Aliases for CAMK1D Gene
External Ids for CAMK1D Gene
Previous GeneCards Identifiers for CAMK1D Gene
This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
GeneCards Summary for CAMK1D Gene
CAMK1D (Calcium/Calmodulin Dependent Protein Kinase ID) is a Protein Coding gene. Diseases associated with CAMK1D include Ceroid Lipofuscinosis, Neuronal, 6 and Wolfram Syndrome 1. Among its related pathways are Oxytocin signaling pathway and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK1.
UniProtKB/Swiss-Prot Summary for CAMK1D Gene
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.