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Aliases for CAMKK1 Gene

Aliases for CAMKK1 Gene

  • Calcium/Calmodulin Dependent Protein Kinase Kinase 1 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha 2 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha 2 3
  • CaM-Kinase Kinase Alpha 3 4
  • CaM-Kinase IV Kinase 3 4
  • CaM-Kinase Kinase 1 3 4
  • CaM-KK Alpha 3 4
  • CaM-KK 1 3 4
  • CaMKK 1 3 4
  • CAMKKA 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 3
  • CAMKK Alpha Protein 3
  • EC 2.7.11.17 4
  • CaMKK Alpha 4

External Ids for CAMKK1 Gene

Previous GeneCards Identifiers for CAMKK1 Gene

  • GC17M004076
  • GC17M003714
  • GC17M003970
  • GC17M003710
  • GC17M003763

Summaries for CAMKK1 Gene

Entrez Gene Summary for CAMKK1 Gene

  • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMKK1 Gene

CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are Post NMDA receptor activation events and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMKK2.

UniProtKB/Swiss-Prot for CAMKK1 Gene

  • Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Tocris Summary for CAMKK1 Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMKK1 Gene

Additional gene information for CAMKK1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK1 Gene

Genomics for CAMKK1 Gene

GeneHancer (GH) Regulatory Elements for CAMKK1 Gene

Promoters and enhancers for CAMKK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003885 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.7 +4.4 4355 10.9 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 CAMKK1 ANKFY1 MYBBP1A ENSG00000235085 PELP1 LOC105371492 P2RX1 OR1E2 OR3A4P OR1E3
GH17J003896 Enhancer 0.7 ENCODE dbSUPER 655.3 -1.7 -1727 1.1 ZNF341 SCRT2 PRDM10 ZIC2 ZNF423 CAMKK1 P2RX1 GC17P003894 GC17M003905
GH17J003944 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 12.1 -50.2 -50178 0.9 KLF1 ZNF777 ZNF837 KLF17 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 P2RX1 CAMKK1 SHPK CYB5D2 ATP2A3 GC17P003938
GH17J004001 Enhancer 1.3 Ensembl ENCODE 11.6 -108.8 -108817 3.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 LOC101927979 LOC105371492 ATP2A3 ANKFY1 CAMKK1 MYBBP1A CYB5D2 GC17P004012 GC17P004011 GC17M003990
GH17J003969 Enhancer 1.1 ENCODE dbSUPER 11.2 -74.5 -74471 0.9 HDAC1 PKNOX1 ATF1 ARNT NFRKB TCF12 POLR2B ZNF766 ATF7 CREM CAMKK1 ATP2A3 LINC01975
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAMKK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAMKK1 gene promoter:
  • Nkx5-1
  • AREB6
  • E47
  • Olf-1
  • ER-alpha

Genomic Locations for CAMKK1 Gene

Genomic Locations for CAMKK1 Gene
chr17:3,860,315-3,894,891
(GRCh38/hg38)
Size:
34,577 bases
Orientation:
Minus strand
chr17:3,763,609-3,798,185
(GRCh37/hg19)
Size:
34,577 bases
Orientation:
Minus strand

Genomic View for CAMKK1 Gene

Genes around CAMKK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMKK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMKK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKK1 Gene

Proteins for CAMKK1 Gene

  • Protein details for CAMKK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5S9-KKCC1_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 1
    Protein Accession:
    Q8N5S9
    Secondary Accessions:
    • Q9BQH3

    Protein attributes for CAMKK1 Gene

    Size:
    505 amino acids
    Molecular mass:
    55735 Da
    Quaternary structure:
    • Interacts with CAMK4 and calmodulin.

    Three dimensional structures from OCA and Proteopedia for CAMKK1 Gene

    Alternative splice isoforms for CAMKK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMKK1 Gene

Post-translational modifications for CAMKK1 Gene

  • Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMKK1 Gene

Domains & Families for CAMKK1 Gene

Gene Families for CAMKK1 Gene

Protein Domains for CAMKK1 Gene

Suggested Antigen Peptide Sequences for CAMKK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5S9

UniProtKB/Swiss-Prot:

KKCC1_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with CAMKK1: view

Function for CAMKK1 Gene

Molecular function for CAMKK1 Gene

UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.

Enzyme Numbers (IUBMB) for CAMKK1 Gene

Phenotypes From GWAS Catalog for CAMKK1 Gene

Gene Ontology (GO) - Molecular Function for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004683 calmodulin-dependent protein kinase activity TAS --
GO:0005515 protein binding IPI 18242179
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with CAMKK1: view
genes like me logo Genes that share phenotypes with CAMKK1: view

Animal Models for CAMKK1 Gene

MGI Knock Outs for CAMKK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMKK1

CRISPR Products

miRNA for CAMKK1 Gene

miRTarBase miRNAs that target CAMKK1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMKK1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMKK1 Gene

Localization for CAMKK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKK1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMKK1 gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAMKK1: view

Pathways & Interactions for CAMKK1 Gene

genes like me logo Genes that share pathways with CAMKK1: view

SIGNOR curated interactions for CAMKK1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with CAMKK1: view

