The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008] See more...

Aliases for CAMK4 Gene

Aliases for CAMK4 Gene

  • Calcium/Calmodulin Dependent Protein Kinase IV 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain 2 3
  • Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type IV 3 4
  • CAM Kinase- GR 2 3
  • CAM Kinase IV 2 3
  • CaMK IV 3 4
  • CaMK-GR 2 3
  • CaMKIV 2 3
  • Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV 3
  • CaM Kinase-GR 4
  • EC 2.7.11.17 4
  • EC 2.7.11 51
  • CAMK-GR 4
  • CAMKIV 4
  • CAMK4 5
  • CaMK 3
  • CAMK 4

External Ids for CAMK4 Gene

Previous GeneCards Identifiers for CAMK4 Gene

  • GC05P110183
  • GC05P111005
  • GC05P110590
  • GC05P110636
  • GC05P110587
  • GC05P105739

Summaries for CAMK4 Gene

Entrez Gene Summary for CAMK4 Gene

  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK4 Gene

CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV) is a Protein Coding gene. Diseases associated with CAMK4 include Cerebral Hypoxia and Gingival Fibromatosis. Among its related pathways are DAG and IP3 signaling and Neuroscience. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK3.

UniProtKB/Swiss-Prot Summary for CAMK4 Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Gene Wiki entry for CAMK4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAMK4 Gene

Genomics for CAMK4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAMK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J111223 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 620.9 +7.9 7911 17 CREB1 PRDM10 ZNF629 ZNF692 POLR2A BACH1 LARP7 PRDM1 ZIC2 ZSCAN4 CAMK4 WDR36 RPS3AP21 TSLP ENSG00000249318 RF00017-4819 STARD4
GH05J111222 Enhancer 0.3 Ensembl dbSUPER 600.7 -1.4 -1382 0.4 CAMK4 TSLP ENSG00000249318 RPS3AP21 WDR36 RF00017-4819
GH05J111251 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +29.5 29518 7 SP1 CREB1 ZNF629 POLR2A BACH1 STAT3 ZNF143 RELA ZSCAN4 PKNOX1 CAMK4 TSLP TMEM232 WDR36 ENSG00000249318 RF00017-4819 STARD4
GH05J112109 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 4.3 +885.1 885118 5 REST IKZF2 SP1 PKNOX1 DPF2 JUND CEBPB RUNX3 IKZF1 RFX5 lnc-NREP-7 NREP EPB41L4A CAMK4 piR-36746-028
GH05J111247 Enhancer 0.8 Ensembl dbSUPER 5.5 +24.8 24818 1.6 PRDM1 RUNX3 OSR2 ZBTB17 RCOR1 JUND PRDM6 SMARCA4 CHD2 HSF1 ENSG00000249318 TSLP CAMK4 RF00017-4819 STARD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAMK4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAMK4

Top Transcription factor binding sites by QIAGEN in the CAMK4 gene promoter:
  • AhR
  • AML1a
  • CREB
  • deltaCREB
  • FAC1
  • HFH-1
  • Nkx2-5
  • Pax-3
  • Pax-4a
  • Pbx1a

Genomic Locations for CAMK4 Gene

Genomic Locations for CAMK4 Gene
chr5:111,223,583-111,498,503
(GRCh38/hg38)
Size:
274,921 bases
Orientation:
Plus strand
chr5:110,559,351-110,830,584
(GRCh37/hg19)
Size:
271,234 bases
Orientation:
Plus strand

Genomic View for CAMK4 Gene

Genes around CAMK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK4 Gene

Proteins for CAMK4 Gene

  • Protein details for CAMK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16566-KCC4_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type IV
    Protein Accession:
    Q16566
    Secondary Accessions:
    • D3DSZ7

    Protein attributes for CAMK4 Gene

    Size:
    473 amino acids
    Molecular mass:
    51926 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
    SequenceCaution:
    • Sequence=AAH16695.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK4 Gene

neXtProt entry for CAMK4 Gene

Selected DME Specific Peptides for CAMK4 Gene

Q16566:
  • AKDLVRK
  • HPNIIKL
  • VTGGELF
  • GGELFDR
  • LKPENLL
  • RDLKPEN
  • FNARRKL
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for CAMK4 Gene

