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Aliases for CAMKK2 Gene

Aliases for CAMKK2 Gene

  • Calcium/Calmodulin Dependent Protein Kinase Kinase 2 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta 2 4
  • CaM-Kinase Kinase Beta 3 4
  • CaM-Kinase Kinase 2 3 4
  • CaM-KK Beta 3 4
  • CaM-KK 2 3 4
  • CAMKKB 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Beta 3
  • CAMKK Beta Protein 3
  • EC 2.7.11.17 4
  • CaMKK Beta 4
  • EC 2.7.11 56
  • KIAA0787 4
  • CaMKK 2 4
  • CAMKK 3

External Ids for CAMKK2 Gene

Previous GeneCards Identifiers for CAMKK2 Gene

  • GC12M120537
  • GC12M121458
  • GC12M120087
  • GC12M120138
  • GC12M120159
  • GC12M121675
  • GC12M118685

Summaries for CAMKK2 Gene

Entrez Gene Summary for CAMKK2 Gene

  • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

GeneCards Summary for CAMKK2 Gene

CAMKK2 (Calcium/Calmodulin Dependent Protein Kinase Kinase 2) is a Protein Coding gene. Among its related pathways are Longevity regulating pathway and Immune response Function of MEF2 in T lymphocytes. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is CAMKK1.

UniProtKB/Swiss-Prot for CAMKK2 Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Tocris Summary for CAMKK2 Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMKK2 Gene

Additional gene information for CAMKK2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK2 Gene

Genomics for CAMKK2 Gene

GeneHancer (GH) Regulatory Elements for CAMKK2 Gene

Promoters and enhancers for CAMKK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I121295 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 562.1 +1.5 1500 3 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 E2F8 CAMKK2 UNC119B ANAPC5 ENSG00000272849 SETD1B RPL31P52 KDM2B C12orf43 LOC105370032
GH12I121274 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.3 +23.8 23816 0.1 CAMKK2 C12orf43 LOC105370032
GH12I121351 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.1 -54.1 -54077 2.7 MLX DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 ANAPC5 SETD1B PSMD9 CAMKK2 RNF34 SRSF9 MLXIP ENSG00000272849 ENSG00000258435
GH12I121276 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19 +20.0 20016 3.8 BATF YY1 SCRT2 ATF7 FOS IKZF2 RUNX3 SMARCA5 USF2 JUNB P2RX4 CAMKK2 OASL P2RX7 LOC105370032
GH12I121783 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.2 -497.7 -497684 24.5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000272849 SETD1B RHOF ZCCHC8 RSRC2 PSMD9 ANAPC5 KNTC1 LINC01089 HPD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAMKK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAMKK2 gene promoter:

Genomic Locations for CAMKK2 Gene

Genomic Locations for CAMKK2 Gene
chr12:121,237,691-121,298,308
(GRCh38/hg38)
Size:
60,618 bases
Orientation:
Minus strand
chr12:121,675,495-121,736,111
(GRCh37/hg19)

Genomic View for CAMKK2 Gene

Genes around CAMKK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMKK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMKK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKK2 Gene

Proteins for CAMKK2 Gene

  • Protein details for CAMKK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RR4-KKCC2_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 2
    Protein Accession:
    Q96RR4
    Secondary Accessions:
    • A8K7Q7
    • O94883
    • Q8IUG2
    • Q8IUG3
    • Q8N3I4
    • Q8WY03
    • Q8WY04
    • Q8WY05
    • Q8WY06
    • Q96RP1
    • Q96RP2
    • Q96RR3
    • Q9BWE9
    • Q9UER3
    • Q9UES2
    • Q9Y5N2

    Protein attributes for CAMKK2 Gene

    Size:
    588 amino acids
    Molecular mass:
    64746 Da
    Quaternary structure:
    • Interacts with calmodulin.
    SequenceCaution:
    • Sequence=AAC72943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34507.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38990.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMKK2 Gene

    Alternative splice isoforms for CAMKK2 Gene

neXtProt entry for CAMKK2 Gene

Selected DME Specific Peptides for CAMKK2 Gene

Q96RR4:
  • DLITRML
  • GTPAFMAPE
  • GHIKIAD
  • GKGSYGVV

Post-translational modifications for CAMKK2 Gene

  • Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CAMKK2 Gene

Gene Families for CAMKK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CAMKK2 Gene

Suggested Antigen Peptide Sequences for CAMKK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RR4

UniProtKB/Swiss-Prot:

KKCC2_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with CAMKK2: view

Function for CAMKK2 Gene

Molecular function for CAMKK2 Gene

GENATLAS Biochemistry:
calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small cell lung cancer
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin (By similarity).
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
UniProtKB/Swiss-Prot Induction:
Isoform 1 is up-regulated by PKA pathway.

