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This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functi... See more...
Aliases for CAMP Gene
Aliases for CAMP Gene
External Ids for CAMP Gene
- HGNC: 1472
- Entrez Gene: 820
- Ensembl: ENSG00000164047
- OMIM: 600474
- UniProtKB: P49913
Previous GeneCards Identifiers for CAMP Gene
- GC03P048066
- GC03P047547
- GC03P048225
- GC03P048240
- GC03P048264
- GC03P048227
- GC03P048229
- GC03P048250
Summaries for CAMP Gene
-
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
GeneCards Summary for CAMP Gene
CAMP (Cathelicidin Antimicrobial Peptide) is a Protein Coding gene. Diseases associated with CAMP include Rosacea and Eczema Herpeticum. Among its related pathways are Tuberculosis and Sterol Regulatory Element-Binding Proteins (SREBP) signalling.
UniProtKB/Swiss-Prot Summary for CAMP Gene
-
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
Additional gene information for CAMP Gene
- HGNC(1472)
- Entrez Gene(820)
- Ensembl(ENSG00000164047)
- OMIM(600474)
- UniProtKB(P49913)
- Open Targets Platform(ENSG00000164047)
- Search for CAMP at DataMed
- Search for CAMP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAMP Gene
Genomics for CAMP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CAMP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAMP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAMP
- Top Transcription factor binding sites by QIAGEN in the CAMP gene promoter:
-
- CREB
- deltaCREB
- E2F
- E2F-3a
- STAT3
Genomic Locations for CAMP Gene
Genomic Locations for CAMP Gene
- chr3:48,223,347-48,225,491
- (GRCh38/hg38)
- Size:
- 2,145 bases
- Orientation:
- Plus strand
- chr3:48,264,837-48,266,981
- (GRCh37/hg19)
- Size:
- 2,145 bases
- Orientation:
- Plus strand
Genomic View for CAMP Gene
Genes around CAMP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by HGNC
- 3p21.31 by Entrez Gene
- 3p21.31 by Ensembl
CAMP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMP Gene
Proteins for CAMP Gene
-
Protein details for CAMP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49913-CAMP_HUMAN
- Recommended name:
- Cathelicidin antimicrobial peptide
- Protein Accession:
- P49913
- Q71SN9
Protein attributes for CAMP Gene
- Size:
- 170 amino acids
- Molecular mass:
- 19301 Da
- Quaternary structure:
- No Data Available
Protein Expression for CAMP Gene
Post-translational modifications for CAMP Gene
- The N-terminus is blocked.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAMP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Cathelicidin Antibody and Immunotag™ CAMP Antibody
- BioLegend CAP-18 Antibody
- Novus Biologicals Antibodies for CAMP
-
Abcam antibodies for CAMP
- Invitrogen Antibodies for CAMP (AFLGC-CAMP)
-
Boster Bio Antibodies for CAMP
-
Custom Antibody ServicesProSci Antibodies for CAMP
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMP
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMP
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- ProSpec Recombinant Proteins for CAMP
-
Abcam proteins for CAMP
Assay Products
- antibodies-online: Show 39 available Cathelicidin Elisa Kits ranked by validation data
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-
Quality Products:
- ABIN2014337
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- ABIN2542568
- ABIN6199563
- ABIN6202297
- ABIN425615
- ABIN2851011
- ABIN4947438
- ABIN627620
- ABIN5652686
- ABIN2542569
- ABIN6199564
- ABIN6202298
- ABIN2043085
- ABIN5074221
- ABIN4947437
- ABIN626798
- ABIN432798
- ABIN5652684
- ABIN6199566
- ABIN6202299
- ABIN6199565
-
Signalway ELISA kits for CAMP
No data available for DME Specific Peptides for CAMP Gene
Domains & Families for CAMP Gene
Gene Families for CAMP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for CAMP Gene
- InterPro:
- Blocks:
-
- Cathelicidin
- ProtoNet:
Suggested Antigen Peptide Sequences for CAMP Gene
- GenScript: Design optimal peptide antigens:
-
- 18 kDa cationic antimicrobial protein (CAMP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P49913- Family:
-
- Belongs to the cathelicidin family.
