Aliases for CAMK2A Gene
- Calcium/Calmodulin Dependent Protein Kinase II Alpha 2 3 5
- Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
- Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
- Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
- CaM Kinase II Subunit Alpha 3 4
- CaM Kinase II Alpha Subunit 2 3
- CaM-Kinase II Alpha Chain 2 3
- CaMK-II Subunit Alpha 3 4
External Ids for CAMK2A Gene
Previous HGNC Symbols for CAMK2A Gene
Previous GeneCards Identifiers for CAMK2A Gene
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for CAMK2A Gene
CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include Mental Retardation, Autosomal Dominant 53 and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.
UniProtKB/Swiss-Prot for CAMK2A Gene
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on Ser-298 (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.