Enzyme Numbers (IUBMB) for CAMKK2 Gene

Phenotypes From GWAS Catalog for CAMKK2 Gene

Gene Ontology (GO) - Molecular Function for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004683 calmodulin-dependent protein kinase activity IEA,IBA --
GO:0004713 protein tyrosine kinase activity TAS 11395482
genes like me logo Genes that share ontologies with CAMKK2: view
genes like me logo Genes that share phenotypes with CAMKK2: view

Animal Models for CAMKK2 Gene

MGI Knock Outs for CAMKK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMKK2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMKK2 Gene

Localization for CAMKK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKK2 Gene

Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMKK2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS,IMP 11395482
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CAMKK2: view

Pathways & Interactions for CAMKK2 Gene

genes like me logo Genes that share pathways with CAMKK2: view

SIGNOR curated interactions for CAMKK2 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CAMKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 11395482
GO:0001934 positive regulation of protein phosphorylation IMP 26103054
GO:0006468 protein phosphorylation IDA 11395482
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with CAMKK2: view

Drugs & Compounds for CAMKK2 Gene

(9) Drugs for CAMKK2 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
ATP Investigational Nutra Agonist 0
A 484954 Pharma EEF2K Inhibitor, CaM kinase III (eEF-2 kinase) inhibitor 0

(3) Additional Compounds for CAMKK2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Autocamtide-2-related inhibitory peptide, myristoylated
201422-04-0
KN 93
139298-40-1

(4) Tocris Compounds for CAMKK2 Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor 142557-61-7
Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide 201422-04-0
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
NH 125 CaM kinase III (eEF-2 kinase) inhibitor 278603-08-0
genes like me logo Genes that share compounds with CAMKK2: view

Transcripts for CAMKK2 Gene

Unigene Clusters for CAMKK2 Gene

Calcium/calmodulin-dependent protein kinase kinase 2, beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - - -
SP12: -
SP13: -
SP14: - - - - - -
SP15: - - - - -
SP16: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - -
SP2:
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CAMKK2 Gene

GeneLoc Exon Structure for
CAMKK2
ECgene alternative splicing isoforms for
CAMKK2

Expression for CAMKK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMKK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMKK2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.3) and Brain - Cerebellum (x7.2).

Protein differential expression in normal tissues from HIPED for CAMKK2 Gene

This gene is overexpressed in Lung (33.9) and Amniocyte (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMKK2 Gene



Protein tissue co-expression partners for CAMKK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAMKK2 Gene:

CAMKK2

SOURCE GeneReport for Unigene cluster for CAMKK2 Gene:

Hs.297343

mRNA Expression by UniProt/SwissProt for CAMKK2 Gene:

Q96RR4-KKCC2_HUMAN
Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.

Evidence on tissue expression from TISSUES for CAMKK2 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Stomach(4.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CAMKK2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMKK2 Gene

Orthologs for CAMKK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMKK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMKK2 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMKK2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMKK2 33 34
  • 90.88 (n)
cow
(Bos Taurus)
Mammalia CAMKK2 33 34
  • 89.83 (n)
rat
(Rattus norvegicus)
Mammalia Camkk2 33
  • 87.91 (n)
mouse
(Mus musculus)
Mammalia Camkk2 33 16 34
  • 87.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAMKK2 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMKK2 33 34
  • 79.1 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia camkk2 33
  • 71.3 (n)
zebrafish
(Danio rerio)
Actinopterygii CAMKK2 34
  • 69 (a)
OneToOne
zgc:194737 33
  • 66.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002250 33
  • 60.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17698 35 34
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea ckk-1 35 33 34
  • 57.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOS3 34 36
  • 22 (a)
ManyToMany
SAK1 34
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToMany
Species where no ortholog for CAMKK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMKK2 Gene

ENSEMBL:
Gene Tree for CAMKK2 (if available)
TreeFam:
Gene Tree for CAMKK2 (if available)

Paralogs for CAMKK2 Gene

Paralogs for CAMKK2 Gene

genes like me logo Genes that share paralogs with CAMKK2: view

Variants for CAMKK2 Gene

Sequence variations from dbSNP and Humsavar for CAMKK2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_040611 A lung neuroendocrine carcinoma sample p.Pro127Leu
VAR_040612 A colorectal adenocarcinoma sample p.Ala182Thr
rs1000002040 -- 121,293,020(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000022043 -- 121,289,807(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000047916 -- 121,248,896(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAMKK2 Gene

Variant ID Type Subtype PubMed ID
esv1008629 CNV insertion 20482838
esv2660506 CNV deletion 23128226
esv2746484 CNV deletion 23290073
esv2746485 CNV deletion 23290073
esv3336861 CNV duplication 20981092
esv3630945 CNV loss 21293372
nsv1048801 CNV gain 25217958
nsv1054878 CNV gain 25217958
nsv455731 CNV loss 19166990
nsv513372 CNV insertion 21212237
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv560455 CNV gain 21841781
nsv560456 CNV loss 21841781
nsv952494 CNV deletion 24416366
nsv983372 CNV duplication 23825009

Variation tolerance for CAMKK2 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMKK2 Gene

Human Gene Mutation Database (HGMD)
CAMKK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMKK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK2 Gene

Disorders for CAMKK2 Gene

Additional Disease Information for CAMKK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CAMKK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMKK2 Gene

Publications for CAMKK2 Gene

  1. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PMID: 9662074) Hsu LS … Chen JY (Journal of biomedical science 1998) 2 3 4 22 58
  2. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PMID: 17197037) Erhardt A … Holsboer F (Journal of affective disorders 2007) 3 22 44 58
  3. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PMID: 12935886) Ishikawa Y … Kobayashi R (FEBS letters 2003) 3 4 22 58
  4. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PMID: 11395482) Hsu LS … Chen JY (The Journal of biological chemistry 2001) 3 4 22 58
  5. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PMID: 9822657) Anderson KA … Means AR (The Journal of biological chemistry 1998) 3 4 22 58

Products for CAMKK2 Gene