Function for CAMP Gene
Molecular function for CAMP Gene
- UniProtKB/Swiss-Prot Function:
- Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
- GENATLAS Biochemistry:
- cathelicidin cationic antimicrobial peptide,cathelin family,expressed in the specific granules of neutrophils,also expressed in bone marrow and testis
Phenotypes From GWAS Catalog for CAMP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IBA | 21873635 |
Phenotypes for CAMP Gene
- MGI mutant phenotypes for CAMP:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CAMP:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased IL-8 secretion
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased NF-kappaB reporter expression
- Decreased Sindbis virus (SINV) infection
- Decreased viability after Maraba virus infection
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Increased homologous recombination repair frequency
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAMP - Select products 50% OFF >
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-
OriGene CRISPR knockouts for CAMP
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMP
miRNA for CAMP Gene
- miRTarBase miRNAs that target CAMP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAMP
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Clone Products
- Applied Biological Materials (abm): Clones for CAMP - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for CAMP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAMP
Cell Line Products
-
Horizon Cell Lines for CAMP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMP Gene
Localization for CAMP Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 12759353 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0035580 | specific granule lumen | TAS | -- |
| GO:0042581 | specific granule | IEA,IDA | 12759353 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAMP Gene
Pathways & Interactions for CAMP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | NOD-like receptor signaling pathway | ||
| 3 | Salivary secretion | ||
| 4 | Staphylococcus aureus infection | ||
| 5 | Tuberculosis | ||
Pathways by source for CAMP Gene
1 BioSystems pathway for CAMP Gene
4 Reactome pathways for CAMP Gene
4 KEGG pathways for CAMP Gene
Interacting Proteins for CAMP Gene
Selected Interacting proteins:
P49913-CAMP_HUMAN
ENSP00000296435
for CAMP Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CAMP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
| GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
| GO:0006952 | defense response | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0019730 | antimicrobial humoral response | TAS | -- |
Drugs & Compounds for CAMP Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) ApexBio Compounds for CAMP Gene
| Compound | Action | Cas Number |
|---|---|---|
| 6-Bnz-cAMP sodium salt | cAMP analog,PKA activator | 1135306-29-4 |
| 8-Bromo-cAMP, sodium salt | cAMP-analogue | 76939-46-3 |
| cAMPS-Rp, triethylammonium salt | 151837-09-1 | |
| cAMPS-Sp, triethylammonium salt | ||
| Dibutyryl-cAMP, sodium salt | 16980-89-5 |
Transcripts for CAMP Gene
mRNA/cDNA for CAMP Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000652295 591 nts (view in UCSC)
- ENST00000296435 745 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAMP - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CAMP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAMP
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAMP
- Browse OriGene Inhibitory RNA Products For CAMP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMP
Clone Products
- Applied Biological Materials (abm): Clones for CAMP - Select products 50% OFF >
- * CAMP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for CAMP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAMP
Relevant External Links for CAMP Gene
- GeneLoc Exon Structure for
- CAMP
Expression for CAMP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Bone Marrow CD105+ Cells
- neutrophils
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Granulosa Cells Primary Follicle
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for CAMP Gene
This gene is overexpressed in Whole Blood (x45.6).
This gene is overexpressed in Nasal epithelium (25.5), Neutrophil (12.7), and Blymphocyte (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAMP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAMP
SOURCE GeneReport for Unigene cluster for CAMP Gene:
Hs.51120mRNA Expression by UniProt/SwissProt for CAMP Gene:
P49913-CAMP_HUMAN
Tissue specificity:
Expressed in bone marrow and testis and neutrophils.
Evidence on tissue expression from TISSUES for CAMP Gene
- Bone marrow(4.8)
- Blood(3.8)
- Lung(3.5)
- Spleen(3.3)
- Lymph node(2.9)
- Intestine(2.8)
- Skin(2.8)
- Heart(2.6)
- Nervous system(2.4)
- Kidney(2.4)
- Liver(2.4)
- Saliva(2.4)
- Muscle(2.3)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for CAMP
-
OriGene qPCR primer pairs and template standards for CAMP
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMP Gene
Orthologs for CAMP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CAMP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CATHL5 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| CATHL7 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| CATHL4 31 |
|
OneToMany | |||
| CATHL6 31 |
|
OneToMany | |||
| CATHL1 31 31 |
|
OneToMany | |||
| CATHL2 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| CATHL3 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | CAMP 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Camp 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Camp 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | CAMP 31 |
|
OneToOne |
- Species where no ortholog for CAMP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CAMP Gene
- ENSEMBL:
- Gene Tree for CAMP (if available)
- TreeFam:
- Gene Tree for CAMP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAMP: view image
Paralogs for CAMP Gene
No data available for Paralogs for CAMP Gene
Variants for CAMP Gene
Residual Variation Intolerance Score:
76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.21;
24.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAMP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMP Gene
Disorders for CAMP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rosacea |
|
|
| eczema herpeticum |
|
|
| cellulitis |
|
|
| mycobacterium marinum |
|
|
| guttate psoriasis |
|
|
Search CAMP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAMP
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CAMP Gene
Publications for CAMP Gene
- Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. (PMID: 7890387) Larrick JW … Wright SC (Infection and immunity 1995) 3 4 23
- Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. (PMID: 19645825) Mallbris L … Ståhle M (Experimental dermatology 2010) 3 23
- LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells. (PMID: 20042575) Hurtado P … Peh CA (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 23
- Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. (PMID: 20190140) Niyonsaba F … Okumura K (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 23
- Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils. (PMID: 19750480) Zhang Z … Shively JE (European journal of immunology 2009) 3 23
ExternalLinks
Products for CAMP Gene
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- VectorBuilder Custom and pre-made DNA vectors for CAMP (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 101 available Cathelicidin Antibodies ranked by validation data
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- antibodies-online: Show 39 available Cathelicidin Elisa Kits ranked by validation data
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- Quality Products:
- ABIN2014337
- ABIN829509
- ABIN1028474
- ABIN509887
- ABIN1114012
- ABIN5652682
- ABIN5652685
- ABIN2542568
- ABIN6199563
- ABIN6202297
- ABIN425615
- ABIN2851011
- ABIN4947438
- ABIN627620
- ABIN5652686
- ABIN2542569
- ABIN6199564
- ABIN6202298
- ABIN2043085
- ABIN5074221
- ABIN4947437
- ABIN626798
- ABIN432798
- ABIN5652684
- ABIN6199566
- ABIN6202299
- ABIN6199565
- antibodies-online: Show 7 available Cathelicidin Proteins ranked by validation data
- Compare Top Cathelicidin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CAMP
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- Search for CAMP Proteins at ProSci
- Horizon Cell Lines for CAMP
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- Boster Bio Antibodies for CAMP
- Browse Boster Bio ELISA Kits
Sources for CAMP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
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