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Aliases for CAMK2N2 Gene

Aliases for CAMK2N2 Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2 2 3 5
  • CaM-KII Inhibitory Protein 3 4
  • CAM-KIIN 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 3
  • CAMKIIN 3

External Ids for CAMK2N2 Gene

Previous GeneCards Identifiers for CAMK2N2 Gene

  • GC03M185461
  • GC03M183977
  • GC03M181384

Summaries for CAMK2N2 Gene

Entrez Gene Summary for CAMK2N2 Gene

  • This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK2N2 Gene

CAMK2N2 (Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N1.

UniProtKB/Swiss-Prot for CAMK2N2 Gene

  • Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

Additional gene information for CAMK2N2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2N2 Gene

Genomics for CAMK2N2 Gene

GeneHancer (GH) Regulatory Elements for CAMK2N2 Gene

Promoters and enhancers for CAMK2N2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I184261 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 553.6 -0.7 -725 2.4 ARID4B ZNF76 FEZF1 ZNF48 ZNF335 GLIS2 EGR1 ZNF366 SCRT2 ZNF391 CAMK2N2 VWA5B2 DVL3 RPS3P3 POLR2H EIF2B5 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 PSMD2
GH03I184171 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.4 +86.3 86301 8 HDGF ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 FOS AP2M1 VWA5B2 ABCF3 EIF2B5 DVL3 ALG3 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 MIR1224
GH03I184184 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +75.4 75366 3.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B ZNF766 ABCF3 VWA5B2 POLR2H EIF2B5 ALG3 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 MIR1224 CAMK2N2
GH03I184154 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.6 +105.1 105066 4.2 HDGF FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF121 GLIS2 ELK1 ZNF143 DVL3 EIF2B5 RPS3P3 POLR2H ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 ALG3 ABCF3 CAMK2N2
GH03I184015 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 9.6 +244.5 244461 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ABCC5 YEATS2 HTR3C EIF2B5 AP2M1 ALG3 CAMK2N2 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CAMK2N2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAMK2N2 gene promoter:

Genomic Locations for CAMK2N2 Gene

Genomic Locations for CAMK2N2 Gene
chr3:184,259,213-184,261,463
(GRCh38/hg38)
Size:
2,251 bases
Orientation:
Minus strand
chr3:183,977,001-183,979,251
(GRCh37/hg19)

Genomic View for CAMK2N2 Gene

Genes around CAMK2N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2N2 Gene

Proteins for CAMK2N2 Gene

  • Protein details for CAMK2N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S95-CK2N2_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase II inhibitor 2
    Protein Accession:
    Q96S95

    Protein attributes for CAMK2N2 Gene

    Size:
    79 amino acids
    Molecular mass:
    8658 Da
    Quaternary structure:
    • Interacts with CAMK2A and CAMK2B in the presence of Ca(2+)/calmodulin or after autophosphorylation.

neXtProt entry for CAMK2N2 Gene

Post-translational modifications for CAMK2N2 Gene

No Post-translational modifications

Other Protein References for CAMK2N2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMK2N2 Gene

Domains & Families for CAMK2N2 Gene

Gene Families for CAMK2N2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAMK2N2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAMK2N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S95

UniProtKB/Swiss-Prot:

CK2N2_HUMAN :
  • The inhibitory domain blocks CAMK2 binding to GRIN2B.
  • Belongs to the CAMK2N family.
Domain:
  • The inhibitory domain blocks CAMK2 binding to GRIN2B.
Family:
  • Belongs to the CAMK2N family.
genes like me logo Genes that share domains with CAMK2N2: view

Function for CAMK2N2 Gene

Molecular function for CAMK2N2 Gene

UniProtKB/Swiss-Prot Function:
Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

Gene Ontology (GO) - Molecular Function for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008427 calcium-dependent protein kinase inhibitor activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view
genes like me logo Genes that share phenotypes with CAMK2N2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAMK2N2 Gene

Localization for CAMK2N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2N2 Gene

Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMK2N2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view

Pathways & Interactions for CAMK2N2 Gene

SuperPathways for CAMK2N2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view

No data available for Pathways by source and SIGNOR curated interactions for CAMK2N2 Gene

