CAP18 2 3 4
  • 18 KDa Cationic Antimicrobial Protein 3 4
  • FALL-39 2 3
  • CAP-18 3 4
  • LL37 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • HCAP-18 4
  • CRAMP 3
  • HSD26 3
  • CAMP 5

External Ids for CAMP Gene

Previous GeneCards Identifiers for CAMP Gene

  • GC03P048066
  • GC03P047547
  • GC03P048225
  • GC03P048240
  • GC03P048264
  • GC03P048227
  • GC03P048229
  • GC03P048250

Summaries for CAMP Gene

Entrez Gene Summary for CAMP Gene

  • This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CAMP Gene

CAMP (Cathelicidin Antimicrobial Peptide) is a Protein Coding gene. Diseases associated with CAMP include Rosacea and Eczema Herpeticum. Among its related pathways are Tuberculosis and Sterol Regulatory Element-Binding Proteins (SREBP) signalling.

UniProtKB/Swiss-Prot Summary for CAMP Gene

  • Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

Gene Wiki entry for CAMP Gene

Additional gene information for CAMP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAMP Gene

Genomics for CAMP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAMP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J048215 Enhancer 0.9 Ensembl ENCODE 600.7 -1.9 -1946 15.2 CEBPG GATAD2A ZIC2 TCF12 IKZF2 CEBPA SCRT2 EED CEBPB ARID3A CAMP piR-48493 ZNF589 ATRIP CDC25A NDUFB1P1 RNU7-128P NME6 TMA7 CCDC51
GH03J048038 Enhancer 1.1 Ensembl ENCODE 10.3 -182.9 -182947 6 GATAD2A ATF7 PRDM10 ZNF629 IKZF1 ZNF300 PRDM1 RBFOX2 PATZ1 IRF2 ENSG00000270285 lnc-CAMP-3 ZNF589 DHX30 BOLA2P2 FCF1P2 ENSG00000235236 SETD2 RNU7-128P NDUFB1P1
GH03J048267 Enhancer 0.8 Ensembl ENCODE 11 +45.2 45200 3.5 POLR2A PAX8 BCL11A NBN ZFHX2 KLF9 ELF1 TBX21 FOS ATF7 piR-54294 ZNF589 WDR6 FBXW12 PLXNB1 CDC25A NME6 SPINK8 CAMP ATRIP
GH03J048273 Enhancer 0.8 Ensembl ENCODE 10.5 +50.5 50506 0.6 CTCF ZNF143 REST RAD21 TRIM22 ZBTB48 SMC3 DEK ZNF207 ZNF654 NME6 ZNF589 PLXNB1 TMA7 ATRIP CCDC51 FBXW12 SPINK8 CAMP CDC25A
GH03J048247 Enhancer 0.5 ENCODE 11.2 +24.7 24736 2 IKZF1 SOX6 SPI1 PRDM10 NFE2 MAFF ARID1B MLLT1 CAMP NME6 CDC25A FBXW12 TMA7 ATRIP CCDC51 NDUFB1P1 RNU7-128P SPINK8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAMP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAMP

Top Transcription factor binding sites by QIAGEN in the CAMP gene promoter:
  • CREB
  • deltaCREB
  • E2F
  • E2F-3a
  • STAT3

Genomic Locations for CAMP Gene

Genomic Locations for CAMP Gene
chr3:48,223,347-48,225,491
(GRCh38/hg38)
Size:
2,145 bases
Orientation:
Plus strand
chr3:48,264,837-48,266,981
(GRCh37/hg19)
Size:
2,145 bases
Orientation:
Plus strand

Genomic View for CAMP Gene

Genes around CAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMP Gene

Proteins for CAMP Gene

  • Protein details for CAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49913-CAMP_HUMAN
    Recommended name:
    Cathelicidin antimicrobial peptide
    Protein Accession:
    P49913
    Secondary Accessions:
    • Q71SN9

    Protein attributes for CAMP Gene

    Size:
    170 amino acids
    Molecular mass:
    19301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAMP Gene

neXtProt entry for CAMP Gene

Post-translational modifications for CAMP Gene

Other Protein References for CAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMP Gene

Domains & Families for CAMP Gene

Gene Families for CAMP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CAMP Gene

InterPro:
Blocks:
  • Cathelicidin
ProtoNet:

Suggested Antigen Peptide Sequences for CAMP Gene

GenScript: Design optimal peptide antigens:
  • 18 kDa cationic antimicrobial protein (CAMP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49913

UniProtKB/Swiss-Prot:

CAMP_HUMAN :
  • Belongs to the cathelicidin family.
Family:
  • Belongs to the cathelicidin family.
genes like me logo Genes that share domains with CAMP: view

Function for CAMP Gene

Molecular function for CAMP Gene

UniProtKB/Swiss-Prot Function:
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
GENATLAS Biochemistry:
cathelicidin cationic antimicrobial peptide,cathelin family,expressed in the specific granules of neutrophils,also expressed in bone marrow and testis

Phenotypes From GWAS Catalog for CAMP Gene

Gene Ontology (GO) - Molecular Function for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IBA 21873635
genes like me logo Genes that share ontologies with CAMP: view
genes like me logo Genes that share phenotypes with CAMP: view

Animal Models for CAMP Gene

MGI Knock Outs for CAMP:
  • Camp Camp<tm1.1Jimw>
  • Camp Camp<tm1Rlg>

Animal Model Products

CRISPR Products

miRNA for CAMP Gene

miRTarBase miRNAs that target CAMP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMP Gene

