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Aliases for CAMLG Gene

Aliases for CAMLG Gene

  • Calcium Modulating Ligand 2 3 5
  • Calcium-Modulating Cyclophilin Ligand 2 3
  • Cyclophilin B-Binding Protein 2 3
  • CAML 3 4
  • Calcium Signal-Modulating Cyclophilin Ligand 3
  • Calcium-Signal Modulating Cyclophilin Ligand 2
  • GET2 3

External Ids for CAMLG Gene

Previous GeneCards Identifiers for CAMLG Gene

  • GC05P133724
  • GC05P134588
  • GC05P134106
  • GC05P134150
  • GC05P134102
  • GC05P134074
  • GC05P129260

Summaries for CAMLG Gene

Entrez Gene Summary for CAMLG Gene

  • The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMLG Gene

CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Diseases associated with CAMLG include Cogan-Reese Syndrome. Among its related pathways are RANK Signaling in Osteoclasts and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding.

UniProtKB/Swiss-Prot for CAMLG Gene

  • Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

Gene Wiki entry for CAMLG Gene

Additional gene information for CAMLG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMLG Gene

Genomics for CAMLG Gene

GeneHancer (GH) Regulatory Elements for CAMLG Gene

Promoters and enhancers for CAMLG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J134737 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.8 774 3.3 CLOCK MLX ZFP64 YBX1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 CAMLG DDX46 C5orf66-AS1 ENSG00000270021 GC05M134654
GH05J134738 Enhancer 0.4 Ensembl 650.7 -1.2 -1226 0.2 ZNF18 SPI1 CAMLG GC05M134725 GC05M134654
GH05J134736 Enhancer 0.3 ENCODE 650.7 -1.0 -1048 0 ZNF18 CAMLG GC05M134725 GC05M134654
GH05J134739 Enhancer 0.2 Ensembl 650.7 -1.6 -1626 0.2 CAMLG GC05M134725 GC05M134654
GH05J134844 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.7 +108.7 108696 3.5 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF207 C5orf24 DDX46 C5orf66 TXNDC15 CAMLG JADE2 SEC24A ENSG00000270021 GC05M134654
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAMLG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAMLG gene promoter:

Genomic Locations for CAMLG Gene

Genomic Locations for CAMLG Gene
chr5:134,737,927-134,752,160
(GRCh38/hg38)
Size:
14,234 bases
Orientation:
Plus strand
chr5:134,074,170-134,087,850
(GRCh37/hg19)

Genomic View for CAMLG Gene

Genes around CAMLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMLG Gene

Proteins for CAMLG Gene

  • Protein details for CAMLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49069-CAMLG_HUMAN
    Recommended name:
    Calcium signal-modulating cyclophilin ligand
    Protein Accession:
    P49069
    Secondary Accessions:
    • A1L3Y3

    Protein attributes for CAMLG Gene

    Size:
    296 amino acids
    Molecular mass:
    32953 Da
    Quaternary structure:
    • The N-terminal domain binds to TNFRSF13B/TACI. Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.

neXtProt entry for CAMLG Gene

Post-translational modifications for CAMLG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMLG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMLG Gene

Domains & Families for CAMLG Gene

Gene Families for CAMLG Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CAMLG Gene

Suggested Antigen Peptide Sequences for CAMLG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAMLG: view

No data available for UniProtKB/Swiss-Prot for CAMLG Gene

Function for CAMLG Gene

Molecular function for CAMLG Gene

UniProtKB/Swiss-Prot Function:
Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.
GENATLAS Biochemistry:
calcium-modulating cyclophilin ligand,involved in the regulation of calcium signaling in T lymphocytes and other cells (signal transduction)

Phenotypes From GWAS Catalog for CAMLG Gene

Gene Ontology (GO) - Molecular Function for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15451437
genes like me logo Genes that share ontologies with CAMLG: view
genes like me logo Genes that share phenotypes with CAMLG: view

Animal Models for CAMLG Gene

MGI Knock Outs for CAMLG:

Animal Model Products

CRISPR Products

miRNA for CAMLG Gene

miRTarBase miRNAs that target CAMLG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMLG

Clone Products

  • Addgene plasmids for CAMLG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMLG Gene