Drugs & Compounds for CAMKK1 Gene

(5) Drugs for CAMKK1 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
calcium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
A 484954 Pharma EEF2K Inhibitor, CaM kinase III (eEF-2 kinase) inhibitor 0
NH125 Pharma Selective eEF-2 kinase inhibitor, CaM kinase III (eEF-2 kinase) inhibitor 0

(3) Additional Compounds for CAMKK1 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Autocamtide-2-related inhibitory peptide, myristoylated
201422-04-0
KN 93
139298-40-1

(4) Tocris Compounds for CAMKK1 Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor 142557-61-7
Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide 201422-04-0
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
NH 125 CaM kinase III (eEF-2 kinase) inhibitor 278603-08-0
genes like me logo Genes that share compounds with CAMKK1: view

Transcripts for CAMKK1 Gene

Unigene Clusters for CAMKK1 Gene

Calcium/calmodulin-dependent protein kinase kinase 1, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMKK1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK1 Gene

No ASD Table

Relevant External Links for CAMKK1 Gene

GeneLoc Exon Structure for
CAMKK1
ECgene alternative splicing isoforms for
CAMKK1

Expression for CAMKK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMKK1 Gene

mRNA differential expression in normal tissues according to GTEx for CAMKK1 Gene

This gene is overexpressed in Brain - Cortex (x5.2) and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for CAMKK1 Gene

This gene is overexpressed in Lung (51.2) and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAMKK1 Gene



Protein tissue co-expression partners for CAMKK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMKK1 Gene:

CAMKK1

SOURCE GeneReport for Unigene cluster for CAMKK1 Gene:

Hs.8417

Evidence on tissue expression from TISSUES for CAMKK1 Gene

  • Nervous system(4.4)
  • Liver(4)
genes like me logo Genes that share expression patterns with CAMKK1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMKK1 Gene

Orthologs for CAMKK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMKK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMKK1 34 33
  • 97.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CAMKK1 34 33
  • 90.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CAMKK1 34 33
  • 89.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Camkk1 16 34 33
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia Camkk1 33
  • 88.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAMKK1 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMKK1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMKK1 34 33
  • 70.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMKK1 34
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia CaM-KK 33
zebrafish
(Danio rerio)
Actinopterygii camkk1 34 33
  • 70.58 (n)
OneToMany
CAMKK1 (1 of 2) 34
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17698 34 33
  • 50.63 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ckk-1 34
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOS3 34
  • 21 (a)
ManyToMany
SAK1 36 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Species where no ortholog for CAMKK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAMKK1 Gene

ENSEMBL:
Gene Tree for CAMKK1 (if available)
TreeFam:
Gene Tree for CAMKK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAMKK1: view image

Paralogs for CAMKK1 Gene

Paralogs for CAMKK1 Gene

(21) SIMAP similar genes for CAMKK1 Gene using alignment to 3 proteins:

  • KKCC1_HUMAN
  • F8W9H1_HUMAN
  • J3KPJ3_HUMAN
genes like me logo Genes that share paralogs with CAMKK1: view

Variants for CAMKK1 Gene

Sequence variations from dbSNP and Humsavar for CAMKK1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000002416 -- 3,879,303(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000119243 -- 3,887,561(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000205315 -- 3,893,083(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000227626 -- 3,860,819(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000232169 -- 3,874,137(-) CAGACA/CA genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAMKK1 Gene

Variant ID Type Subtype PubMed ID
dgv405e201 CNV deletion 23290073
dgv406e201 CNV deletion 23290073
esv1243821 CNV deletion 17803354
esv2150356 CNV deletion 18987734
esv2662233 CNV deletion 23128226
esv2662801 CNV deletion 23128226
esv2715534 CNV deletion 23290073
esv2715535 CNV deletion 23290073
esv2761940 CNV gain 21179565
esv28673 CNV gain 19812545
esv3438240 CNV insertion 20981092
esv3554025 CNV deletion 23714750
esv3639757 CNV loss 21293372
esv3639758 CNV gain 21293372
esv3639759 CNV loss 21293372
esv992121 CNV deletion 20482838
esv998088 CNV deletion 20482838
nsv1055740 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv1070379 CNV deletion 25765185
nsv1135824 CNV deletion 24896259
nsv469791 CNV loss 16826518
nsv512473 CNV loss 21212237
nsv521340 CNV gain 19592680
nsv524296 CNV loss 19592680
nsv526126 CNV loss 19592680
nsv820660 CNV deletion 20802225
nsv833343 CNV loss 17160897

Variation tolerance for CAMKK1 Gene

Residual Variation Intolerance Score: 9.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.43; 94.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMKK1 Gene

Human Gene Mutation Database (HGMD)
CAMKK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMKK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK1 Gene

Disorders for CAMKK1 Gene

Additional Disease Information for CAMKK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CAMKK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMKK1 Gene

Publications for CAMKK1 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  3. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. (PMID: 20106900) Truong T … Hung RJ (Carcinogenesis 2010) 3 44 58
  4. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N … Bergen AW (PloS one 2009) 3 44 58
  5. Variants in the GH-IGF axis confer susceptibility to lung cancer. (PMID: 16741161) Rudd MF … GELCAPS Consortium (Genome research 2006) 3 44 58

Products for CAMKK1 Gene

Sources for CAMKK1 Gene

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