Localization for CAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMP gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 12759353
GO:0005737 cytoplasm IEA --
GO:0035580 specific granule lumen TAS --
GO:0042581 specific granule IEA,IDA 12759353
genes like me logo Genes that share ontologies with CAMP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAMP Gene

Pathways & Interactions for CAMP Gene

genes like me logo Genes that share pathways with CAMP: view

SIGNOR curated interactions for CAMP Gene

Activates:

Gene Ontology (GO) - Biological Process for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006952 defense response IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0019730 antimicrobial humoral response TAS --
genes like me logo Genes that share ontologies with CAMP: view

Drugs & Compounds for CAMP Gene

(47) Drugs for CAMP Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitoxantrone Approved, Investigational Pharma 299
Prednisone Approved, Vet_approved Pharma 1738
Selenocysteine Experimental Pharma Target 0
Analgesics Pharma 13606
Anti-Inflammatory Agents Pharma 12267

(34) Additional Compounds for CAMP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for CAMP Gene

Compound Action Cas Number
6-Bnz-cAMP sodium salt cAMP analog,PKA activator 1135306-29-4
8-Bromo-cAMP, sodium salt cAMP-analogue 76939-46-3
cAMPS-Rp, triethylammonium salt 151837-09-1
cAMPS-Sp, triethylammonium salt
Dibutyryl-cAMP, sodium salt 16980-89-5
genes like me logo Genes that share compounds with CAMP: view

Drug Products

Transcripts for CAMP Gene

mRNA/cDNA for CAMP Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMP

Alternative Splicing Database (ASD) splice patterns (SP) for CAMP Gene

No ASD Table

Relevant External Links for CAMP Gene

GeneLoc Exon Structure for
CAMP

Expression for CAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMP Gene

This gene is overexpressed in Whole Blood (x45.6).

Protein differential expression in normal tissues from HIPED for CAMP Gene

This gene is overexpressed in Nasal epithelium (25.5), Neutrophil (12.7), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAMP Gene



Protein tissue co-expression partners for CAMP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAMP

SOURCE GeneReport for Unigene cluster for CAMP Gene:

Hs.51120

mRNA Expression by UniProt/SwissProt for CAMP Gene:

P49913-CAMP_HUMAN
Tissue specificity: Expressed in bone marrow and testis and neutrophils.

Evidence on tissue expression from TISSUES for CAMP Gene

  • Bone marrow(4.8)
  • Blood(3.8)
  • Lung(3.5)
  • Spleen(3.3)
  • Lymph node(2.9)
  • Intestine(2.8)
  • Skin(2.8)
  • Heart(2.6)
  • Nervous system(2.4)
  • Kidney(2.4)
  • Liver(2.4)
  • Saliva(2.4)
  • Muscle(2.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with CAMP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMP Gene

Orthologs for CAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAMP 30 31
  • 99.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CATHL5 30 31
  • 78.12 (n)
OneToMany
-- 31
  • 60 (a)
OneToMany
CATHL7 31
  • 59 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
CATHL4 31
  • 57 (a)
OneToMany
CATHL6 31
  • 56 (a)
OneToMany
CATHL1 31 31
  • 54 (a)
OneToMany
CATHL2 31
  • 49 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
CATHL3 31
  • 45 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CAMP 30 31
  • 76.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Camp 30
  • 72.62 (n)
Mouse
(Mus musculus)
Mammalia Camp 30 17 31
  • 70.48 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
OneToMany
-- 31
  • 34 (a)
OneToMany
-- 31
  • 28 (a)
OneToMany
-- 31
  • 26 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 32 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
-- 31
  • 22 (a)
OneToMany
-- 31
  • 20 (a)
OneToMany
-- 31
  • 9 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia CAMP 31
  • 25 (a)
OneToOne
Species where no ortholog for CAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CAMP Gene

ENSEMBL:
Gene Tree for CAMP (if available)
TreeFam:
Gene Tree for CAMP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAMP: view image

Paralogs for CAMP Gene

No data available for Paralogs for CAMP Gene

Variants for CAMP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAMP Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
708654 Benign: not provided 48,224,434(+) A/G SYNONYMOUS_VARIANT
733963 Benign: not provided 48,225,345(+) A/G MISSENSE_VARIANT
756687 Likely Benign: not provided 48,224,637(+) ACCAGGCC/A FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for CAMP Gene

Structural Variations from Database of Genomic Variants (DGV) for CAMP Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV gain 17160897

Variation tolerance for CAMP Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMP Gene

Human Gene Mutation Database (HGMD)
CAMP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMP Gene

Disorders for CAMP Gene

MalaCards: The human disease database

(35) MalaCards diseases for CAMP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rosacea
  • acne roscea
eczema herpeticum
  • herpes simplex dermatitis
cellulitis
mycobacterium marinum
  • fish tank granuloma
guttate psoriasis
  • psoriasis guttate
- elite association - COSMIC cancer census association via MalaCards
Search CAMP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAMP

genes like me logo Genes that share disorders with CAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMP Gene

Publications for CAMP Gene

  1. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. (PMID: 7890387) Larrick JW … Wright SC (Infection and immunity 1995) 3 4 23
  2. Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. (PMID: 19645825) Mallbris L … Ståhle M (Experimental dermatology 2010) 3 23
  3. LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells. (PMID: 20042575) Hurtado P … Peh CA (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 23
  4. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. (PMID: 20190140) Niyonsaba F … Okumura K (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 23
  5. Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils. (PMID: 19750480) Zhang Z … Shively JE (European journal of immunology 2009) 3 23

Products for CAMP Gene

Sources for CAMP Gene