Aliases for CAMK2A Gene
- Calcium/Calmodulin Dependent Protein Kinase II Alpha 2 3 5
- Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha 3 4
- Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
- Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
- CaM Kinase II Alpha Subunit 2 3
- CaM Kinase II Subunit Alpha 3 4
- CaM-Kinase II Alpha Chain 2 3
- CaMK-II Alpha Subunit 2 3
- CaMK-II Subunit Alpha 3 4
External Ids for CAMK2A Gene
Previous HGNC Symbols for CAMK2A Gene
Previous GeneCards Identifiers for CAMK2A Gene
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]
GeneCards Summary for CAMK2A Gene
CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include Mental Retardation, Autosomal Recessive 63 and Mental Retardation, Autosomal Dominant 53. Among its related pathways are Neuroscience and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.
UniProtKB/Swiss-Prot Summary for CAMK2A Gene
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.