Drugs & Compounds for CAMK2N2 Gene

No Compound Related Data Available

Transcripts for CAMK2N2 Gene

mRNA/cDNA for CAMK2N2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMK2N2 Gene

Calcium/calmodulin-dependent protein kinase II inhibitor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2N2 Gene

No ASD Table

Relevant External Links for CAMK2N2 Gene

GeneLoc Exon Structure for
CAMK2N2
ECgene alternative splicing isoforms for
CAMK2N2

Expression for CAMK2N2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMK2N2 Gene

mRNA differential expression in normal tissues according to GTEx for CAMK2N2 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.3), Brain - Cerebellum (x5.3), Brain - Cerebellar Hemisphere (x5.0), and Brain - Amygdala (x4.7).

Protein differential expression in normal tissues from HIPED for CAMK2N2 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAMK2N2 Gene



Protein tissue co-expression partners for CAMK2N2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMK2N2 Gene:

CAMK2N2

SOURCE GeneReport for Unigene cluster for CAMK2N2 Gene:

Hs.585003

mRNA Expression by UniProt/SwissProt for CAMK2N2 Gene:

Q96S95-CK2N2_HUMAN
Tissue specificity: Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitts lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells.

Evidence on tissue expression from TISSUES for CAMK2N2 Gene

  • Nervous system(4.5)
  • Blood(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with CAMK2N2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK2N2 Gene

Orthologs for CAMK2N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMK2N2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK2N2 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia CAMK2N2 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMK2N2 33 34
  • 97.05 (n)
dog
(Canis familiaris)
Mammalia CAMK2N2 33 34
  • 96.2 (n)
rat
(Rattus norvegicus)
Mammalia Camk2n2 33
  • 96.2 (n)
mouse
(Mus musculus)
Mammalia Camk2n2 33 16 34
  • 95.36 (n)
chicken
(Gallus gallus)
Aves LOC101747380 33
  • 84.52 (n)
lizard
(Anolis carolinensis)
Reptilia CAMK2N2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2n2 33
  • 75.11 (n)
zebrafish
(Danio rerio)
Actinopterygii camk2n2 34
  • 73 (a)
OneToMany
camk2n1a 33 34
  • 72.15 (n)
Species where no ortholog for CAMK2N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMK2N2 Gene

ENSEMBL:
Gene Tree for CAMK2N2 (if available)
TreeFam:
Gene Tree for CAMK2N2 (if available)

Paralogs for CAMK2N2 Gene

Paralogs for CAMK2N2 Gene

(1) SIMAP similar genes for CAMK2N2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAMK2N2: view

Variants for CAMK2N2 Gene

Sequence variations from dbSNP and Humsavar for CAMK2N2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1002374443 -- 184,263,370(-) A/G upstream_transcript_variant
rs1002762361 -- 184,260,473(-) A/G intron_variant
rs1002792509 -- 184,260,144(-) C/G 3_prime_UTR_variant
rs1002941412 -- 184,260,323(-) G/A intron_variant
rs1002992139 -- 184,259,496(-) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2N2 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV loss 17160897
nsv592666 CNV loss 21841781
nsv528639 CNV loss 19592680
nsv4146 CNV insertion 18451855
nsv1074644 CNV deletion 25765185

Variation tolerance for CAMK2N2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAMK2N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMK2N2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2N2 Gene

Disorders for CAMK2N2 Gene

Additional Disease Information for CAMK2N2

No disorders were found for CAMK2N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMK2N2 Gene

Publications for CAMK2N2 Gene

  1. Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells. (PMID: 11444830) Zhang J … Cao X (Biochemical and biophysical research communications 2001) 2 3 4 22 58
  2. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. (PMID: 19586909) Ma S … Cao X (The Journal of biological chemistry 2009) 3 22 58
  3. Characterization of a calmodulin kinase II inhibitor protein in brain. (PMID: 9724800) Chang BH … Soderling TR (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 58
  4. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. (PMID: 23545117) Convertini P … Stamm S (Biochimica et biophysica acta 2013) 3 58
  5. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. (PMID: 23153928) Esteras N … Martín-Requero A (Neurobiology of aging 2013) 3 58

Products for CAMK2N2 Gene

Sources for CAMK2N2 Gene

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