Localization for CAMLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMLG Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMLG gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12919676
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CAMLG: view

Pathways & Interactions for CAMLG Gene

genes like me logo Genes that share pathways with CAMLG: view

Pathways by source for CAMLG Gene

1 GeneTex pathway for CAMLG Gene
1 GeneGo (Thomson Reuters) pathway for CAMLG Gene
1 Cell Signaling Technology pathway for CAMLG Gene

Gene Ontology (GO) - Biological Process for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IEA --
GO:0006952 defense response TAS 7522304
GO:0007165 signal transduction TAS 7522304
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CAMLG: view

No data available for SIGNOR curated interactions for CAMLG Gene

Drugs & Compounds for CAMLG Gene

(3) Drugs for CAMLG Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor, inhibitor, Target, binder Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
calcium Approved Nutra 0
CYCLOSPORINE A Pharma 0

(1) Additional Compounds for CAMLG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CAMLG: view

Transcripts for CAMLG Gene

mRNA/cDNA for CAMLG Gene

(200) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMLG Gene

Calcium modulating ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMLG

Clone Products

  • Addgene plasmids for CAMLG

Alternative Splicing Database (ASD) splice patterns (SP) for CAMLG Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4
SP1: -
SP2: - - -
SP3:
SP4: - - - -
SP5:

Relevant External Links for CAMLG Gene

GeneLoc Exon Structure for
CAMLG
ECgene alternative splicing isoforms for
CAMLG

Expression for CAMLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAMLG Gene

This gene is overexpressed in Bone (27.9) and Fetal Brain (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAMLG Gene



Protein tissue co-expression partners for CAMLG Gene

NURSA nuclear receptor signaling pathways regulating expression of CAMLG Gene:

CAMLG

SOURCE GeneReport for Unigene cluster for CAMLG Gene:

Hs.529846

mRNA Expression by UniProt/SwissProt for CAMLG Gene:

P49069-CAMLG_HUMAN
Tissue specificity: Ubiquitous. Highest levels in brain, testis and ovary.

Evidence on tissue expression from TISSUES for CAMLG Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CAMLG: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMLG Gene

Orthologs for CAMLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMLG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMLG 34 33
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CAMLG 34 33
  • 92.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CAMLG 34 33
  • 91.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Caml 16 34 33
  • 83.45 (n)
rat
(Rattus norvegicus)
Mammalia Camlg 33
  • 82.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CAMLG 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMLG 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMLG 34 33
  • 74.76 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMLG 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camlg 33
  • 65.91 (n)
Str.3785 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53900 33
zebrafish
(Danio rerio)
Actinopterygii camlg 34 33
  • 54.68 (n)
OneToOne
Species where no ortholog for CAMLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMLG Gene

ENSEMBL:
Gene Tree for CAMLG (if available)
TreeFam:
Gene Tree for CAMLG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAMLG: view image

Paralogs for CAMLG Gene

No data available for Paralogs for CAMLG Gene

Variants for CAMLG Gene

Sequence variations from dbSNP and Humsavar for CAMLG Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000686100 -- 134,740,335(+) A/G intron_variant
rs1000823516 -- 134,740,548(+) T/G intron_variant
rs1000970115 -- 134,738,194(+) GGGGGG/GGGGGGG 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001366238 -- 134,736,882(+) T/C upstream_transcript_variant
rs1001461849 -- 134,736,340(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CAMLG Gene

Variant ID Type Subtype PubMed ID
esv3575882 CNV gain 25503493
nsv830493 CNV loss 17160897

Variation tolerance for CAMLG Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMLG Gene

Human Gene Mutation Database (HGMD)
CAMLG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMLG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMLG Gene

Disorders for CAMLG Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMLG Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cogan-reese syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CAMLG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAMLG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CAMLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMLG Gene

Publications for CAMLG Gene

  1. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. (PMID: 8824814) Bram RJ … Copeland NG (Genomics 1996) 2 3 22 58
  2. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. (PMID: 7522304) Bram RJ … Crabtree GR (Nature 1994) 3 4 22 58
  3. WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane. (PMID: 24392163) Vilardi F … Schwappach B (PloS one 2014) 2 3 58
  4. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58

Products for CAMLG Gene

Sources for CAMLG Gene

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