CAMKK2 Gene (Protein Coding)

Calcium/Calmodulin Dependent Protein Kinase Kinase 2

GC12M121341
GIFtS:
47
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kina... See more...

Aliases for CAMKK2 Gene

Aliases for CAMKK2 Gene

  • Calcium/Calmodulin Dependent Protein Kinase Kinase 2 2 3 5
  • CAMKKB 2 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta 2 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 3 4
  • CaM-Kinase Kinase Beta 3 4
  • CaM-Kinase Kinase 2 3 4
  • CaM-KK Beta 3 4
  • CaM-KK 2 3 4
  • KIAA0787 2 4
  • CAMKK 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Beta 3
  • CAMKK Beta Protein 3
  • EC 2.7.11.17 4
  • CaMKK Beta 4
  • EC 2.7.11 51
  • MGC15254 2
  • CaMKK 2 4
  • CAMKK2 5

External Ids for CAMKK2 Gene

Previous GeneCards Identifiers for CAMKK2 Gene

  • GC12M120537
  • GC12M121255
  • GC12M121458
  • GC12M120087
  • GC12M120138
  • GC12M120159
  • GC12M121675
  • GC12M118685
  • GC12M121276
  • GC12M121309

Summaries for CAMKK2 Gene

Entrez Gene Summary for CAMKK2 Gene

  • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

GeneCards Summary for CAMKK2 Gene

CAMKK2 (Calcium/Calmodulin Dependent Protein Kinase Kinase 2) is a Protein Coding gene. Diseases associated with CAMKK2 include Parkinson Disease, Late-Onset. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Immune response Function of MEF2 in T lymphocytes. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is CAMKK1.

UniProtKB/Swiss-Prot Summary for CAMKK2 Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Tocris Summary for CAMKK2 Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMKK2 Gene

Additional gene information for CAMKK2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAMKK2 Gene

Genomics for CAMKK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CAMKK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAMKK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAMKK2

Top Transcription factor binding sites by QIAGEN in the CAMKK2 gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for CAMKK2 Gene

Latest Assembly
chr12:121,237,675-121,298,308
(GRCh38/hg38)
Size:
60,634 bases
Orientation:
Minus strand

Previous Assembly
chr12:121,675,495-121,735,622
(GRCh37/hg19 by Entrez Gene)
Size:
60,128 bases
Orientation:
Minus strand

chr12:121,675,497-121,736,111
(GRCh37/hg19 by Ensembl)
Size:
60,615 bases
Orientation:
Minus strand

Genomic View for CAMKK2 Gene

Genes around CAMKK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMKK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMKK2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CAMKK2 Gene

Proteins for CAMKK2 Gene

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  • Protein details for CAMKK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RR4-KKCC2_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 2
    Protein Accession:
    Q96RR4
    Secondary Accessions:
    • A8K7Q7
    • O94883
    • Q8IUG2
    • Q8IUG3
    • Q8N3I4
    • Q8WY03
    • Q8WY04
    • Q8WY05
    • Q8WY06
    • Q96RP1
    • Q96RP2
    • Q96RR3
    • Q9BWE9
    • Q9UER3
    • Q9UES2
    • Q9Y5N2

    Protein attributes for CAMKK2 Gene

    Size:
    588 amino acids
    Molecular mass:
    64746 Da
    Quaternary structure:
    • Interacts with calmodulin.
    SequenceCaution:
    • Sequence=AAC72943.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA34507.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD38990.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 1]: Major isoform.
    • [Isoform 2]: Major isoform.
    • [Isoform 5]: Inactive. Does not activate CAMK1 and CAMK4.
    • [Isoform 6]: Inactive. Does not activate CAMK1 and CAMK4.

    Three dimensional structures from OCA and Proteopedia for CAMKK2 Gene

    Alternative splice isoforms for CAMKK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMKK2 Gene

Protein Expression for CAMKK2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CAMKK2 Gene

Q96RR4:
  • DLITRML
  • GTPAFMAPE
  • GHIKIAD
  • GKGSYGVV

Post-translational modifications for CAMKK2 Gene

  • Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMKK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CAMKK2 Gene

Gene Families for CAMKK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CAMKK2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAMKK2 Gene

GenScript: Design optimal peptide antigens:
  • Calcium/calmodulin-dependent protein kinase kinase beta (KKCC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RR4

UniProtKB/Swiss-Prot:

KKCC2_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with CAMKK2: view

Function for CAMKK2 Gene

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Molecular function for CAMKK2 Gene

UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17;.
UniProtKB/Swiss-Prot Induction:
[Isoform 1]: Up-regulated by PKA pathway.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin (By similarity).
GENATLAS Biochemistry:
calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small cell lung cancer

Enzyme Numbers (IUBMB) for CAMKK2 Gene

Phenotypes From GWAS Catalog for CAMKK2 Gene

Gene Ontology (GO) - Molecular Function for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS 11395482
genes like me logo Genes that share ontologies with CAMKK2: view
genes like me logo Genes that share phenotypes with CAMKK2: view

Animal Models for CAMKK2 Gene

MGI Knock Outs for CAMKK2:

Animal Models for research

  • Taconic Biosciences Mouse Models for CAMKK2

Inhibitory RNAs for research

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Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMKK2 Gene

Localization for CAMKK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKK2 Gene

Nucleus. Cytoplasm. Cell projection, neuron projection. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000269 PubMed:21957496}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMKK2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CAMKK2: view

Pathways & Interactions for CAMKK2 Gene

PathCards logo

SuperPathways for CAMKK2 Gene

SuperPathway Contained pathways
1 AMP-activated Protein Kinase (AMPK) Signaling
AMPK signaling pathway
.40
AMP-activated Protein Kinase (AMPK) Signaling
.40
2 Immune response Function of MEF2 in T lymphocytes
Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
.36
Immune response Function of MEF2 in T lymphocytes
.36
3 Glucose / Energy Metabolism
Glucose / Energy Metabolism
-
4 Neuroscience
Neuroscience
-
5 Adipocytokine signaling pathway
Adipocytokine signaling pathway
-
genes like me logo Genes that share pathways with CAMKK2: view

Pathways by source for CAMKK2 Gene

1 BioSystems pathway for CAMKK2 Gene
4 GeneGo (Thomson Reuters) pathways for CAMKK2 Gene
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Immune response Function of MEF2 in T lymphocytes
  • Signal transduction Calcium signaling
  • Signal transduction IP3 signaling
2 Qiagen pathways for CAMKK2 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • IP3 Pathway
2 Cell Signaling Technology pathways for CAMKK2 Gene

SIGNOR curated interactions for CAMKK2 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 11395482
GO:0001934 positive regulation of protein phosphorylation IMP 26103054
GO:0006468 protein phosphorylation IDA 11395482
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with CAMKK2: view

Drugs & Compounds for CAMKK2 Gene

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(9) Drugs for CAMKK2 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra 0
Calcium Nutra 6876
A 484954 Pharma EEF2K Inhibitor, CaM kinase III (eEF-2 kinase) inhibitor 0
NH125 Pharma Selective eEF-2 kinase inhibitor, CaM kinase III (eEF-2 kinase) inhibitor 0

(3) Additional Compounds for CAMKK2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
Autocamtide-2-related inhibitory peptide, myristoylated
201422-04-0
KN 93
139298-40-1

(4) Tocris Compounds for CAMKK2 Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor 142557-61-7
Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide 201422-04-0
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
NH 125 CaM kinase III (eEF-2 kinase) inhibitor 278603-08-0
genes like me logo Genes that share compounds with CAMKK2: view

Transcripts for CAMKK2 Gene

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mRNA/cDNA for CAMKK2 Gene

9 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMKK2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - - -
SP12: -
SP13: -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - -
SP2:
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CAMKK2 Gene

GeneLoc Exon Structure for
CAMKK2

Expression for CAMKK2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAMKK2 Gene

mRNA expression in normal human tissues for CAMKK2 Gene
mRNA expression by BioGPS for CAMKK2 GenemRNA expression by GTEx for CAMKK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMKK2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.3) and Brain - Cerebellum (x7.2).

Protein differential expression in normal tissues from HIPED for CAMKK2 Gene

This gene is overexpressed in Lung (33.9) and Amniocyte (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAMKK2 Gene



Protein tissue co-expression partners for CAMKK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAMKK2

SOURCE GeneReport for Unigene cluster for CAMKK2 Gene:

Hs.297343

mRNA Expression by UniProt/SwissProt for CAMKK2 Gene:

Q96RR4-KKCC2_HUMAN
Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.