  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
  • Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
  • Glycosylation at Thr57, Ser58, Ser137, Ser189, Ser344, Ser345, and Ser356
  • Ubiquitination at Lys190 and Lys303
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CAMK4

Protein Products

  • Signalway Proteins for CAMK4
  • Abcam proteins for CAMK4

Domains & Families for CAMK4 Gene

Gene Families for CAMK4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CAMK4 Gene

Suggested Antigen Peptide Sequences for CAMK4 Gene

GenScript: Design optimal peptide antigens:
  • CaM kinase-GR (KCC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16566

UniProtKB/Swiss-Prot:

KCC4_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK4: view

Function for CAMK4 Gene

Molecular function for CAMK4 Gene

UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
GENATLAS Biochemistry:
protein kinase,type IV,calcium/calmodulin dependent,brain

Enzyme Numbers (IUBMB) for CAMK4 Gene

Phenotypes From GWAS Catalog for CAMK4 Gene

Gene Ontology (GO) - Molecular Function for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004683 calmodulin-dependent protein kinase activity IDA 8107230
GO:0005516 calmodulin binding IBA 21873635
genes like me logo Genes that share ontologies with CAMK4: view
genes like me logo Genes that share phenotypes with CAMK4: view

Animal Models for CAMK4 Gene

MGI Knock Outs for CAMK4:

Animal Model Products

CRISPR Products

miRNA for CAMK4 Gene

miRTarBase miRNAs that target CAMK4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMK4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK4 Gene

Localization for CAMK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK4 Gene

Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMK4 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 4
mitochondrion 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CAMK4: view

Pathways & Interactions for CAMK4 Gene

genes like me logo Genes that share pathways with CAMK4: view

Pathways by source for CAMK4 Gene

6 GeneGo (Thomson Reuters) pathways for CAMK4 Gene
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Immune response Function of MEF2 in T lymphocytes
  • Signal transduction Calcium signaling
  • Signal transduction cAMP signaling
  • Signal transduction IP3 signaling
16 Qiagen pathways for CAMK4 Gene
  • Activation of cAMP-Dependent PKA
  • Alpha-Adrenergic Signaling
  • BMP Pathway
  • Breast Cancer Regulation by Stathmin1
  • cAMP Pathway
2 Cell Signaling Technology pathways for CAMK4 Gene

SIGNOR curated interactions for CAMK4 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002372 NOT myeloid dendritic cell cytokine production IMP 17909078
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IEA,TAS 8089075
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CAMK4: view

Drugs & Compounds for CAMK4 Gene

(13) Drugs for CAMK4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one Experimental Pharma Target 0
K-00546 Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
Calcium Nutra 6556

(3) Additional Compounds for CAMK4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with CAMK4: view

Transcripts for CAMK4 Gene

mRNA/cDNA for CAMK4 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMK4

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2:
SP3:

Relevant External Links for CAMK4 Gene

GeneLoc Exon Structure for
CAMK4

Expression for CAMK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAMK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.4), Brain - Cerebellum (x11.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CAMK4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Lymph node (14.7), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAMK4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAMK4

SOURCE GeneReport for Unigene cluster for CAMK4 Gene:

Hs.591269

mRNA Expression by UniProt/SwissProt for CAMK4 Gene:

Q16566-KCC4_HUMAN
Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

Evidence on tissue expression from TISSUES for CAMK4 Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Liver(4.3)
  • Lung(4.3)
  • Spleen(2.1)
  • Muscle(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CAMK4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK4 Gene

Orthologs for CAMK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMK4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CAMK4 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAMK4 30 31
  • 90.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CAMK4 30 31
  • 85.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Camk4 30 17 31
  • 83.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Camk4 30
  • 82.51 (n)
Oppossum
(Monodelphis domestica)
Mammalia CAMK4 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CAMK4 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CAMK4 30 31
  • 76.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAMK4 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia camk4 30
  • 76.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia camk4-A 30
Zebrafish
(Danio rerio)
Actinopterygii camk4 30 31
  • 72.07 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CaMKI 31
  • 36 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cmk-1 31
  • 42 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 31
  • 29 (a)
ManyToMany
CMK2 31
  • 26 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.9956 30
Species where no ortholog for CAMK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAMK4 Gene

ENSEMBL:
Gene Tree for CAMK4 (if available)
TreeFam:
Gene Tree for CAMK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAMK4: view image

Paralogs for CAMK4 Gene

Paralogs for CAMK4 Gene

(42) SIMAP similar genes for CAMK4 Gene using alignment to 4 proteins:

  • KCC4_HUMAN
  • D6RCD6_HUMAN
  • D6RE65_HUMAN
  • D6REY7_HUMAN
genes like me logo Genes that share paralogs with CAMK4: view

Variants for CAMK4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAMK4 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
729717 Benign: not provided 111,446,758(+) G/A MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
776053 Benign: not provided 111,484,438(+) A/G MISSENSE_VARIANT
783442 Benign: not provided 111,484,418(+) T/G SYNONYMOUS_VARIANT
rs1239950009 A lung large cell carcinoma sample p.Ile469Met
rs1561515242 Conflicting Interpretations: Intellectual disability; Involuntary movements; not provided 111,482,938(+) G/A SPLICE_DONOR_VARIANT

Additional dbSNP identifiers (rs#s) for CAMK4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAMK4 Gene

Variant ID Type Subtype PubMed ID
dgv1038e199 CNV deletion 23128226
dgv3148n106 CNV deletion 24896259
esv1341497 CNV deletion 17803354
esv2313843 CNV deletion 18987734
esv2647908 CNV deletion 19546169
esv2730592 CNV deletion 23290073
esv29054 CNV loss 19812545
esv3304986 CNV mobile element insertion 20981092
esv3307644 CNV mobile element insertion 20981092
esv3380070 CNV insertion 20981092
esv3416809 CNV insertion 20981092
esv3451295 CNV insertion 20981092
esv3566453 CNV deletion 23714750
esv3570341 CNV loss 25503493
esv3606259 CNV loss 21293372
esv3606265 CNV loss 21293372
esv3606267 CNV loss 21293372
esv3606269 CNV loss 21293372
esv3606270 CNV loss 21293372
esv3606274 CNV loss 21293372
esv4209 CNV loss 18987735
esv8952 CNV loss 19470904
nsv1073480 CNV deletion 25765185
nsv1076589 CNV duplication 25765185
nsv1150235 CNV duplication 26484159
nsv1153730 CNV deletion 26484159
nsv328700 CNV deletion 16902084
nsv518727 CNV gain 19592680
nsv823173 CNV loss 20364138
nsv823174 CNV loss 20364138
nsv830449 CNV gain+loss 17160897
nsv955749 CNV deletion 24416366

Variation tolerance for CAMK4 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMK4 Gene

Human Gene Mutation Database (HGMD)
CAMK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK4 Gene

Disorders for CAMK4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CAMK4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral hypoxia
  • brain hypoxia
gingival fibromatosis
  • fibromatosis, gingival, hereditary
lung large cell carcinoma
  • large cell carcinoma of lung
crouzon syndrome with acanthosis nigricans
  • can
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards
Search CAMK4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAMK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CAMK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK4 Gene

Publications for CAMK4 Gene

  1. Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PMID: 15143065) Anderson KA … Means AR (The Journal of biological chemistry 2004) 3 4 23
  2. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PMID: 8855261) Enslen H … Soderling TR (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23
  3. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PMID: 8107230) Mosialos G … Chatila TA (Journal of virology 1994) 3 4 23
  4. The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus. (PMID: 8194751) Bland MM … Ohmstede CA (Gene 1994) 3 4 23
  5. cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PMID: 8089075) Kitani T … Fujisawa H (Journal of biochemistry 1994) 3 4 23

Products for CAMK4 Gene

  • Signalway Proteins for CAMK4

Sources for CAMK4 Gene