Evidence on tissue expression from TISSUES for CAMKK2 Gene

  • Nervous system(5)
  • Liver(4.5)
  • Stomach(4.4)
  • Muscle(2.6)
  • Blood(2.6)
  • Kidney(2.4)
  • Heart(2.4)
  • Lung(2.3)
  • Skin(2.3)
  • Intestine(2.2)
  • Spleen(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with CAMKK2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMKK2 Gene

Orthologs for CAMKK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMKK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CAMKK2 31
  • 99 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CAMKK2 31
  • 93 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CAMKK2 30 31
  • 90.88 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CAMKK2 30 31
  • 89.83 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Camkk2 30
  • 87.91 (n)
Mouse
(Mus musculus)
 Mammalia Camkk2 30 17 31
  • 87.09 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CAMKK2 31
  • 77 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CAMKK2 30 31
  • 79.1 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 74 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia camkk2 30
  • 71.3 (n)
Zebrafish
(Danio rerio)
 Actinopterygii CAMKK2 31
  • 69 (a)
 OneToOne
zgc:194737 30
  • 66.75 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002250 30
  • 60.11 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG17698 31 32
  • 33 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea ckk-1 30 31 32
  • 57.56 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TOS3 31 33
  • 22 (a)
 ManyToMany
SAK1 31
  • 13 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 48 (a)
 OneToMany
Species where no ortholog for CAMKK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAMKK2 Gene

ENSEMBL:
Gene Tree for CAMKK2 (if available)
TreeFam:
Gene Tree for CAMKK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAMKK2: view image

Paralogs for CAMKK2 Gene

Paralogs for CAMKK2 Gene

(38) SIMAP similar genes for CAMKK2 Gene using alignment to 5 proteins:

  • KKCC2_HUMAN
  • F5GZ00_HUMAN
  • F5H360_HUMAN
  • F5H4I7_HUMAN
  • Q8IZW1_HUMAN
genes like me logo Genes that share paralogs with CAMKK2: view

Variants for CAMKK2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAMKK2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
871740 Uncertain Significance: not provided 121,240,713(-) T/TGGCCTCCTCC
NM_001270485.2(CAMKK2):c.1743_1752dup (p.Met585fs) 		FRAMESHIFT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON
rs115336463 Benign: not provided 121,274,173(-) G/A
NM_001270485.2(CAMKK2):c.354C>T (p.Asn118=) 		SYNONYMOUS
rs1207121718 A colorectal adenocarcinoma sample p.Ala182Thr
rs139606987 Benign: not provided 121,255,566(-) G/A
NM_001270485.2(CAMKK2):c.891C>T (p.Ile297=) 		SYNONYMOUS
rs35407516 Benign: not provided 121,274,077(-) G/A
NM_001270485.2(CAMKK2):c.450C>T (p.His150=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CAMKK2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CAMKK2 Gene

Variant ID Type Subtype PubMed ID
esv1008629 CNV insertion 20482838
esv2660506 CNV deletion 23128226
esv2746484 CNV deletion 23290073
esv2746485 CNV deletion 23290073
esv3336861 CNV duplication 20981092
esv3630945 CNV loss 21293372
nsv1048801 CNV gain 25217958
nsv1054878 CNV gain 25217958
nsv455731 CNV loss 19166990
nsv513372 CNV insertion 21212237
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv560455 CNV gain 21841781
nsv560456 CNV loss 21841781
nsv952494 CNV deletion 24416366
nsv983372 CNV duplication 23825009

Variation tolerance for CAMKK2 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMKK2 Gene

Human Gene Mutation Database (HGMD)
CAMKK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMKK2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK2 Gene

Disorders for CAMKK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMKK2 Gene - From: COP

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CAMKK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CAMKK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMKK2 Gene

Publications for CAMKK2 Gene

  1. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PMID: 9662074) Hsu LS … Chen JY (Journal of biomedical science 1998) 2 3 4 23
  2. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PMID: 17197037) Erhardt A … Holsboer F (Journal of affective disorders 2007) 3 23 41
  3. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PMID: 12935886) Ishikawa Y … Kobayashi R (FEBS letters 2003) 3 4 23
  4. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PMID: 11395482) Hsu LS … Chen JY (The Journal of biological chemistry 2001) 3 4 23
  5. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PMID: 9822657) Anderson KA … Means AR (The Journal of biological chemistry 1998) 3 4 23

ExternalLinks

View latest publications for CAMKK2 gene in Mastermind

Products for CAMKK2 Gene